• Journal of Broadcast Engineering
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• v.17 no.5
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• pp.742-755
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• 2012

In this paper, we propose a parallel deblocking algorithm to resolve workload imbalance when the deblocking filter of high efficiency video coding (HEVC) decoder is parallelized. In HEVC, the deblocking filter which is one of the in-loop filters conducts two-step filtering on vertical edges first and horizontal edges later. The deblocking filtering can be conducted with high-speed through data-level parallelism because there is no dependency between adjacent edges for deblocking filtering processes. However, workloads would be imbalanced among regions even though the same amount of data for each region is allocated, which causes performance loss of decoder parallelization. In this paper, we solve the problem for workload imbalance by predicting the complexity of deblocking filtering with coding unit (CU) depth information at a coding tree block (CTB) and by allocating the same amount of workload to each core. Experimental results show that the proposed method achieves average time saving (ATS) by 64.3%, compared to single core-based deblocking filtering and also achieves ATS by 6.7% on average and 13.5% on maximum, compared to the conventional uniform data-level parallelism.

• The Journal of Internal Korean Medicine
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• v.37 no.3
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• pp.539-547
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• 2016

Myelodysplastic syndrome (MDS) is a typical myeloid malignancy characterized by cell dysplasia in bone marrow. Currently, there is no therapeutic treatment for MDS. The only available therapies either relieve symptoms or prevent the development of acute myeloid leukemia (AML). This study aimed to report the effects of traditional Korean medicine (TKM) on MDS by presenting two case reports. The patient in Case 1 was diagnosed with primary MDS and regularly received acupuncture treatments and herbal medicine. In Case 2, a patient with ovarian cancer was diagnosed with secondary MDS, which resulted from an adverse reaction to chemotherapy. This patient took herbal medicine for four years and was hospitalized three times. In order to have their condition evaluated, both patients underwent regular blood tests. The patient in Case 1, who showed blood transfusion dependency, received only two blood transfusions after TKM treatment, and the person’s health condition was stable as of January 2016 without any signs of AML development. The patient in Case 2 also has stable health condition. TKM treatment effectively treated their MDS symptoms and improved their general health conditions without any adverse effects. It also prevented the rapid development of AML and maximized the effects of conservative therapy.

• Journal of agricultural medicine and community health
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• v.40 no.4
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• pp.221-227
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• 2015

Objective: This study assessed whether both physical disability and perceived dependence relate to depression or whether perceived dependence in personal care activities, household activities, community mobility and recreational activities is an intermediate step in the relationship between physical disability and depressive symptoms. Methods: Data come from a cross-sectional survey of 209 women, aged 55 or older, with osteoarthritis (OA). Mediation analyses occurred in four step and included logistic regression analyses as outlined by Baron & Kenny. Results: The results from step 1 showed that greater difficulty with each domain of physical disabilities was significantly related to greater perceived dependence. In step 2, greater perceived dependence was significantly associated with greater depressive symptoms in all domains. Step 3 analyses showed that greater physical disabilities in each domain were significantly associated with depression. The final step testing mediation indicated that personal care activities, household activities and community mobility were fully mediated by perceived dependence. That was, once dependence was taken into account, the relationship between physical disabilities and depression was no longer significant. Partial mediation was found for dependence and recreational activity limitations. Conclusion: It is important to take into account the experience of perceived dependence as a mediator in understanding the relationship between disability and depression in the domains of personal care, household, and community mobility. To conclude, these findings point to the importance of taking into account an individual's reaction to their disability rather than just focusing on the severity of disability.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.49 no.4
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• pp.15-25
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• 2012

