• Neonatal Medicine
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• 제15권1호
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• pp.38-43
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• 2008

목 적 : 태아 시기의 성장이 출생 이후 성인기에 이르기까지 대사 질환 및 심혈관 질환, 제2형 당뇨병 등의 발현에 영향을 미친다는 보고들이 있어왔다. 이에, 정상 체중 만삭아의 제대혈 내 APN 과 IGF-I 농도와 태아 성장 간의 관계에 대해서 알아보고자 하였다. 방 법 : 2003년 10월부터 2005년 3월 사이에 이대목동병원에서 출생한 정상 체중 만삭아 72명을 대상으로 하였다. 대상아들의 제대혈 내 APN과 IGF-I 농도를 ELISA 방법을 이용하여 측정하였고 측정치와 출생체중, 신장, 머리둘레, 성별, ponderal index, 태반 무게, 태아-태반 무게 비, 산모의 임신 중 체중 증가, 산모의 임신 전 BMI와의 관계를 분석하였다. 결 과: 제대혈 평균 APN 농도는 29.2${\pm}$10.46 $\mu$g/mL 였으며, 제대혈 APN 농도와 체중의 관계는 체중이 증가할수록 APN 농도가 증가하다가 일정 체중에 도달한 이후에는 APN이 감소하는 종모양의 관계를 보였다. 제대혈 APN 농도는 여아에서 남아 보다 높았으며(P=0.001), 제대혈 APN 농도와 산모의 BMI는 유의한 음의 상관관계를 보였다(r=-0.301, P=0.027). 평균제대혈 IGF-I 농도는 51.26${\pm}$21.54 ng/mL 였다. 제대혈 IGF-I 농도는 출생체중과 양의 상관관계를 보였다(r=0.312, P=0.009). 결 론: 건강한 만삭아에서 제대혈 APN 농도는 출생 체중에 따라 증가하다가 일정 체중에서부터 감소하는 패턴의 종모양의 관계를 보였다. IGF-I 은 태아 성장, 특히 출생체중과 밀접한 관계가 있었다.

• 생명과학회지
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• 제22권3호
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• pp.332-339
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• 2012

본 연구는 서낙동강 표층퇴적물 내에 잔류하고 있는 유기염소계화합물의 수평적 분포와 잠재적 생태독성 영향력을 평가하였다. 표층퇴적물 내 PCBs, DDTs, HCHs 및 HCB의 잔류농도는 각각 0.57~3.68, 0.41~8.35, 0.63~1.65 및 n.d~0.56 ng/g의 범위로 주요 유기염소계화합물은 DDT 화합물이었다. PCBs, DDTs 농도와 총 유기탄소 함량은 유의한 상관관계(PCB: r=0.874, p<0.001, and DDTs: r=0.762, p<0.05)를 보여 서낙동강 수계에서 퇴적물 내 유기물 함량은 유기염소계화합물의 수평적 분포에 작용하는 주요 인자로 나타났다. 퇴적물 오염기준을 이용하여 서낙동강 표층퇴적물의 저서생물에 대한 잠재적인 생태독성 영향을 평가한 결과 ${\gamma}PCBs$, p,p'-DDD 그리고 ${\gamma}$-HCH의 농도는 ER-L (저서생물에 10% 악영향이 나타날 수 있는 농도)과 PEL (악영향 기대수준)보다 낮아 독성학적 관점에서 저서생물에 미치는 악영향은 낮은 것으로 평가되었다. 그러나 p,p'-DDE, p,p'-DDT 및 ${\Sigma}DDTs$는 각각 30, 17 및 19%의 퇴적물에서 잠정퇴적물권고기준(ISQG)과 최초영향수준(TEL)을 초과하였다.

