• Nuclear Engineering and Technology
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• v.41 no.10
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• pp.1333-1346
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• 2009

To assure the reliability of cylinders or shells with fluid-filled annulus, it is necessary to investigate the modal characteristics considering fluid-structure interaction effect. In this study, theoretical background and several finite element models are developed for cylindrical shells with fluid-filled annulus considering fluid-structure interaction. The effect of the inclusion of the fluid-filled annulus on the natural frequencies is investigated, which frequencies are used for typical dynamic analyses such as responses spectrum, power spectral density and unit load excitation. Their response characteristics are addressed with respect to the various representations of the fluid-structure interaction effect.

• Journal of Multimedia Information System
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• v.8 no.2
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• pp.111-120
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• 2021

As recent virtual reality technologies provide a more natural three-dimensional interactive environment, users naturally learn to explore space and interact with synthetic objects. The virtual reality researcher develops a technique that realizes realistic sensory feedback to get appropriate feedback to sense input behavior. Although much recent virtual reality research works extensively consider the human factor, it is not easy to adapt to all new virtual environment contents. Among many human factors, distance perception has been treated as very important in virtual environment interaction accuracy. We study the experiential virtual environment with the feature of the virtual object connected with the real object. We divide the three-dimensional interaction, in which distance perception and behavior have a significant influence, into two types (whole-body movement and direct manipulation) and analyze the real and virtual visual distance perception heterogeneity phenomenon. Also, we propose a statistical correction method that can reduce a near-body movement and manipulation error when changing the interaction location and report the experiment results proving its effectiveness.

• Molecules and Cells
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• v.39 no.3
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• pp.229-241
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• 2016

We have previously reported the role of miR-326-HDAC3 loop in anti-cancer drug-resistance. CAGE, a cancer/testis antigen, regulates the response to anti-cancer drug-resistance by forming a negative feedback loop with miR-200b. Studies investigating the relationship between CAGE and HDAC3 revealed that HDAC3 negatively regulated the expression of CAGE. ChIP assays demonstrated the binding of HDAC3 to the promoter sequences of CAGE. However, CAGE did not affect the expression of HDAC3. We also found that EGFR signaling regulated the expressions of HDAC3 and CAGE. Anti-cancer drug-resistant cancer cell lines show an increased expression of $pEGFR^{Y845}$. HDAC3 was found to negatively regulate the expression of $pEGFR^{Y845}$. CAGE showed an interaction and co-localization with EGFR. It was seen that miR-326, a negative regulator of HDAC3, regulated the expression of CAGE, $pEGFR^{Y845}$, and the interaction between CAGE and EGFR. miR-326 inhibitor induced the binding of HDAC3 to the promoter sequences in anti-cancer drug-resistant $Malme3M^R$ cells, decreasing the tumorigenic potential of $Malme3M^R$ cells in a manner associated with its effect on the expression of HDAC3, CAGE and $pEGFR^{Y845}$. The down-regulation of HDAC3 enhanced the tumorigenic, angiogenic and invasion potential of the anti-cancer drug-sensitive Malme3M cells in CAGE-dependent manner. Studies revealed that $PKC{\delta}$ was responsible for the increased expression of $pEGFR^{Y845}$ and CAGE in $Malme3M^R$ cells. CAGE showed an interaction with $PKC{\delta}$ in $Malme3M^R$ cells. Our results show that HDAC3-CAGE axis can be employed as a target for overcoming resistance to EGFR inhibitors.

• Coupled systems mechanics
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• v.5 no.3
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• pp.223-234
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• 2016

The main purpose of current study is to find the soil effects on natural period of elevated tank. The coupled analytical method is used to assess in this study. The current study presented models which are capable to consider the soil dynamic stiffness changes and fluid- structure interaction effects on natural period of elevated tanks. The basic of mentioned models is extracted from elastic beam and lumped mass theory. The finite element is used to verify the results. It is observed that, external excitation can change the natural period of elevated tanks. Considering the increase of excitation frequency, the natural period will be decreased. The concluded values of natural period in case of soft and very soft soil are more affected from excitation frequency values. The high range of excitation frequency may reduce the natural period values. In addition it is observed that the excitation frequency has no significant effect on convective period compare with impulsive period.

• Bulletin of the Korean Chemical Society
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• v.33 no.3
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• pp.1081-1084
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• 2012

• Bulletin of the Korean Chemical Society
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• v.32 no.12
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• pp.4441-4443
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• 2011

• 한국전산유체공학회:학술대회논문집
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• 1997.10a
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• pp.10-15
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• 1997

Unsteady natural convection of an enclosed fluid has been one of the fundamental thermo-fluid problems, of which dynamic relevance is found in many engineering applications. Together with the inherent coupling between the boundary layers and the interior core, and strong interaction between flow and temperature fields, the unsteadiness poses serious hurdles for analytical and experimental approaches. With the recent development of computers and solution algorithms, computational fluid dynamics has become the prevailing tool to tackle the underlying problems. In this presentation, a few examples of numerical studies are introduced. The usefulness and potential of numerical simulations in investigating unsteady natural convection are elaborated.

• Proceedings of the Korean Society of Life Science Conference
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• 2008.10a
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• pp.72.2-72.2
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• 2008

• Journal of the Mineralogical Society of Korea
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• v.10 no.2
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• pp.97-104
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• 1997

Based on the method of determination for relative stability of each phase from the difference among the interaction parameters of the phases consisting the mixed layer, the types of interactions between layers were specified and interaction parameter between layers in ordered domain was analytically derived as a function parameter between layers in ordered domain was analytically derived as a function of not only temperature and mole fraction of layers but also ordering parameter. Interaction parameter between the different layers in ordered phase, L is as follows:{{{{ {L }_{1 } (X,Q,T)= { C} over { Q} -4(1-2Q) { L}^{2 } - { RT} over {2} ln { 1} over {2 } - { 2RT} over { { X}_{ s} } ln { { 4QX}`_{s } ^{2 } } over {(1- { X}_{s }- { QX}_{s })( { X}_{s }- {QX }_{s } ) } }}}}L2 is the interaction parameter between ordered and disordered phase in domain and is the mole fraction of the domain which represent the infinite length of mixed layer mineral and Q and C are the reaction progress parameter and arbitrary constant, respectively. This equation was used for the I/S mixed layer clay minerals to infer the relative stability of R1 type I/S mixed layer in the temperature range from 373K to 450K. The result of calculation suggest that, owing to the decrease in interaction parameter with increasing temperature. The interaction parameter decreases more rapidly with decreasing mole fraction of smectite in domain, which is consistent with the fact that the probability of finding the series smectite layer is lo in the domain with small mole fraction of smectite layers in natural system.

• Journal of Photoscience
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• v.7 no.2
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• pp.63-66
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• 2000

A study of the interaction between lysozyme and phospholipid liposomes is essential for a systematic approach for understanding the action mechanism of lysozyme. So we want to clarify the interactions of lysozyme with phospholipid liposmes. We observed that lysozyme more interacts with negatively charged liposomes than with neutral liposome. More hydroxy groups of the phospholipid was very important on that interactions. We recognized the importance of electrostatic interactions in the process of fusion induced by lysozyme. As indicated by UV/Vis experiments, leakage and fusion are two uncoupled process.