• Title/Summary/Keyword: NOTCH4

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EFFECTS OF DENTIN SURFACE WETNESS OR DESICCATION AFTER ACID ETCHING ON DENTIN BONDING (산부식후 상아질 표면의 습윤 또는 건조가 상아질 결합에 미치는 영향)

  • Yang, Won-Kyung;Kwon, Hyuk-Choon;Son, Ho-Hyun
    • Restorative Dentistry and Endodontics
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    • v.25 no.2
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    • pp.243-253
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    • 2000
  • The purpose of this in vitro study was to evaluate dentin bonding by two different dentin bonding systems(DBS) using acetone based primer or adhesive [All Bond 2(AB2), One Step(OS)] when they were applied by wet or dry bonding technique. Morphology of resin-dentin interface and hybrid layer thickness(HLT) were investigated using Confocal Laser Scanning Microscope(CLSM) and compared to shear bond strength(SBS). 72 extracted sound human molars were randomly divided into 4 groups of 18 teeth each - Group 1.(AW); AB2 by wet bonding. Group 2(AD); AB2 by dry bonding. Group 3.(OW); OS by wet bonding, Group 4.(OD); OS by dry bonding. In 6 teeth of each group, notch-shaped class V cavities(depth 2mm) were prepared on buccal and lingual surface at the cementoenamel juction(12 cavities per group). To obtain color contrast in CLSM observation, bonding resins of each DBS were mixed with rhodamine B and primer of AB2 was mixed with sodium fluorescein. Prepared teeth of each group were treated with AB2, OS, respectively according to the manufacturer's instructions except for dentin surface moisture treatment after acid etching. In group 1 and 3, after acid etching, excess water was removed with wet tissue(Kimwipes), leaving consistently shiny, visibly hydrated dentin surface. In group 2 and 4, dentin surface was dried for 10 seconds at 1 inch distance. The treated teeth were then packed with composite resin(${\AE}$litefil) and light-cured. 12 microscopic samples($60{\sim}80{\mu}m$ thickness) of each group were obtained after longitudinal section and grinding(Exakt cutting and grinding system). Morphological investigation of resin-dentin interface and HLT measurement using CLSM were done. For measurement of SBS, remaining 12 teeth of each group were flattened occlusally to remove all enamel and grinded to 500 grit SiC(Pedemet Specimen Preparation Equipment). After applying DBS on the exposed dentin surface, composite resin was applied in the shape of cylinder, which has 5mm diameter, 1.5mm thickness, and light cured. SBS was measured using Instron with a crosshead speed of 0.5mm/min. It was concluded as follows, 1. HLT of AW(mean: $2.59{\mu}m$) was thicker than any other group, and followed by AD, OW, OD in descending order(mean; 2.37, 2.28, $1.92{\mu}m$). Only OD had statistically significant differences(p<0.05) to AW and AD. 2. There were intimate contact of resin and dentin at the interface in wet bonding groups, but gaps or irregular interfaces were observed in dry bonding groups. 3. The length, diameter, density of resin tags were various even in the same group without significant differences between groups and lots of adhesive lateral branches were observed. 4. There were no statistically significant difference of SBS between AB2 and OS, but SBS of wet bonding groups were significantly higher(p<0.05) than dry bonding groups. 5. There were no consistent relationships between HLT and SBS.

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The effect of heat input and PWHT on the mechanical properties and microstructure of HSB600 steel weldments with GMAW (HSB600강 가스메탈아크용접부에서 입열량과 용접후 열처리가 기계적 특성과 미세조직에 미치는 영향)

  • Ju, Dong-Hwi;Jang, Bok-Su;Lim, Young-Min;Koh, Jin-Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.5
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    • pp.1939-1946
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    • 2012
  • High performance steel for bridges requires higher performance in tensile and yield strength, toughness, weldability, etc. The purpose of this study is to investigate the weldability of HSB 600 steel. The effects of heat input (1.4~3.2kJ/mm) and postweld heat treatment (PWHT, $600^{\circ}C$, 40hr.) on the TMCP HSB600 steel weldments made by GMAW process were investigated. The tensile strength and hardness of as-welded specimens decreased with increasing heat input. Charpy V-notch impact energy did not show any significant difference by postweld heat treatment. The fine-grained acicular ferrite was mainly formed in the 2.1kJ/mm of heat input while polygonal and side plate ferrites were dominated in the high inputs. Meanwhile, tensile strength and hardness of PWHT weldments decreased due to the coarsening and globularization of ferrite microstructure and reduction of residual stresses with increasing heat inputs. However, there was no significant difference in the impact energy absorption.