• 한국임상수의학회지
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• 제36권1호
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• pp.46-52
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• 2019

Pimobendan has inotropic and vasodilating effects on cardiovascular system, and pentoxifylline is known to decrease blood viscosity and improve blood flow to the heart. This study investigated the pharmacokinetics and pharmacodynamics following oral administration of pimobendan-pentoxifylline powder mixture in dogs. Eight healthy dogs were included and were divided into control (n = 4) and experimental (n = 4) groups. Vehicle powder and pimobendan-pentoxifylline powder mixture (pimobendane 0.25 mg/kg, pentoxifylline 15 mg/kg) were administrated orally to control and experimental groups, respectively. Plasma samples and measurement of echocardiographic indices were obtained for 24 hours following administration. Pimobendan and pentoxifylline concentrations were investigated using liquid chromatography-mass spectrometer (LC-MS) assay. The elimination half-life ($T_{1/2}$) were $2.65{\pm}1.42hours$ for pimobendan and $0.29{\pm}0.23hours$ for pentoxifylline. The time to reach maximum concentration ($T_{max}$) were $1.08{\pm}0.72hours$ for pimobendan and $0.29{\pm}0.14hours$ for pentoxifylline. The maximum blood concentration ($C_{max}$) were $2.83{\pm}1.50ng/mL$ for pimobendan and $1184.33{\pm}932.37ng/mL$ for pentoxifylline. Among echocardiographic indices, fractional shortening (FS), left ventricular internal diameter at end systole (LVIDs), and pre-ejection period (PEP) showed significant changes at 1-4 hours after the administration of pimobendan-pentoxifylline powder mixture. No adverse effects were observed during the investigation. This study demonstrates that pimobendan-pentoxifylline powder mixture can be used to control cardiovascular diseases in dogs.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2649-2656
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• 2013

Background: Depression is common in breast cancer patients. The aim of this paper was to make a systematic review of its prevalence and associated factors oin breast cancer survivors. Materials and Methods: An extensive systematic electronic review (PUBMED, CINAHL, PsyINFO and Ovid) and handsearch were carried out to retrieve published articles up to November 2012, using Depression OR Dysthymia AND (Cancer OR Tumor OR Neoplasms as the keywords. Information about the design of the studies, measuring scale, characteristics of the participants, prevalence of depression and its associated factors from the included studies were extracted and summarized. Results: We identified 32 eligible studies that recruited 10,826 breast cancer survivors. Most were cross-sectional or prospective designed. The most frequent instrument used to screen depression was the Center for Epidemiological Studies for Depression (CES-D, n=11 studies) followed by the Beck Depression Inventory (BDI, n=6 studies) and the Hospital Anxiety and Depression Scale (HADS, n=6 studies). CES-D returned about similar prevalence of depression (median=22%, range=13-56%) with BDI (median=22%, range=17-48%) but higher than HADS (median=10%, range=1-22%). Depression was associated with several socio-demographic variables, cancer-related factors, treatment-related factors, subject psychological factors, lifestyle factors, social support and quality of life. Conclusions: Breast cancer survivors are at risk for depression so that detection of associated factors is important in clinical practice.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5483-5488
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• 2012

Background: Although nicotine dependence plays a role as a main barrier for smoking cessation, there is still a lack of solid evidence on the validity of biomarkers to determine nicotine dependence in clinical settings. This study aimed to investigate whether urinary cotinine levels could reflect the severity of nicotine dependence in active smokers. Materials and Methods: Data regarding general characteristics and smoking status was collected using a self-administered smoking questionnaire. The Fagerstr$\ddot{o}$m test for nicotine dependence (FTND) was used to determine nicotine dependence of the participants, and a total of 381 participants were classified into 3 groups of nicotine dependence: low (n=205, 53.8%), moderate (n=127, 33.3%), and high dependence groups (n=49, 12.9%). Stepwise multiple linear regression model and receiver operating characteristic (ROC) curves analyses were used to determine the validity of urinary cotinine for high nicotine dependence. Results: In correlation analysis, urinary cotinine levels increased with FTND score (r=0.567, P<0.001). ROC curves analysis showed that urinary cotinine levels predicted the high-dependence group with reasonable accuracy (optimal cut-off value=1,000 ng/mL; AUC=0.82; P<0.001; sensitivity=71.4%; specificity=74.4%). In stepwise multiple regression analysis, the total smoking period (${\beta}$=0.042, P=0.001) and urinary cotinine levels (${\beta}$=0.234, P<0.001) were positively associated with nicotine dependence, whereas an inverse association was observed between highest education levels (>16 years) and nicotine dependence (${\beta}$=-0.573, P=0.034). Conclusions: The results of this study support the validity of using urinary cotinine levels for assessment of nicotine dependence in active smokers.

