• 한국지구과학회지
• /
• 제36권1호
• /
• pp.109-124
• /
• 2015

레이더 반사도를 이용한 강수추정의 개선을 위해 새로운 접근 방식인 경북대학교에서 개발한 하이브리드 고도면을 이용한 강수량 추정기법(Hybrid Surface Rainfall, KNU-HSR)을 사용하였다. KNU-HSR기법은 지형에코와 레이더 빔차폐의 영향을 받지 않는 2차원 하이브리드 고도면에서의 반사도를 이용하여 강수량을 추정한다. 본 연구에서는 정적 HSR 및 동적 HSR기법이 사용되었으며 비교 검증되었다. 정적 HSR은 빔차폐지도와 지형에코지도를 사용하며, 동적 HSR은 정적 HSR에 추가적으로 실시간 퍼지로직 품질관리를 통한 품질지수지도를 사용한다. 검증을 위해 상관계수(correlation coefficient), 총비율(total ratio), 평균편의(mean bias), 정규화된 표준편차(normalized standard deviation), 평균 상대오차(mean relative error)를 사용하였으며, 10개 강우사례의 지상우량계 강우자료를 이용하여 두 HSR의 강우추정 성능을 평가하였다. 모든 검증지수에서 동적 HSR은 반사도 보정을 하지 않은 정적 HSR에 비해 더 우수한 성능을 보였다. 동적 HSR은 레이더로부터 근거리에서는 과대추정하였으며 원거리에서는 빔 폭 확장 및 빔 고도증가로 인해 과소추정하였다. 동적 HSR의 정규화된 표준편차와 평균상대오차는 레이더로부터의 거리에 관계없이 가장 좋은 결과를 보였다. 정적 HSR은 약한 강우강도에서 상당히 과대추정하였으나 동적 HSR은 모든 강우강도에서 1.0에 총비율을 보였다. 반사도의 시스템오차 보정 후, 동적 HSR의 정규화된 표준편차와 평균상대오차는 각각 약 20%와 15%로 개선되었다.

• Journal of Periodontal and Implant Science
• /
• 제30권2호
• /
• pp.359-374
• /
• 2000

Cyclosporine A(CsA) is a widely used immunosuppressant for transplant patients and is also used for the treatment of a wide variety of systemic diseases with immunologic disorders. However, its use is frequently limited because of complications such as nephrotoxicity or gingival hyperplasia. Although several hypotheses have been postulated for CsA-induced gingival hyperplasia, i.e. various cytokine effects of inflammatory cells, existence of plaque or CsA itself, but its pathogenesis is still unclear. For experimental chronic CsA toxicity, salt depletion has been shown to increased susceptibility of rodents to the effects of CsA, and this maneuver facilitates production of arteriolopathy and interstitial fibrosis in kidney that mimic the changes found in human. The purpose of this study was to evaluate pathogenesis of CsA-induced gingival hyperplasia by comparing changes between CsA administration groups of normal standard diet and those of low salt diet group. Specific pathogen-free, 20 to 25 days old(120 to 150 g), male Fisher-344 rats(KIST, Korea), 120 to 150g of body weight, were assigned to four groups of six animals each after one week of adaptation period for powder food. Group 1 received olive oil($300{\mu}l/g\;of\;diet$) with normal standard diet(0.4% of sodium)(NSD). Group 2 received CsA(Cypol-N, Jonggundang, Korea; $300{\mu}g/g\;of\;diet$) with normal standard diet(NSD+CsA). Group 3 received same amount of olive oil with low salt diet(0.05 % of sodium, Teklad Premier, U.S.A.)(LSD). Group 4 received same dose of CsA with low salt diet(LSD+CsA). Rats were pair fed and were sacrificed after six weeks. Renal histologic lesions associated with CsA, consisted of cortical interstitial fibrosis, tubular atrophy and hyalinization of arterioles and the impairment of renal function including increase of serum creatinine and decrease of glomerular filtration rate was more severe in low salt diet group. These were proved as the results of activated of renin-angiotensin system in the kidney by low salt condition. Meanwhile the degree of gingival hyperplasia at incisor and molar tooth was less severe in low salt diet group compared with normal sodium diet group. Hyperplastic gingiva showed mild epithelial hyperplasia and expanded underlyng stroma which consisted of matrix increasement, capillary proliferation and dilatation. While the number and the activation of fibroblasts were increased, inflammatory cells were rare in the stroma. The immunohistochemistry for TGF-${\beta}_1$ in the kidney and gingiva revealed stronger positive in LSD+CsA in kidney but in gingiva of NSD+CsA. These results suggested followings; Gingival hyperplasia can be developed without inflammatory cells infiltration and seemed not induced by CsA by itself. The major role for gingival hyperplasia by CsA would be the secondary effect of TGF-${\beta}$, which maybe upregulated by CsA administration. Low salt diet can attenuate this hyperplasia perhaps by decreasing the activation of $TGF-{\beta}$.

