• Research in Plant Disease
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• v.24 no.2
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• pp.123-131
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• 2018

Kiwifruit has been cultivated in southern coastal regions of Korea since late 1970s. New cultivars have been successively released in recent years. In this study, we investigated major disease and pest incidences in new kiwifruit cultivars 'Goldone', 'Redvita' and 'Garmrok' at open field in Sacheon for 3 years and rain-proof field in Jeju for 2 years. For the bacterial canker, the 3 new cultivars showed more disease occurrence in Sacheon but rare in Jeju. For leaf spot disease, compared to disease incidence of 20% on 'Hayward' in Sacheon, cv. 'Garmrok' had high incidence about 60% but cv. 'Goldone' and cv. 'Redvita' had low incidence less than 20%. However, in Jeju, diseases incidences of all the new cultivars were lesser than 20%. In the case of Hemiptera, many Halyomorpha halys and Nezara antennata appeared in Sacheon but in Jeju Plautia stali was dominated. Isolated bacterial canker pathogen was identified as Pseudomonas syringae pv. actinidiae biovar 3. Leaf spots pathogens were Phomopsis sp., Phoma sp., Fusarium tricinctum and Alternaria alternata. This study shows the disease information on new kiwifruit cultivars and the adequate disease managements will be required.

• BMB Reports
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• v.51 no.2
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• pp.55-56
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• 2018

Long terminal repeat retrotransposons (LTR-Rs) are major elements creating new genome structure for expansion of plant genomes. However, in addition to the genome expansion, the role of LTR-Rs has been unexplored. In this study, we constructed new reference genome sequences of two pepper species (Capsicum baccatum and C. chinense), and updated the reference genome of C. annuum. We focused on the study for speciation of Capsicum spp. and its driving forces. We found that chromosomal translocation, unequal amplification of LTR-Rs, and recent gene duplications in the pepper genomes as major evolutionary forces for diversification of Capsicum spp. Specifically, our analyses revealed that the nucleotide-binding and leucine-rich-repeat proteins (NLRs) were massively created by LTR-R-driven retroduplication. These retoduplicated NLRs were abundant in higher plants, and most of them were lineage-specific. The retroduplication was a main process for creation of functional disease-resistance genes in Solanaceae plants. In addition, 4-10% of whole genes including highly amplified families such as MADS-box and cytochrome P450 emerged by the retroduplication in the plants. Our study provides new insight into creation of disease-resistance genes and high-copy number gene families by retroduplication in plants.

• Journal of Medicine and Life Science
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• v.16 no.2
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• pp.39-42
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• 2019

While the notified crude incidence rates(per 100,000 persons, CIR) of new tuberculosis between 2016 and 2017 decreased in nationwide and 16 provinces, except Jeju Province, Korea. The aim of this study was to compare CIRs of Jeju Province and nationwide by calendar years and age groups in order to interpret the increasing trend of CIR in Jeju Province. The data source was the Integrated Diseases and Health Control System of the Korea Centers for Disease Control and Prevention. The selection criteria were the notified new cases as tuberculosis, who had the address as Jeju Province at diagnosis, between 2011 and 2018. The 95% confidence interval of CIR was estimated based on Poisson distribution. There was not statistically significant difference of CIRs between Nationwide and Jeju Province of 2011 and 2018, except 2016. Especially the CIR of group aged over 65 years in Jeju Province, 2016 was significantly lower compared to Nationwide CIR. But, the CIR of group aged 30~50 between 2017 and 2018 showed significantly higher compared to Nationwide CIR. Based on the results, the fact of increasing CIR from 2016 to 2017 in Jeju Province might be interpreted as an introduction of new tuberculosis screening project rather than real increased CIRs.

• Biomolecules & Therapeutics
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• v.28 no.3
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• pp.222-229
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• 2020

The process of drug discovery and drug development consumes billions of dollars to bring a new drug to the market. Drug development is time consuming and sometimes, the failure rates are high. Thus, the pharmaceutical industry is looking for a better option for new drug discovery. Drug repositioning is a good alternative technology that has demonstrated many advantages over de novo drug development, the most important one being shorter drug development timelines. In the last two decades, drug repositioning has made tremendous impact on drug development technologies. In this review, we focus on the recent advances in drug repositioning technologies and discuss the repositioned drugs used for inflammatory diseases such as sepsis, asthma, and atopic dermatitis.

• Genomics & Informatics
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• v.14 no.1
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• pp.2-11
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• 2016

The advances in mass spectrometry-based proteomics technologies have enabled the generation of global proteome data from tissue or body fluid samples collected from a broad spectrum of human diseases. Comparative proteomic analysis of global proteome data identifies and prioritizes the proteins showing altered abundances, called differentially expressed proteins (DEPs), in disease samples, compared to control samples. Protein biomarker candidates that can serve as indicators of disease states are then selected as key molecules among these proteins. Recently, it has been addressed that cellular pathways can provide better indications of disease states than individual molecules and also network analysis of the DEPs enables effective identification of cellular pathways altered in disease conditions and key molecules representing the altered cellular pathways. Accordingly, a number of network-based approaches to identify disease-related pathways and representative molecules of such pathways have been developed. In this review, we summarize analytical platforms for network-based protein biomarker discovery and key components in the platforms.

• Journal of Animal Science and Technology
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• v.57 no.4
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• pp.10.1-10.7
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• 2015

Control and prevention of foot and mouth disease (FMD) by vaccination remains unsatisfactory in endemic countries. Indeed, consistent and new FMD epidemics in previously disease-free countries have precipitated the need for a worldwide control strategy. Outbreaks in vaccinated animals require that a new and safe vaccine be developed against foot and mouth virus (FMDV). FMDV can be eradicated worldwide based on previous scientific information about its spread using existing and modern control strategies.

