• Archives of Plastic Surgery
• /
• v.34 no.3
• /
• pp.291-297
• /
• 2007

Purpose: Platelet-rich plasma(PRP) contains protein growth factors, which are actively secreted by platelets to promote wound healing. However, it is not clear whether the injection of PRP into the autologous fat grafts increases the survival rate and the degree of angiogenesis. Methods: New Zealand White rabbit ears were injected fat with PRP, saline, insulin or isoproterenol (n=8/each group) for observation of the survival and degree of angiogenesis of the injected fat. The volume of the harvested fat and the degree of angiogenesis from dorsum of rabbit ears were evaluated 4, 8, and 12 weeks after the autologous fat graft. The degree of angiogenesis was measured with microvascular density (MVD) counts. Results: The volume of harvested fat decreased in a time-dependent manner after autologous fat grafts, but the decrease rate in volume of harvested fat was slower in PRP-injected group compared to that of other control groups. The difference in the volume of the harvested fat between PRP-injected group and other control groups became significant from 4 weeks after the autologous fat graft, and was maintained up to 12 weeks. However, there was no significant difference between PRP-injected group and insulin-injected group 8 and 12 weeks after the autologous fat graft. On the contrary, MVD counts increased in a time-dependent manner after autologous fat grafts. The MVD counts were significantly higher in PRP-and insulin-injected groups than in other control groups from 4 weeks after the autologous fat graft, and these differences were maintained up to 12 weeks. There was no correlation between mean platelet numbers and the volume of harvested fat. Conclusion: The present study demonstrates that PRP-injection into autologous fat grafts increases the survival rate and the degree of angiogenesis. Thus, PRP injection with autologous fat grafts would be a promising tool for maintaining the volume of the grafted fat.

• Journal of Environmental Impact Assessment
• /
• v.20 no.5
• /
• pp.651-661
• /
• 2011

The purpose of this study is to estimate the characteristics and pollutant loadings of non-point pollutants that flowed in the streams on precipitation for pollutant loading reduction of Hwa-sung lake inflow streams. Although it has been made an effort to improve the water quality of Hwa-sung basin through the strategies for the preservation of water quality, it is shown that the water quality is not greatly improved. Because it has been industrialized and urbanized near Hwa-sung basin so that it is difficult to reduce the water pollution due to the increase in pollutant loadings of point and non-point sources. In this study, it is investigated the outflow characteristics of non-point pollutants that discharged with storm runoff and estimated the effect of runoff on Hwa-sung basin. The final goal of this study is to utilize the basic information for proper management and strategies of non-point sources on Hwa-sung basin. At the result of inflow streams, Ja-an stream that has the greatest pollutant loadings on precipitation is strongly influenced on the water quantity of Hwa-sung basin. On the other hand, it is shown that Nam-yang stream is strongly influenced on the SS concentration of Hwasung basin among them. Also, all streams; Nam-yang, Ja-ahn, Ah-eun stream; has the degree of slope more than or near 1 in the correlation results so that they have strong pollutant loading impact and the concentration of SS is the highest among other pollutants. So, specific studies on initial rain phenomena are more necessary to manage the pollutants economically. Also, the proper control of SS concentration is required to manage the effluent pollutants effectively on precipitation. So, it is necessary to consider the strategies for non-point pollutants as well as point pollutants when the new management is imposed to reduce the pollutant load for improvement of Hwa-sung basin.

• Journal of radiological science and technology
• /
• v.39 no.4
• /
• pp.661-667
• /
• 2016

The purpose of this was to study and analyze smart learning the self directed learning, self efficacy, learning satisfaction about department of radiology in a college. For this study total students 102 in 3 classes were surveyed at the end of semester. The research data was analyzed using SPSS also self directed learning, self learning efficacy, learning satisfaction analyzed t-test, ANOVA and Pearson's correlation coefficient results were followings. First, Men is more higher than women in a self learning efficacy, self directed learning, learning satisfaction. Second, in a learning satisfaction smart learning ever heard in a first time group more satisfaction. Third, during the smart learning classes a students appeared a positive response. As a results, learning satisfaction will increase a learning when learners need a ability of self control planning and learning motivation by themselves in voluntarily and actively. Suggest to change a paradigm in a radiology classes so we have to improve a teaching skills this solution recommend is two way communication. In conclusion, smart learning applied for classes of college is meaningful as a new teaching, which can be change gradually learning satisfaction by teaching methods.

