• Clinics in Shoulder and Elbow
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• v.24 no.4
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• pp.224-230
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• 2021

Background: Local anesthetics often are used in rotator cuff tears as therapeutic tools, although some cases have reported that they have detrimental effects. Neurotropin (NTP) is used widely in Japan as a treatment for various chronic pain conditions and is shown to have protective effects on cartilage and nerve cells. In this study, we investigated the protective effect of NTP against lidocaine-induced cytotoxicity. Methods: Tenocytes from rotator cuff tendons were incubated with lidocaine, NTP, lidocaine with NTP, and a control medium. Cell viability was evaluated using the WST-8 assay. Cell apoptosis was detected via annexin V staining using flow cytometry. The expression of BCL-2 and cytochrome c, which are involved in the intrinsic mitochondrial pathway of apoptosis, was evaluated via Western blotting and immunohistochemical staining. Results: In the cell viability assay, lidocaine decreased cell viability in a dose-dependent manner, and NTP did not affect cell viability. Moreover, NTP significantly inhibited the cytotoxic effect of lidocaine. The flow cytometry analysis showed that lidocaine significantly induced apoptosis in tenocytes, and NTP considerably inhibited this lidocaine-induced apoptosis. Western blotting experiments showed that lidocaine decreased the protein expression of BCL-2, and that NTP conserved the expression of BCL-2, even when used with lidocaine. Immunohistochemical staining for cytochrome c showed that 0.1% lidocaine increased cytochrome c-positive cells, and NTP suppressed lidocaine-induced cytochrome c expression. Conclusions: NTP suppresses lidocaine-induced apoptosis of tenocytes by inhibiting the mitochondrial apoptotic pathway. Intra-articular/bursal injection of NTP with lidocaine could protect tenocytes in rotator cuff tendons against lidocaine-induced apoptosis.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.42 no.1
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• pp.61-66
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• 2005

Location Positioning is a major technology for ubiquitous computing. Recently the research on Location Positioning using UWB is on going. In order to construct an in-door location network, synchronization of base stations is very important. NTP is Popularly used as clock synchronization protocol ranging from LAN to WAN. Also Master-Slave scheme is the simplest method to synchronize in-door network. We compare and analyze NTP and Master-Slave schemes according to the statistical channel model for indoor multipath propagation environment. In this paper, error ranges are calculated at various circumstances that in-door network expands from one primary base station into several base stations. We compared the correctness of NTP and Master-Slave synchronization methods. NTP is more reasonable synchronization protocol in in-door environment.

• Nuclear Engineering and Technology
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• v.53 no.4
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• pp.1079-1087
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• 2021

NTP-ERSN is a package developed for solving the multigroup form of the discrete ordinates, characteristics and collision probability of the Boltzmann transport equation in one-dimensional cartesian geometry, by combining pin cells. In this work, C5G7 MOX benchmark is used to verify the accuracy and efficiency of NTP-ERSN package, by treating reactor core problems without spatial homogenization. This benchmark requires solutions in the form of normalized pin powers as well as the vectors and the eigenvalue. All NTP-ERSN simulations are carried out with appropriate spatial and angular approximations. A good agreement between NTP-ERSN results with those obtained with OpenMC calculation code for seven energy groups. In addition, our studies about angular and mesh refinements are carried out to produce better quality solution. Moreover, NTP-ERSN GUI has also been updated and adapted to python 3 programming language.

• Proceedings of the Korean Information Science Society Conference
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• 1998.10a
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• pp.621-623
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• 1998

본 논문에서는 공용 접근이 가능한 NTO 서버들에 대한 동기화 특성을 조사, 분석했다. 분석 주요 항목은 서버 신뢰도, 정확도 그리고 오프셋(offeset)과 전송지연의 관계이다. 이러한 분석을 위해 NTP알고리즘에서 최적 시간 동기를 위해 선택하는 값인 클럭 옻프셋, 일주지연, 분산 그리고 동기화 거리를 사용하였다. 분석 결과는동기화 거리 값의 경우 최대 700ms의 정도의 차이를 보이고, 분산의 경우 최대 300ms정도의 차이를 나타내었다. 또한 전송 지연과 오프셋은 타워 분포를 보이며, 이는 그간의 오프셋 근거의 단순 선택이 효율적이지 못할 수 있음을 보여주었다. 본 논문에서 살펴본 NTP서버 동기화 특성은 많은 NTP 서버중 최적의 조건을 찾는데 유용하게 쓰일 수 있다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.05a
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• pp.647-649
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• 2013

This paper is the study of effective recovery system in the android set-top box, using NTP (Network Time Protocol). Because of Response to the user react quickly in case of a set-top box, needs compared to other electronic products, set-top box is one of always powered features to work at home. But general-purpose OS such as Android-based set-top box have to reset for cache & main memory initialization. In this paper, we introduce system reset & recovery by NTP client utilizing.

