• Journal of Pharmaceutical Investigation
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• v.41 no.2
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• pp.67-73
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• 2011

Ion exchange resins can be one of the good carriers for sustained drug release. However, the sustained release may not be enough only with themselves and hence film coating with rate controlling polymers can be applied to have a further effect on the drug release. Due to the environmental and economic issues of organic solvent for the polymer coating, aqueous polymeric systems were selected to develop dosage forms. Among the many aqueous polymeric dispersions for the film coating, EC (ethylcellulose) based polymers such as Aquacoat$^{(R)}$ ECD and Surelease$^{(R)}$ were evaluated.A fluid-bed coating was applied as a processing method. The drug release rate was quite dependent on the coating level so the release rate could be modified easily by changing different levels of the coating. The drug release rate in the Aquacoat$^{(R)}$ coated resin particles was strongly dependent on curing, which is a thermal treatment to make homogeneous films and circumvent drug release changes during storage. After dissolution test using the compressed tablets in which the coated resin particles are contained, inhomogeneous coating and even pores could be observed showing that the mechanical properties of EC were not resistant to granulation and compaction process. However, when tablets were prepared in different batches, the release profiles were almost identical showing the feasibility of the coated resin particle as incorporated into the tablet formulation.

• Korean Journal of Veterinary Research
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• v.57 no.3
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• pp.155-158
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• 2017

Surgical castration performed to reduce male-associated problems results in pain and microbial infections in male animals. Therefore, immunocontraception, which is mediated by the animal's own antibodies against reproductive hormones, has been recommended as an alternative to surgical castration when considering the animal's welfare. In this study, a new immunocontraceptive vaccine composed of six tandem copies of gonadotropin-releasing hormone (GnRH) fused to rat granulocyte-macrophage colony-stimulating factor (GM-CSF) was developed, and its efficacy was evaluated in male rats. Three different doses (10, 50, and $100{\mu}g$) of recombinant GM-CSF-GnRH protein were injected three times at intervals of two weeks into male rats. The rats vaccinated with three doses of GM-CSF-GnRH produced a significantly higher level of antibodies against GnRH than that in the negative control rats. Severe atrophy of gonads was observed in rats vaccinated with three doses of GM-CSF-GnRH but not in the negative control rats. The results reveal that the new GnRH vaccine conjugated with rat GM-CSF induces efficient immunocontraception in male rats. This formulation of the immunocontraceptive vaccine would be applicable to both domestic and pet male animals.

• Journal of the Microelectronics and Packaging Society
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• v.12 no.1 s.34
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• pp.9-16
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• 2005

This paper presents the development of new anisotropic conductive adhesives with enhanced thermal conductivity for the wide use of adhesive flip chip technology with improved reliability under high current density condition. The continuing downscaling of structural profiles and increase in inter-connection density in flip chip packaging using ACAs has given rise to reliability problem under high current density. In detail, as the bump size is reduced, the current density through bump is also increased. This increased current density also causes new failure mechanism such as interface degradation due to inter-metallic compound formation and adhesive swelling due to high current stressing, especially in high current density interconnection, in which high junction temperature enhances such failure mechanism. Therefore, it is necessary for the ACA to become thermal transfer medium to improve the lifetime of ACA flip chip joint under high current stressing condition. We developed thermally conductive ACA of 0.63 W/m$\cdot$K thermal conductivity using the formulation incorporating $5 {\mu}m$ Ni and $0.2{\mu}m$ SiC-filled epoxy-bated binder system to achieve acceptable viscosity, curing property, and other thermo-mechanical properties such as low CTE and high modulus. The current carrying capability of ACA flip chip joints was improved up to 6.7 A by use of thermally conductive ACA compared to conventional ACA. Electrical reliability of thermally conductive ACA flip chip joint under current stressing condition was also improved showing stable electrical conductivity of flip chip joints. The high current carrying capability and improved electrical reliability of thermally conductive ACA flip chip joint under current stressing test is mainly due to the effective heat dissipation by thermally conductive adhesive around Au stud bumps/ACA/PCB pads structure.

