• Journal of Global Scholars of Marketing Science
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• v.16 no.1
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• pp.13-26
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• 2006

In this research, we develope a procedure for detecting a random non-stationarity to the individual's purchasing rate in a stationary NED model. On this purpose, we derive the likelihood ratio statistic for a testing null and alternative hypotheses defined as whether there is no significant structural change in a stationary NED model or any. Where the structural change comes from a random non-stationarity(marketing mix activities or seasonality, for example) to the individual's purchasing rate. We also apply the developed method to a panel data for a frequently purchased good. This research could be a solution to include the non-stationarity in a stationary NED model. We also expect that the developed model could give a signal for an early detection of significant changes in marketing environment, and a mean for a measurement of the effects of marketing mix activities.

• Journal of Global Scholars of Marketing Science
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• v.11
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• pp.129-146
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• 2003

This study explores whether a NBD type of model can be applied to characterize the underlying frequency distribution of online consumer's visit behavior. In this study, the following two research questions are addressed: (1) How can we characterize the underlying distribution pattern(s) of the number of repeat i i visits to a site? (2) How can consumer's Internet usages and his/her demographics affect the average number of visits to the site? Through the empirical investigation, this study found that NBD models are directly applicable to characterize the underlying distribution of visit frequency on the Internet. Furthermore, this study addresses some managerial implications for understanding how site visits are determined. Especially this study highlights the relationship between repeated visits and the visitors' Internet Usages and demographics. The proposed models are estimated and validated by online panel data that covers more than 1000 different sites and has 800,000 observations.

• Journal of Integrative Natural Science
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• v.5 no.3
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• pp.190-194
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• 2012

Human P-gp is one of the protein responsible for the multidrug resistance (MDR) develpment. MDR is a major cause of the cancer chemotherapy. In this paper, we performed homology modeling, docking study of papayriferic acid into the P-gp nucleotide binding domain (NBD2). For human P-gp, X-ray crystal structure is not known yet. We developed homology model for human NBD2 using HlyB ABC transporter structure (PDB code: 1XEF, resolution 2.5 ${\AA}$). Docking study was performed using Autodock. Docking result was analyzed, which shows that ligand docks into steroid binding site and interacts through hydrophobic and hydrophilic interactions.

• Journal of Integrative Natural Science
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• v.5 no.1
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• pp.18-21
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• 2012

The resistance of tumour cells against cytotoxic drug is significant limitation in successful chemotherapeutic treatment of cancer. To date, no crystal structure is available for human P-gp. We developed homology model for human P-gp NBD2 by using coordinates of transporter associated protein (TAP1). Docking study was performed for 8-geranyl-chrysin (Flavonoids) inhibitor in the NBD2 model. Ligand-protein interactions were determined which indicates that the 8-geranyl chrysin shares two overlapping sites in the cytosolic domains of P-gp, the ATP site and a hydrophobic steroid-binding site.

• Journal of Distribution Research
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• v.4 no.1
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• pp.17-29
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• 1999

We investigated the consumer behavior of store choice using consumer panel data. The NBD-Dirichlet model known to be predictive of the consumer's brand choice was also found to be well fitted for the store choice behavior. Understanding the regularity in the store choice will provide both manufacturers and sistributors with the necessary guidelines for their competitive strategies.

• Structural Engineering and Mechanics
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• v.66 no.3
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• pp.379-386
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• 2018

The present study addresses the direct and indirect methods of determining the mode-I fracture toughness of concrete using experimental tests and particle flow code. The direct method used is compaction tensile test and the indirect methods are notched Brazilian disc test, semi-circular bend specimen test, and hollow center cracked disc. The experiments were carried out to determine which indirect method yields the fracture toughness closer to the one obtained by the direct method. In the numerical analysis, the PFC model was first calibrated with respect to the data obtained from the Brazilian laboratory test. The crack paths observed in the simulated tests were in reasonable accordance with experimental results. The discrete element simulations demonstrated that the macro fractures in the models are caused by microscopic tensile breakages on large numbers of bonded particles. The mode-I fracture toughness in the direct tensile test was smaller than the indirect testing results. The fracture toughness obtained from the SCB test was closer to the direct test results. Hence, the semi-circular bend test is recommended as a proper experiment for determination of mode-I fracture toughness of concrete in the absence of direct tests.

