• 한국자기학회지
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• 제27권1호
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• pp.23-29
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• 2017

시료 크기별 자화 역전과 자기 상호작용이 보자력에 미치는 영향을 조사한 결과, 자구생성보다 자벽고착에 의한 자화 역전 현상이 지배적인 시료일수록 보자력과 각형비가 컸다. 이와 같은 현상은 자벽이 낟알 경계면이나 시료 내부에 존재하는 고착점에 강하게 포획되기 때문인 것으로 판단된다. 한편 자기 상호작용을 분석한 결과, 시료의 크기에 무관하게 모든 시료는 쌍극자 상호작용이 지배적인 상호작용 기구이며, 쌍극자 상호작용이 강한 시료일수록 보자력이 작았다. 따라서 보자력은 자화 역전 현상, 자기 상호작용 기구와 세기에도 깊이 관련됨을 알 수 있다.

• Animal cells and systems
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• 제8권Supplyment
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• pp.51-51
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• 2004

• IMMUNE NETWORK
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• 제4권4호
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• pp.205-215
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• 2004

In the early host defense system, effector function of natural killer (NK) cells results in natural killing against target cells such as microbe-infected, malignant, and certain allogenic cells without prior stimulation. NK cell cytotoxicity is selectively regulated by homeostatic prevalence between a repertoire of both activating and inhibitory receptors, and the discrimination of untransformed cells is achieved by recognition of major histocompatibility complex (MHC) class I alleles through inhibitory signals. Although it is well known that the bipotential T/NK progenitors are derived from the common precusor, functional mechanisms in terms of the development of NK cells remain to be further investigated. NK cells are mainly involved in innate immunity, but recent studies have been reported that they also play a critical role in adaptive immune responses through interaction with dendritic cells (DC). This interaction will provide effector functions and development of NK cells, and elucidation of its precise mechanism may lead to therapeutic strategies for effective treatment of several immune diseases.

• BMB Reports
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• 제47권9호
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• pp.488-493
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• 2014

Adaptor protein FADD forms the death inducing signaling complex (DISC) by recruiting the initiating caspases-8 and -10 through homotypic death effector domain (DED) interactions. Cellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of death ligand-induced apoptosis downstream of death receptors, and FADD competes with procaspase-8/10 for recruitment for DISC. However, the mechanism of action of FADD and c-FLIP proteins remain poorly understood at the molecular level. In this study, we provide evidence indicating that the death effector domain (DED) of FADD interacts directly with the death effector domain of human c-FLIP. In addition, we use homology modeling to develop a molecular docking model of FADD and c-FLIP proteins. We also find that four structure-based mutants (E80A, L84A, K169A and Y171A) of c-FLIP DEDs disturb the interaction with FADD DED, and that these mutations lower the stability of the c-FLIP DED.

• 한국안전학회지
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• 제17권2호
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• pp.8-15
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• 2002

In order to investigate the vibration characteristics of fluid-structure interaction problem, we modeled two identical rectangular plates coupled with fluid. A commercial computer code, ANSYS was used to perform finite element analysis and FEM solutions were compared with the experimental results to verify the finite element model. As a result, comparison of FEM and experiment showed good agreement, and the transverse vibration modes, in-phase and out-of-Phase, were observed alternately in the fluid-coupled system. The effect of fluid gap size on the fluid-coupled natural frequency were investigated. It was shown that the mode numbers increased, the normalized natural frequencies monotonically increased. And it was also found that an increase of the fluid gap reduced the coupled natural frequencies for the in-phase modes but increased the coupled natural frequencies for the out-of phase modes, and eventually converged to the results of an infinite fluid gap.

