• Title/Summary/Keyword: Negative feedback

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Serine 389 phosphorylation of 3-phosphoinositide-dependent kinase 1 by UNC-51-like kinase 1 affects its ability to regulate Akt and p70 S6kinase

  • Kim, Kidae;Park, Sung Goo;Park, Byoung Chul;Kim, Jeong-Hoon;Kim, Sunhong
    • BMB Reports
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    • v.53 no.7
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    • pp.373-378
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    • 2020
  • Phosphorylation of the signaling component by protein kinase often leads to a kinase cascade or feedback loop. 3-Phosphoinositide-dependent kinase 1 (PDK1) signaling pathway diverges into various kinases including Akt and p70 S6 kinase (p70S6k). However, the PDK1 feedback mechanism remains elusive. Here, we demonstrated that UNC-51-like kinase (ULK1), an autophagy initiator kinase downstream of mechanistic target of rapamycin (mTOR), directly phosphorylated PDK1 on serine 389 at the linker region. Furthermore, our data showed that this phosphorylation affected the kinase activity of PDK1 toward downstream substrates. These results suggest a possible negative feedback loop between PDK1 and ULK1.

Document Summarization using Pseudo Relevance Feedback and Term Weighting (의사연관피드백과 용어 가중치에 의한 문서요약)

  • Kim, Chul-Won;Park, Sun
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.16 no.3
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    • pp.533-540
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    • 2012
  • In this paper, we propose a document summarization method using the pseudo relevance feedback and the term weighting based on semantic features. The proposed method can minimize the user intervention to use the pseudo relevance feedback. It also can improve the quality of document summaries because the inherent semantic of the sentence set are well reflected by term weighting derived from semantic feature. In addition, it uses the semantic feature of term weighting and the expanded query to reduce the semantic gap between the user's requirement and the result of proposed method. The experimental results demonstrate that the proposed method achieves better performant than other methods without term weighting.

The Educatees' Perception Change of Learning Motivation and Fairness on Feedback using App (앱기반 피드백에 대한 피교육자의 학습동기 및 공정성 인식 변화)

  • Kim, Sangkyun
    • Journal of Korea Game Society
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    • v.15 no.3
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    • pp.79-86
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    • 2015
  • Effective feedback plays a key role in education environments to motivate the students and to maintain their flow. However, there usually lacks in providing effective feedbacks in education environments due to an excessive number of students and insufficient class times. The purpose of this paper is to analyze the educatees' response on game like feedback using App. In this paper, Class123 App developed and published by BravePops was used. During one semester, Class123 App had been used in engineering class and the educatees' responses on game like feedbacks using Class123 App are analyzed. Statistical analysis results show that the feedbacks using Class123 App made positive effects to motivate the students. Especially, the positive feedbacks were more effective than the negative feedbacks.

Electrostatic Suspension System of Glass Panels using Relay Feedback Control (릴레이 제어법을 이용한 유리패널의 정전부상에 관한 연구)

  • Jeon, Jong-Up
    • Journal of the Korean Society for Precision Engineering
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    • v.25 no.6
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    • pp.71-79
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    • 2008
  • In the manufacture of flat panel display devices, there is a strong demand for contactless glass panel handling devices that can manipulate a glass panel without contaminating or damaging it. To fulfill this requirement, an electrostatic suspension device far glass panels where the glass panel is supported by electrostatic forces without any mechanical contact is proposed. To implement the system with low cost and compactness, switched-voltage control scheme that is based on the relay feedback control is utilized. Relay feedback control method deploys only a single high-voltage power supply that can deliver a DC voltage of positive and/or negative polarity and thus high voltage amplifiers that are costly and bulky are not needed any more. It is shown that despite the inherent limit cycle property of the relay feedback based control, an excellent performance in vibration suppression is attained due to the presence of a relatively large squeeze film damping originating from the electrodes and levitated object. Using this scheme, a $100{\times}100mm^2$ glass panel was levitated stably with airgap variation decreasing down to $1\;{\mu}m$ at an airgap of $100\;{\mu}m$.

