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http://dx.doi.org/10.7314/APJCP.2015.16.14.5749

Association between RASSF1A Promoter Hypermethylation and Oncogenic HPV Infection Status in Invasive Cervical Cancer: a Meta-analysis  

Li, Jin-Yun (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University)
Huang, Tao (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University)
Zhang, Cheng (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University)
Jiang, Dan-Jie (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University)
Hong, Qing-Xiao (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University)
Ji, Hui-Hui (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University)
Ye, Meng (The Affiliated Hospital, Ningbo University)
Duan, Shi-Wei (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.14, 2015 , pp. 5749-5754 More about this Journal
Abstract
Cervical carcinoma is the main cause of cancer-related mortality in women and is correlated with more than 15 risk cofactors, including infection of cervical cells with high-risk types of HPV (hrHPV). Indeed, both aberrant methylation of the RASSF1A promoter and hrHPV infection are often observed in cervical carcinomas. The purpose of our meta-analysis was to evaluate the role of RASSF1A promoter methylation and hrHPV infection in cervical cancer. Our meta-analysis involved 895 cervical cancer patients and 454 control patients from 15 studies. Our results suggested that RASSF1A promoter hypermethylation increased the risk of cervical cancer (OR=9.77, 95%CI=[3.06, 31.26], P=0.0001, $I^2=78%$). By grouping cases according to cancer subtypes, we found that HPV infection was higher in cervical squamous cell carcinomas (SCCs) than in cervical adenocarcinomas/adenosquamous cancers (ACs/ASCs) (OR=4.00, 95%CI=[1.41, 11.30], P=0.009, $I^2=55%$). Interestingly, HPV infection tended to occur in cervical cancers with relatively low levels of RASSF1A promoter methylation (OR=0.59, 95%CI=[0.36, 0.99], P=0.05, I2=0%). Our study provides evidence of a possible interaction between HPV infection and RASSF1A promoter methylation in the development of cervical cancers.
Keywords
Cervical cancer; RASSF1A methylation; human papilloma virus; HPV infection; meta-analysis;
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