• 한국방사선학회논문지
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• 제9권5호
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• pp.269-277
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• 2015

세계적으로 수명을 다한 원자력발전소들이 증가하면서 노후화 된 원전의 해체에 대한 관심도 커져가고 있다. 특히 국토가 좁고 자원이 부족한 국내의 경우 원전을 해체하는데 있어 부지 재이용 문제는 하나의 중요한 사안이지만, 아직까지 부지 재이용을 위한 구체적인 법적 부지해제기준이 마련되어 있지 않다. 따라서 본 연구에서는 부지해제를 위한 IAEA의 국제적 안전기준(Safety Guide No. WS-G-5.1) 및 국내 관련기준, 미국 유럽 등 선진국들의 부지해제 사례들을 분석하였으며, 이를 바탕으로 적절한 선량기준 및 국내 부지해제 기준 수립 시 고려해야하는 사항들을 제언하였다. 이는 원전 해체 후 부지 재이용을 위한 국내 부지해제 기준 수립을 위한 기초자료로 활용될 것으로 판단된다.

• 한국유기농업학회지
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• 제4권2호
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• pp.86-96
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• 1995

This experiment was carried out to investigate the effect of slow-release fertilizers on yield of chinese cabbage and spinach. Fertilizers were treated with CDU, MEISTER, Jobi Gohyungbokhapbiryo, Kyungki Wonyebokbi 1ho, kyungkibokbi Nojeok, Kyungki Jeonjakgohyungbokbi, Traditional manuring, and No manuring. Yields of chinese cabbage were increased with slow-release fertilizers, and CDU was more effective to the head than to the out-leaf, especially. Spinach was increased with slow-release fertilizers, also. However, analysis of chemical components of plants and soil were no difference. It was very effective to increase yields of chinese cabbage and spinach, to reduce in number of supplementary manuring and laboring.

• 약학회지
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• 제43권2호
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• pp.150-159
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• 1999

Hollow type suppositories inserted polyvinyl alcohol (PVA) hydrogel capsule containing propranolol·HCI (PPH) were prepared using different bases, polyethylene glycol (PEG), Witepsol H-15 (WH-15) and Witepsol W-35 (WW-35) to improve the controlled release of PPH. The release of PPH from the hollow type suppository inserted PVA hydrogel capsule was retarded than that from PEG, WH-15, or WW-35 hollow type suppositories in rat rectal cavity. When the suppositories were administered to rats, the controlled release of PPH was proved by the plasma concentration-time-profiles of PPH. No significant difference (p〈0.05) among the three different hollow type suppositories was observed in terms of AUC and MRT of PPH. WH-15 hollow type suppository inserted 12% of PVA hydrogel capsule caused irritation to rat rectal mucosa. However, the WH-15 hollow type suppository inserted PVA hydrogel capsule caused no severe irritation on rectal mucosa. The application of the hollow type suppositories using PVA in sustained rectal delivery of drugs might be feasible.

• Biomolecules & Therapeutics
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• 제9권4호
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• pp.263-269
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• 2001

In this study, we tried to investigate whether poly-L-arginine (PLA) (MW 10,800) significantly affect mucin release from cultured hamster airway goblet cells and the mucosubstances of hypersecretory air-way goblet cells of rats. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with $^3$H-glucosamine for 24 hr and chased for 30 min in the presence of varying concentrations of PLA to assess the effects on $^3$H-mucin release. Possible cytotoxicities of PLA were assessed by measuring both Lactate Dehydrogenate (LDH) release and by checking the possible changes on the morphology of HTSE cells during treatment. For in vivo experiment, hyperplasia of rat airway goblet cells and increase in intraepithelial mucosubstances were induced by exposing rats to SO$_2$ for 3 weeks and varying concentrations of PLA were administered inhalationally to assess the effects on the mucosubstances of airway goblet cells of rats. The results were as follows : (1) PLA significantly inhibited mucin release from cultured HTSE cells in a dose-dependent manner; (2) there was no significant release of LDH and no significant change on the morphology of cultured HTSE cells during treatment; (3) PLA also affected the intraepithelial mucosubstances of hypersecretory rats and restored them to the levels of control animals. We conclude that PLA inhibit mucin release from airway goblet cells without significant cytotoxicity and possibly normalize the hypersecretion of airway mucosubstances in vivo. This finding suggests that PLA might function as an airway mucoregulative agent.

