• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.4
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• pp.366-376
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• 2021

Purpose: There is no consensus regarding adjuvant therapies following Kasai portoenterostomy (KP) for biliary atresia (BA). This study aimed to analyze the effect of extended perioperative intravenous antibiotics (PI-Abx) and adjuvant corticosteroid on cholangitis and jaundice clearance rates in the 3 years post-KP in children with BA. Methods: Data of patients who underwent KP between 1999-2018 at a single center were retrospectively analyzed. Group A (1999-2010) received PI-Abx for 5 days, Group B (2010-2012) received PI-Abx for 5 days plus low-dose prednisolone (2 mg/kg), and Group C (2012-2017) received PI-Abx for 14 days plus high-dose prednisolone (5 mg/kg). Results: Fifty-four patients were included with groups A, B, and C comprising 25, 9, and 20 patients, respectively. The number of episodes of cholangitis was 1.0, 1.6, and 1.3 per patient (p=NS) within the first year and 1.8, 2.3, and 1.7 (p=NS) over 3 years in Groups A, B, and C, respectively. The jaundice clearance rate at 6 months was 52%, 78%, and 50% (p=NS), and the 3-year native liver survival (NLS) rate was 76%, 100%, and 80% (p=NS) in Groups A, B, and C, respectively. A near-significant association was observed between the incidence of cholangitis within the first year and decompensated liver cirrhosis/death at 3 years post KP (p=0.09). Persistence of jaundice at 6 months was significantly associated with decompensated cirrhosis/death at 3 years (p<0.001). Conclusion: The extended duration of PI-Abx and adjuvant corticosteroids was not associated with improved rates of cholangitis, jaundice clearance, or NLS in patients with BA.

• Journal of Life Science
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• v.34 no.4
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• pp.271-278
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• 2024

Redox factor (Ref)-1, a ubiquitously expressed protein, acts as a modulator of redox-sensitive tran- scription factors and as an endonuclease in the repair pathway of damaged DNA. However, the function of Ref-1 in the differentiation of monocytes into macrophages has not been defined. In this study, we investigated the effects of Ref-1 on the monocyte differentiation process using the human monocytic cell line THP-1. The differentiation agent PMA increased cell adhesion over time and showed a sig- nificant increase in phagocytic function but decreased the intracellular amount of Ref-1. Ref-1 inhibitor E3330 and Ref-1 knockdown using the siRNA technique reduced cell adhesion and the expression of differentiation markers, such as CD14, ICAM-1, and CD11b, by PMA stimulation. This means that the role of Ref-1 is absolutely necessary in the initial process of differentiating THP-1 cells stimulated by PMA. Next, the distribution of Ref-1 was examined in the cytoplasm and nucleus of THP-1 cells stimulated with PMA. Surprisingly, PMA stimulation resulted in the rapid translocation of Ref-1 to the nucleus. To prove that movement of Ref-1 to the nucleus is required for monocyte differentiation, a Ref-1 vector with the nuclear localization sequence (NLS) deleted was used. As a result, overexpression of ∆NLS Ref-1, which restricted movement to the nucleus, suppressed the expression of differentiation markers and notably reduced phagocytic function in PMA-stimulated THP-1 cells. In conclusion, these data suggest that the differentiation of monocytic THP-1 cells requires Ref-1 nuclear translocation during the initial process of biochemical events following stimulation from PMA.

• Proceedings of the IEEK Conference
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• 2001.09a
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• pp.113-116
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• 2001

제로트리 부호화 알고리즘 중 효율적이며 잘 알려진 SPIHT는 높은 메모리 요구로 인해 하드웨어 구현에 큰 어려움을 가지고 있다. 이 논문에서는 저 메모리 사용과 빠른 제로트리 부호화 알고리즘을 제안한다. 메모리를 줄이고 빠른 코딩을 위한 방법으로 다음 3가지를 사용한다. 첫 번째, 리프팅을 이용한 웨이블릿 변환은 기존의 필터뱅크 방식의 변환보다 저 메모리와 계산량의 감소를 가진다. 두 번째, 웨이블릿 변환된 계수들은 블럭으로 나누어져 각각 코딩된다. 여기서 블록은 제로트리 구조가 유지되는 STB(spatial tree-based block)이다. 세 번째, Wheeler 와 Pearlman이 제안한 NLS (no list SPIHT)를 이용한 부호화이다. NLS는 효율성에서 SPIHT와 거의 같으며 작고 고정된 메모리와 빠른 부호화 속도를 보여준다.