• Bulletin of the Korean Chemical Society
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• 제27권10호
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• pp.1581-1586
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• 2006

A La (III) ion-selective membrane sensor has been fabricated from poly vinyl chloride (PVC) matrix membrane, containing 3-hydroxy-N'-(pyridin-2-ylmethylene)-2-naphthohydrazide (HPMN) as a neutral carrier, potassium tetrakis (p-chlorophenyl) borate (KTpClPB) as an anionic excluder and ortho-nitrophenyloctyl ether (NPOE) as a plasticizing solvent mediator. The effects of membrane composition and pH as well as the influence of the anionic additive on the response properties were investigated. The sensor with 30% PVC, 62% solvent mediator, 6% ionophore and 2% anionic additive, shows the best potentiometric response characteristics. It displays a Nernstian behavior (19.2 mV per decade) across the range of $1.0{\times}10^{-2}-1.0{\times}10^{-7}$ M. The detection limit of the electrode is $7.0{\times}10^{-8}$ M ($\sim$10 ng/mL) and the response time is 15 s from $1.0{\times}10^{-2}$ up to $1.0{\times}10^{-4} $M and 30 s in the range of $1.0 {\times}10^{-5}-1.0{\times}10^{-7}$ M. The sensor can be used in the pH values of 3.0-9.0 for about seven weeks. The membrane sensor was used as an indicator electrode in the potentiometric titration of lanthanum ions with EDTA. It was successfully applied to the lanthanum determination in some mouth wash preparations.

• Journal of Nutrition and Health
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• 제33권1호
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• pp.49-58
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• 2000

The purpose of this study was to investigate the relationship among urn leptin, nutritional status, and urn lipids, glucose of 99 middle school girls residing in Kyluggi-do, Korea. Subjects were assigned to one of three groups such as underweight(BMI < 20, n=38), normal(20$\leq$BMI<25, n=36) and over weight(BMI$\geq$25, n=25) groups. The nutritional status of the subjects was evaluated by anthropometric measurements, questionnaires, 24-hr dietary recalls and blood anal),sis. The results were as follows : The mean age, body weight, height and BMI were 13.93 years, 55.19kg, 158.40cm and 21.96kg/㎡ respectively. The mean menarche age of the subjects was 12.64 years and the mean daily energy intake was 94.22% off RDA for Koreans. The energy ratio from carbohydrate fat and protein was 63: 24: 13. Underweight group showed the lowest intakes of oils and fats among three groups(p<0.05). The mean serum levels of leptin, glucose, total cholesterol, HDL-cholesterol. LDL-cholesterol and triglyceride were 10.57ng/ml 78.80mg/dl, 12.29mg/dl, 48.07mg/dl, 93.50mg/dl and 78.61mg/d1, respectively. The mean atherogenic index was 2.37. There were significant increases in serum leptin, glucose, LDL-cholesterol, triglyceride and atherogenic index of subjects with increases in their BMIs. Serum leptin showed a significantly positive correlation with BMI(p<0.001), body fat percent(p<0.001). When BMI was adjused, serum leptin showed a significantly positive partial correlations with intakes of animal protein(p<0.05), milks and animal foods(p<0.05), Serum leptin showed a significantly positive correlation with serum glucose(p<0.05) total cholesterol(p<0.01), LDL-cholesterol(p<0.001), triglyceride(p<0.001) and atherogenic index(p<0.001), however, it had significantly negative correlations with HDL-cholesterol(p<0.05). Therefore, these results suggest that the increase of serum levels of leptin may elevate the risk of cardiovascular disease and lipids and some nutrient intakes may be related with serum leptin levels. (Korean J Nutrition 33(1) : 49-58, 2000)

• 한국축산시설환경학회지
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• 제8권2호
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• pp.115-118
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• 2002