• Tuberculosis and Respiratory Diseases
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• v.71 no.3
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• pp.163-171
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• 2011

Recently published articles on interstitial lung disease (ILD) have focused on the accurate diagnosis of idiopathic pulmonary fibrosis (IPF), serum biomarkers, acute exacerbation of IPF, the prognostic factors of ILD and the trial of new treatment. In particular, reports on the serum biomarkers such as CC-chemokine ligand 18, surfactant protein, circulating fibrocytes, and acute exacerbation of IPF are sufficient to be mentioned here. Pirfenidone therapy is the most important trial for the treatment of IPF. Other newer treatment trials such as interferon-gamma, sildenafil and imatinib have been reported to be unsuccessful. On the other hand, the sirolimus trial for lymphangioleiomyomatosis is promising. Combined pulmonary fibrosis and emphysema and IgG4-related disease are established to be the new disease entities of ILD.

• Journal of Preventive Medicine and Public Health
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• v.38 no.4
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• pp.386-390
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• 2005

Influenza A viruses periodicall y cause worldwide epidemics, or pandemics, with high rates of illness and death. A pandemic can occur at any time, with the potential to cause serious illness, death and social and economic disruption throughout the world. Historic evidence suggests that pandemics occurred three to four times per century. In the last century there were three influenza pandemics. The circumstances still exist for a new influenza virus with pandemic potential to emerge an d spread. The unpredictability of the timing of the next pandemic is underlined by the occurrence of several large outbreaks of highly pathogenic avian influenza since the early 1980s. In 1999, the World Health Organization published the Influenza pandemic plan. The role of WHO and guidelines for national and regional planning. And in 2005, WHO revised the global influenza preparedness plan for new national measures before and during pandemics. This document outlines briefly the Korean Centers for Disease Control's plan for responding to an influenza pandemic. According to the new pandemic phases of WHO, we set up the 4 national levels of preparedness and made guidelines for preventing and control the epidemics in each phase. And also we described the future plans to antiviral stockpiles and pandemic vaccine development.

• The Journal of Pediatrics of Korean Medicine
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• v.12 no.1
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• pp.63-76
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• 1998

BACKGROUND : The purpose of this study was to investigate the new effective oriental medical treatments in pediatric diseases and its clinical applicability. METHOD : The study was composed of 1725 new patients who had been treated at the pediatric unit in the Dongguk Bun-Dang Oriental Medicine Hospital for 1 year, from 1 January 1997 to 31 December 1997, and had ages between 0 and 18 years. The chief complaint was mainly categorized by oral examination on patients and their care-givers. RESULT 1. The ratio of male to female was 1.35:1 and the number of each age group and its percentage distribution was 228 patients (13.2%) for the age group between 0 and 1 year, 746 patients (43.2%) between 2 and 6 years, and 751 patients (43.6%) for the age group over 7 years. 2. The chief complaint of the new outpatients was weakness, asthma, common cold, sinustis, skeletal disease, atopic dermatitis, stomach-ache, short stature, diarrhea, nasal blooding, night terror, allergic rhinitis, gastric disorder, enuresis, dermatitis, strabismus in the order of majority.3. The number of patients and its percentage for the most three complaints was 494 patients (28.6%) for weakness, 647 patients (37.4%) for respiratory disease, 144 patients (8.3%) for digestive disease. 4. The digestive disease tended to increase in summer, and appeared mostly in the age group between 0 and 2 years. The respiratory disease increased In inter-season and winter, but decreased significantly in summer. The age group between 1 and 5 years was the largest group of respiratory disease. CONCLUSION 1. The chief complaint in pediatric diseases that needed an oriental medical treatment was mainly the disease that tends to take long time and the weakness, and appeared frequently in digestive and respiratory diseases. 2. The oriental medical treatment was still preferred as a way to improve the weakness by patients, rather than a way to overcome their disease. In particular, the study shows that the oriental medical treatment should be emphasized in terms of preventing the disease. 3. The new diseases, which were developed with the change of human life and environment, (atopic dermatitis, enuresis, short stature, obesity, dysthymic disorder, strabismus), should be investigated as a new field of oriental medical treatment.

• Journal of Sasang Constitutional Medicine
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• v.31 no.1
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• pp.65-78
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• 2019

Objectives This study aims to investigate how the Korean disease-related vocabulary is established or changed when it is translated into French or English. Through this, we examine changes in the meaning of diseases and the ecosystem of disease-related vocabulary in transition period of $19^{th}$ to $20^{th}$ century. Methods Korean disease-related vocabulary are extracted from a total of 148,000 Korean headwords included in our corpus of three bilingual dictionaries. Among them, the scope of analyisis is limited to group of vocabularies that include a high frequency words, disease(病) and symptom(症). Results The first type of change is the emergence of a neologism. In this case, coexistence of existing vocabulary and new words is observed. The second change is the appearance of loan words written in Hangul. The third is the case where the interpretation of meaning is changed while maintaining the word form. Finally, the fourth change is that the orthographic variants are displayed while maintaining the meaning of the existing vocabulary. Discussion Disease-related vocabulary increased greatly between 1897 and 1931. The increasing factor of vocabulary was the emergence of coined words, compound words and the influx of foreign words. The Korean language and the Western language made a new lexical form in order to introduce a new unknown concept to the Korean. We could also confirm that the way in which English word expanded its semantic field by modifying the way of representing the meaning of Korean Disease-related vocabulary.