• 동남아시아연구
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• 제21권1호
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• pp.1-48
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• 2011

This study examines the perception and its meaning of child education and mother]s role for children of Korean mothers for their children to study abroad in Malaysia. For this purpose, data was collected through in-depth interviews with seven mothers and one grandmother. All participants were lived in Malaysia for at least 6 months above. As a result, the most of recommenders of studying in Malaysia were fathers. And the purposes of studying in Malaysia were the improvement of their children's English learning skills and abilities, and not-good academic achievement in Korea. They made a decision for their children to study in Malaysia in that it was good to study in Malaysia for early 'spec' management for their children. But in the case of Korean mothers, they had a diverse desires internally. For example, they had a desire to escape from the relationships with mother-in law or complicated social relations of their family, kin, and neighbors in Korea. In Malaysia, Koran mothers carried out their roles of children's time management, information network management and 'distinction' strategies to their friends and neighbors for their children to study well and up their achievements' levels. Lately, they had planning to develop for their children's long term life design and their choices of universities in Korea, with special reference to the various connections of school-ties and religion-ties in Malaysia.

• Biomolecules & Therapeutics
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• 제30권3호
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• pp.238-245
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• 2022

Previous reports have demonstrated that genetic mechanisms greatly mediate responses to drugs of abuse, including methamphetamine (METH). The circadian gene Period 2 (Per2) has been previously associated with differential responses towards METH in mice. While the behavioral consequences of eliminating Per2 have been illustrated previously, Per2 overexpression has not yet been comprehensively described; although, Per2-overexpressing (Per2 OE) mice previously showed reduced sensitivity towards METH-induced addiction-like behaviors. To further elucidate this distinct behavior of Per2 OE mice to METH, we identified possible candidate biomarkers by determining striatal differentially expressed genes (DEGs) in both drug-naïve and METH-treated Per2 OE mice relative to wild-type (WT), through RNA sequencing. Of the several DEGs in drug naïve Per2 OE mice, we identified six genes that were altered after repeated METH treatment in WT mice, but not in Per2 OE mice. These results, validated by quantitative real-time polymerase chain reaction, could suggest that the identified DEGs might underlie the previously reported weaker METH-induced responses of Per2 OE mice compared to WT. Gene network analysis also revealed that Asic3, Hba-a1, and Rnf17 are possibly associated with Per2 through physical interactions and predicted correlations, and might potentially participate in addiction. Inhibiting the functional protein of Asic3 prior to METH administration resulted in the partial reduction of METH-induced conditioned place preference in WT mice, supporting a possible involvement of Asic3 in METH-induced reward. Although encouraging further investigations, our findings suggest that these DEGs, including Asic3, may play significant roles in the lower sensitivity of Per2 OE mice to METH.

• 스마트미디어저널
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• 제10권4호
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• pp.71-79
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• 2021

인터넷의 사용이 광범위 해져감에 따라 변화되는 사회적 측면 중 하나는 온라인 공간에서의 의사소통이다. 과거에는 물리적으로 같은 공간에 있을 때를 제외하고는 일대일 대화만 원격으로 가능했지만, 요즘은 게시판이나 커뮤니티, 소셜네트워크서비스(SNS) 등을 통해 다수의 사람들과 원격으로 소통할 수 있는 기술이 발달했다. 이러한 정보통신망의 발달로 생활이 편리해지고, 동시에 급격한 정보교류에 따른 피해도 끊임없이 증가하고 있다. 최근에는 연예인뿐 아니라 인플루언서 등 인터넷에서 인지도가 높은 특정인에게 성적인 메시지를 보내거나 인신공격을 가하는 등의 사이버 범죄가 발생하고 있으며, 이들 사이버 범죄에 노출된 이들 중 일부는 극단적인 선택을 하기도 하였다. 본 논문에서는 악성 댓글로 인한 피해를 줄이기 위해 음성 부분별 기능추출을 통한 차별적 악성 댓글의 성능향상 방안을 연구하였다.