• Journal of the Korean Operations Research and Management Science Society
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• v.34 no.4
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• pp.15-26
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• 2009

Bass diffusion model have played a central role in studying the diffusion of the new products since 1969, the year of publication of Bass model. Almost 750 publications based on the Bass diffusion model have explored extensions and applications. Extension models can be divided into two types. One is the model containing marketing-mix variables and the other is the model containing additional parameters. This paper presents another extension model of the latter type. Our model allows the time varying coefficients of innovation and imitation. Two pieces approximation of time varying coefficients is introduced and it's parameters are estimated based on NLS(Non-Linear Mean Square) method. Empirical studies are performed and the results show that our model is superior to the basic Bass model and the NUI(Non-Uniform Influence) model which is the well-known extension of the Bass model. The model developed in this paper is, also, transformed into the Bass model with the ready potential adopters in order to enhance the descriptive power.

• The Journal of Information Systems
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• v.14 no.2
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• pp.257-276
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• 2005

This study adopts diffusion of innovation theory and analyses product life cycle on two different information communication technology (ICT) products. One is telematics located on introduction and the other one is MP3 located on maturity. The analytical results were mixed. ordinary least square (OLS) result showed that adoption of MP3 player is affected by white noise error ($\varepsilon$) and telematics is influenced by innovation effect (p coefficient) rather than imitation effect (q coefficient) or white noise error. However, nonlinear least square (NLS) result showed that adoption of MP3 player is affected by imitation effect (q coefficient) rather than innovation effect (p coefficient). In addition, the ratio of imitation effect/innovation effect of MP3 player is larger than that of telematics.

• Journal of Families and Better Life
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• v.13 no.2
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• pp.94-102
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• 1995

본 연구에서는 가사노동의 책임이 취업여성들의 임금수준에 어떠한 영향을 미치는 지를 연구하기 위해 가사노동의 책임이 거의 없는 미혼여성과 가사노동의 책임이 큰 기혼여 성사이의 취업성향과 임금수준을 비교분석하였다 미국의 NLS Young Women 데이터를 이 용하여 평균과 표준편차 및 백분율을 구하였고 Probit 분석과 최소자승법에 의한 희귀분석 을 SAS Program을 이용하여 분석하였다 가사노동책임관련변인은 기.미혼여성의 지속적인 전일제 근무자가 될 가능성에 별로 영향을 미치지 않는 것으로 나타났다 회귀분석결과 결혼 여부나 가사노동의 책임등은 임긍에 유의한 영향을 미치지 않았고 인적자본관련변인은 임금 에 긍적적인 효과가 있었으며 직업차별화변인은 여성지배직종에 근무하는 여성의 임금을 낮 추는 것으로 나타났다 본 연구결과 가사노동책임으로 인하여 기혼여성이 미혼여성보다 취업 하는 비율이 낮기는 하지만 그것을 취업주부의 임금이 낮아야하는 원인으로 보기에는 어렵 고 직업차별화가 여성들의 저임금의 이유일수있음을 알수 있다 따라서 여성 스스로 여성지 배직종을 선택하는지 그리고 그러한 결정에 의하여 낮은 임금을 받는지에 대새허는 후속연 구가 필요하리라 본다.