• 한국동물학회:학술대회논문집
• /
• 한국동물학회 2000년도 한국생물과학협회 학술발표대회
• /
• pp.203.2-204
• /
• 2000

No Abstract, See Full Text

• Bulletin of the Korean Chemical Society
• /
• 제29권6호
• /
• pp.1141-1148
• /
• 2008

Geometry optimizations and electronic structure calculations are reported for meso-tetraphenyl porphyrin (TPP) and a series of meso-substituted catecholic porphyrins (KP99150, KP99151, KP99152, KP99153, and KP99090) using density functional theory (DFT). The calculated B3LYP//RHF bond lengths are slightly longer than those of LSDA//RHF. The calculated electronic structures clearly show that TPP and meso-catecholic group contribute to π-electron conjugation along porphyrin ring for HOMO and LUMO, significantly reduced the HOMO-LUMO gap. The wavelength due to B3LYP energy gaps is favored with experimental value in Soret (B), and LSDA energy gaps are favored with experimental value in visible bands (Q). The electronic effect of the catecholic groups is to reduced energies of both the HOMOs and LUMOs. However, the distortion of porphyrin predominantly raises the energies of the HOMOs, so the net result is a large drop in HOMO and smaller drop in LUMO energies upon meso-substituted catecholic group of the porphyrin macrocycle as shown in KP99151 and KP99152 of Figure 5(a). These results are in reasonable agreement with normal-coordinate structural decomposition (NSD) results. The HOMO-LUMO gap is an important factor to consider in the development of photodynamic therapy (PDT).

• 한국균학회소식:학술대회논문집
• /
• 한국균학회 2015년도 추계학술대회 및 정기총회
• /
• pp.28-28
• /
• 2015

Asexual reproduction or conidiation in aspergilli is a primary mean to produce their progenies that is environmentally and genetically controlled tightly. Previously, intensive researches in the model fungus Aspergillus nidulans disclosed some genes playing important roles in asexual and sexual development. Among them, one gene encoding a putative helix-loop-helix (HLH) transcription factor, named ndrA, has been isolated and characterized as a downstream regulator of developmental master regulator NsdD. By using comparative genome search of A. niduans NdrA protein, its orthologues have been identified in A. fumigatus and A. flavus, respectively (AfudrnA and AfldrnA). Deletion of the ndrA genes in both Aspergillus species made them unable to produce the conidia yet abundant production of sclerotia in A. flavus. Complementation of ndrA deletion strains by intact ndrA ORFs has restored the conidiation as in the control strains. In A. fumigatus, ndrA deletion also resulted in loss of conidiation phenotype. Northern analyses showed that the ndrA genes in both Aspergillus species are highly expressed at the early stage of the conidiation. Interestingly, the ndrA genes were found to be necessary for the proper expression of brlA genes. Antifungal sensitivity test revealed that the ndrA genes might be responsible for the sensitivity or resistance to some antifungal agents. However, ndrA deletion did not greatly influence the growth in both strains. And the A. flavus ndrA gene did not affect the aflatoxin production. Taken together, ndrA genes in Aspergillus species could be an important positive regulator of conidiation under the regulation of the nsdD gene yet upstream of the brlA gene.