Evaluation of PWHT cracking susceptibility of the Cr-Mo steel alloys (Cr-Mo 합금강의 후열처리 균열 감수성 평가)

  • Kim, Sang-Jin;Kim, Ki-Soo;Lee, Young-Ho
    • 대한공업교육학회지
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    • v.31 no.1
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    • pp.200-210
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    • 2006
  • This C-ring test, normally employed for evaluating susceptibility to stress-corrosion cracking, was determined to be a suitable small scale test to evaluate PWHT(Post-Weld Heat Treatment) cracking susceptibility. This test is possible to incorporate an actual weld, to introduce a notch into the coarse grained HAZ(Heat Affected Zone), to load the coarse grained HAZ any level of stress ad, most importantly, since the C-ring is an approximately constant strain type test, the stress decreases with time at temperature in a manner similar to that of an actual steel weldment. The procedure employed in making the C-ring was presented in the experimental procedure section, however, several points deserve further discussion. The walls of the weld groove are made along radial lines form the center of th var in order to obtain an HAZ which is oriented perpendicular to the walls of the machined C-ring. Therefore, the plane of maximum stress will be aligned through the HAZ and, therefore, crack propagation will not be forced to deviate form the plane of maximum stress in order to remain in the coarse grained HAZ as is the case with the Y groove test.

Suprascapular Nerve Entrapment Syndrome Caused by Ganglion (결절종에 의한 견갑상신경 포착 증후군)

  • Kim Soung Yon;An Sung Chan;Chun Jae Myeung
    • Journal of Korean Orthopaedic Sports Medicine
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    • v.1 no.1
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    • pp.65-70
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    • 2002
  • Purpose : To review the operative results and find out better method of a treatment of suprascapular nerve entrapment syndrome caused by ganglion. Materials and Methods : From March of 1996 to May of 2001, thirteen cases of suprascapular nerve entrapment syndrome caused by ganglion were reviewed which were diagnosed using physical examination, EMG and MRI. All of them were treated with open exision of ganglion, nerve decompression and arthroscopic examination. The clinical results were evaluated using subjective recovery of muscle power and ASES (American Shoulder and Elbow Surgeons) score. Results : Nine cases (69$\%$) showed residual symptom such as intermittent pain, insufficient recovery of muscle power, persistent muscle atrophy. Complete recovery in four cases (31$\%$). Mean value of ASES score was 86.4 (70-99.8) points. Postopertively, pain was relieved in 84$\%$ of patients and muscle power was improved in 53$\%$ of the patients but the atrophy persisted. Conclusions : Excision of ganglion is insuffient to relieve the nerve entrapment. Not only excision of ganglion but also treatment of intraarticular lesion, decompression of suprascapular and spinoglenoid notch which attributable to entrapment should be considered for the better clinical results.

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Hepatic microRNAome reveals potential microRNA-mRNA pairs association with lipid metabolism in pigs

  • Liu, Jingge;Ning, Caibo;Li, Bojiang;Li, Rongyang;Wu, Wangjun;Liu, Honglin
    • Asian-Australasian Journal of Animal Sciences
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    • v.32 no.9
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    • pp.1458-1468
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    • 2019
  • Objective: As one of the most important metabolic organs, the liver plays vital roles in modulating the lipid metabolism. This study was to compare miRNA expression profiles of the Large White liver between two different developmental periods and to identify candidate miRNAs for lipid metabolism. Methods: Eight liver samples were collected from White Large of 70-day fetus (P70) and of 70-day piglets (D70) (with 4 biological repeats at each development period) to construct sRNA libraries. Then the eight prepared sRNA libraries were sequenced using Illumina next-generation sequencing technology on HiSeq 2500 platform. Results: As a result, we obtained 346 known and 187 novel miRNAs. Compared with the D70, 55 down- and 61 up-regulated miRNAs were shown to be significantly differentially expressed (DE). Gene ontology and Kyoto encyclopedia of genes and genomes enrichment analysis indicated that these DE miRNAs were mainly involved in growth, development and diverse metabolic processes. They were predicted to regulate lipid metabolism through adipocytokine signaling pathway, mitogen-activated protein kinase, AMP-activated protein kinase, cyclic adenosine monophosphate, phosphatidylinositol 3 kinase/protein kinase B, and Notch signaling pathway. The four most abundantly expressed miRNAs were miR-122, miR-26a and miR-30a-5p (miR-122 only in P70), which play important roles in lipid metabolism. Integration analysis (details of mRNAs sequencing data were shown in another unpublished paper) revealed that many target genes of the DE miRNAs (miR-181b, miR-145-5p, miR-199a-5p, and miR-98) might be critical regulators in lipid metabolic process, including acyl-CoA synthetase long chain family member 4, ATP-binding casette A4, and stearyl-CoA desaturase. Thus, these miRNAs were the promising candidates for lipid metabolism. Conclusion: Our study provides the main differences in the Large White at miRNA level between two different developmental stages. It supplies a valuable database for the further function and mechanism elucidation of miRNAs in porcine liver development and lipid metabolism.