The research on the FPGA CAD tools in academia has been lacking practicality due to the underlying FPGA fabric architecture which is too simple and inefficient to be applied for commercial FPGAs. Recently, the database of placement positions and routing graphs on commercial FPGA architectures has been built, and provided for enabling the academic development of placement and routing tools. To extend the limit of academic CAD tools even further, we have developed the evaluation toolkit for the K-FPGA architecture which is under development. By providing interface for exchanging data with a commercial FPGA toolkit at every step of mapping, packing, placement and routing in the tool chain, the toolkit enables individual tools to be developed without waiting for the results of the preceding step, and with no dependency on the quality of the results, and compared in detail with commercial tools at any step. Also, the fabric primitive library is developed by extracting the prototype from a reporting file of a commercial FPGA, restructuring it, and modeling the behavior of basic gates. This library can be used as the benchmarking target, and a reference design for new FPGA architectures. Since the architecture is described in a standard HDL which is familiar with hardware designers, and read in the tools rather than hard coded, the tools are "data-driven", and tolerable with the architectural changes due to the design space exploration. The experiments confirm that the developed library is correct, and the functional correctness of applications implemented on the FPGA fabric can be validated by simulation. The placement and routing tools are under development. The completion of the toolkit will enable the development of practical FPGA architectures which, in return, will synergically animate the research on optimization CAD tools.

• YAKHAK HOEJI
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• v.34 no.4
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• pp.238-243
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• 1990

Pharmacokinetic characteristics of recombinant human interleukin-2 (rH IL-2) wre studied in the rat. First, different doses of rH IL-2 ranging from 6,400 to 1,600,000 U/kg were injected intravenously and the effect of dose size on the pharmacokinetics was examined. There was no dose dependency in the pharmacokinetics of rHIL-2 in the dose range of 6,400-40,000 U/kg. But at the dose of 1,600,000 U/kg, there was a severe hemolysis throughout the experiment and the pharmacokinetic parameters such as Vdss and CLt were significantly increased compared to those obtained from lower doses. It also showed that this drug is hardly distributed to the peripheral tissues and hardly eliminated from the body, since the valume of distribution (Vdss) and total body clearance (CLt) were 45-75 ml/kg and 1-2 ml/min/kg, respectively. The Vdss is close to the actual plasma volume and the CLt is less than glomerular filtration rate (GFR). Therefore it seemed that rH IL-2 is distributed only in the plasma pool and hardly filtered in the kidney due to its very large molecular weight. Second, rH IL-2 was administered to the rat via several routes such as hepatic portal vein (PV), intraperitoneal (IP), peroral (PO) and intranasal (IN) routes. The bioavailabilities (BA) of PV, IP, PO and IN routes were 96.8, 4.9, 0 and 0.1%, respectively. The addition of some nasal absorption enhancers such as taurocholate, taurodeoxycholate, glycocholate and glycodeoxycholate did not increase the BA of intranasaly administered rH IL-2. The result is contrast to the effect of these bile salts on the nasal absorption of ${\alpha}-inteferon$. Considering it together with the pharmacokinetic parameters, very large molecular weight of rH IL-2 seemed again to be the cause to very poor membrane permeability.

• Journal of Dairy Science and Biotechnology
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• v.34 no.2
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• pp.137-144
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• 2016

The ultimate research goal of the current study was a development of hydrolyzed whey protein powder (7%-GNANA) manufactured with normal content of sialic acid, a marker compound, that is naturally occurring at 7% concentration in GMP obtained from the milk protein. GMP is a safe food, used worldwide in infant and baby foods, etc. The test substance was prepared using (7% sialic acid containing) GMP as a raw material, and then using alcalase, an enzyme approved as a food additive, after separation of sialic acid with 100% efficiency and 7%-GNANA (containing 7% sialic acid and protein; product name: HELICOBACTROL-7) provided by MEDINUTROL Inc. (Korea). Bacterial reverse mutation (Ames) test was conducted in accordance with GLP Guideline using the test substance specified above. To identify its mutagenic potential against microorganisms, histidine auxotrophic strains of Salmonella Typhimurium, TA98, TA100, TA1535, and TA1537, and tryptophan auxotrophic strain of Escherichia coli, WP2uvrA, were used. The bacterial reverse mutation (Ames) test was performed by dividing the test substances into five different concentration groups (0, 61.7, 185, 556, 1,670, $5,000{\mu}g/plate$). Results of this experiment did not reveal repetitive increase of colony generating values or positive criteria for reverse mutagenicity for any concentration of test substances in any of the five strains, regardless of the presence of a metabolic activation system, and no dose-dependency was identified. In conclusion, the safety of 7%-GNANA test substance was verified by bacterial reverse mutation test conducted before registration of 7%-GNANA as a food additive.

