• Plant Resources
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• v.6 no.2
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• pp.94-97
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• 2003

The objective of this study is to investigate morphological characteristics of seeds and effects of environmental factors such as light and temperature on the germination and seedling growth of Adenophora triphylla var. japonica, Codonopsis lanceolata, Platycodon glandiflorum, Which belongs to Campanulaceae and useful for on oriental medicine materials. Seed shape of Codonopsis lanceolata is Elliptic. Platycodon glandiflorum is Oblong. Color of seed coats varied from yellow to dark brown. Seed size of Adenophora triphylla var. japonica is 1.37mm in length, 0.69mm in width. One thousand-seed weight of Adenophora triphylla var. japonica is 258mg. Seed size of Codonopsis lanceolata is 4.45mm in length, 2.11mm in width. One thousand-seed weight of Codonopsis lanoceolata is 1,278mg. Seed size of Platycodon glandiflorum is 2.31mm in length, 1.10mm in width. One thousand-seed weight of Platycodon glandiflorum is 988mg. Optimum temperatures for seed germination and seedling growth range from 20 to $25^{\circ}C$.

• Journal of Korean Medical classics
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• v.27 no.3
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• pp.183-188
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• 2014

Objectives : The Phrase, Ki goes to Essence and Essence goes to Change in Eumyangeungsangdaeron in Suwen have contradiction in direction of Ki. Because this phrase linked to relation of Taste, Shape, Ki, Essence and Change, each others are supposed to be treated systematically. Methods : We will review on annotations of past doctors and new opinions of resent scholars. Results : Ki has two meanings in this phrase ; Ki of food and Ki of ability in human nature. Conclusions : From the Taste through Shape to Ki of food are the way of Eum aspect and from the Ki of ability through Essence to Change are the way of Yang aspect.

• Radiation Oncology Journal
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• v.29 no.3
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• pp.135-146
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• 2011

With the advance of modern radiation therapy technique, radiation dose conformation and dose distribution have improved dramatically. However, the progress does not completely fulfi ll the goal of cancer treatment such as improved local control or survival. The discordances with the clinical results are from the biophysical nature of photon, which is the main source of radiation therapy in current field, with the lower linear energy transfer to the target. As part of a natural progression, there recently has been a resurgence of interest in particle therapy, specifically using heavy charged particles, because these kinds of radiations serve theoretical advantages in both biological and physical aspects. The Korean government is to set up a heavy charged particle facility in Korea Institute of Radiological & Medical Sciences. This review introduces some of the elementary physics of the various particles for the sake of Korean radiation oncologists' interest.

• Genomics & Informatics
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• v.16 no.4
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• pp.32.1-32.7
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• 2018

Ovarian cancer is one of the leading causes of cancer-related deaths in gynecological malignancies. Over 70% of ovarian cancer cases are high-grade serous ovarian cancers and have high death rates due to their resistance to chemotherapy. Despite advances in surgical and pharmaceutical therapies, overall survival rates are not good, and making an accurate prediction of the prognosis is not easy because of the highly heterogeneous nature of ovarian cancer. To improve the patient's prognosis through proper treatment, we present a prognostic prediction model by integrating high-dimensional RNA sequencing data with their clinical data through the following steps: gene filtration, pre-screening, gene marker selection, integrated study of selected gene markers and prediction model building. These steps of the prognostic prediction model can be applied to other types of cancer besides ovarian cancer.

• Journal of Chest Surgery
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• v.57 no.2
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• pp.109-119
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• 2024

Varicose veins usually present in the superficial veins of the lower extremities and are one of the main clinical presentations of chronic venous disease (CVD). Patients' symptoms may vary according to the pathophysiology, location, and severity of CVD. The prevalence of CVD in Korea has been increasing gradually. However, due to its broad clinical spectrum and the subjective nature of its diagnosis using ultrasound, discrepancies in diagnostic and treatment quality may exist among treating physicians. There have been recent efforts to improve the quality of the diagnosis and treatment of varicose veins in Korea by standardizing the diagnostic criteria and the indications for treatment. This study is a comprehensive review of the clinical manifestations and diagnostic criteria of CVD based on the most recent international and domestic guidelines and reports.