A Study of Establishment of the Infrastructure for Consequence Analysis of Metallic Dust Explosion (금속성 분진폭발의 영향 분석을 위한 기반구축에 관한 연구)

  • Jang, Chang Bong;Lee, Kyung Jin;Moon, Myong Hwan;Baek, Ju Hong;Ko, Jae Wook
    • Journal of the Korean Institute of Gas
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    • v.21 no.4
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    • pp.84-91
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    • 2017
  • Recent years have witnessed the increased usage of flammable metals, such as aluminum or magnesium, in wide range of high-tech industries. These metals are indispensable for the improvement of physical properties of materials as well as the design capability of the final product. During the process, unwanted metal dusts could be released to the environment. This can lead to an occupational health and safety issues. Due to their flammable nature, more serious problem of an explosion can happen in extreme cases. The explosion is the combustion of tiny solid particles and vapor mixture, caused by pyrolysis. This complex composition makes engineering analysis more difficult, compared to simple gas explosions or vapor cloud combustions. The study was conducted to assess this light metal dust explosion in an effort to provide the bases for a risk assessment. Dust explosion characteristics of each material was carefully evaluated and an appropriate analysis tool was developed. A comprehensive database was also constructed and utilized for the calibration of the developed response model and the verification for its accuracy. Subsequently, guidelines were provided to prevent dust explosions that could occur in top-notch industrial processes.

Development and Application of Mode II Fracture Toughness Test Method Using Rock Core Specimen (시추코어를 이용한 암석의 mode II 파괴인성 시험법 개발과 적용)

  • Jung, Yong-Bok;Park, Eui-Seob;Kim, Hyunwoo
    • Tunnel and Underground Space
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    • v.26 no.5
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    • pp.396-408
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    • 2016
  • Rock fracture mechanics has been widely applied to various fields of rock and civil engineering. But most researches covered mode I behavior, though mode II behavior is dominant in rock engineering. Until now, there is only one ISRM suggested method for mode II toughness of rock. A new SCC (Short Core in Compression) mode II toughness test method was developed considering 1) application of confining pressure, 2) easiness of notch creation, 3) utilization of existing equipment, 4) simple test procedure. The stress intensity factors were determined by 3D finite element method considering line and distributed loading conditions. The tests with granite specimens were carried out using MTS 815 rock test system with a loading rate of 0.002 mm/s. The mean value of mode II fracture toughness of granite showed $2.33MPa{\sqrt{m}}$. Mode I toughness of the same granite was $1.12MPa{\sqrt{m}}$, determined by Brazilian disk test and $K_{IIC}/K_{IC}=2.08$. The smooth fracture surface with rock powder formation also supported mode II behavior of SCC method. The SCC method can be used for the determination of mode II fracture toughness of rocks based on the current results.

Development of a Short-term Failure Assessment of High Density Polyethylene Pipe Welds - Application of the Limit Load Analysis - (고밀도 폴리에틸렌 융착부에 대한 단기간 파손 평가법 개발 - 한계하중 적용 -)