• Journal of Dairy Science and Biotechnology
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• v.34 no.2
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• pp.91-98
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• 2016

The goal of this study was to develop hydrolyzed whey protein powder (23%-GNANA) manufactured with high content of sialic acid, a marker compound that is usually present at 7% concentration in GMP obtained from the milk protein. It is a safe food, used worldwide in infant and baby foods, etc. The test substance was prepared using (7% sialic acid containing) GMP as a raw material. Alcalase, an enzyme approved as a food additive, was used after separating sialic acid, with 100% efficiency, and 23%-GNANA (composed of 23% sialic acid and protein; product name: HELICOBACTROL-23), provided by MEDINUTROL Inc. (Korea), manufactured to have high (23%) content through ethanol soaking and enrichment. Bacterial reverse mutation (Ames) test was conducted in accordance with the GLP Guideline using the test substance specified above. To detect its mutagenicity potential in microorganisms, histidine auxotrophic strains of Salmonella typhimurium, TA98, TA100, TA1535, and TA1537, and tryptophan auxotrophic Escherichia coli strain, WP2uvrA, were used. The bacterial reverse mutation (Ames) test was performed using five concentrations of the test substances (0, 61.7, 185, 556, 1,670, $5,000{\mu}g/plate$). The evaluation did not reveal repetitive increase of colony generating values and positive criteria for reverse mutagenicity for any tested concentration in the five strains regardless of the presence of metabolic activation system, and no dose-dependency. In conclusion, the safety of 23%-GNANA test substance was verified by the bacterial reverse mutation test conducted before registration of 23%-GNANA as a food additive.

• Journal of Distribution Science
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• v.11 no.10
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• pp.63-72
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• 2013

Purpose - This study analyzes the relationship and dynamic interactions between stock price index, interest rate, price index, and housing price indices using Korean monthly data from 2000 to 2013, based on a VAR model. This study also examines Granger causal relationships among these variables in order to determine whether the time series of one is useful in forecasting another, or to infer certain types of causal dependency between stochastic variables. Research design, data, and methodology - We used Korean monthly data for all variables from 2000: M1 to 2013: M3. First, we checked the correlations among different variables. Second, we conducted the Augmented Dickey-Fuller (ADF) test and the co-integration test using the VAR model. Third, we employed Granger Causality tests to quantify the causal effect from time series observations. Fourth, we used the impulse response function and variance decomposition based on the VAR model to examine the dynamic relationships among the variables. Results - First, stock price Granger affects interest rate and all housing price indices. Price index Granger, in turn, affects the stock price and six metropolitan housing price indices. However, none of the Granger variables affect the price index. Therefore, it is the stock markets (and not the housing market) that affects the housing prices. Second, the impulse response tests show that maximum influence on stock price is its own, and though it is influenced a little by interest rate, price index affects it negatively. One standard deviation (S.D.) shock to stock price increases the housing price by 0.08 units after two months, whereas an impulse shock to the interest rate negatively impacts the housing price. Third, the variance decomposition results report that the shock to the stock price accounts for 96% of the variation in the stock price, and the shock to the price index accounts for 2.8% after two periods. In contrast, the shock to the interest rate accounts for 80% of the variation in the interest rate after ten periods; the shock to the stock price accounts for 19% of the variation; however, shock to the price index does not affect the interest rate. The housing price index in 10 periods is explained up to 96.7% by itself, 2.62% by stock price, 0.68% by price index, and 0.04% by interest rate. Therefore, the housing market is explained most by its own variation, whereas the interest rate has little impact on housing price. Conclusions - The results of the study elucidate the relationship and dynamic interactions among stock price index, interest rate, price index, and housing price indices using VAR model. This study could help form the basis for more appropriate economic policies in the future. As the housing market is very important in Korean economy, any changes in house price affect the other markets, thereby resulting in a shock to the entire economy. Therefore, the analysis on the dynamic relationships between the housing market and economic variables will help with the decision making regarding the housing market policy.