• Korean journal of communication and information
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• v.58
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• pp.242-261
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• 2012

This study was intended to analyze media in education policy from the governance perspective and suggested some orientations and innovative ideas to a new governance in media in Education. For these purposes, this study reviewed related literature about media in education and governance policy and drew a governance model of educational community as an analytic scheme to understand a governance approach to orientation-order-performance of Schmank. Thereafter, the study analyzed formulation and implementation processes of media in education policy, based on some criteria to operate the model, and also analyzed the policy governance in a comprehensive way. Based on the results, this study suggested recommendations to innovate current media in education governance as follows: (1) working towards an idea of operative cooperation through reforms (2) constructing a rational policy system to incorporate socio-political variables, and (3) activating cooperative governance to transform 'governing' into 'governance'.

• International Journal of Aeronautical and Space Sciences
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• v.8 no.1
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• pp.95-104
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• 2007

A new design approach of complex geometries such as wing/body configuration is arranged by using overset mesh techniques under large scale computing environment. For an in-depth study of the flow physics and highly accurate design, several special overlapped structured blocks such as collar grid, tip-cap grid, and etc. which are commonly used in refined drag prediction are adopted to consider the applicability of the present design tools to practical problems. Various pre- and post-processing techniques for overset flow analysis and sensitivity analysis are devised or implemented to resolve overset mesh techniques into the design optimization problem based on Gradient Based Optimization Method (GBOM). In the pre-processing, the convergence characteristics of the flow solver and sensitivity analysis are improved by overlap optimization method. Moreover, a new post-processing method, Spline-Boundary Intersecting Grid (S-BIG) scheme, is proposed by considering the ratio of cell area for more refined prediction of aerodynamic coefficients and efficient evaluation of their sensitivities under parallel computing environment. With respect to the sensitivity analysis, discrete adjoint formulations for overset boundary conditions are derived by a full hand-differentiation. A smooth geometric modification on the overlapped surface boundaries and evaluation of grid sensitivities can be performed by mapping from planform coordinate to the surface meshes with Hicks-Henne function. Careful design works for the drag minimization problems of a transonic wing and a wing/body configuration are performed by using the newly-developed and -applied overset mesh techniques. The results from design applications demonstrate the capability of the present design approach successfully.

• Journal of National Security and Military Science
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• s.7
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• pp.55-89
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• 2009

This article aims to critically review recent U. S. RMA-centered theories of warfare having prevailed after the 1991-92 Gulf War upon which the current ROKA military transformation project, the Vision 2020, largely based. In order to evaluate validity as a universal warfighing theory of NCW (Network Centric Warfare) and EBO (Effects-Based Operations), this article reviews the intrinsic strength and weakness of the theories as well as results of several recent wars that the U. S. Army conducted based on doctrines derived form such theories, In addition, this article examines the impact of certain military technology or weapon system in some well-known historical wars to draw lessons regarding the relationship between technology(weapon system) and military victory. Historical examples has shown that victories in war were not achieved by new technologies alone in most cases. Rather military victories tended to owe to combination of new technology, original doctrine and well conceived organization. Although the U. S. Armed Forces showed brilliant records of operational successes anchored on the system of PGMs and NCW concepts in Iraq (1991-92; 2003) and Afghanistan (2001-02), it must be pointed out that the operational successes did not bring about political ones in cases of Iraq and Afghanistan. It reminds us of perils of too technologically tilted approach to the conduct of war. In sum, one ought to recognize that superior technology nowadays became a necessary condition of success but is not yet a sufficient condition, the ROKA needs to be abreast with development trends of military technologies and related theoretical concepts, it need not too be in a hurry in adopting cutting edged war-making technologies at the expense of large amount of budget. The essay recommends for the ROKA several basic requirements for coping with conduct of future wars as well as establishing a 'Korean style military thought'; (1) Recognition of importance of technology in conduct of war; (2) Imposition of officer self-study hours in working days; (3) Establishing a lifestyle of military professionalism in the Korean officer corps; (4) Setting up small or large groups of think-tanks that are specialized in army doctrinal formulation.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.18 no.4 s.70
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• pp.395-404
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• 2005

