• Bulletin of the Korean Mathematical Society
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• v.54 no.3
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• pp.917-933
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• 2017

In this paper, seven equivalent conditions of complete moment convergence and complete integral convergence for negatively orthant dependent (NOD, in short) sequences are shown under two cases: identical distribution and stochastic domination. The results obtained in the paper improve and generalize the corresponding ones of Liang et al. [10]). In addition, an extension of the Baum-Katz complete convergence theorem: six equivalent conditions of complete convergence is established.

• The Transactions of the Korea Information Processing Society
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• v.7 no.6
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• pp.1766-1777
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• 2000

In multimedia new service on the internet, there are problems such as server overload, network congestion and initial latency. To overcome these problems, we propose a proxy push-caching scheme that stores a portion of continuous media stream or entire stream, and a transmission scheme of NOD continuous media, RTP-RR and RTP-nR to exploit push-caching scheme. With the proposed push-caching scheme, NOD server pushes fixed portion of stream to a proxy when new data is generated, and the cached size of each stream changes dynamically according to the caching utility value of each stream. As a result, the initial latency of client side could be reduced and the amount of data transmitted fro ma proxy server to client could be increased. Moreover, we estimate a caching utility value of each stream using correlation between disk space occupied by the stream and the amount of data stream requested by client. And we applied the caching utility value ot replacement policies. The performance of the proxy push-caching and continuous media transmission schemes proposed were compared with other schemes using simulations. In the simulation, these schemes show better results than other schemes in terms of BHR (Byte Hit Rate), initial latency, the number of replacement and packet loss rate.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.4
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• pp.766-770
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• 2008

Bone is a dynamic tissue that is regulated by the balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Curcumin isolated from Kang-hwang (Turmeric) is widely used as a foodstuff, cosmetic, and medicine. However, the effect of curcumin isolated from Kang-hwang in osteoclast differentiation remains unknown. In this study, we sought to examine the role of curcumin in osteoclast differentiation. Here we show that curcumin greatly inhibited RANKL-mediated osteoclast differentiation in osteoclast precursors without cytotoxicity. RANKL induced the phosphorylation of p38 and JNK mitogen-activated protein kinase (MAPK) and mediated $I-{\kappa}B$ degradation in bone marrow macrophages (BMMs). However, RANKL-mediated p38 MAPK phosphorylation was inhibited by the addition of curcumin. Curcumin inhibited the mRNA expression of TRAP, c-Fos, and NFATc1 in BMMs treated with RANKL. Furthermore, the protein expression of c-Fos and NFATc1 induced by RANKL was suppressed by curcumin treatment. Taken together, our results suggest that curcumin may have a potential therapeutic role in bone-related diseases such as osteoporosis by inhibiting osteoclast differentiation.

• Proceedings of the Zoological Society Korea Conference
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• 1995.10b
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• pp.331.2-331
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• 1995

• Proceedings of the KIEE Conference
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• 1999.07e
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• pp.2287-2289
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• 1999

In this paper, a new method for calculating capacitance in multi-electrode system with arbitrarily shape is presented. This new approach based on divergence theorem and Gauss's law is achieved by Surface-Contacted Element(SCE) for Gaussian surface. To evaluate capacitance in multi-electrode system, two dimensional finite element method using only the elements which is contacted one nod (PE: Point-Element) or two nod (FE: Face-Element) with surface is employed. The proposed SCE method has short computing time to calculate capacitance which is because it uses only SCE elements and needs one calculation loop while exiting FEM method in servral loops. This method is verified by application in calculating capacitance using potential detection device model which is composed with anode, cathode, and floating electrode.

• Speech Sciences
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• v.8 no.4
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• pp.59-72
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• 2001

In this paper, we experimented with speaker change detection that uses a statistical method for NOD (News On Demand) service. A specified speaker's change can find out content of each data in speech if analysed because it means change of data contents in news data. Speaker change detection acts as preprocessor that divide input speech by speaker. This is an important preprocessor phase for speaker tracking. We detected speaker change using GLR(generalized likelihood ratio) distance base division and BIC (Bayesian information criterion) base division among matrix method. An experiment verified speaker change point using BIC base division after divide by speaker unit using GLR distance base method first. In the experimental result, FAR (False Alarm Rate) was 63.29 in high noise environment and FAR was 54.28 in low noise environment in MDR (Missed Detection Rate) 15% neighborhood.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1999.05a
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• pp.399-402
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• 1999

In this paper, a new method for calculating capacitance in arbitrarily shape structure is Presented. This new approach based on divergence theorem of Gauss\`s law is acheive by Surface-Contacted Element(SCE) for Gaussian surface. To evaluate accurate capacitance value in nonuniform electric field. in two dimensional analysis the interpolation using the elements which contact one nod (PE: Point-Element) or two nod (FE: Face-Element) is employed. Because the elements contacted with surface are very small compared with total elements in analytic model, SCE method has shorter computing time to calculate capacitance. This proposed method is verified by comparing the simulated results with value obtained by analytic method.

• Korean Circulation Journal
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• v.48 no.11
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• pp.951-963
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• 2018

HMG-CoA reductase inhibitors, i.e. statins, are effective in reducing cardiovascular disease events but also in cardiac-related and overall mortality. Statins are in general well-tolerated, but currently the concerns are raised if statins may increase the risk of new-onset diabetes mellitus (NOD). In this review, the possible effects of statins on organs/tissues being involved in glucose metabolism, i.e. liver, pancreas, adipose tissue, and muscles, had been discussed. The net outcome seems to be inconsistent and often contradictory, which may be largely affected by in vitro experimental settings or/and in vivo animal conditions. The majority of studies point out statin-induced changes of regulations of isoprenoid metabolites and cellassociated cholesterol contents as predisposing factors related to the statin-induced NOD. On the other hand, it should be considered that dysfunctions of isoprenoid pathway and mitochondrial ATP production and the cholesterol homeostasis are already developed under (pre)diabetic and hypercholesterolemic conditions. In order to connect the basic findings with the clinical manifestation more clearly, further research efforts are needed.

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.108-108
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• 2000

• International Journal of Oral Biology
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• v.33 no.3
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• pp.77-82
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• 2008

Innate immune response is initiated by the recognition of unique microbial molecular patterns through pattern recognition receptors (PRRs). The purpose of this study is to dissect the expression of various PRRs in gingival epithelial cells of differentiated versus undifferentiated states. Differentiation of immortalized human gingival epithelial HOK-16B cells was induced by culture in the presence of high $Ca^{2+}$ at increased cell density. The expression levels of various PRRs in HOK-16B cells were examined by realtime reverse transcription polymerase chain reaction (RTPCR) and flow cytometry. In addition, the expression of human beta defensins (HBDs) was examined by real time RT-PCR and the amounts of secreted cytokines were measured by enzyme linked immunosorbent assay. In undifferentiated HOK-16B cells, NACHT-LRR-PYDcontaining protein (NALP) 2 was expressed most abundantly, and toll like receptor (TLR) 2, TLR4, nucleotide-binding oligomerization domain (NOD) 1, and NOD2 were expressed in substantial levels. However, TLR3, TLR7, TLR8, TLR9, ICE protease-activating factor (IPAF), and NALP6 were hardly expressed. In differentiated cells, the levels of NOD2, NALP2, and TLR4 were different from those in undifferentiated cells at RNA but not at protein levels. Interestingly, differentiated cells expressed the increased levels of HBD-1 and -3 but secreted reduced amount of IL-8. In conclusion, the repertoire of PRRs expressed by gingival epithelial cells is limited, and undifferentiated and differentiated cells express similar levels of PRRs.