Desigining a Feedback for Exercises Using a Wearable Device (웨어러블 디바이스를 활용한 운동 중 피드백 방식 연구 - 근력 운동에 대한 멀티 모달 피드백 적용을 중심으로 -)

  • Yoo, Hyunjin;Maeng, Wookjae;Lee, Joongseek
    • Journal of the HCI Society of Korea
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    • v.11 no.3
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    • pp.23-30
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    • 2016
  • The landscape of the current fitness trackers is not only limited to the aerobic exercises but also the weight training is comparatively excluded. Recently, a few weight training fitness tracker was released, human-computer interaction was not well designed due to the lack of considering the context. Because body movement would be intense while doing exercises, having exercise performers hold or operate a device makes a negative experience. As the wearable device is always inseparable to body, it could provide effective feedback because holding or operating a device is not necessary. Therefore, this study aims to make the exercise performers feel a natural feedback through the wearable device to do effective exercises. As a result, this study identified three findings. First, the information which exercise performers most needed was 'during exercise.' and the most necessary information for exercise performers through wearable device's sensory feedback was about 'pace control' with counting and motivation. Second, the order of the most preferred presentation type of sensory feedback was auditory feedback, haptic feedback and visual feedback. Third, the satisfaction, utility, usefulness score of sensory feedback as same as the personal trainer's feedback. In conclusion, this study illustrated the feedback design implications using a wearable device while doing weight training and the possibilities that wearable device could be substitute for personal trainer.

Organizational Commitment and Job characteristics of Hospital Foodservice Employees (병원급식 종사자의 조직헌신성 분석)

  • Kim, Hye-Jin
    • Journal of the Korean Dietetic Association
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    • v.2 no.1
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    • pp.49-61
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    • 1996
  • For the purpose of disclosing the relationship between job characteristics and satisfaction and organizational commitment for foodservice employees, questionnaire survey was carried out on 427 subjects of 14 general hospitals in Seoul, Korea. Questionnaire items consisted of general characteristics, organizational commitment, job satisfaction and characteristics. Data were analyzed by ANOVA, Duncan's multiple range test and Pearson correlation using SPSS PC package. The results were as follows 1. Mean score of value commitment and commitment to stay were 3.57 and 3.67. 2. There were significant differences between value commitment and age, marital status department, period and management, and between commitment to stay and experience and management. 3. Mean score of job satisfaction was the highest in co-workers(3.37) and work itself (3.37) and followed by in supervision(3.25), wage(2.43) and promotion(2.01). There were significant differences between job satisfaction for work itself and age, educational status and job department and management, between job satisfaction for wage and position, department, period and management, between job satisfaction for supervision and age, educational status and department, between job satisfaction for promotion and age, marital status, position, period, and management, between job satisfaction for co-workers and sex and educational status. 4. Mean score of job characteristics was the highest in dealing with others(4.13) and followed by in feedback(3.51), autonomy(3.29), task identify(3.07), variety(2.71) and friendship(2.47). 5. Job satisfaction for work itself, supervision and co-workers were significantly increased with increasing value commitment. Job satisfaction for work itself, supervision were significantly increased with increasing commitment to stay. Job satisfaction for promotion had negative correlation with organizational commitment in all job position. 6. Value commitment had significantly positive correlations with variety, autonomy, identity, feedback and dealing with others, and significantly negative correlation with friendship. Commitment to stay had significantly positive correlations with dealing with others, and significantly negative correlations with friendship. In all job position organizational commitment had significantly negative correlations with friendship.

