• Title/Summary/Keyword: NICE

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Quorum-Sensing Mechanisms in Bacterial Communities and Their Potential Applications (세균의 의사 소통(Quorum-Sensing) 기구와 그 잠재적 응용성)

  • Yoon, Sung-Sik
    • Food Science of Animal Resources
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    • v.26 no.3
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    • pp.402-409
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    • 2006
  • Although microorganisms are, in fact, the most diverse and abundant type of organism on Earth, the ecological functions of microbial populations remains poorly understood. A variety of bacteria including marine Vibrios encounter numerous ecological challenges, such as UV light, predation, competition, and seasonal variations in seawater including pH, salinity, nutrient levels, temperature and so forth. In order to survive and proliferate under variable conditions, they have to develop elaborate means of communication to meet the challenges to which they are exposed. In bacteria, a range of biological functions have recently been found to be regulated by a population density-dependent cell-cell signaling mechanism known as quorum-sensing (QS). In other words, bacterial cells sense population density by monitoring the presence of self-produced extracellular autoinducers (AI). N-acylhomoserine lactone (AHL)-dependent quorum-sensing was first discovered in two luminescent marine bacteria, Vibrio fischeri and Vibrio harveyi. The LuxI/R system of V. fischeriis the paradigm of Gram-negative quorum-sensing systems. At high population density, the accumulated signalstrigger the expression of target genes and thereby initiate a new set of biological activities. Several QS systems have been identified so far. Among them, an AHL-dependent QS system has been found to control biofilm formation in several bacterial species, including Pseudomonas aeruginosa, Aeromonas hydrophila, Burkholderia cepacia, and Serratia liquefaciens. Bacterial biofilm is a structured community of bacterial cells enclosed in a self-produced polymeric matrix that adheres to an inert or living surface. Extracellular signal molecules have been implicated in biofilm formation. Agrobacterium tumefaciens strain NT1(traR, tra::lacZ749) and Chromobacterium violaceum strain CV026 are used as biosensors to detect AHL signals. Quorum sensing in lactic acid bacteria involves peptides that are directly sensed by membrane-located histidine kinases, after which the signal is transmitted to an intracellular regulator. In the nisin autoregulation process in Lactococcus lactis, the NisK protein acts as the sensor for nisin, and NisR protein as the response regulator activatingthe transcription of target genes. For control over growth and survival in bacterial communities, various strategies need to be developed by which receptors of the signal molecules are interfered with or the synthesis and release of the molecules is controlled. However, much is still unknown about the metabolic processes involved in such signal transduction and whether or not various foods and food ingredients may affect communication between spoilage or pathogenic bacteria. In five to ten years, we will be able to discover new signal molecules, some of which may have applications in food preservation to inhibit the growth of pathogens on foods.

A Study on The Family Life Consciousness of Dasan Jeong Yak-yong for Educational Contents Development (교육콘텐츠 개발을 위한 다산(茶山) 정약용(丁若鏞) 가정생활관(家庭生活觀)에 대한 고찰(考察))

  • Ju, Young-Ae
    • The Journal of the Korea Contents Association
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    • v.18 no.6
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    • pp.529-544
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    • 2018
  • In this research, the significance and practice on life of Dasan Jeong Yak-Young's family is reviewed. Articles, letter, poetry written by Dasan and research papers regarding to him are mainly referred for the research. Family life consciousness is divided into three sections in terms of family, food clothing and shelter life, and the economy of the family. Dasan's family life consciousness has been organized with self-management, temperance, thrift, sharing and giving for family and others. He emphasized practical efforts in daily life to realize sense of family life. First, Dasan sought self-managing and temperance as follows. He suggested attitude of careful speech and behavior, filial duty, peace within a family, reading, and training the body and mind including nice and independent temperament with being in good shape. Second, Dasan has been taught to practice the following to save money. It is important to be diligent, to live a simple life, to work hard on one's work, and to avoid extravagant behavior and heavy drinking. Third, Dasan emphasized to practice rational sharing and giving. It is to adapt to the environment, to live within one's means, to cope with difficult circumstances, not to have desire, and to practice giving. Dasan's family life consciousness includes the rules and values for implementing a welfare society. The welfare society is a society that shares good values and practices norms. In the future, the content of education should be developed to provide education about Dasan's family life consciousness. I hope this study can provide an opportunity that the moral teachings of Dasan can be handed down and practiced in relation to family life.