• Journal of Animal Science and Technology
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• 제65권2호
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• pp.401-411
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• 2023

Many studies have been conducted to improve technology for semen cryopreservation in pigs. However, computer-assisted analysis of sperm motility and morphology is insufficient to predict the molecular function of frozen-thawed semen. More accurate expression patterns of boar sperm proteins may be derived using the isobaric tags for relative and absolute quantification (iTRAQ) technique. In this study, the iTRAQ-labeling system was coupled with liquid chromatography tandem-mass spectrometry (LC-MS/MS) analysis to identify differentially expressed CM10-fractionated proteins between fresh and frozen-thawed boar semen. A total of 76 protein types were identified to be differentially expressed, among which 9 and 67 proteins showed higher and lower expression in frozen-thawed than in fresh sperm samples, respectively. The classified functions of these proteins included oxidative phosphorylation, mitochondrial inner membrane and matrix, and pyruvate metabolic processes, which are involved in adenosine triphosphate (ATP) synthesis; and sperm flagellum and motile cilium, which are involved in sperm tail structure. These results suggest a possible network of biomarkers associated with survival after the cryopreservation of Duroc boar semen.

• 디자인융복합연구
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• 제15권1호
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• pp.233-246
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• 2016

모바일 헬스 산업은 IT 기술과 융합하여 주목받고 있으며, 헬스 애플리케이션은 사용자의 건강한 라이프 스타일을 제공하는 방향으로 발전하고 있다. 본 연구는 4개의 모바일 헬스 애플리케이션을 선정하여 서비스의 동향을 살펴 보았고 그 결과 모두 신체 데이터 이외의 감정에 관한 데이터를 포함하고 있지 않고 있음을 알 수 있었다. 추가적으로 사용자의 감정을 추출을 위한 기술을 분류 및 분석하였고, 이를 통해 텍스트 기반 감정인식 기술이 모바일 헬스 서비스와 가장 적합하다고 판단하였다. 감정인식 서비스를 구현하고자 소셜 네트워크 서비스와 1차원 감정 모델을 시스템의 소스로 설정한 감정인식 시스템의 프로세스 설계를 하여 개발하였다. 뿐만 아니라, 본 시스템이 모바일 헬스 애플리케이션에서 어떻게 사용 가능할지 제안하고자 설득형 기술과 결합하였다. 결과적으로 사용자의 5가지 감정과 감정이 지속되는 시간에 따른 15가지의 제안을 포함하는 가이드라인과 구체적 서비스 방안 제안하였다. 이에 본 연구는 기존의 헬스 애플리케이션이 정신적 건강, 감정적 건강과 같은 개인의 심리적 컨텍스트까지 고려하는 제안형 서비스로 나아가기 위한 지침이 될 것으로 기대하는 바이다.

• 영어영문학
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• 제58권6호
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• pp.1001-1021
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• 2012

This paper is concerned with John Ashbery's poetics of difficulty, questioning in particular the nature of communication in his difficult poems. Ashbery has an idea of poetry as 'information' to be transmitted to the reader. Meaning, however, is to be created by a series of selections among equally probable choices. Ashbery's poetry has been characterized by resistance to the interpretive system of meaning. But the resistance itself, as I will argue, can be an effective medium of communication as the communicated message is not simply transmitted but 'selected' and thus created by the reader. In Ashbery's poetry, disruptive 'noise' elements can be processed as constructive information. What is normally considered a hindrance or noise can be reversed and added to the information. In Ashbery's poems, random ambiguities or noises can be effectively integrated into the final structure of meaning. Such a stochastic sense of information transfer has been embodied in Ashbery's idea of creating a network of verbal elements in his poetry, analogous to the interconnecting web of hypertext, the most dynamic medium 'information technology' has brought to us. John Ashbery, whose poems are simultaneously incomprehensible and intelligent, employs ambiguities or noise in his poetry, with an attempt to reach through linear language to express nonlinear realities. It is therefore my intention to examine Ashbery's poetics of difficulty, from a perspective of communication transmission, using the theories of information technology and the principles of hypertext theory. Ashbery's poetry raises precisely the problem confronted in the era of communication and information technology. The paper will also show how his aesthetics of difficulty reflects the culture of our uncertain times with overflowing information. With his difficult enigmatic poems, Ashbery was able to move ahead of the technological advances of his time to propose a new way of perceiving the world and life.

• 한국심리학회지 : 문화 및 사회문제
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• 제15권4호
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• pp.565-589
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• 2009

본 연구에서는 게임 사용의 부정적 결과에 초점을 둔 선행 연구와 달리, 게임활용의 긍정적 결과로서의 적응적 게임활용도를 측정하는 도구를 개발하고 타당화하였다. 예비조사를 통해 적응적 게임활용 측정 도구를 개발하고, 유층표집을 통해 선정된 전국 중고등학생 600명을 대상으로 본조사를 실시하였다. 연구결과 활력 경험, 생활경험 확장, 여가 선용, 몰입 경험, 자긍심 경험, 통제력 경험, 사회적 지지망 유지 및 확장 등 7개의 요인으로 구성되는 척도의 신뢰도와 시간에 걸친 안정성이 확인되었다. 또한, 척도의 구성타당도, 변별타당도, 및 공인타당도를 확인하였다. 게임 연구의 외연 확장과 관련한 본 연구의 시사점과 장래 연구 방향을 논의하였다.