This paper presents a reliable numerical procedure for nonlinear time-history analysis of space steel frames subjected to dynamic loads. Geometric nonlinearities of member (P-$\delta$) and frame (P-$\Delta$) are taken into account by the use of stability functions in framed stiffness matrix formulation. The gradual yielding along the member length and over the cross section is included by using a tangent modulus concept and a softening plastic hinge model based on the New-Orbison yield surface. A computer program utilizing the average acceleration method for the integration scheme is developed to numerically solve the equation of motion of framed structure formulated in an incremental form. The results of several numerical examples are compared with those derived from using beam element model of ABAQUS program to illustrate the accuracy and the computational efficiency of the proposed procedure.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.17 no.3
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• pp.279-293
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• 2004

The analysis of linear static and free vibration problems of isotropic and laminated composite plates and shells is performed by the improved 9-node shell element with the new strain displacement relationship. In that relationship, the effect of new additional terms between the bending strain and displacement has been investigated in the warping problem. Natural co ordinate based strains, stresses and constitutive equations are used. The assumed natural strain method is used to alleviate both membrane and shear locking behavior from the element. The Lanczos method is employed in the calculation of the eigenvalues of laminated composite structures and the Gauss integration rule is adopted to evaluate the mass matrix. The numerical examples are compared with the analytical solutions to validate the current formulation and the results presented could be useful for the understanding of the behaviour of laminates under free vibration conditions.

• Structural Engineering and Mechanics
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• v.76 no.1
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• pp.1-15
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• 2020

The aim of this paper is to simply present live load factor calculation methodology formulation with the addition of a simple new future load projection procedure to previously proposed two methods. For this purpose, Oregon Weigh-in-Motion (WIM) data were used to calculate live load factors by using WIM data. These factors were calculated with two different approaches and by presenting new simple modifications in these methods. A very simple future load projection method is presented in this paper. Using four different WIM sites with different average daily truck traffic (ADTT) volume, and all year data, live load factors were obtained. The live load factors, were proposed as a function of ADTT. ADTT values of these sites correspond to three different levels which are approximately ADTT= 5,000, ADTT = 1,500 and ADTT ≤ 500 cases. WIM data for a full year were used from each site in the calibration procedure. Load effects were projected into the future for the different span lengths considering five-year evaluation period and seventy-five-years design life. The live load factor for ADTT=5,000, AASHTO HS20 loading case and five-year evaluation period was obtained as 1.8. In the second approach, the methodology established in the Manual for Bridge Evaluation (MBE) was used to calibrate the live load factors. It was obtained that the calculated live load factors were smaller than those in the MBE specifications, and smaller than those used in the initial calibration which did not convert to the gross vehicle weight (GVW) into truck type 3S2 defined by AASHTO equivalents.

• Polymer(Korea)
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• v.27 no.5
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• pp.436-442
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• 2003

Thermosetting elastomer such as EPDM (Ethylene Propylene Dien Rubber) has been applied to the sponge weatherstrip of a vehicle as a main material. However, the thermosetting elastomers have limited recycling and have brought about the environmental problems. Furthermore, many steps of the manufacturing process such as formulation, mastication and vulcanization make difficult to control uniformity of the endproducts. These problems of current EPDM weatherstrip necessitated development of a new recyclable material, Thermoplastic Vulcanizates (TPV). In this study the influence of the water contents, and the processing conditions. On the foam density and structure in water blowing process was carried out. We found that TPV also can be foamed with water, maintaining the uniformity form this study. Therefore, many inevitable problems of EPDM weatherstrip can be solved, and this new technique is expected to take a roll of making a breakthrough in the rubber industry.