Object Tracking And Elimination Using Lod Edge Maps Generated from Modified Canny Edge Maps (수정된 캐니 에지 맵으로부터 만들어진 LOD 에지 맵을 이용한 물체 추적 및 소거)

  • Park, Ji-Hun;Jang, Yung-Dae;Lee, Dong-Hun;Lee, Jong-Kwan;Ham, Mi-Ok
    • The KIPS Transactions:PartB
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    • v.14B no.3 s.113
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    • pp.171-182
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    • 2007
  • We propose a simple method for tracking a nonparameterized subject contour in a single video stream with a moving camera and changing background. Then we present a method to eliminate the tracked contour object by replacing with the background scene we get from other frame. First we track the object using LOD (Level-of-Detail) canny edge maps, then we generate background of each image frame and replace the tracked object in a scene by a background image from other frame that is not occluded by the tracked object. Our tracking method is based on level-of-detail (LOD) modified Canny edge maps and graph-based routing operations on the LOD maps. We get more edge pixels along LOD hierarchy. Our accurate tracking is based on reducing effects from irrelevant edges by selecting the stronger edge pixels, thereby relying on the current frame edge pixel as much as possible. The first frame background scene is determined by camera motion, camera movement between two image frames, and other background scenes are computed from the previous background scenes. The computed background scenes are used to eliminate the tracked object from the scene. In order to remove the tracked object, we generate approximated background for the first frame. Background images for subsequent frames are based on the first frame background or previous frame images. This approach is based on computing camera motion. Our experimental results show that our method works nice for moderate camera movement with small object shape changes.

Appraisal of Guidelines for Research & Evaluation II Appraisal of Clinical Practice Guidelines for Traffic Injuries (Appraisal of Guidelines for Research & Evaluation (AGREE) II를 이용한 교통사고 상해증후군의 국내·외 기개발 임상진료지침의 평가)

  • Park, Kyeong-Won;Lee, Jun-Seok;Kim, Hyun-Tae;Park, Sun-Young;Heo, In;Shin, Byung-Cheul
    • Journal of Korean Medicine Rehabilitation
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    • v.31 no.4
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    • pp.129-143
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    • 2021
  • Objectives This study was aimed to evaluate clinical practice guidelines (CPGs) of traffic injuries, which has already been developed at domestic or outside of country, and to explore the Korean medical treatments included in the CPGs. Methods Twelve electronic databases (PubMed, Cochrane library, China National Knowledge Infrastructure [CNKI {Chinese Academic Journals, CAJ}], Research Information Sharing Service [RISS], Oriental Medicine Advanced Searching Integrated System [OASIS], KoreaMed, Korean Medical Guideline Information [KoMGI), National Guideline Clearinghouse [AHRQ], Core Outcome Measures in Effectiveness Trials Initiative Website [COMET], Turning Research into Practice [TRIP], The National Institute for Health and Care Excellence [NICE], and Medical Research Information Center [MedRIC]) up to July 2021 were searched. Only systematically developed CPGs for traffic injuries were selected and appraised. The appraisal was conducted by using Appraisal of Guidelines for Research & Evaluation (AGREE) II tool. Results Six CPGs were included and evaluated. All CPGs were appraised as highly recommended because they exceeded 60% in more than 4 among 6 domains of AGREE II, including domain of 'rigor of development', and 30% in the rest. Recommendations related to Korean medicine treatments such as on manual therapy related to Chuna were given in 6 CPGs, 4 for acupuncture, 1 for Qigong and 1 for Taping. Conclusions The 6 CPGs were developed up to now through a systematic development methodology and there were many recommendations for Korean medical treatments related to manual (Chuna) treatment, acupuncture and Qigong. However, the evidence for the side effects and risk factors of Korean medical treatments was scantly reflected in CPGs. Therefore, it is considered that balanced CPG with benefits and risks should be developed, covering Korean medical diagnosis, treatment and prognosis.

Applications of Surface Cover Materials for Reduction of Soil Erosion (토양유실 저감을 위한 지표피복재 적용)