• 대한의용생체공학회:의공학회지
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• 제45권2호
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• pp.95-100
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• 2024

Vitiligo is a condition characterized by the destruction or dysfunction of melanin-producing cells in the skin, resulting in a loss of skin pigmentation. Facial vitiligo, specifically affecting the face, significantly impacts patients' appearance, thereby diminishing their quality of life. Evaluating the efficacy of facial vitiligo treatment typically relies on subjective assessments, such as the Facial Vitiligo Area Scoring Index (F-VASI), which can be time-consuming and subjective due to its reliance on clinical observations like lesion shape and distribution. Various machine learning and deep learning methods have been proposed for segmenting vitiligo areas in facial images, showing promising results. However, these methods often struggle to accurately segment vitiligo lesions irregularly distributed across the face. Therefore, our study introduces a framework aimed at improving the segmentation of vitiligo lesions on the face and providing an evaluation of vitiligo lesions. Our framework for facial vitiligo segmentation and lesion evaluation consists of three main steps. Firstly, we perform face detection to minimize background areas and identify the face area of interest using high-quality ultraviolet photographs. Secondly, we extract facial area masks and vitiligo lesion masks using a semantic segmentation network-based approach with the generated dataset. Thirdly, we automatically calculate the vitiligo area relative to the facial area. We evaluated the performance of facial and vitiligo lesion segmentation using an independent test dataset that was not included in the training and validation, showing excellent results. The framework proposed in this study can serve as a useful tool for evaluating the diagnosis and treatment efficacy of vitiligo.

• IMMUNE NETWORK
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• 제16권4호
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• pp.242-248
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• 2016

Thymic atrophy is a complication that results from exposure to many environmental stressors, disease treatments, and microbial challenges. Such acute stress-associated thymic loss can have a dramatic impact on the host's ability to replenish the necessary naïve T cell output to reconstitute the peripheral T cell numbers and repertoire to respond to new antigenic challenges. We have previously reported that treatment with the orexigenic hormone ghrelin results in an increase in the number and proliferation of thymocytes after dexamethasone challenge, suggesting a role for ghrelin in restraint stress-induced thymic involution and cell apoptosis and its potential use as a thymostimulatory agent. In an effort to understand how ghrelin suppresses thymic T cell apoptosis, we have examined the various signaling pathways induced by receptor-specific ghrelin stimulation using a restraint stress mouse model. In this model, stress-induced apoptosis in thymocytes was effectively blocked by ghrelin. Western blot analysis demonstrated that ghrelin prevents the cleavage of pro-apoptotic proteins such as Bim, Caspase-3, and PARP. In addition, ghrelin stimulation activates the Akt and Mitogen-activated protein kinases (MAPK) signaling pathways in a time/dose-dependent manner. Moreover, we also revealed the involvement of the FoxO3a pathway in the phosphorylation of Akt and ERK1/2. Together, these findings suggest that ghrelin inhibits apoptosis by modulating the stress-induced apoptotic signal pathway in the restraint-induced thymic apoptosis.

• IMMUNE NETWORK
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• 제19권1호
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• pp.7.1-7.11
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• 2019

Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disorder that affects mainly salivary and lacrimal glands, but its cause remains largely unknown. Clinical data indicating that SS occurs in a substantial proportion of patients with lupus points to common pathogenic mechanisms underlying the two diseases. To address this idea, we asked whether SS develops in the lupus-prone mouse strain sanroque (SAN). Owing to hyper-activation of follicular helper T (Tfh) cells, female SAN mice developed lupus-like symptoms at approximately 20 wk of age but there were no signs of SS at that time. However, symptoms typical of SS were evident at approximately 40 wk of age, as judged by reduced saliva flow rate, sialadenitis, and IgG deposits in the salivary glands. Increases in serum titers of SS-related autoantibodies and numbers of autoantibody-secreting cells in cervical lymph nodes (LNs) preceded the pathologic manifestations of SS and were accompanied by expansion of Tfh cells and their downstream effector cells. Thus, our results suggest that chronic dysregulation of Tfh cells in salivary gland-draining LNs is sufficient to drive the development of SS in lupus-prone mice.