• CELLMED
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• v.10 no.2
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• pp.9.1-9.7
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• 2020

Nature is full of precious treasure to cure us from various disorders. One of them is Curcuma longa belonging to Zingiberaceae family, present with outstanding therapeutic value and used since time immemorial. Part used from the plant is rhizome native to India (south east continent) which is the world's largest producer, consumer and exporter of turmeric. The active principle called curcumin or diferuloylmethane is a yellow pigment that exhibits numerous activities and wide spectrum of biological actions which include anti-inflammatory, hepatoprotective, anti-cancerous, anti-fungal, neuroprotective activities and many more. This paper focuses on the comparative evaluation of medicinal properties of Curcuma longa as mentioned in Unani classical literature with its modern scientific researches.

• Genomics & Informatics
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• v.10 no.4
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• pp.214-219
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• 2012

The recent advent of next-generation sequencing technologies has dramatically changed the nature of biomedical research. Human genetics is no exception－it has never been easier to interrogate human patient genomes at the nucleotide level to identify disease-associated variants. To further facilitate the efficiency of this approach, whole exome sequencing (WES) was first developed in 2009. Over the past three years, multiple groups have demonstrated the power of WES through robust disease-associated variant discoveries across a diverse spectrum of human diseases. Here, we review the application of WES to different types of inherited human diseases and discuss analytical challenges and possible solutions, with the aim of providing a practical guide for the effective use of this technology.

• Applied Microscopy
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• v.52
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• pp.11.1-11.9
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• 2022

Zoonotic poxvirus infections pose significant threat to human health as we have witnessed recent spread of monkeypox. Therefore, insights into molecular mechanism behind poxvirus replication cycle are needed for the development of efficient antiviral strategies. Virion assembly is one of the key steps that determine the fate of replicating poxviruses. However, in-depth understanding of poxvirus assembly is challenging due to the complex nature of multi-step morphogenesis and heterogeneous virion structures. Despite these challenges, decades of research have revealed virion morphologies at various maturation stages, critical protein components and interactions with host cell compartments. Transmission electron microscopy has been employed as an indispensable tool for the examination of virion morphology, and more recently for the structure determination of protein complexes. In this review, we describe some of the major findings in poxvirus morphogenesis and the contributions of continuously advancing electron microscopy techniques.

• The Korean Journal of Nuclear Medicine
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• v.25 no.2
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• pp.280-285
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• 1991

We analyzed Radioisotope scan findings of 46 patients of thyroiditis which were proven pathologically at K.C.H. The results were as follows 1) 45 patients were female, one was male and average age of patients was 37 years old. 2) The lesion site was predominant in both lobe (67%) 3) Hashimoto's thyroiditis showed enlarged thyroid (85%) with cold nodule (20%), diffuse decreased activity (10%), while subacute thyroiditis was presented absent activity (53%), poor visualization (20%) or cold nodule (7%) 4) Radioisotope scan was valuable in evaluations function of thyroid gland and detection of lesion but there was a limit of pathological nature.

• Sleep Medicine and Psychophysiology
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• v.1 no.1
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• pp.29-35
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• 1994

Overall purposes of neuropsychological tests are summarized as follows: 1) Indentifying brain damage in individuals who have symptoms of uncertain etiology; 2) Assessing the extent and nature of deficits for forensic purposes and planning appropriate intervention; 3) Evaluating the effects of intervention or rehabilitation; 4) Examining the effects of various types of brain damage across different populations; and 5) Testing theoretical propositions about brain-behavior relationship. Of the neuropsychological tests, the Luria-Nebraska Neuropsychological Battery(LNNB) is easily transportable, relatively inexpensive, and performable by trained technician. The Korean version of LNNB is now being designed and will be used clinically in the near future. Localization and equipotential theories of brain function had been prevalent until Luria's theory of brain function. Brain, composed of three brain units in the theory, is the functional system in which each brain area has specific function and produce the function-related behavior. LNNB consists of 11 clinical scales, 5 summary scales, 8 localization scales, and 28 factor scales.