• Journal of Acupuncture Research
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• v.21 no.3
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• pp.283-302
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• 2004

Background : Angiogenesis is the proliferation of a network of blood vessels emanating from pre-existing vessels, supplying nutrients and oxygen and removing waste products. Angiogenesis occurs in a variety of normal physiologic and pathologic conditions and is regulated by a balance of stimulatory and inhibitory angiogenic factors. Excessive angiogenesis should be suppressed. However, if blood supply is insufficient, it should be encouraged. Hyul-Mek(血脈) or Hyul-Rark(血絡), known as blood vessels in western medicine, is deeply related to Chung-Ki-Hyul(精 氣 血). The goal of this study is to review the effects of herbal medicines on angiogenesis that is involved in wound healing and enhancement of blood supply. Methods : We conducted a systematic and comprehensive literature search for the identification, retrieval, and bibliographic management of independent studies to locate information on the topic. A computerized search of the published literature of Korea(KISS, RISS), China(CNKI), Japan(Kampo medicine, etc), and western countries(MEDLINE) was performed, and further supplemented with manual searches of print sources(1999 to 2003). Results : The herbal medicines with angiogenic activity were mainly found among herbs that carry replenish Shin-Cheng(補腎益精), foster Eum and improve the circulation of blood(養陰活血), or warm and circulate Kyung-Rark(溫經通絡). In particular, herbs with improve the circulation of blood and clear blood(活血化瘀) activity contain a significant amount of tannin, saponin, and pyrazine. Conclusion : Replenish Ki-Hyul(補氣血) and circulate Kyung-Rark(通經絡) could contribute to the induction of angiogenesis because various growth factors and proliferation, differentiation, and migration of vascular endothelial cells are involved in angiogenic activity.

• The Journal of the Acoustical Society of Korea
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• v.21 no.6
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• pp.566-575
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• 2002

Low-titrate audio coding enables a number of Internet and mobile multimedia streaming service more efficiently. For the help of next-generation mobile telephone technologies and digital audio/video compression algorithm, we can enjoy the real-time multimedia contents on our mobile devices (cellular phone, PDA notebook, etc). But the limited available bandwidth of mobile communication network prohibits transmitting high-qualify AV contents. In addition, most bandwidth is assigned to transmit video contents. In this paper, we design a novel and simple method for reproducing high frequency components. The spectrum of high frequency components, which are lost by down-sampling, are modeled by the energy rate with low frequency band in Bark scale, and these values are multiplexed with conventional coded bitstream. At the decoder side, the high frequency components are reconstructed by duplicating with low frequency band spectrum at a rate of decoded energy rates. As a result of segmental SNR and MOS test, we convinced that our proposed method enhances the subjective sound quality only 10%∼20% additional bits. In addition, this proposed method can apply all kinds of frequency domain audio compression algorithms, such as MPEG-1/2, AAC, AC-3, and etc.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.25 no.5
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• pp.1043-1057
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• 2015

In order to recognize intelligent threats quickly and detect and respond to them actively, major public bodies and private institutions operate and administer an Intrusion Detection Systems (IDS), which plays a very important role in finding and detecting attacks. However, most IDS alerts have a problem that they generate false positives. In addition, in order to detect unknown malicious codes and recognize and respond to their threats in advance, APT response solutions or actions based systems are introduced and operated. These execute malicious codes directly using virtual technology and detect abnormal activities in virtual environments or unknown attacks with other methods. However, these, too, have weaknesses such as the avoidance of the virtual environments, the problem of performance about total inspection of traffic and errors in policy. Accordingly, for the effective detection of intrusion, it is very important to enhance security monitoring, consequentially. This study discusses a plan for the reduction of false positives as a plan for the enhancement of security monitoring. As a result of an experiment based on the empirical data of G, rules were drawn in three types and 11 kinds. As a result of a test following these rules, it was verified that the overall detection rate decreased by 30% to 50%, and the performance was improved by over 30%.