• 약학회지
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• 제35권6호
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• pp.509-514
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• 1991

The effect of diacylglycerol on glucose release was studied by using 1,2-dioctanoyl-sn-glycerol ($diC_8$), a cell permeable diacylglycerol, in perfused rat liver. The glucose release was increased by $diC_8(50\;{\mu}M$), and the effect was depended on calcium ions. The increment of glucose release by $diC_8(50\;{\mu}M$) was inhibited by indomethacin ($50\;{\mu}M$); the amount of glucose release was almost the same with that of control group. Arachidonic acid($200\;{\mu}M$) also increased glucose release and the release was inhibited by indomethacin. There was no synergistic effect on glucose release by the combination of $diC_8(50\;{\mu}M$) and phenylephrine($10\;{\mu}M$).

• 한국환경농학회지
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• 제28권2호
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• pp.165-170
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• 2009

환원상태가 발달된 담수상태의 토양이나 습지생태계에서 $NO_3^-$는 환원상태의 진전을 지연시키는 완충역할을 할 수 있다. 논토양에서 $NO_3^-$가 Fe의 환원과 그에 따른 P의 가용화에 미치는 영향을 조사하였다. 담수 후 10 cm 깊이 토양의 산화환원전위 변화는 $NO_3^-$를 처리한 토양과 처리하지 않은 토양에서 현저하게 달리 나타났으며, $NO_3^-$의 환원이 일어나는 동안에는 산화환원전위가 330${\sim}$360 mV 범위에서 유지되었다. 그리고 이 기간 동안 Fe의 환원은 현저히 억제되었다. $NO_3^-$를 처리한 토양 용액의 $PO_4^{3-}$ 함량은 담수 이후 0.2${\sim}$0.3 mg/L 수준 또는 그 이하로 유지되었으며, 반면 $NO_3^-$를 처리하지 않은 경우에는 담수 후 9일째부터 Fe의 환원과 함께 토양 용액의 $PO_4^{3-}$ 함량이 급격히 증가하였다. 일반적인 토양에서 무기태 P의 상당부분이 Fe 산화물에 고정된 형태 및 Fe와 결합된 형태로 존재하므로 Fe의 환원에 따라서 $PO_4^{3-}$가 함께 용출되는 것이다. 이상의 결과를 보면 토양중의 $NO_3^-$가 $Fe^{2+}$와 $PO_4^{3-}$의 용출을 조절하는 요인인 것으로 확인할 수 있다. 토양 용액중의 $NO_3^-$ 농도가 1 mg/L 이상으로 유지되는 상태에서는 토양의 산화환원전위가 330 mV 이하로 낮아지지 못하며, 따라서 Fe의 환원과 그에 따른 P의 용출 또한 현저히 억제되는 것으로 판단된다.

• The Korean Journal of Physiology
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• 제10권1호
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• pp.55-59
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• 1976

Most investigators have come to stress two different concepts of mechanism controlling renin release; intrarenal baroreceptor theory and the macula densa theory(Vander 1967, Thurau and Masson 1974). In the macula densa theory, the specific macula densa parameter, most commonly suggested as a possible signal, is either the osmolality or the concentration of sodium in the tubular fluid (Thurau 1964, Vander and Miller 1964, Reeves and Sommers 1965). It has been shown that sodium plays an important role in the release of renin either in vivo (Thurau 1964, Vander and Miller 1964, Thurau et al 1972) or in vitro experiments(Oelkers et al 1970, Hammerson et al 1971, Michelakis 1971). On the other hand the osmolality appears to have no effect on the release of renin in vivo (Vander 1967, Thurau and Masson 1974). However, there has been little attempt to study the effect of osmolality on in vitro renin release. We therefore undertook the present investigation to elucidate the effect of osmolality on renin release and to further test the sodium influence upon the release of renin from isolated kidney slice preparations. Isolated renal cortical slices were washed with normal Krebs-Hensenleit bicarbonate buffer solution and incubated for 30 minutes in a medium containing an appropriate concentration of sodium and osmolality. The renin released into the medium was measured by the method of radioimmunoassay(Haber et al 1969). The results obtained are as follows; 1. The release of renin from renal cortical slices was progressively inhibited as the sodium concentration in the medium increased. 2. No significant alteration in renin release was observed when osmolality of the medium was changed. These results suggest that the release of renin from the renal cortical slices is directly affected by the changes in sodium concentration in the medium, but is not influenced by the alterations in osmolality.