• Journal of Distribution Science
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• v.13 no.8
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• pp.97-104
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• 2015

Purpose - This study examines the positive impact of the social distance between producers and users of online content, investigating and analyzing the most popular Web content. In addition, it tries to elicit the matching effect that appears when the individuals'cultural background is consistent with social distance. Research design, data, and methodology - We collected and analyzed actual data about 4,981 videos clips on YouTube, looking at six countries in order to verify the content of this study. Based on the results of the data analysis, the study conducted behavioral measurements on popularity, social distance, culture, and user engagement. The unit of analysis was the content and we collected information about the content producers and the content records. We controlled the views, comments, likes, calendar dates, and ages in the empirical models. The data was collected in 2011, with the records coming from South Korea, Japan, China, U.S., German, and France. A total of 4,980 elements were analyzed in the model. The empirical model estimated is the bivariate negative binomial distribution (NBD) model. Results - It turns out that there is a possibility that the matching effect can be diminished by variables that reflect the psychological involvement of user engagement. This study proposes academic and practical implications based on these research results. This research shows the positive effect of social distance between users and producers on the increased performance of the online content. We find the effect of social distance to be a stronger tendency in collectivism. The collectivists follow their sense of friendship and intimacy in their culture and, the social congruence effect can be found there as well. The effect, however, could erode in a social case where users are motivated by strong intrinsic and psychological factors. In addition, user engagement complicates the process of user decision making regarding the information. Conclusions - This study examines how the differential effects of social distance caused by culture could disappear through user commitment as a complicated user motivation. Some potential implications are as follows. First, a firm in the collectivism culture has to communicate based on the social distance. In fact, most online channels do not have a function that indicates the social distance as measured by favorites or subscribers. This function could help increase the performance of the content in online channels, but this increasing effect can only be found in a collectivist culture. Based on this, the firms have to communicate and announce to users the actual social distance between users and producers. Second, firms should develop a system that discovers the social distance and culture and shows these measures to users and producers, since the congruence effect between social distance and culture is found only for low user engagement. The firms can take the advantage of the congruence effect only for the development of the social distance and culture visualized system.

• Journal of the Korean Society of Food Science and Nutrition
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• v.26 no.4
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• pp.743-750
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• 1997

Direct measurement of the kinetics of free fatty acid transfer between phospholipid model membrane is technically limited by the rapid nature of the transfer process. Separation of membrane-bound fatty acid by centrifugation has shown that although the equilibrium distribution of free fatty acid is determined by this method, fatty acid transfer occurs too rapidly for accurate kinetic measurements. Recently fluorescence resonance energy transfer(FRET) assay has been developed to examine transfer of fatty acids between membranes. Donor membranes which has fluorescent fatty acid, anthroyloxy fatty acid(AOFA), is mixed with acceptor membranes which has non-interchangeable fluorescent quencher, nitrobenzo-xadiazol(NBD), using stopped flow apparatus. As the fluorescent fatty acids transfer from donor membrane to acceptor membrane, fluorescence intensity would be decreased and the rate and degree of fatty acid transfer can be analyzed. Fatty acid transfer between micelles is more complicated because of bile salt. Therefore in experiments with micelles, fluorescence self quenching assay is used. At high concentrations, a fluorophore tends to quench its own fluorescence causing a reduction in fluorescence intensity. Donor micelles contained self quenching concentrations of fluorophore and acceptor micelles had no fluorophore. Upon mixing of donor and acceptor micelles, the rate of transfer of the fluorophore from the donor to the acceptor was measured by monitoring the release in self quenching when its concentration in donor decreased over time.