• Journal of Genetic Medicine
• /
• 제11권2호
• /
• pp.74-78
• /
• 2014

Sotos syndrome (SS, OMIM 117550) is characterized by prenatal and postnatal overgrowth with multiple congenital anomalies. However, there have been few cases of growth retardation caused by renal failure from infancy. We report a case of dysplasia of the bilateral kidneys with renal failure and poor postnatal growth. A 2-month-old boy visited the emergency room owing to poor oral intake and abdominal distension. He was born at the gestational age of 38 weeks with a birth weight of 4,180 g. After birth, he had feeding difficulty and abdominal distension. Upon physical examination, his height and weight were in less than the 3rd percentile, while his head circumference was in the 50th percentile on the growth curve. He also showed a broad and protruding forehead and high hairline. Blood laboratory tests showed severe azotemia; emergent hemodialysis was needed. Abdominal ultrasonography revealed bilateral renal dysplasia with multiple cysts and diffuse bladder wall thickening. A posterior urethral valve was suggested based on vesicoureterography and abdominal magnetic resonance findings. Results of a colon study to rule out congenital megacolon did not reveal any specific findings. The conventional karyotype of the patient was 46, XY. Array comparative genomic hybridization study revealed a chromosome 5q35 microdeletion including the NSD1 gene, based on which SS was diagnosed. We describe a case of SS presenting with end stage renal disease due to posterior urethral valve. The typical somatic overgrowth of SS in the postnatal period was not observed due to chronic renal failure that started in the neonatal period.

• 한국기계가공학회지
• /
• 제10권1호
• /
• pp.8-15
• /
• 2011

ATV(All Terrain Vehicle) has been developed to be used for agricultural fields on unpaved roads but now it is mostly used to transport a short distance and play leisure sports at mountains. Recently, main concerns on the automobile industry is developing not only a car safe, high fuel efficient and friendly related with environment but also two-wheeled vehicles. In order to maintain high fuel efficiency and safety of two-wheeled vehicle, it is essential that ATV should be set up differential gear. But we worried for ATV which had been set up differential gear not to run on unpaved roads. Therefore, it is necessary to develop LSD(Limited Slip Differential) that maintains existing advantages of ATV and ensures ATV to travel safely on roads. Now LSD equipped cars have a complicated structure, so setting up on ATV is unsuitable. Therefore, in this study, we have developed simple, small and well operating LSD.

• Structural Monitoring and Maintenance
• /
• 제5권1호
• /
• pp.15-38
• /
• 2018

Negative stiffness dampers (NSDs) have been proven an efficient solution to vibration control of stay cables. Although previous studies usually assumed a linear negative stiffness behavior of NSDs, many negative stiffness devices produce negative stiffness with nonlinear behavior. This paper systematically evaluates the impact of nonlinearity in negative stiffness on vibration control performance for stay cables. A linearization method based on energy equivalent principle is proposed, and subsequently, the impact of two types of nonlinear stiffness, namely, displacement hardening and softening stiffness, is evaluated. Through the Hilbert transform (HT) of free vibration responses, the effects of nonlinear stiffness of an NSD on the modal frequencies, damping ratios and frequency response functions of a stay cable is also investigated. The HT analysis results validate the accuracy of the linearization method.

• Biomolecules & Therapeutics
• /
• 제17권1호
• /
• pp.12-16
• /
• 2009

One of the WHSC1/MMSET/NSD2 variant RE-IIBP is a histone H3-K27 methyltransferase with transcriptional repression activity. Overexpression of RE-IIBP in various types of leukemia suggests it's role in leukemogenesis. Here we identify two proteins, KRAB zinc finger protein ZNF 350 and enolase-1 as RE-IIBP interacting proteins by yeast two-hybrid screening and confirmed direct interaction in vivo and in vitro. Both proteins have been known for their role in transcriptional repression. Reporter assays using transient transfection demonstrated that both ZNF 350 and enolase-1 proteins synergistically repressed transcription with RE-IIBP, respectively. These results indicate both proteins have roles in RE-IIBP mediated transcriptional repression by involving co-repressor complex.

• 한국IT서비스학회:학술대회논문집
• /
• 한국IT서비스학회 2009년도 춘계학술대회
• /
• pp.91-105
• /
• 2009

현 정부는 신성장동력의 녹색기술산업 분야에서 첨단그린도시를 선정하여, 향후 많은 지자체 등에서 앞다투어 U-City 건설을 목표로 많은 서비스를 도입할 것으로 예상된다. 그러나, U-City 서비스, 프로세스, 필요한 H/W 등에 대한 표준화는 이루어져 있지 않은 상황이다. 이에 본 연구에서는 U-City 건설에 활용될 수 있는 IT 기반의 U-City 서비스 개발 방법론을 제안하고자 한다. 이를 위해 본 연구에서는 U-City와 NSD(New Service Development) 방법론들에 대한 문헌연구를 중심으로 U-City Service 개발 방법론 도출을 위한 분석을 하였다. 이러한 U-City 서비스 개발 방법론 연구결과를 통하여 U-City 서비스 도입을 위한 지침서를 제공할 수 있는 토대를 마련할 것이다.