• Archives of design research
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• 제20권1호
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• pp.33-44
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• 2007

It is a general survey and evaluation on the works of short lived 'KHDC', the first design promotion institution established in Korea in 1957 by Americans and supported by the US government. The chapter 1 summarizes the achievements of Arkon Office in the USA. Chapter 2 introduces the process of the establishment, organization and function of KHDC. In Chapter 3, the KHDC's activities are examined on the basis of the research on specific contents of Handcrafts projects, light industry projects, exhibitions, field trips, local industry support activities, education programs, and press releases, etc. in Korea. In Chapter 4, KHDC's general accomplishments as well as the results and products developed by handicraft projects and light industry projects are examined. In chapter 5, the results and influences to Korean design development are examined and evaluated.

• Journal of the Korean Society for information Management
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• 제18권3호
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• pp.139-158
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• 2001

In the print world libraries have served as the archival repository for journals that they owned. In the age of digital information, however, with the licensing of electronic journals libraries purchase access to journal contents rather than paying for ownership. Libraries note the potential benefits of electronic journals, but also quake at the thought of inaccessible electronic journal contents caused by lack of preservation, changing technology, or publisher requirements. It is real that libraries have not yet stepped in to create archives of the electronic journals they are purchasing. In the digital environments, publishers, libraries, and other information providers are not the independent units that we used to be. It will take us all working together to solve the problem of preserving access to electronic journals. Thus, it is reasonable that a national library would be charge of making a comprehensive archiving policy on electronic journals, and that cooperative agreements of local libraries can help divide responsibility for different subject areas or materials.

• Journal of the Korea Institute of Information and Communication Engineering
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• 제21권12호
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• pp.2333-2340
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• 2017

Recently industry is suffering severe losses of important internal information, and most of the leaks result from the insiders. Thus, various technological counter measures are being studied in order to protect private organization information. In this paper, among various internal information leakage path protection mechanisms, we propose a technique for preventing files which are defined as confidential from being copied or moved through USB. The implemented confidential file loss prevention system is composed of both signature insert manager and confidential file detect manager. The signature insert manager allows a system administrator to insert a special pattern specifying a classified confidential file, while the confidential file detect manager protects confidential file leakage when a user attempts to move or copy a confidential file to the USB memory. This results would be contributed to reducing the damage caused by leakage of confidential files outside of the company via USB.

• Journal of Korean Library and Information Science Society
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• 제46권4호
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• pp.511-527
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• 2015

The study aims at constructing adaptation model, CampusQual, to evaluate the services which Tsinghua provides for Korean Students. The study is based on ServQual's "expectation-feeling difference" via conducting a survey on satisfaction on their campus life. We implement a survey including 30 questions in 5 sections: demographic statistics, study & information literacy, campus life, social & culture and regulations. Then through CampusQual model, we analyze the Korean students' adaptation level. CampusQual is a new service model that would enable Korean students to better live and study in universities in China. It also provides feasible suggestions and guidance for administrators on improving campus services for Korean Students.

• Archives of Pharmacal Research
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• 제27권9호
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• pp.906-911
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• 2004

In order to evaluate estrogenic compounds in natural products, an in vitro detection system was established. For this system, the human breast cancer cell line MCF7 was stably trans-fected using an estrogen responsive chloramphenicol acetyltransferase (CAT) reporter plas-mid yielding MCF7/pDsCAT-ERE119-Ad2MLP cells. To test the estrogenic responsiveness of this in vitro assay system, MCF7/pDsCAT-ERE119-Ad2MLP cells were treated with various concentrations of 17f3-estradiol. Treatments of 10$^{-8}$ to 10$^{-12}$ M 17$\beta$-estradiol revealed significant concentration dependent estrogenic activities compared with ethanol. We used in vitro assay system to detect estrogenic effects in Puerariae radix and Ginseng radix Rubra extracts. Treat-ment of 500 and 50 $\mu\textrm{g}$/ml of Puerariae radix extracts increased the transcriptional activity approximately 4- and 1.5-fold, respectively, compared with the ethanol treatment. Treatment of 500, 50, and 5 $\mu\textrm{g}$/ml of Ginseng radix Rubra extracts increased the transcriptional activity approximately 3.2-,2.7, and 1.4-fold, respectively, compared with the ethanol treatment. These observations suggest that Puerariae radix and Ginseng radix Rubra extracts have effective estrogenic actions and that they could be developed as estrogenic supplements.

• Archives of Pharmacal Research
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• 제27권9호
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• pp.923-929
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• 2004

Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries. Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E$_2$ (PGE$_2$), tumor necrosis factor-a (TNF-$\alpha$) and interleukin-1$\beta$(IL-1$\beta$), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation. The levels of inducible nitric oxide synthase (iNOS) and COX-2 protein expressions were markedly suppressed by stylopine in a concentration dependent manner. These results suggest that stylopine suppress the NO and PGE$_2$ production in macrophages by inhibiting the iNOS and COX-2 expressions. These biological activities of stylopine may contribute to the anti-inflammatory activity of Cheli-donium majus.