• Journal of Preventive Medicine and Public Health
• /
• v.26 no.1 s.41
• /
• pp.74-85
• /
• 1993

To measure the serum succinyl trialanine p-nitroanilide hydrolytic activity as new index of liver function in workers exposed to organic solvents, this study conducted 114 workers in department of shoe-making of shoes factories. The results obtained from this study were as follows : 1. The mean values of serum GOT, GPT, ${\gamma}GT$ in whole workers were $22{\pm}12.32,\;20{\pm}9.05,\;28{\pm}21.35IU/l$, respectively and the mean value of serum STN hydrolytic activity was $0.08{\pm}0.05$. 2. The serum STN hydrolytic activity was significantly higher for male (p<0.05) and there was no difference among the groups of age. 3. There was no difference in the groups by working hours but significant difference in persons who worked over 3 years or were exposed to toluene over 100ppm (p<0.05). 4. The correlation of the exposed dose of toluene and serum GOT, GPT, ${\gamma}GT$ and serum STN hydrolytic activity were statistically significant (r=0.027-0.518). 5. The exposed dose of toluene was most explainable variable and statistically significant among the factors affecting serum STN hydrolytic activity (p<0.05).

• Korean Journal of Head & Neck Oncology
• /
• v.15 no.1
• /
• pp.46-51
• /
• 1999

Background: Total thyroidectomy and postoperative radiodiodine ablation therapy in differentiated thyroid carcinomas enhance the reliability of serum thyroglobulin(Tg) levels and radioiodine scan in detecting recurrence or distant metastasis. There have been, however, some limitations in using these methods under certain conditions. Recently, several reports have indicated that thyroid peroxidase(TPO) could be used as an alternative tumor marker. We aimed to estimate the significance of serum TPO levels in differentiated thyroid carcinoma. Materials and Methods: Forty-eight patients who had undergone total thyroidectomy due to papillary thyroid carcinomas and who had been followed-up for at least 3 years were classified into two groups: 27 patients without any evidence of recurrence in group 1; and 20 patients with recurrence or distant metastasis in group 2. All patients were examined by radioiodine scans. Serum Tg, TSH, antithyroglobulin antibody, and TPO were measured and the relationships were statistically analyzed. The sensitivity and specificity of $^{131}I$ scan, serum Tg, and serum TPO were evaluated. Results: Serum Tg levels were $3.81{\pm}5.16ng/mL$ in group 1 and $147.02{\pm}193.75ng/mL$ in group 2. Only 2 patients in group 1 showed Tg levels exceeding 10ng/mL. In contrast, 4 patients in group 2 were under 10ng/mL. Serum antithyroglobulin antibody and TSH levels showed no statistical difference between the two groups. In group 1, 16 patients showed negative serum TPO results, and 4 patients in group 2 showed negative results. There was no correlation among serum Tg levels, antithyroglobulin antibody titers, and serum TPO levels in each group. In group 2, 4 patients with negative serum Tg levels showed positive TPO results and positive whole body scans. Two cases with false negative $^{131}I$ scans showed positive serum TPO and Tg results. In 4 cases showing false negative serum TPO levels, serum Tg levels and $^{131}I$ scans were positive. Conclusion: Serum Tg levels, radioiodine scans, and serum TPO levels can be clinically used as complementary methods in the diagnosis of recurrent or metastatic thyroid carcinomas. Serum TPO levels may be helpful when other methods fail to detect recurrences or distant metastasis in highly suspected patients.