  • Ryu, Ho-Wan;Han, Jae-Jun;Kim, Yun-Jae;Kim, Jong-Sung;Kim, Jeong-Hyeon;Jang, Chang-Heui
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.39 no.4
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    • pp.405-413
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    • 2015
  • In the US, the number of cases of subterranean water contamination from tritium leaking through a damaged buried nuclear power plant pipe continues to increase, and the degradation of the buried metal piping is emerging as a major issue. A pipe blocked from corrosion and/or degradation can lead to loss of cooling capacity in safety-related piping resulting in critical issues related to the safety and integrity of nuclear power plant operation. The ASME Boiler and Pressure Vessel Codes Committee (BPVC) has recently approved Code Case N-755 that describes the requirements for the use of polyethylene (PE) pipe for the construction of Section III, Division 1 Class 3 buried piping systems for service water applications in nuclear power plants. This paper contains tensile and slow crack growth (SCG) test results for high-density polyethylene (HDPE) pipe welds under the environmental conditions of a nuclear power plant. Based on these tests, the fracture surface of the PENT specimen was analyzed, and the fracture mechanisms of each fracture area were determined. Finally, by using 3D finite element analysis, limit loads of HDPE related to premature failure were verified.

A Study on the Manufacturing, Mechanical Properties,Abrasion Resistance, and Slow Crack Growth Resistance of the Recycled Polyethylene/Fly Ash Composites (재생 폴리에틸렌/비산회 분말 충전 복합체 제조와 기계적 물성, 내마모성 및 저속균열성장 저항성에 관한 연구)

  • Kye, Hyoung-San;Shin, Kyung-Chul
    • Elastomers and Composites
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    • v.46 no.4
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    • pp.335-342
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    • 2011
  • The virgin and recycled polyethylene composites with various ratio of fly ash were manufactured by using a fully intermeshing co-rotating twin screw extruder for the reuse of fly ash from power plant and post-consumed polyethylene. Fly ash were blended with virgin HDPE and recycled polyethylene at the weight fraction of 0 to 40 wt.%. Mechanical properties such as yield strength, abrasion resistance, and slow crack resistance were measured with ISO and ASTM standards. The experimental results for the various composites showed that the elongation at break and the yield stress of the composites decreased with increasing fly ash contents. Generally, the abrasion resistance of PEs decreased with increasing sandpaper grits but the abrasion resistance of the composites increased with fly ash content at finer abrasive surface. The slow crack growth resistance of virgin HDPE, recycled JRPE and the JRPE composite showed higher slow crack growth resistance up to 50% of load at notch depth of 20% and 30%, but KRPE and the KRPE composite showed much lower resistance than virgin HDPE, JRPE and the JRPE composite. Time to break, measured with NCLS test method, of all PEs and the composites satisfies the regulation of Korean Industrial Specification for sewer pipe and support application.

Measurement of Various Dimensions of the Larynx in Korea Adult (한국인 성인의 후두계측에 관한 연구)

  • 박승훈;박성남;김미자;윤희병;정대현;장혁순;전승하;강주원
    • Proceedings of the KOR-BRONCHOESO Conference
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    • 1982.05a
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    • pp.9.1-9
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    • 1982
  • The authors have measured various dimensions of the larynx of twenty adult cadavers. (male; 13, female; 7) The result were as follows, 1) Transverse diameter between the greater horns of the hyoid bone; M.52.58mm, F.43.07mm. 2) Transverse diameter between the lesser horns of the hyoid bone; M.36.20mm, F.30.20mm. 3) Transverse diameter of the thyroid cartilage; M.50.58mm, F.42.58mm. 4) Transverse diameter of the cricoid cartlage; M.30.14mm, F.26.94mm. 5) Distance from the lower margin of the hyoid bone to the thyroid notch; M.12.83mm, F.10.92mm. 6) Distance from the lower margin of the thyroid cartilage to the lower margin of the cricoid cartilage; M.16.40mm, F.10.26mm. 7) Distance from the upper margin of the thyroid cartilage to the lower margin of the cricoid cartilage; M.34.65mm, F.34.61mm. 8) Anteroposterior diameter of the cricoid cartilage; M.25.32mm, F.20.01mm. 9) Transverse diameter of the epiglottis; M.29.32mm, F.22.08mm. 10) Vertical diameter of the epiglottis; M.35.90mm, F.27.90mm. 11) Transverse diameter between the cuneiform tubercles; M.17.69mm, F.13.52mm. 12) Length of the vocal fold; M.11.61mm, F.10.40mm. 13) Transvers diameter of the vocal fold; M.18.62mm, F.18.27mm. 14) Distance from the upper margin of the epiglottis to the vocal fold; M.42.45mm, F.34.52mm. 15) Anteroposterior length of the vocal fold; M.19.25mm, F.10.70mm.

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