• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.4
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• pp.1266-1285
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• 2022

Compact E-cash is the first scheme which can withdraw 2^l coins within 𝒪(1) operations and then store them in 𝒪(𝑙) bits. Because of its high efficiency, a lot of research has been carried out on its basis, but no previous research pay attention to the privacy of payees and in some cases, payees have the same privacy requirement as payers. We propose a double-blind compact E-cash scheme, which means that both the payer and the payee can keep anonymous while spending. In our scheme, the payer and the bank cannot determine whether the payees of two different transactions are the same one and connect the payee with transactions related to him, in this way, the privacy of the payee is protected. And our protocols disconnect the received coin from previous transaction, then, the coin can be transferred into an unspent coin which belongs to the payee. The proposed e-cash scheme is secure within y-DDHI and LRSW assumption.

• BMB Reports
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• v.43 no.4
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• pp.291-296
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• 2010

Cyclin-dependent kinase 2 (CDK2) is a member of serine/threonine protein kinases, which initiates the principal transitions of the eukaryotic cell cycle and is a promising target for cancer therapy. The present study was designed to inhibit cdk2 gene expression to induce cell cycle arrest and cell proliferation suppression. Here, we constructed a series of RNA interference (RNAi) plasmids which can successfully express small interference RNA (siRNA) in the transfected human cells. The results showed that the RNAi plasmids containing the coding sequences for siRNAs down-regulated the cdk2 gene expression in human cancer cells at the mRNA and the protein levels. Furthermore, we found that the cell cycle was arrested at G0G1 phases and the cell proliferation was inhibited by different siRNAs. These results demonstrate that suppression of CDK2 activity by RNAi may be an effective strategy for gene therapy in human cancers.

• Journal of Applied Biological Chemistry
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• v.58 no.4
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• pp.363-368
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• 2015

The pharmacokinetics of florfenicol were studied in healthy and vibriosis-infected large yellow croaker (Pseudosciaena crocea) following administration of a single oral dose of $20mg{\cdot}kg^{-1}$ at $25{\pm}2^{\circ}C$. After oral administration, florfenicol levels in tissues (liver, kidney, muscle, serum, and skin) were analyzed using high-performance liquid chromatography. A two-compartment open model was used to describe the pharmacokinetics of florfenicol following oral administration. Compared to the healthy group, the absorption rate of vibriosis-infected fish significantly decreased, peak-time ($T_{max}$) delayed, maximum concentration ($C_{max}$) declined, total body clearance decreased, the elimination half-life ($T_{1/2{\beta}}$) was extended, and the area under the curve increased. These results indicate that a $20mg{\cdot}kg^{-1}$ oral dose of florfenicol administered once daily continuously for 4 or 5 days can be used for the treatment of Vibrio alginolyticus infection in large yellow croaker (Pseudosciaena crocea).

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6269-6273
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• 2014

Growing evidence suggests that miR-150-5p has an important role in regulating genesis of various types of cancer. However, the roles and the underlying mechanisms of miR-150-5p in development of colorectal cancer (CRC) remain largely unknown. Transwell chambers were used to analyze effects on cell migration and invasion by miR-150-5p. Quantitative real-time PCR (qRT-PCR), Western blotting and dual-luciferase 3' UTR reporter assay were carried out to identify the target genes of miR-150-5p. In our research, miR-150-5p suppressed CRC cell migration and invasion, and MUC4 was identified as a direct target gene. Its effects were partly blocked by re-expression of MUC4. In conclusiomn, miR-150-5p may suppress CRC metastasis through directly targeting MUC4, highlighting its potential as a novel agent for the treatment of CRC metastasis.

• Proceedings of the Korean Magnestics Society Conference
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• 2007.05a
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• pp.284.2-284.2
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• 2007

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.14
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• pp.5749-5754
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• 2015