• Journal of Agricultural Extension & Community Development
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• v.23 no.4
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• pp.459-470
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• 2016

The purpose of this study was to examine the accomplishments and problems of National Target Program on New Rural Development(NTP-NRD) of the Vietnam government during the 1st stage(2011-2015). Based on the literature review and interview, the following suggestions were drawn with related to 19 criteria and 39 indicators; 1) the relationship between the overall goal and 19 criteria as its measures seems to be inconsistence, so that the meet of the 19 criteria regarded as the goal of the NTP-NRD, 2) there was no measures for the communes, where met the requirement of 19 criteria early, 3) most indicators were output oriented, while outcome level were little, 4) it needed to adjust for the some indicators as the implementation unit from commune level to more wider spatial level.

• Journal of Microbiology and Biotechnology
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• v.16 no.7
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• pp.1144-1148
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• 2006

DNA can oxidatively be deaminated by ROS, which converts DNA base amino groups to keto groups and can trigger abnormal mutations, resulting in mutagenesis in organisms. In this study, a noncanonical purine dNTP pyrophosphatase (AfPPase) from a hyperthermophilic archaeon Archaeoglobus fulgidus, which hydrolyzes aberrant nucleoside triphosphates, was overexpressed in E. coli, purified, and characterized. The purified AfPPase showed remarkably high activity for XTP and dITP, suggesting that the 6-keto group of these nucleotides is critical for the reactivity. Under optimal reaction conditions, the reaction rate for these substrates was about 120 times that with dGTP. Therefore, AfPPase may play a significant role in DNA repair by hydrolysis of noncanonical nucleotides before they are misincorporated into DNA.

• Journal of Korean Society for Atmospheric Environment
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• v.16 no.E
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• pp.39-46
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• 2000

Volatile Organic Compounds (VOCs) are considered as the precursors of atmospheric ozone and photochemical smog formation. In particular, chemical plants have produced a lot of VOCs and thus they have been forced to reduce or remove air emissions from the on-site chemical facilities. For the effective removal of VOCs produced in the chemical plants, the authors employed a titanium oxide(TiO$_2$) mediated photo-catalytic oxidation method. The initiation methods employed in this study to produce oxygen radicals for th photo-catalytic oxidation of the VOCs were Ultra-Violet(UV), Non-Thermal Plasma(NTS), and a combination of Uv and NTP. This study focused on a comparison of the removal efficiencies of VOCs as a function of the initiation method such as NTP and/or UV techniques. Removal efficiency change of VOCs as was investigated as a function of the wavelength of the UV lamp(254, 302, and 365 nm) and the degree of TiO$_2$ coating (10 and 30%). In this study, it was identified that removal efficiencies if the VOCs under the normal air environment were much better than those under the nitrogen gas environment containing small amount of oxygen. Removal efficiency by NTP technique was much better than the UV or the combination of UV and NTP techniques. In a comparison if UV wavelengths employed, it was found that shorter wavelength showed better removal efficiency, compared with longer ones. When the removal efficiencies of VOCs were compared in terms of the degree of TiO$_2$ coating, the higher TiO$_2$coating showed better removal efficiency that the lower TiO$_2$ coating

• The Journal of the Korea Contents Association
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• v.5 no.4
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• pp.227-236
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• 2005

We study, in terms of VoIP user assessment of voice quality, the synchronization of measurement system is important. Commonly the synchronization system uses NTP(Network Time Protocol) or GPS(Global Positioning System), these synchronization method has time error of distance, system overhead of data processing, and system specialized clock error. we propose and implement the synchronization method to correct time error between two measurement system in the internet. So the time synchronization of systems can get time error, then user assessment of voice quality become reliable.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.10
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• pp.1442-1449
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• 2003

We investigated the amount of the toxic gases emitted from the Electrostatic Precipitators(ESPs), which are currently used as the indoor air cleaners. The existing wire-to-plate(WTP) and neddle-to-plate(NTP) types of ESP designs are considered as the experimental corona dischargers. Using the voltage, the polarity of wire, the number of needles of NTP as the input variables, we studied the generation characteristics of ozone and $NO_{x}$ and the particle removal efficiency in the ESPs. As the results, we found out that the concentration of ozone, $NO_{2}$ and $NO_{x}$ is increased with increasing the voltage and the number of needles, but the amount of NO is decreased. And we observed that the generation rates of ozone and $NO_{x}$ are mainly related with the corona region through the photographs. Finally the experimental results showed that the particle removal efficiency of ESP with WTP type charger is more superior to that with NTP type chargers at the same voltage.