• Journal of Microbiology and Biotechnology
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• 제26권4호
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• pp.637-647
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• 2016

Proliferating cell nuclear antigen (PCNA) is a critical eukaryotic replication accessory factor that supports DNA binding in DNA processing, such as DNA replication, repair, and recombination. PCNA consists of three toroidal-shaped monomers that encircle double-stranded DNA. The diverse functions of PCNA may be regulated by its interactions with partner proteins. Many of the PCNA partner proteins generally have a conserved PCNA-interacting peptide (PIP) motif, located at the N- or C- terminal region. The PIP motif forms a 3₁₀ helix that enters into the hydrophobic groove produced by an interdomain-connecting loop, a central loop, and a C-terminal tail in the PCNA. Post-translational modification of PCNA also plays a critical role in regulation of its function and binding partner proteins. Structural and biochemical studies of PCNA-protein will be useful in designing therapeutic agents, as well as estimating the outcome of anticancer drug development. This review summarizes the characterization of eukaryotic PCNA in relation to the protein structures, functions, and modifications, and interaction with proteins.

• 한국소음진동공학회논문집
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• 제26권1호
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• pp.27-38
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• 2016

The purpose of this study is to investigate the influence of moving mass on the vibration characteristics and the dynamic response of the simply supported beam. The three types of the moving mass(moving load, unsprung mass, and sprung mass) are applied to the vehicle-bridge interaction analysis. The numerical analyses are then conducted to evaluate the effect of the mass, spring and damper properties of the moving mass on natural frequencies and dynamic responses of the simply supported beam. Particularly, in the case of the sprung mass, variations of the natural frequency of simply supported beam are explored depending on the position of the moving mass and the frequency ratio of the moving mass and the beam. Finally the parametric studies on the resonance phenomena are performed with changing mass, spring and damper parameters through the dynamic interaction analyses.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송공학회 2009년도 IWAIT
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• pp.341-345
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• 2009

We present an augmented reality (AR) application for cell phone where users put a virtual pet on their palms and play/interact with the pet by moving their hands and fingers naturally. The application is fundamentally based on hand/palm pose recognition and finger motion estimation, which is the main concern in this paper. We propose a fast and efficient hand/palm pose recognition method which uses natural features (e.g. direction, width, contour shape of hand region) extracted from a hand image with prior knowledge for hand shape or geometry (e.g. its approximated shape when a palm is open, length ratio between palm width and pal height). We also propose a natural interaction method which recognizes natural motion of fingers such as opening/closing palm based on fingertip tracking. Based on the proposed methods, we developed and tested the AR application on an ultra-mobile PC (UMPC).

• Asia pacific journal of information systems
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• 제6권1호
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• pp.39-74
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• 1996

Most of the research on a group decision support system [GDSS] has focused on directly examining its effect on the decision outcomes. Under this research framework, however, the role of group interaction process is largely ignored. This study focuses on the effect of the group interaction process on decision-making performance when a GDSS is used as the only medium for group interaction. Specifically, this study sought to determine whether significant relationships exist between the quality of the decision and the decision functions, contingent phases, and different decision paths. Natural interaction processes of decision -making groups was simulated in an experimental setting in which volunteer subjects from several business classes were assigned to dispersed three-person groups undertook the experimental task via a decision network. A baseline GDSS was developed for this setting. The results of this study confirmed earlier studies in a non - GDSS setting to suggest significant effects of decision functions and contingent phases on the quality of decision but no significant relationship between decision path and the quality of group decision.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2002년도 추계 학술발표회 논문집
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• pp.106-113
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• 2002

In this study, a numerical analysis method for soil-pile interaction in frequency domain problem is presented. The total soil-pile interaction system is divided into two parts so called near field and far field. In the near field, beam elements are used for a pile and plain strain finite elements for soil. In the far field, dynamic fundamental solution for multi-layered half planes based on boundary element formulation is adopted for soil. These two fields are coupled using FE-BE coupling technique In order to verify the proposed soil-pile interaction analysis, the dynamic responses of pile on multi-layered half planes are simulated and the results are compared with the experimental results. Also, the dynamic response analyses of interface spring elements are performed. As a result, less spring stiffness makes the natural frequency decrease and the resonant amplitude increase.