약학회지 (YAKHAK HOEJI)

  • 제43권2호
  • /
  • Pages.150-159
  • /
  • 1999
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

폴리비닐알코올 하이드로겔 캅셀을 삽입한 중공좌제로부터 염산프로프라놀롤의 조절 방출

Controlled Release of Propranolol.HCI from Hollow Type Suppositories Inserted Polyvinyl Alcohol Hydrogel Capsule

  • 진선경 (이화여자대학교 약학대학) ;
  • 문이렌 (이화여자대학교 약학대학) ;
  • 구영순 (이화여자대학교 약학대학)
  • 발행 : 1999.04.01
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초록

Hollow type suppositories inserted polyvinyl alcohol (PVA) hydrogel capsule containing propranolol·HCI (PPH) were prepared using different bases, polyethylene glycol (PEG), Witepsol H-15 (WH-15) and Witepsol W-35 (WW-35) to improve the controlled release of PPH. The release of PPH from the hollow type suppository inserted PVA hydrogel capsule was retarded than that from PEG, WH-15, or WW-35 hollow type suppositories in rat rectal cavity. When the suppositories were administered to rats, the controlled release of PPH was proved by the plasma concentration-time-profiles of PPH. No significant difference (p〈0.05) among the three different hollow type suppositories was observed in terms of AUC and MRT of PPH. WH-15 hollow type suppository inserted 12% of PVA hydrogel capsule caused irritation to rat rectal mucosa. However, the WH-15 hollow type suppository inserted PVA hydrogel capsule caused no severe irritation on rectal mucosa. The application of the hollow type suppositories using PVA in sustained rectal delivery of drugs might be feasible.

키워드

참고문헌

  1. Yakugaku Zasshi v.104 Pharmaceutical evaluation of hollow type suppository Ⅰ. Brilliant blue FCF release characteristics of oleagenous hollow type suppository Watanabe, Y.;Matsumoto, M.
  2. Yakugaku Zasshi v.105 Pharmaceutical evaluation of hollow type suppository Ⅱ. Indomethacin added form release characteristics of hollow type suppository Watanabe, Y.;Yokoyama, K.;Yamaji, M.;Tanaka, F.;Matsumoto, M.
  3. J. Pharmacobio-Dyn. v.9 Pharmaceutical evaluation of hollow type suppositories Ⅳ. Improvement of bioavailability of propranolol in rabbits Watanabe, Y.;Matsumoto, Y.;Baba, K.;Matsumoto, M.
  4. Yakuzaigaku v.48 Rectal absorption of propranolol in rabbits from release-restricted hollow type suppositories Matsumoto, Y.;Watanabe, Y.;Hirota, O.;Matsumoto, M.
  5. Int. J. Pharm. v.58 Swelling and mechanical properties of poly (vinyl alcohol) hydrogels Urushizaki, F.;Yamaguchi, H.;Nakamura, K.;Numajiri, S.;Sugibayashi, K.;Morimoto, Y.
  6. Pharm. Res. v.6 Effect of polymeric network structure on drug release from cross-linked poly(vinyl alcohol) micromatrices Gander, B.;Gurny, R.;Doelker, E.;Peppas, N. A.
  7. yakugaku Zasshi v.106 Pressure sensitive adhesion and viscoelasticity of polyvinyl alcohol aqueous gel Urushizaki, F.;Yamaguchi, H.;Mizumachi, H.
  8. J. Kor, Res. Institute Better Living v.49 Drug release from hollow type suppository(Ⅱ)-release rate of indomethacin from polyvinyl alcohol hydrogel supository Rhie, J. Y.;Ku, Y. S.
  9. J. Kor. Pharm. Sci. v.26 Controlled release of propranolol hydrochloride (PPH) from PPH-solid dispersion system-polyvinyl alcohol hydrogel hollow type suppository Chung, J. H.;Rhie, J. Y.;Ku, Y. S.
  10. Pharm. Res. v.6 Evaluation of polyvinyl alcohol hydrogel as a sustained-release vehicle for rectal administration of indomethacin Morimoto, K.;Nagayasu, A.;Fukanoki, S.;Morisaka, K.;Hyon, S. H.;Ikada, Y.
  11. Br. J. Clin. Pharmacol. v.6 Direct measurement of Propranolol Bioavailability during accumulation to steady-state Wood, A. J.;Carr, K.;Vestal, R. E.;Belcher, S.;Wilkinson, G. R.;Shand, D. G.
  12. Pharm. Res. v.8 Rectal mucosa damage in rabbits after subchronical application of suppository bases Muynck, C. D.;Cuvelier, C.;Steenkiste, D. V.;Bommarens, L.;Remon, J. P.
  13. Int. J. Pharm. v.40 Formulation of Fenbufen suppositories Ⅰ. Quantitative histological asessment of the rectal mucosa of rats following treatment with suppository base Reid, A. S.;Thomas, N. W.;Palin, K. J.;Gould, P. L.
  14. Int. J. Pharm. v.44 Formulation of fenbufen suppositories Ⅲ. Histology of the rectal mucosa of rats following repeat dosing of fenbufen Witepsol H12 and PEG vehicles Thomas, N. W.;Lack, L. J.;Woodhouse, B. A.;Palin, K. J.;Gould, P. L.
  15. Int,. J. Pharm. v.40 Formulation of fenbufen suppositories Ⅱ. Selection of a suppository base using dissolution studies and histological studies in rats Young, C.;Palin, K. J.;Reid, A. S.;Thomas, N. W.;Gould, P. L.