• Journal of Contemporary Eastern Asia
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• v.15 no.1
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• pp.27-40
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• 2016

This study uses a network approach to investigate the structural characteristics of sub-organizations within public research institutes in order to obtain their implications for organizational structures. We construct a network based on research similarities between sub-organizations because sub-organizations generally build their own research portfolios. We examine how sub-units are organized based on their structural features. The structural features are compared between three public research institutes in different countries: the Korean the Government-funded Research Institutes (GRIs), the Max-Planck-Gesellschaft in Germany, and the National Laboratories (NLs) in the United States. The structural comparison helps to identify organizational characteristics and to differentiate between them. We found little common ground in the research areas between the GRIs because individual sub-organizations have distinct research portfolios. Therefore, the organizational hierarchy of research in the GRIs is less matured than it is in other public research institutes. This study suggests that the GRIs need to establish integrated strategies in order to strengthen the common knowledge base.

• Proceedings of the Optical Society of Korea Conference
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• 2000.02a
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• pp.296-297
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• 2000

프라운호퍼 회절에 의하여 주어진 세기 무늬를 발생시키는 회절광학소자(Diffractive Optical Element, DOE)는 회절무늬소자, 키노폼(kinoform), 컴퓨터 푸리에 홀로그램 (computer-generated Fourier hologram) 등으로 불리우며, 광정보처리, 광연결, 레이저가공에서 중요한 역할을 한다. 이 소자를 설계하는 매우 다양한 방법들이 제안되었는데, iterative Fourier transform 알고리즘(IFTA)과 이를 변형한 알고리즘들이 가장 널리 사용된다. IFTA는 fast Fourier transform(FFT)를 활용하므로 계산시간이 절감되지만 국소 최소점에 고착되는 stagnation문제가 있어 이를 해결하기 위한 많은 변형된 알고리즘들이 제안되었다. 본 연구에서는 최근에 제안한 new Pnoise algorithm with hybrid input-output algorithm(NPA-HIOA)$^{(1)}$ 의 설계 성능을 IFTA, hybrid input-output 알고리즘(HIOA), new Pnoise 알고리즘(NPA)$^{(2)}$ , Nonlinear Least-Square (NLS)$^{(3)}$ 등의 기존의 알고리즘들과 비교하고자 한다. (중략)

• Kyungpook Mathematical Journal
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• v.47 no.3
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• pp.381-392
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• 2007

In 1906, da Rios, a student of Leivi-Civita, wrote a master's thesis modeling the motion of a vortex in a viscous fluid by the motion of a curve propagating in $R^3$, in the direction of its binormal with a speed equal to its curvature. Much later, in 1971 Hasimoto showed the equivalence of this system with the non-linear Schr$\ddot{o}$dinger equation (NLS) $$q_t=i(q_{ss}+\frac{1}{2}{\mid}q{\mid}^2q$$. In this paper, we use the same idea as Terng used in her lecture notes but different technique to extend the above relation to the case of $R^3$, and obtained an analogous equation that $$q_t=i[q_{ss}+(\frac{1}{2}{\mid}q{\mid}^2+1)q]$$.

• International Journal of Industrial Entomology and Biomaterials
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• v.37 no.2
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• pp.49-54
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• 2018

To artificially enhance antimicrobial peptide expression in Bombyx mori, we constructed genetically engineered silkworms overexpressing Rel family transcription factor. The truncated BmRelish1 (BmRelish1t) gene contained a Rel homolog domain (RHD), nuclear localization signal (NLS), acidic and hydrophobic amino acid (AHAA)-rich region, and death domain (DD), but no ankyrin-repeat (ANK) domain. The BmRelish1t gene was controlled by B. mori cytoplasmic actin 3 promoter in the PiggyBac transposon vector. Chromosome analysis of G1 generations of a transgenic silkworm with EGFP expression confirmed stable insertion of BmRelish1t. BmRelish1t gene overexpression in transgenic silkworms resulted in higher mRNA expression levels of B. mori antimicrobial peptides such as lebocin(~20.5-fold), moricin(~8.7-fold), and nuecin(~17.4-fold) than those in normal silkworms.