• Magazine of the Korean Society of Agricultural Engineers
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• v.35 no.4
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• pp.55-66
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• 1993

Upon freezing a soil swells due to phase change and its compression stress increase a lot. As the soil undergo thawing, however, it becomes a soft soil layer because the 'soil changes from a solid state to a plastic state. These changes are largely dependent on freezing temperature and repeated freezing-thawing cycle as well as the density of the soil and applied loading condition. This study was initiated to describe the effect of the freezing temperature and repeated freezing-thawing cycle on the unconfined compressive strength. Soil samples were collected at about 20 sites where soil structures were installed in Kangwon provincial area and necessary laboratory tests were conducted. The results could be used to help manage effectively the field structures and can be used as a basic data for designing and constructing new projects in the future. The results were as follows ; 1. Unconfined compressive strength decreased as the number of freezing and thawing cycle went up. But the strength increased as compression speed, water content and temperature decreased. The largest effect on the strength was observed at the first freezing and thawing cycle. 2. Compression strain went up with the increase of deformation speed, and was largely influenced by the number of the freezing-thawing cycle. 3. Secant modulus was responded sensitivefy to the material of the loading plates, increased with decrease of temperature down to - -10$^{\circ}$C, but was nearly constant below the temperature. Thixotropic ratio characteristic became large as compression strain got smaller and was significantly larger in the controlled soil than in the soil treated with freezing and thawing processes 4. Vertical compression strength of ice crystal(development direction) was 3 to 4 times larger than that of perpendicular to the crystal. The vertical compression strength was agreed well with Clausius-Clapeyrons equation when temperature were between 0 to 5C$^{\circ}$, but the strength below - 5$^{\circ}$C were different from the equation and showed a strong dependency on temperature and deformation speed. When the skew was less then 20 degrees, the vertical compression strength was gradually decreased but when the skew was higher than that, the strength became nearly constant. Almost all samples showed ductile failure. As considered above, strength reduction of the soil due to cyclic freezing-thawing prosses must be considered when trenching and cutting the soil to construct soil structures if the soil is likely subject to the processes. Especially, if a soil no freezing-thawing history, cares for the strength reduction must be given before any design or construction works begin. It is suggested that special design and construction techniques for the strength reduction be developed.

• The KIPS Transactions:PartB
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• v.15B no.6
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• pp.575-584
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• 2008

According to the network condition, the communication network overload could be occurred when media transmitting. Many researches are being carried out to lessen the network overload, such as the filtering, load distributing, frame dropping and many other methods. Among these methods, one of effective method is frame dropping that reduces specified video frames for bandwidth diminution. B frames are dropped and then I, P frames are dropped according to dependency among the frames in frame dropping. This paper proposes a scheme for protecting copyrights by encryption, when we apply frame dropping to reduce bandwidth of media following MPEG-4 file format. We designed two kinds of frame dropping: first one stores and then sends the dropped files and the other drops frames in real-time when transmitting. We designed three kinds of encryption methods in which DES algorithm is used to encrypt MPEG-4 data: macro block encryption in I-VOP, macro block and motion vector encryption in P-VOP, and macro block and motion vector encryption in I, P-VOP. Based on these three methods, we implemented a digital right management solution for MPEG-4 data streaming. We compared the results of dropping, encryption, decryption and quality of video sequences to select an optimal method, and there is no noticeable difference between the video sequences recovered after frame dropping and the ones recovered without frame dropping. The best performance in encryption and decryption of frames was obtained when we apply the macro block and motion vector encryption in I, P-VOP.