• IMMUNE NETWORK
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• v.12 no.1
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• pp.33-39
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• 2012

Background: Therapeutic approaches using monoclonal antibodies (mAbs) against complement regulatory proteins (CRPs:i.e.,CD46,CD55 and CD59) have been reported for adjuvant cancer therapy. In this study, we generated a recombinant 1E8 single-chain anti-CD59 antibody (scFv-Fc) and tested anti-cancer effect.by using complement dependent cytotoxicity (CDC). Methods: We isolated mRNA from 1E8 hybridoma cells and amplified the variable regions of the heavy chain (VH) and light chain (VL) genes using reversetranscriptase polymerase chain reaction (RT-PCR). Using a linker, the amplified sequences for the heavy and light chains were each connected to the sequence for a single polypeptide chain that was designed to be expressed. The VL and VH fragments were cloned into the pOptiVEC-TOPO vector that contained the human CH2-CH3 fragment. Then, 293T cells were transfected with the 1E8 single-chain Fv-Fc (scFv-Fc) constructs. CD59 expression was evaluated in the prostate cancer cell lines using flow cytometry. The enhancement of CDC effect by mouse 1E8 and 1E8 scFv-Fc were evaluated using a cytotoxicity assay. Results: The scFv-Fc constructs were expressed by the transfected 293T cells and secreted into the culture medium. The immunoreactivity of the secreted scFv-Fc construct was similar to that of the mouse 1E8 for CCRF-CEM cells. The molecular masses of 1E8 scFv-Fc were about 120 kDa and 55 kDa under reducing and non-reducing conditions, respectively. The DNA sequence of 1E8 scFv-Fc was obtained and presented. CD59 was highly expressed by the prostate cancer cell line. The recombinant 1E8 scFv-Fc mAb revealed significantly enhanced CDC effect similar with mouse 1E8 for prostate cancer cells. Conclusion: A 1E8 scFv-Fc construct for adjuvant cancer therapy was developed.

• Journal of Advanced Navigation Technology
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• v.19 no.6
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• pp.623-629
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• 2015

In the present study, a coplanar waveguide (CPW)-fed printed monopole antenna with an inverted n-shaped slot is newly proposed for dual band operations which cover bandwidths of CDMA (1.85~2.025 GHz) and WLAN (2.4~2.484 GHz) as well as implementation of omnidirectional radiation pattern. For enhancement of impedance bandwidth ($S11{\leq}10dB$) in 2.4 GHz WLAN frequency band, an inverted n-shaped slot instead of the previous n-shaped slot is etched on the printed radiating monopole. The proposed antenna is designed and fabricated on one side of FR4 substrate with dielectric constant of 4.4, thickness of 1.6 mm, and size of $50{\times}25mm^2$. It has been observed that the measured impedance bandwidths are 280 MHz (1.84~2.12 GHz) in frequency band of CDMA and 420 MHz (2.38~2.8 GHz) in WLAN frequency band respectively. It is noticeable that impedance bandwidth in 2.4 GHz frequency band of WLAN is enlarged to three times due to use of inverted L-shaped slot in comparison with impedance bandwidth 140 MHz (2.39~2.53 GHz) obtained by use of the previous n-shaped slot. In addition, good omnidirectional radiation patterns have been observed over the entire frequency band of interest.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.627-635
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• 2017

Modern warfare is gradually changing into a network war, and information electronic warfare is also progressing. In modern war, electronic warfare is all military activity concerned with electromagnetic field use, such as signal collecting, communication monitoring, information analysis, and electronic attack. The one key function of signal collecting for enemy signal analysis, direction finding, collects the signal radiated from enemy area and then calculates the enemy direction. This paper examined the Watson-Watt algorithm for an amplitude direction finding system and CVDF algorithm for phase direction finding system and analyzed the difference in the direction finding accuracy between in the clean electromagnetic field environment and in the real operating field environment of electronic warfare system. In the real field, the direction finding accuracy was affected by the reflected field from the surrounding obstacles. Therefore, this paper proposesan enhanced direction finding process for reducing the effect. The result of direction finding by applying the proposed process was enhanced above $1.24^{\circ}$ compared to the result for the existing process.