  • Won, Chul-hee;Shin, Min-hwan;Choi, Yong-hun;Shin, Jae-young;Park, Woon-ji;Choi, Joong-dae
    • Journal of Korean Society on Water Environment
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    • v.27 no.6
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    • pp.848-854
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    • 2011
  • The objective of this research was to experimentally test the effect of rice straw mats on the reduction of runoff, sediment and discharge under a laboratory scale with different rainfall intensity and slopes. We used the small runoff plots of $1m{\times}1m{\times}0.65m$ ($L{\times}W{\times}H$) in size were filled with loamy sand. Experimental treatments were bare (control), rice straw mats + PAM(SP), rice straw mats + PAM + sawdust(SPS) and rice straw mats + PAM + rice husks(SPR); slope of 10% or 20%; and rainfall intensity of 30 or 60 mm/hr. Runoff volume and coefficient from covered plots were significantly lower than those from control plots. Under the 30 mm/hr and 10% simulations, average runoff coefficient of covered plots decreased more than 92%. Under 60 mm/hr and 20% simulations, the ratios were between 39.8~58.1%. Under the condition of 30 mm/hr rainfall and 10% slope, sediment discharge from covered plots was practically zero. And at 20% plots, sediment reduction ratio was more than 95%. Under the condition of 60 mm/hr rainfall, sediment reduction ratio of 10 and 20% plots ranged between 86.3~95.3% and between 79.8~86.5%, respectively. The differences in initial runoff time, runoff and sediment discharge among different cover materials were not significant. Rainfall intensity showed higher impact on initial runoff time, runoff, and sediment discharge than slope. It was also shown that even if runoff reduction by surface cover were low, sediment discharge reduction could be very significant and contribute to improve the water quality of streams in sloping agricultural regions. It was concluded that the use of straw mat and PAM on sloping agricultural fields could reduce soil erosion and muddy runoff significantly and help improve the water quality and aquatic ecosystem in receiving waters.

Financial Status of Korean Ppuri Industry based on Credit Evaluation (2017-2019) (신용평가에 기반한 한국 뿌리기업 재무상황 (2017-2019))

  • Kim, Bo Kyung;Kim, Taek-Soo;Lee, Sangmok;Kim, Chang Kyung
    • Journal of Korea Foundry Society
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    • v.42 no.2
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    • pp.83-93
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    • 2022
  • Throughout this research course, we have analyzed the financial situation of more than 2,700 companies using credit evaluation disclosures from 2017 to 2019. The population was gathered based on the certification of Ppuri companies and Ppuri Expertise companies through the Korea National Ppuri Industry Center, accompanied by the NICE credit evaluation index. For the first time in Korea, we wanted to look at growth, profitability, and stability through financial analysis of the Ppuri industry. Through an indepth analysis, we identified operating income (rate), net income (rate), asset size, and debt ratio, along with three years of Ppuri company workers and total sales fluctuations, and looked at the financial structure per capita. In addition, financial status per person was compared by dividing Ppuri companies into six groups by employee size. Groups were 10 or fewer people, 11 to 20 people, 21 to 50 people, 51 to 200 people, 201-300 people, and 300 or more people; single individual companies were excluded for research convenience. Overall, the financial situation of Ppuri companies was judged to be in a very bad downturn, and financial indicators deteriorated over the course of the three years of investigation. In particular, the smaller the number of employees, the greater the financial fluctuations were and the worse the situations were. Among Ppuri companies, the casting industry, which is the technical starting point for the value chain of the industry, was found to also be in a very bad state, with continued workforce declines, total assets and sales reductions at severe levels, and operating income (rate) and net income (rate) also very poor. This is why we need a suitable and feasible policy direction, something that is difficult but must be allowed to develop.

Updates of Evidence-Based Nursing Practice Guideline for Prevention of Venous Thromboembolism (근거기반 정맥혈전색전증 예방 간호실무지침 개정)

  • Cho, Yong Ae;Eun, Young;Lee, Seon Heui;Jeon, Mi Yang;Jung, Jin Hee;Han, Min Young;Kim, Nari;Huh, Jin Hyung
    • Journal of Korean Clinical Nursing Research
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    • v.29 no.1
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    • pp.24-41
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    • 2023
  • Purpose: This study aimed to update the previously published nursing practice guideline for prevention of venous thromboembolism (VTE). Methods: The guideline was updated according to the manuals developed by National Institute for Health and Care Excellence (NICE) and Scottish Intercollegiate Guidelines Network (SIGN), and a Handbook for Clinical Practice Guideline Developer Version 10. Results: The updated nursing practice guideline for prevention of VTE was consisted of 16 domains, 46 subdomains, and 216 recommendations. The recommendations in each domain were: 4 general issues, 8 assessment of risk and bleeding factors, 5 interventions for prevention of VTE, 18 mechanical interventions, 36 pharmacological interventions, 36 VTE prevention starategies for medical patients, 25 for cancer patients, 13 for pregnancy, 8 for surgical patients, 7 for thoractic and cardiac surgery, 16 for orthopedic surgery, 10 for cranial and spinal surgery, 5 for vascular surgery, 13 for other surgery, 3 educations and information, and 2 documentation and report. For these recommendations, the level of evidence was 32.1% for level I, 51.8% for level II, and 16.1% for level III according to the infectious diseases society of America (IDSA) rating system. A total of 112 new recommendations were developed and 49 previous recommendations were deleted. Conclusion: The updated nursing practice guideline for prevention of VTE is expected to serve as an evidence-based practice guideline for prevention of VTE in South Korea. It is recommended that this guideline will disseminate to clinical nursing settings nationwide to improve the effectiveness of prevention of VTE practice.