This study was conducted to determine the effects of pig manure composting on emission of dinitrogen oxide ($N_2O$) that is greenhouse gas. Fresh pig manure was mixed with sawdust as bulking agent and moisture content of mixed compost was adjusted by 61.9%. After mixing bulking agent with pig manure that was left to compost with aeration in composting chamber for an initial period of 30 days. At the end of this period, that was decomposed and a second period of composting was conducted without aeration for 60 days. Temperature during the initial composting period was above $55^{\circ}C$ for 7 days. Moisture reduction rate by composting pig manure was 36.7%. $N_2O$ Produced during composting was 0.043g/T-Ng.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6407-6412
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• 2015

Purpose: To predict prostatic carcinoma using a logistic regression model on prebiopsy peripheral blood samples. Materials and Methods: Data of a total of 873 patients who consulted Urology Outpatient Clinics of Fatih Sultan Mehmet Training and Research Hospital between February 2008 and April 2014 scheduled for prostate biopsy were screened retrospectively. PSA levels, prostate volumes, prebiopsy whole blood cell counts, neutrophil and platelet counts, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), biopsy results and Gleason scores in patients who had established diagnosis of prostate cancer (PCa) were evaluated. Results: This study was performed on a total of 873 cases, with an age range 48-76 years, divided into three groups as for biopsy results. with diagnoses of benign prostatic hyperplasia (BPH) (n=304, 34.8 %), PCa (n=265, 30.4 %) and histological prostatitis (n=304; 34.8 %). Intra- and intergroup comparative evaluations were performed. White blood cell and neutrophil counts in the histological prostatitis group were significantly higher than those of the BPH and PCa groups (p=0.001; p=0.004; p<0.01). A statistically significant intergroup difference was found for PLR (p=0.041; p<0.05) but not lymphocyte count (p>0.05). According to pairwise comparisons, PLR were significantly higher in the PCa group relative to BPH group (p=0.018, p<0.05, respectively). Though not statistically significant, higher PLR in cases with PCa in comparison with the prostatitis group was remarkable (p=0.067, and p>0.05, respectively). Conclusions: Meta-analyses showed that in patients with PSA levels over 4 ng/ml, positive predictive value of PSA is only 25 percent. Therefore, novel markers which can both detect clinically significant prostate cancer, and also prevent unnecessary biopsies are needed. Relevant to this issue in addition to PSA density, velocity, and PCA3, various markers have been analyzed. In the present study, PLR were found to be the additional predictor of prostatic carcinoma.

• Preventive Nutrition and Food Science
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• 제5권4호
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• pp.189-193
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• 2000

Preservative and antimutagenic effects of green tea leaves added Chinese cabbage kimchi (GK1, GK2, GK3, and GK4 : 1, 2, 3 and 4 of green tea leaves (GTL) in proportion of 100 of salted Chinese cabbage were added to kimchi) were compared to those of the Chinese cabbage kimchi without GTL (control kimchi, CK). Fermentation period of GKs was further delayed than that of CK. The initial pH and acidity between GKs an CK were similar, but the time reach optimally ripened status of kimchi (pH 4.3) was different. CK took 6 days, while GK1, GK2, GK3 and GK4 took 6, 10, 12 and 14 days at 10℃, respectively. The growth of Leuconostoc sp. and Lactobacilus sp. in GKs delayed comparing to those in FCK. Among GKs, as the added amount of green tea leaves increased, the growth of lactic acid bacteria was retarded. The antimutagenic effects of juices from GKs and CK were studied against aflatoxin B₁(AFB₁) in the Ames test on Salmonella typehimurium TA100 and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the SOS chromotest using E. coli PQ37. Juices from optimally ripened GKs (pH 4.3) showed 52∼76% inhibition rates against the indirect mutagen, aflatoxin B₁ induced mutagenicity while 49% inhibition rate by CK in the Ames test. Juices from GKs and CK showed 44∼67% and 36% inhibition rate against direct mutagen, MNNG (70 ng/assay) induce mutagenicity in the SOS chromotest. Thus GKs delayed fermentation period of kimchi and exhibited higher antimutagenic activity than CK.