• 대한물리치료과학회지
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• 제31권1호
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• pp.1-15
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• 2024

Background: This study was conducted to apply active release techniques to male youth basketball players to help improve physical development and damage prevention and improve performance through improved balance and functional movement. Design: Randomized control trial. Methods: The subjects included 33 youth basketball players who were randomly assigned to the experimental group (n=17) and the control group (n=16). For the experimental group, the active release technique was applied to the hip muscles, calf muscles, posterior thigh muscles based on the distribution of injuries surveyed in youth basketball players in the Korean Basksetball League. The Y-balance test and the functional reach test (FRT) were used to assess balance and the Functional Movement Screen (FMS) was used to assess functional movement. Interventions were conducted twice a week for 4 weeks at 40 minutes per session. The experimental group was the active release technique group, and static stretching, a common exercise therapy technique, and self-myofascial release using a foam roller were applied for 20 minutes. The control group received general exercise therapy and placebo active release technique. The placebo active release technique applies pressure only. results:The experimental group showed a greater improvement in balance, as evidenced by the FRT, compared to the control group, which received general exercise treatment. However, there was no statistically significant difference in improvement between the 2 groups. In the case of the experimental group, the difference in the Y balance test before and after the intervention was larger than that of the control group, but there was no statistically significant difference. Significant improvement was found in functional movement, as evidence by the FMS, for the trunk stability test (p < 0.05), in-line lunge test (p < 0.05), rotational stability test (p < 0.05), total score (p < 0.05). Conclusion: In this study, the active release technique improved the balance and functional movement of young basketball players more than general exercise therapy. The application of the active release technique is therefore expected to assist in physical development, prevent damage, and improve the performance of youth basketball players.

• 약학회지
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• 제57권6호
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• pp.388-393
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• 2013

Previously, we have reported that lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, increased melanin synthesis through intracellular $Ca^{2+}$ release in B16 cells. In this study we investigated the possible involvement of nitric oxide (NO) in the mechanism of lovastatin-induced melanogenesis. Lovastatin elevated NO formation in a dose-dependent manner. Treatment with mevalonate, farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), precursors of cholesterol, did not significantly alter the lovastatin-induced NO production, suggesting that inhibition of cholesterol metabolism may not be involved in the mechanism of this action of lovastatin. Both NO formation and melanogenesis induced by lovastatin was significantly suppressed by treatment with $N^G$-nitro-L-arginine methyl ester (L-NAME) and 2-(4-carboxy-2-phenyl)-4,4,5,5-tetramethylinidazoline-1-oxyl-3-oxide (cPTIO), an inhibitor of NO synthase and a NO scavenger, respectively. The lovastatin-induced NO production was significantly affected not by EGTA, an extracellular $Ca^{2+}$ chelator, but by an intracellular $Ca^{2+}$ chelator (BAPTA/AM) and intracellular $Ca^{2+}$ release blockers (dantrolene and TMB-8). Taken together, these results suggest that lovastatin may induce melanogenesis through NO formation mediated by intracellular $Ca^{2+}$ release in B16 cells. These results further suggest that lovastatin may be a good candidate for the therapeutic application of various hypopigmentation disorders.

• 국제물리치료학회지
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• 제11권4호
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• pp.2237-2243
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• 2020

Background: The myofascial release technique is known to be an effective technique for increasing posterior fascia flexibility in short hamstring syndrome (SHS) subjects. But therapeutic mechanism of myofascial relaxation remains unclear. Recently, the theory of autonomic nervous system domination has been raised, however, a proper study to test the theory has not been conducted. Objectives: To investigate whether the application of the myofascial release technique can induce changes in the autonomic nervous system and affect the secretion of stress hormones and myofascial relaxation. Design: Quasi-experimental study. Methods: Twenty-four subjects with SHS were randomly divided into two groups. In the experimental group, the suboccipital muscle inhibition (SMI) technique was applied to the subjects for 4 min in supine position, and in the control group, the subjects were lying in the supine position only. A forward flexion distance (FFD) was conducted, blood pressure, heart rate, and cortisol levels were measured before and after the intervention and 30 min after intervention to determine myofascial relaxation and stress hormone levels. The evaluation was conducted separately in blind by an evaluator. Results: A FFD decreased in the experimental group, no change in cortisol was observed. On the contrary, a decrease in cortisol appeared in the control group after 30 minutes. Conclusion: The myofascial release technique is an effective treatment to increase the range of motion through posterior superior myofascial chain, but there is no evidence that myofascial release technique can control the autonomic nervous system.