3SLS Analysis of Technology Innovation, Employment, and Corporate Performance of South Korean Manufacturing Firms: A Quantity and Quality of Employment Perspective (한국 제조기업의 기술혁신, 고용, 기업성과 간 관계에 대한 3SLS 분석: 고용의 양적·질적 특성 관점에서)

  • Dong-Geon Lim;Jin Hwa Jung
    • Journal of Technology Innovation
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    • v.31 no.3
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    • pp.139-169
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    • 2023
  • This study analyzes the effects of firms' technology innovation(patent applications) on employment(number of workers and proportion of high-skilled workers) and corporate performance(sales per worker), while considering the two-way causal relationships between these variables. We used the three-stage least squares(3SLS) estimation to examine system of equations in which the dependent variables affect each other with a two-year lag wherever relevant, and applied it to firm-level panel data of Korean manufacturers with 100 or more workers. Our data covered the period of 2005-2017. Exogenous variables, such as firms' managerial and other characteristics, were controlled as explanatory variables. The identification variables for each equation included firms' R&D intensity, labor cost per worker(or operation of firms' own R&D center), and investment on worker training. We find that firms' patent applications increased number of workers, proportion of high-skilled workers, and sales per worker; the causal relationships in the opposite direction were also significant. Evidently, firms' technology innovation is critical to the growth and quality improvement of employment as well as sustainable corporate growth.

Analysis of College Students' Life Planning and Career Class Effectiveness (대학생의 인생 설계와 진로 수업 효과 분석)

  • Yoon Ok Han
    • The Journal of the Convergence on Culture Technology
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    • v.10 no.3
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    • pp.37-45
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    • 2024
  • It is important for universities to simply provide students with programs such as special lectures on employment, information on employment, mock interviews, and how to write self-introductions, as well as various information related to life planning and career and employment. However, life planning and career planning are also provided systematically. It is very important to provide. The purpose of this study is to analyze the effects of classes on life design and career felt by students through life planning and career classes and to suggest the direction of classes on life design and career. The research results are as follows. First, through life planning and career courses, college students had time to learn about themselves in the life planning part and developed reflective thinking about how they should live their lives. And it helped me plan for my four years of college. Second, in the career and job search section, it was helpful in finding a job and career path that suited me. I also realized that there are various occupations, and it was nice to be able to think about various things about employment. And it was seen as an opportunity to recognize the existence of various occupations. Third, in terms of class progress, the class progress including experiential activities and various invited lectures were good. He also said that he was interested in the class and was able to gain self-esteem through the class. Classes related to life planning and career guidance for college students provide students with opportunities to explore various career paths, so it is expected that many such classes will be held.

A Study on the Practical Approach of European Union's Market Access through the Understanding of Tariffs and Non-Tariff Barriers in European Union (EU의 관세 및 비관세 장벽 이해를 통한 EU시장 개척 방안)

  • Jung, Jae-Woo;Lee, Kil-Nam
    • International Commerce and Information Review
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    • v.16 no.4
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    • pp.191-225
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    • 2014
  • Most of all, this paper analyzes the current situation of EU(European Union) and ascertain EU's economic condition in terms of tariff lines and non-tariff barriers. and the purpose of this article is to find out the problems of EU's tariff lines and non-tariff barriers. Next, We suggest some future direction of export promotion from Korea to EU more largely for our companies. First, this paper describes the characteristics and outline of EU. The EU is a politico-economic union of 28 member states that are primarily located in Europe. The EU traces its origins from the European Coal and Steel Community(ECSC) and the European Economic Community(EEC), formed by the Inner Six countries in 1951 and 1958, respectively. After that, The Maastricht Treaty established the European Union under its current name in 1993. The latest major amendment to the constitutional basis of the EU, the Treaty of Lisbon, came into force in 2009. There are a combined population of over 500 million inhabitants and generated a nominal gross domestic product(GDP) of 16.692 trillion US dollars in EU. The results are as follows ; First of all, In terms of tariff lines and customs duties, Our companies have to know precisely EU's real tariff lines and other customs duties, and such as value added tax and exercise tax, corporate tax regulated by EU commission and EU's 28 members. second, our companies have to confirm EU's non-tariff barriers. such as RoHS, WEEE, REACH. These non-tariff barriers could be hindrances or obstacles to trade with foreign companies in other countries. We perceive all companies exporting to EU are related with these Technical Barriers to Trade irrespective of their nationality. So, Our companies fulfill the requirements of EU Commission concerning safety, health, environment etc. Also, Our companies choose market-driven strategy to export more largely than before in the field of marketing and logistics.

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