• Korean Journal of Clinical Laboratory Science
• /
• v.49 no.4
• /
• pp.470-476
• /
• 2017

Changes in the mammalian target of the rapamycin (mTOR) signaling proteins have been observed in many types of cancer. Accordingly, these proteins have recently become an exciting new target for molecular therapeutics. This study examined the expression of an activated mTOR signaling protein in patients with colorectal adenocarcinoma (CRAC) and colorectal adenoma lesion. Immunohistochemical analysis was performed on human CRAC and adenoma for the mTOR signaling components, including mTOR, phosphorylation, and activation of S6 kinase (p70-S6K), S6 ribosomal protein (S6), and eukaryotic initiation factor 4E-binding protein (4EBP1). A total of 100 cases with colorectal adenocarcinoma (CARC; N=40), adenoma with high-grade intraepithelial neoplasms (HIN; N=30), and adenoma with low-grade intraepithelial neoplasms (LIN; N=30) were enrolled in this study. p-mTOR expression was observed in 30 cases of the CRAC tissues (75%), 9 cases of adenoma with HIN (30%), and 2 cases of adenoma with LIN (7%). In addition, p-S6 expression was observed in 22 cases of CRAC tissues (55%), 8 cases of adenoma with HIN (27%), and 3 cases of adenoma with LIN (10%). A significant correlation was observed among the p-mTOR, p-S6 expression, and the adenoma-carcinoma sequence. Interestingly, the p-S6 protein was activated more in early CRAC than in advanced CRAC.

• Journal of Preventive Medicine and Public Health
• /
• v.37 no.4
• /
• pp.381-389
• /
• 2004

Objective : To compare the efficacy between SKI306X and Diclofenac by using generalized estimating equations (GEE) methodology in the analysis of correlated bivariate binary outcome data in Osteoarthritis (OA) diseases. Methods : A randomized, double-blind, active comparator-controlled, non-inferiority clinical trial was conducted at 5 institutions in Korea with the random assignment of 248 patients aged 35 to 75 years old with OA of the knee and clinical evidence of OA. Patients were enrolled in this study if they had at least moderate pain in the affected knee joint and a score larger than 35mm as assessed by VAS (Visual Analog Scale). The main exposure variable was treatment (SKI 306X vs. Diclofenac) and other covariates were age, sex, BMI, baseline VAS, center, operation history (Yes/No), NSAIDS (Y/N), acupuncture (Y/N), herbal medicine (Y/N), past history of musculoskeletal disease (Y/N), and previous therapy related with OA (Y/N). The main study outcome was the change of VAS pain scores from baseline to the 2nd and 4th weeks after treatment. Pain scores were obtained as baseline, 2nd and 4th weeks after treatment. We applied GEE approach with empirical covariance matrix and independent(or exchangeable) working correlation matrix to evaluate the relation of several risk factors to the change of VAS pain scores with correlated binary bivariate outcomes. Results : While baseline VAS, age, and acupuncture variables had protective effects for reducing the OA pain, its treatment (Joins/Diclofenac) was not statistically significant through GEE methodology (ITT:aOR=1.37, 95% CI=(0.8200, 2.26), PP:aOR=1.47, 95% CI=(0.73, 2.95)). The goodness-of-fit statistic for GEE (6.55, p=0.68) was computed to assess the adequacy of the fitted final model. Conclusions : Both ANCOVA and GEE methods yielded non statistical significance in the evaluation of non-inferiority of the efficacy between SKI306X and Diclofenac. While VAS outcome for each visit was applied in GEE, only VAS outcome for the fourth visit was applied in ANCOVA. So the GEE methodology is more accurate for the analysis of correlated outcomes.

