• Journal of Pharmaceutical Investigation
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• v.40 no.5
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• pp.313-319
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• 2010

The objectives of this study were to evaluate the effect of formulation ingredients on the drug release and to optimize the novel sustained release matrix tablet formulations of bupropion hydrochloride. A three factor, three-level Box-Behnken design was used for the optimization procedure, with the amounts of PEO ($X_1$), citric acid ($X_2$) and Compritol 888 ATO ($X_3$) as the independent variables. The selected dependent variables were the cumulative percentage values of bupropion hydrochloride that had dissolved after 1, 4 and 8 hr. Various dissolution profiles of the drug from sustained release matrix tablets were obtained. Optimization was performed for $X_1$, $X_2$ and $X_3$ using the following target ranges; $30%{\leq}Y_1{\leq}45%$; $70{\leq}Y_2{\leq}85%$; $85%{\leq}Y_3{\leq}100%$. The optimized formulation for bupropion hydrochloride was achieved with 12.5% PEO ($X_1$), 2.5% citric acid ($X_2$) and 10% Compritol 888 ATO ($X_3$). The sustained release matrix tablets with the optimized formulation provided a release profile that was close to predicted values. In addition, the dissolution profiles of the sustained release matrix tablet with the optimized formulation were similar to those of the commercial product Wellbutrin$^{(R)}$ SR tablets ($f_2$=79.83).

• Proceedings of the KSME Conference
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• 2003.11a
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• pp.1730-1735
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• 2003

In this paper, the absolute nodal coordinate formulation was introduced to describe the large deformation problems. And also, the modal coordinates were employed to represent the small elastic deformation. A new hybrid formulation was developed to combine the modal coordinates and the absolute nodal coordinates. A spherical joint and the DOT1 constraint were developed to carry out the numerical simulation of mechanical systems with kinematic joints. A beam example was suggested to show the new formulation. The simulation results using the modal coordinates and the absolute nodal coordinates show a good agreement to the experiments.

• Transactions of the Korean Society of Automotive Engineers
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• v.2 no.4
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• pp.80-90
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• 1994

Basic constraint equations derived from orthogonality conditions between a pair of body-fixed vectors and a body-fixed vector or a vector between two bodies are reformulated by using relative coordinate kinematics between two adjacent reference frames. Arithmetic numbers of operations required to compute derivatives of the constraint equations are drastically reduced. A mixed formulation of relative and cartesian coordinates is developed to further simplify derivatives of the constraints. Advantages and disadvantages of the new formulation are discussed. Possible singularity problem of para llelism constraints is resolved by introducing an extra generalized coordinate. Kinematic analysis of a McPherson strut suspension system are carried out to illustrate use and efficiency of the new formulation.

• Earthquakes and Structures
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• v.3 no.3_4
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• pp.383-411
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• 2012

The objective of the present paper is to review and implement the most recent developments in the Spectral Element Method (SEM), as well as improve aspects of its implementation in the study of wave propagation by numerical simulation in elastic unbounded domains. The classical formulation of the method is reviewed, and the construction of the mass matrix, stiffness matrix and the external force vector is expressed in terms of matrix operations that are familiar to earthquake engineers. To account for the radiation condition at the external boundaries of the domain, a new absorbing boundary condition, based on the Perfectly Matched Layer (PML) is proposed and implemented. The new formulation, referred to as the Multi-Axial Perfectly Matched Layer (M-PML), results from generalizing the classical Perfectly Matched Layer to a medium in which damping profiles are specified in more than one direction.

• Journal of Magnetics
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• v.16 no.1
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• pp.77-82
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• 2011

This paper presents a new self-adjoint material sensitivity formulation for optimal designs and inverse problems in the high frequency domain. The proposed method is based on the continuum approach using the augmented Lagrangian method. Using the self-adjoint formulation, there is no need to solve the adjoint system additionally when the goal function is a function of the S-parameter. In addition, the algorithm is more general than most previous approaches because it is independent of specific analysis methods or gridding techniques, thereby enabling the use of commercial EM simulators and various custom solvers. For verification, the method was applied to the several numerical examples of dielectric material reconstruction problems in the high frequency domain, and the results were compared with those calculated using the conventional method.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.413.2-413.2
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• 2002

Paclitaxel is an antitumor agent with poor water solubility and its pharmacokinetics are nonlinear. Cremophor EL. a surfactant used in the formulation of paclitaxel. may cause adverse effects. New solubilizer(Aceporol 460) was developed to reduce side effects of Cremophor EL and to increase the effect of drug as surfactant used in the intravenous micelle formulation of anticancer drug paclitaxel. We studied easy, rapid quantitative determination of Aceporol 460 in mouse plasma samples. which was achieved by complexation of the compound with the Coomassie brilliant blue G-250 dye in protein-free extracts. (omitted)