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A Test on the Volatility Feedback Hypothesis in the Emerging Stock Market (신흥주식시장에서의 변동성반응가설 검정)

  • Kim, Byoung-Joon
    • The Korean Journal of Financial Management
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    • v.26 no.4
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    • pp.191-234
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    • 2009
  • This study examined on the volatility feedback hypothesis through the use of threshold GARCH-in-Mean (GJR-GARCH-M) model developed by Glosten, Jaganathan, and Runkle (1993) in the stock markets of 14 emerging countries during the period of January, 1996 to May, 2009. On this study, I found successful evidences which can support the volatility feedback hypothesis through the following three estimation procedures. First, I found relatively strong positive relationship between the expected market risk premiums and their conditional standard deviations from the GARCH-M model in the basis of daily return on each representative stock market index, which is appropriate to investors' risk-averse preferences. Second, I can also identify the significant asymmetric time-varying volatility originated from the investors' differentiated reactions toward the unexpected market shocks by applying the GJR-GARCH-M model and further find the lasting positive risk aversion coefficient estimators. Third, I derived the negative signs of the regression coefficient of unpredicted volatility on the stock market return by re-applying the GJR-GARCH-M model after I controlled the positive effect of predicted volatility through including the conditional standard deviations from the previous GARCH-M model estimation as an independent explanatory variable in the re-applied new GJR-GARCH-M model. With these consecutive results, the volatility feedback effect was successfully tested to be effective also in the various emerging stock markets, although the leverage hypothesis turned out to be insufficient to be applied to another source of explaining the negative relationship between the unexpected volatility and the ex-post stock market return in the emerging countries in general.

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Delay of Gratification in Infancy : Effects of Infants' Temperament and Parenting

  • Rha Jong-Hay
    • International Journal of Human Ecology
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    • v.1 no.1
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    • pp.59-77
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    • 2000
  • The purpose of this study was to extend our understanding of the developmental antecedents of delay of gratification in infancy. The first goal was to examine direct effects of one feature of an infants’ temperament and of positive and negative parenting assumed at age one on children’s delay of gratification six months later. The second goal of the study was to test the interactive effect of early infant temperament and parenting on children’s delay of gratification. It was hypothesized that 1) less negative infants at 12 months would delay gratification longer six months later, 2) children of parents who provided more positive and sensitive feedback would delay gratification longer than children with parents who were more negative and less sensitive, and 3) there would be differential prediction of parenting for children who scored high and low in negative emotionality as infants. Toward this end, 81 infants were observed interacting at one year of age with their mothers and fathers during laboratory assessments to obtain measures of parenting and infant negative emotionality. At 18 months of age, the child’s capacity to delay touching attractive objects was measured. The main effects of infant negative emotionality and of mothering on children’s delay of gratification were not detected at standard levels of significance. Differential effects of parenting on children’s delay of gratification for infants with low or high negative emotionality, too, were not detected. However, the anticipated effect of fathering on delay of gratification was found in some analyses, indicating that the more positive fathering children received, the longer they could delay gratification in the laboratory six months later.

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A Relevance Feedback Method Using Threshold Value and Pre-Fetching (경계 값과 pre-fetching을 이용한 적합성 피드백 기법)

  • Park Min-Su;Hwang Byung-Yeon
    • Journal of Korea Multimedia Society
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    • v.7 no.9
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    • pp.1312-1320
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    • 2004
  • Recently, even if a lot of visual feature representations have been studied and systems have been built, there is a limit to existing content-based image retrieval mechanism in its availability. One of the limits is the gap between a user's high-level concepts and a system's low-level features. And human beings' subjectivity in perceiving similarity is excluded. Therefore, correct visual information delivery and a method that can retrieve the data efficiently are required. Relevance feedback can increase the efficiency of image retrieval because it responds of a user's information needs in multimedia retrieval. This paper proposes an efficient CBIR introducing positive and negative relevance feedback with threshold value and pre-fetching to improve the performance of conventional relevance feedback mechanisms. With this Proposed feedback strategy, we implement an image retrieval system that improves the conventional retrieval system.

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