• The Korean Journal of Nuclear Medicine
• /
• v.28 no.1
• /
• pp.22-30
• /
• 1994

Encephalo-duro-arterio-synangiosis (EDAS) is a relatively new surgical procedure for treatment of childhood moyamoya disease. We assessed regional cerebral perfusion in moyamoya patients before (1.3 mo) and after (6.8 mo) EDAS with $^{99m}Tc$-HMPAO brain SPECT. A total of 21 EDAS operations in 17 moyamoya patients was included. Preoperative CT or MRI showed cerebral infarction in 14 patients and carotid angiography showed Suzuki grade I to V stenosis in 6%, 9%, 62%, 12% and 12% of the hemispheres respectively. Preoperative SPECT showed regional hypoperfusion in all patients, bilateral frontal and temporal lobes being the most frequently involved site. $4{\times}4$ pixel sized ROIs were applied on the frontotemporal cortex in 3 slice averaged transverse tomographic images. An index of regional perfusion was measured as: PI (%)=average F-T activity/average cerebellar activity${\times}100$ Pre-EDAS ipsilateral PI ranged from 23.7 to 98.4% (mean: $74.3{\pm}17%$) and increased significantly after operation ($81.4{\pm}17%$, p<0.001). Individual post-EDAS PI improved in 15/21 cases, showed no significant change in 5 and was slightly aggravated in 1. The amount of clinical improvement (${\Delta}CI$) was graded with a scale of 0 to 4 based on frequency and severity of TIA attacks. When patients were grouped according to pre-EDAS PI, group II (PI 70-89) showed a significantly higher ${\Delta}CI$ (3.3) compared to group I (PI< 70, 1.57) or group III (PI >90, 0.5) (P< 0.001). The amount of perfusion improvement (${\Delta}PI$) showed significant correlation with ${\Delta}CI$ (r=0.42, p=0.04). ${\Delta}PI$ did not, however, correlate with the amount of neovascularization assessed angiographically in 8 patients. Serial HMPAO SPECT is an useful noninvasive study for assessing perfusion improvement after EDAS in childhood moyamoya patients.

• Journal of Wetlands Research
• /
• v.20 no.2
• /
• pp.173-180
• /
• 2018

The utilization of TOC(Total organic carbon), a new environmental standard, was evaluated for 30 lakes in the Nakdong River Basin, which is used for drinking and agricultural usage. The active use of water resources begins with securing satisfactory water quality. Since this allows people and nature to maintain stability of quality, water quality standards are being tightened to ensure good water quality. In order to improve the pollution level of organic matter in lakes in the living environment, it is important to use the appropriate organic substance index. The relationship between the newly introduced TOC and the existing COD(Chemical oxygen demand) in the targeted lake was positively correlated with the possibility of replacing the TOC with COD. However, the environmental grade standard using TOC is better than the environmental grade standard using COD, so it has the same effect as that of the grade of water quality using TOC as an organic substance factor. This indicates the limitation of TOC to directly replace existing COD when trying to determine or improve the quality level using organic indicators of lakes. Therefore, in order to secure the qualitative safety of the lake, it is required to strengthen environmental standards of TOC in terms of water quality grade. In addition, the correlation between TOC and COD shows a great difference depending on the utilization characteristics of the lake. This requires clear scientific identification, and it requires continuous monitoring of COD that has been used to accumulate indicators of lake organic matter.

• Ecology and Resilient Infrastructure
• /
• v.7 no.2
• /
• pp.114-125
• /
• 2020

Despite the various artificial neural networks that have been developed, most of the discharge models in previous studies have been developed using deep neural networks. This study aimed to develop a discharge model using a convolution neural network (CNN), which was used to solve classification problems. Furthermore, the applicability of CNN was evaluated. The photographs (pictures or images) for input data to CNN could not clearly show the characteristics of the study area as well as precipitation. Hence, the model employed in this study had to use numerical images. To solve the problem, the CN of NRCS was used to generate images as input data for the model. The generated images showed a good possibility of applicability as input data. Moreover, a new application of CN, which had been used only for discharge prediction, was proposed in this study. As a result of CNN training, the model was trained and generalized stably. Comparison between the actual and predicted values had an R² of 0.79, which was relatively high. The model showed good performance in terms of the Pearson correlation coefficient (0.84), the Nash-Sutcliffe efficiency (NSE) (0.63), and the root mean square error (24.54 ㎥/s).