• Journal of Korea Technology Innovation Society
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• v.14 no.4
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• pp.833-859
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• 2011

This study aims to draw the characteristics of the regional operation system of the shared research instrument service, which contributes to the R&D investment efficiency by the avoidance of duplicated research instrument investment and the enhancement of the network collaboration. So from the perspective of technology infrastructure policy and regional innovation system, Gyeonggi region of Korean metropolitan area has been analyzed for the case study. The case study has been conducted by 2 step process of within-case analysis and cross-case analysis. Firstly, the characteristics of operation system of the shared research instrument have been examined through various research methods. Secondly, in the cross-case analysis, the examined issues and problems have been organized by the matrix of 3 organizational governance characteristics and 4 issues to facilitate the regional policy approach. The issues deducted by the cross-case analysis have been deducted as (1) 'usage fee charge system', 'relevant method for the performance index and measurement of the instrument service management' for the regional policy led case, (2) 'performance management issue', 'financial and managerial accounting system for the instrument operating division', and 'change of budget support scheme' for the joint operation case and lastly (3) 'usage facilitation after the expiration of research lab support project' for the university led case.

• The KIPS Transactions:PartB
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• v.18B no.5
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• pp.249-254
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• 2011

FGS (fine granularity scalability) supporting scalability in MPEG-4 Part 2 is a scalable video coding scheme that provides bit-rate adaptation to varying network bandwidth thereby achieving of its optimal video quality. In this paper, we proposed FGS coding scheme which performs one more bit-plane coding for residue signal occured in the enhancement-layer of the basic FGS coding scheme. The experiment evaluated in terms of video quality scalability of the proposed FGS coding scheme by comparing with FGS coding scheme of the MPEG-4 verification model (VM-FGS). The comparison was conducted by analysis of PSNR values of three tested video sequences. The results showed that when using rate control algorithm VM5+, the proposed FGS coding scheme obtained Y, U, V PSNR of 0.4 dB, 9.4 dB, 9 dB averagely higher and when using fixed QP value 17, obtained Y, U, V PSNR of 4.61 dB, 20.21 dB, 16.56 dB averagely higher than the existing VM-FGS. From results, we found that the proposed FGS coding scheme has higher video quality scalability to be able to achieve video quality from minimum to maximum than VM-FGS.

• IMMUNE NETWORK
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• v.6 no.4
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• pp.192-198
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• 2006

Background: Investigating strategy to enhance efficiency of gene transfer via adenovirus is critical to sustain gene expression in targeted cells or tissues to regulate immune responses. However, the use of adenovirus as a gene delivery method has been limited by the native tropism of the virus. In this study, the critical parameter is to improve the efficient binding of viral particles to the plasma membrane prior to cellular uptake. Methods: Human immunodeficiency virus (HIV-1) trans-acting activator of transcription (TAT), a protein transduction domain, was fused to the ectodomain of the coxsackie-adenovirus receptor (CAR). The CAR-TAT protein was produced from a Drosophila Schneider 2 cells (S2) transfected with CAR-TAT genes. The function of CARTAT was analyzed the efficiency of adenoviral gene transfer by flow cytometry, and then immunizing AdVGFP with CAR-TAT was transduced on dendritic cells (DCs). Results: S2 transfectants secreting CAR-TAT fusion protein has been stable over a period of 6 months and its expression was verified by western blot. Addition of CAR-TAT induced higher transduction efficiency for AdVGFP at every MOI tested. When mice were vaccinated with DC of which adenoviral transduction was mediated by CAR-TAT, the number of IFN-${\gamma}$ secreting T-cells was increased as compared with those DCs transduced without CAR-TAT. Conclusion: Our data provide evidence that CAR-TAT fusion protein enhances adenoviral transduction and immunogenecity of transgenes on DCs and may influence on the development of adenoviral-mediated anti-tumor immunotherapy.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.47 no.4
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• pp.71-81
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• 2010

In grid system, Task scheduling based on list scheduling models has showed low complexity and high efficiency in fully connected processor set environment. However, earlier schemes did not consider sufficiently the communication cost among tasks and the composition process of lightpath for communication in optical gird environment. In this thesis, we propose LSOG (Leveling Selection in Optical Grid) which sets task priority after forming a hierarchical directed acyclic graph (DAG) that is optimized in optical grid environment. To determine priorities of task assignment in the same level, proposed algorithm executes the task with biggest communication cost between itself and its predecessor. Then, it considers the shortest route for communication between tasks. This process improves communication cost in scheduling process through optimizing link resource usage in optical grid environment. We compared LSOG algorithm with conventional ELSA (Extended List Scheduling Algorithm) and SCP (Scheduled Critical Path) algorithm. We could see the enhancement in overall scheduling performance through increment in CCR value and smoothing network environment.