Cervical carcinoma is the main cause of cancer-related mortality in women and is correlated with more than 15 risk cofactors, including infection of cervical cells with high-risk types of HPV (hrHPV). Indeed, both aberrant methylation of the RASSF1A promoter and hrHPV infection are often observed in cervical carcinomas. The purpose of our meta-analysis was to evaluate the role of RASSF1A promoter methylation and hrHPV infection in cervical cancer. Our meta-analysis involved 895 cervical cancer patients and 454 control patients from 15 studies. Our results suggested that RASSF1A promoter hypermethylation increased the risk of cervical cancer (OR=9.77, 95%CI=[3.06, 31.26], P=0.0001, $I^2=78%$). By grouping cases according to cancer subtypes, we found that HPV infection was higher in cervical squamous cell carcinomas (SCCs) than in cervical adenocarcinomas/adenosquamous cancers (ACs/ASCs) (OR=4.00, 95%CI=[1.41, 11.30], P=0.009, $I^2=55%$). Interestingly, HPV infection tended to occur in cervical cancers with relatively low levels of RASSF1A promoter methylation (OR=0.59, 95%CI=[0.36, 0.99], P=0.05, I2=0%). Our study provides evidence of a possible interaction between HPV infection and RASSF1A promoter methylation in the development of cervical cancers.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.2
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• pp.662-675
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• 2018

Compression history detection plays an important role in digital multimedia forensics. Most existing works, however, mainly focus on digital image and video. Additionally, the existed audio compression detection algorithms aim to detect the trace of double compression. In real forgery scenario, multiple compression is more likely to happen. In this paper, we proposed a detection algorithm to reveal the compression history for MP3 audio. The statistics of the scale factor and Huffman table index which are the parameters of MP3 codec have been extracted as the detecting features. The experimental results have shown that the proposed method can effectively identify whether the testing audio has been previously treated with single/double/triple compression.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.4
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• pp.1538-1552
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• 2021

Machine learning models are vulnerable to adversarial examples generated by adding a deliberately designed perturbation to a benign sample. Particularly, for automatic speech recognition (ASR) system, a benign audio which sounds normal could be decoded as a harmful command due to potential adversarial attacks. In this paper, we focus on the countermeasures against audio adversarial examples. By analyzing the characteristics of ASR systems, we find that frame offsets with silence clip appended at the beginning of an audio can degenerate adversarial perturbations to normal noise. For various scenarios, we exploit frame offsets by different strategies such as defending, detecting and hybrid strategy. Compared with the previous methods, our proposed method can defense audio adversarial example in a simpler, more generic and efficient way. Evaluated on three state-of-the-arts adversarial attacks against different ASR systems respectively, the experimental results demonstrate that the proposed method can effectively improve the robustness of ASR systems.

• Journal of Navigation and Port Research
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• v.34 no.7
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• pp.567-575
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• 2010

Ningbo Port develops quickly in recent years and with the combination of Ningbo Port and Zhoushan Port, it becomes another important port in the Shanghai International Shipping center. Competition between the two biggest ports in this area can't be avoided. The goal of this paper is investigating the competence of port from two angles, which are spatial structure of the ports cluster and neighboring ports' attraction to cargoes at conjunct hinterlands. The paper firstly uses the HHI index model and shift-share method to qualitatively and quantitatively analyze the data of container throughputs of ports in the shipping center, in order that investigates the spatial structure of ports cluster. Basing on above researches, the paper employs the location quotient to study Shanghai port and Ningbo port's hinterland distributions at Zhejiang province. The conclusion of this study:(I)the ports cluster of the Shanghai International Shipping Center is highly centralized, and undergoes a porcess of first centralization then decentralization since the mid of 90s, last century. (2)Hinterlands of Shanghai port includes: Hangzhou, Jiaxing, Huzhou and Quzhou districts; Hinterlands of Ningbo port includes: Ningbo, Taizhou and Zhoushan districts.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.5 no.2
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• pp.408-427
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• 2011

Intensive computational complexity is an obstacle of enabling multiview video coding for real-time applications. In this paper, we present a fast macroblock (MB) mode selection algorithm for B frames which are based on the computational complexity analyses between the MB mode selection and reference frame selection. Three strategies are proposed to reduce the coding complexity jointly. First, the temporal correlation of MB modes between current MB and its temporal corresponding MBs is utilized to reduce computational complexity in determining the optimal MB mode. Secondly, Lagrangian cost of SKIP mode is compared with that of Inter $16{\times}16$ modes to early terminate the mode selection process. Thirdly, reference frame correlation among different Inter modes is exploited to reduce the number of reference frames. Experimental results show that the proposed algorithm can promote the encoding speed by 3.71~7.22 times with 0.08dB PSNR degradation and 2.03% bitrate increase on average compared with the joint multiview video model.