• Journal of Pharmaceutical Investigation
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• v.30 no.2
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• pp.119-125
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• 2000

In an attempt to develop a non-aqueous liquid formulation of practically insoluble biphenyl dimethyl dicarboxylate (DDB), dissolution and permeation studies were performed. Various non-aqueous DDB solutions were formulated and filled into empty hard capsules. Dissolution rates of a new formulation were compared with those of commercially available DDB preparations using one and eight dose units. Dissolution rates after 2 hr of DDB tablets (DDB 25 mg), hard capsules (DDB 7.5 mg) and soft capsules (DDB 7.5 mg) on market and new formulation (DDB 7.5 mg) were 6.3, 15.0, 84.5 and 98.0%, respectively. Higher doses (8 units) resulted in a supersaturation within one hr of dissolution, and dissolved amounts were reduced markedly. Due to the saturation and precipitation, a directly proportional dose-dissolution relationship was not observed. The addition of copolyvidone and/or glycyrrhizic acid ammonium salt to DDB solution in polyethylene glycol 300 and 400 inhibited the formation of precipitates during dissolution and markedly enhanced the rabbit duodenal permeation of DDB. From the site-specific gastrointestinal permeation studies, it was found that permeation rates of DDB after mixing of non-aqueous DDB solutions with aqueous buffered solutions were faster in the order of $rectal\;<\;colonic\;{\risingdotseq}\;ileal\;{\risingdotseq}\;duodenal\;<\;jejunal\;<\;gastric$.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.29 no.6 s.237
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• pp.860-875
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• 2005

A new meshfree method for the analysis of elasto-plastic deformations is presented. The method is based on the proposed first-order least-squares formulation, to which the moving least-squares approximation is applied. The least-squares formulation for the classical elasto-plasticity and its extension to an incrementally objective formulation for finite deformations are proposed. In the formulation, the equilibrium equation and flow rule are enforced in least-squares sense, while the hardening law and loading/unloading condition are enforced exactly at each integration point. The closest point projection method for the integration of rate-form constitutive equation is inherently involved in the formulation, and thus the radial-return mapping algorithm is not performed explicitly. Also the penalty schemes for the enforcement of the boundary and frictional contact conditions are devised. The main benefit of the proposed method is that any structure of cells is not used during the whole process of analysis. Through some numerical examples of metal forming processes, the validity and effectiveness of the method are presented.

• The Journal of Korean Medical History
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• v.27 no.2
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• pp.11-37
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• 2014

Objectives : The purpose of this study was to analyze and identify the problems of the changes in regulations that are relevant to approval, notification, and review of herbal medicinal preparations and crude drug preparations. Methods : I collected the regulations of approval, notification, and review of medicinal products mostly from official gazettes, analyzed enactment and amendments regarding herbal medicinal preparations and crude drug preparations, and studied it from the view point of Korean medicine field. Results : Regulations in regards to approval, notification, and review of herbal medicinal preparations and crude drug preparations were first established in 1978. Herbal drugs started to be categorized as crude drug preparations in 1981 and the regulatory outlines were completed in 1999. From 2008 to 2012, the regulatory standards that let crude drug preparations be new drugs from natural products were established. Through those procedures, the followings became crude drug preparations: 1) wholly new prescriptions that are not recorded in Korean Medical Classics, 2) prescriptions that are recorded in Korean Medical classics but prepared with new standard, composition and efficacy, 3) prescriptions that are recorded in Korean Medical classics but prepared with new formulation, and 4) herbal drugs. In case of herbal medicinal preparations, however, only regulations that are related to 1) drugs prepared with new compositions that are not recorded in Korean Medical Classics, 2) drugs with same prescription and same formulation, and 3) drugs with new formulation were arranged. Conclusions : Actual circumstances on crude drug-oriented regulations regarding approval, notification and review and future forms of prescription and drug administration in Korean Medical Institutions can be expected due to expansion in range of herbal medicinal preparations and shrink in that of on-site preparations. Reasonable improvement in efficient usage of modernized herbal medicinal preparations in Korean medical institutions and prospective cooperation from related pharmaceutical industry are needed.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.22 no.2
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• pp.365-371
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• 1998

In the present study, we attempted to add the incompatible functions as additional variable terms to the conventional u-p formulation. It is derived from the four-field generalized variational principle that encompasses velocity, pressure, velocity strains and stress fields as independent interpolated variables. As a severe test of the present formulation, we have investigated the driven cavity with the corner velocity singularity like leaky lid. Through the test, the present element performs very well without unstable oscillation of pressure distribution.