• Archives of Pharmacal Research
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• 제26권3호
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• pp.214-223
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• 2003

The present study was conducted to investigate the effects of green tea extract (GTE) on arterial blood pressure and contractile responses of isolated aortic strips of the normotensive rats and to establish the mechanism of action. The phenylephrine ($10^{-6}~10^{-5}M$)-induced contractile responses were greatly inhibited in the presence of GTE (0.3~1.2 mg/mL) in a dose-dependent fashion. Also, high potassium ($3.5{\times}10^{-2}~5.6{\times}10^{-2}{\;}M$)-induced contractile responses were depressed in the presence of 0.6~1.2 mg/mL of GTE, but not affected in low concentration of GTE (0.3 mg/mL). However, epigallocatechin gallate (EGCG, $4~12{\;}{\mu}g/mL$) did not affect the contractile responses evoked by phenylephrine and high $K^+$. GTE (5~20 mg/kg) given into a femoral vein of the normotensive rat produced a dose-dependent depressor response, which is transient. Interestingly, the infusion of a moderate dose of GTE (10 mg/kg/30 min) made a significant reduction in pressor responses induced by intravenous norepinephrine. However, EGCG (1 mg/kg/30 min) did not affect them. Collectively, these results obtained from the present study demonstrate that intravenous GTE causes a dose-dependent depressor action in the anesthetized rat at least partly through the blockade of adrenergic $\alpha_1$-receptors. GTE also causes the relaxation in the isolated aortic strips of the rat via the blockade of adrenergic $\alpha_1$-receptors, in addition to the unknown direct mechanism. It seems that there is a big difference in the vascular effect between GTE and EGCG.

• Archives of Pharmacal Research
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• 제28권1호
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• pp.55-60
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• 2005

Leukocyte adhesion to the vascular endothelium is a critical initiating step in inflammation and atherosclerosis. We have herein studied the effect of manassantin A (1) and S (2), dineolignans, on interaction of THP-1 monocytic cells and human umbilical vein endothelial cells (HUVEC) and expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin in HUVEC. When HUVEC were pretreated with 1 and 2 followed by stimulation with $TNF-{\alpha}$, adhesion of THP-1 cells to HUVEC decreased in dose-dependent manner with $IC_{50}$ values of 5 ng/mL and 7 ng/mL, respectively, without cytotoxicity. Also, 1 and 2 inhibited $TNF-{\alpha}-induceda$ up-regulation of ICAM-1, VCAM-1 and E-selectin. The present findings suggest that 1 and 2 prevent monocyte adhesion to HUVEC through the inhibition of ICAM-1, VCAM-1 and E-selectin expression stimulated by $TNF-\alpha$, and may imply their usefulness for the prevention of atherosclerosis relevant to endothelial activation.

• Archives of Craniofacial Surgery
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• 제17권3호
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• pp.146-153
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• 2016

Background: Restoring the orbital cavity in large blow out fractures is a challenge for surgeons due to the anatomical complexity. This study evaluated the clinical outcomes and orbital volume after orbital wall fracture repair using a rapid prototyping (RP) technique and intraoperative navigation system. Methods: This prospective study was conducted on the medical records and radiology records of 12 patients who had undergone a unilateral blow out fracture reconstruction using a RP technique and an intraoperative navigation system from November 2014 to March 2015. The surgical results were assessed by an ophthalmic examination and a comparison of the preoperative and postoperative orbital volume ratio (OVR) values. Results: All patients had a successful treatment outcome without complications. Volumetric analysis revealed a significant decrease in the mean OVR from $1.0952{\pm}0.0662$ (ranging from 0.9917 to 1.2509) preoperatively to $0.9942{\pm}0.0427$ (ranging from 0.9394 to 1.0680) postoperatively. Conclusion: The application of a RP technique for the repair of orbital wall fractures is a useful tool that may help improve the clinical outcomes by understanding the individual anatomy, determining the operability, and restoring the orbital cavity volume through optimal implant positioning along with an intraoperative navigation system.

• Archives of Craniofacial Surgery
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• 제18권1호
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• pp.37-43
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• 2017

Background: Skin cancer is the most common type of cancer. Of the 4 million skin lesions excised annually worldwide, approximately 2 million are considered cancerous. In this study, we aimed to describe a regional experience with skin cancers treated by a single senior surgeon and to provide a treatment algorithm. Methods: The medical records of 176 patients with head and neck non-melanocytic skin cancer (NMSC) who were treated by a single surgeon at our institution between January 2010 and May 2016 were retrospectively reviewed, and their data (age, sex, pathological type, tumor location/size, treatment modality) were analyzed. Patients with cutaneous squamous cell carcinoma (cSCC) who were classified as a high-risk group for nodal metastasis underwent sentinel node mapping according to the National Comprehensive Cancer Network guidelines. Results: Among the patients with NMSC who were treated during this period, basal cell carcinoma (BCC; n=102, 57.9%) was the most common pathological type, followed by cSCC (n=66, 37.5%). Most lesions were treated by complete excision, with tumor-free surgical margins determined via frozen section pathology. Thirty-one patients with high-metastasis-risk cSCC underwent sentinel node mapping, and 17 (54.8%) exhibited radiologically positive sentinel nodes. Although these nodes were pathologically negative for metastasis, 2 patients (6.5%) later developed lymph node metastases. Conclusion: In our experience, BCC treatment should comprise wide excision with tumor-free surgical margins and proper reconstruction. In contrast, patients with cSCC should undergo lymphoscintigraphy, as nodal metastases are a possibility. Proper diagnosis and treatment could reduce the undesirably high morbidity and mortality rates.