• Journal of Veterinary Science
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• 제23권5호
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• pp.64.1-64.9
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• 2022

Background: Fluralaner is a novel drug belonging to the isoxazoline class that acts on external parasites of domestic animals. It is used systemically via drinking water, especially against red poultry mite in layer chickens. Fluralaner is frequently used in layers infected with D. gallinae. However, no study to date has investigated the effects of feed intake and water hardness. Objectives: This study aimed to investigate the effects of variable water hardness and feed intake on the pharmacokinetic profile of fluralaner. Methods: Layer chickens were divided into four groups (n = 8): fed + purified water (Group 1), feed restricted + purified water (Group 2), feed restricted + hard water (Group 3), and feed restricted + soft water (Group 4). After administering a single dose of the drug with drinking water, the blood samples were collected for 21 days. Fluralaner concentrations in plasma samples were determined by liquid chromatography/tandem mass spectrometry. The maximum plasma concentration (C_max), time to reach maximum plasma concentration (t_max), area under the concentration-time curve values (AUC_0-21d), half-life (t_1/2), and other pharmacokinetic parameters were calculated. Results: Although the highest maximum plasma concentration (C_max) was determined in Group 1 (fed + purified water), no statistically significant difference was found in the C_max, t_max, t_1/2, MRT_{0-inf_obs}, Vz/F_obs, and Cl/F_{_obs} parameters between the experimental groups. Conclusions: It was concluded that the feed intake or water hardness did not change the pharmacokinetic profile of fluralaner in layer chickens. Therefore, fluralaner could be used before or after feeding with the varying water hardness in poultry industry.

• 산업기술연구
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• 제21권B호
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• pp.233-240
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• 2001

This research was conducted with the aim of efficiently managing large scale of rivers such like Songyang-river through predicting water quality change with analyzing the characteristics of the flowing in nutrients and pollutants. The main result will be used as basic data for effectively operating reservoirs through controling water quality and quantity. The relationship between quantity of flow and water quality was analyzed and pollution loading into the basin was estimated. Three areas of Soyang-river upstream and one area of Suip-cheon in Yanggu-gun were selected as research sites. Flow and water quality were measured simultaneously. The relation between quantity of discharge and pollution concentration and between quantity of discharge and pollution loading were analyzed by statistical method, respectively. We provided a rating curve through measuring quantity of discharge(collecting quantity of discharge) and pollutograph and pollution loading curve through water quality data. Also, we analyzed the correlation between quantity of discharge per unit area and pollution loading per unit area in each basin. As resurt of this research, Buk-cheon spot revealed an excellent first grade water quality for the items including $BOD_5$, DO, and SS. The correlation coefficient between Buk-cheon spot's quantity of discharge and pollution loading was 0.896~0.996, showing the validity of analysis applying correlation curve formula of quantity of discharge and pollution loading in the same spot. Also, pollution loading per unit area of the items including $BOD_5$, COD, DO, SS, T-N, T-P increased as the area of basins get increased following the sequence of Buk-cheon, Suip-cheon, Naelin-cheon spots.

• 한국전자파학회논문지
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• 제16권6호
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• pp.594-602
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• 2005

본 논문에서는 결함 접지 구조(Defected Ground Structure, DGS)를 이용하여 설계한, 전송 선로의 폭이 매우 넓어진 새로운 형태의 5-단 저역 통과 여파기(5-pole Low Pass Filters, LPF)를 제시한다. 이를 위하여 종래에 제시 되었던 3-단 DGS LPF설계 방법을 임의의 N-단 LPF설계에도 적용할 수 있도록 일반화 시키고$(N\geq5)$, 한 예로써 5-단 LPF를 설계 및 측정 결과가 제시된다. LPF원형 회로로부터 필요한 소자값들을 갖는 서로 다른 크기의 DGS를 결정하기 위하여, 매우 정확한 인덕턴스 값을 예측해 주는 곡선 맞춤(curve-fitting) 방법도 제시되었다. 제안하는 5-단 LPF는 병렬 캐패시턴스 구현을 위해 개방 스터브 대신 선폭이 크게 보상된 낮은 임피던스의 전송 선로를 갖는다. 따라서 개방 스터브를 사용할 때 필수적으로 요구되는 T-나 Cross-불연속 접합 소자가 없고, 또한 기존의 LPF에서 직렬 인덕턴스 때문에 필요했던 높은 임피던스 전송 선로가 없다.

• 조명전기설비학회논문지
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• 제24권8호
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• pp.126-132
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• 2010

본 논문은 준평등전계중에서 임펄스전압에 대한 $N_2$가스의 절연파괴특성에 관한 것으로 실험은 1.2/50[${\mu}s$] 표준뇌임펄스전압, 180/2500[${\mu}s$] 개폐임펄스전압과 500[ns]/1[MHz] 급준성 과도과전압이 인가된 전극계에서 이루어졌다. 구-평판 전극의 간격은 14[mm]이고, 전계이용률은 71.2[%]이었으며 가스압력은 0.2~0.6[MPa]범위로 하였다. 그 결과 절연파괴는 스트리머방전에 의하여 일어났으며, 절연파괴전압은 상승시간이 빠른 급준성 과도과전압에서 가장 높게 나타났다. 정극성 절연파괴전압이 부극성보다 높았으며, 정극성의 경우 절연파괴까지의 시간도 더 긴 것으로 나타났다.

• Korean Journal of Radiology
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• 제25권2호
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• pp.189-198
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• 2024

Objective: To investigate the prognostic utility of radiomics features extracted from ¹⁸F-fluorodeoxyglucose (FDG) PET/CT combined with clinical factors and metabolic parameters in predicting progression-free survival (PFS) and overall survival (OS) in individuals diagnosed with extranodal nasal-type NK/T cell lymphoma (ENKTCL). Materials and Methods: A total of 126 adults with ENKTCL who underwent ¹⁸F-FDG PET/CT examination before treatment were retrospectively included and randomly divided into training (n = 88) and validation cohorts (n = 38) at a ratio of 7:3. Least absolute shrinkage and selection operation Cox regression analysis was used to select the best radiomics features and calculate each patient's radiomics scores (RadPFS and RadOS). Kaplan-Meier curve and Log-rank test were used to compare survival between patient groups risk-stratified by the radiomics scores. Various models to predict PFS and OS were constructed, including clinical, metabolic, clinical + metabolic, and clinical + metabolic + radiomics models. The discriminative ability of each model was evaluated using Harrell's C index. The performance of each model in predicting PFS and OS for 1-, 3-, and 5-years was evaluated using the time-dependent receiver operating characteristic (ROC) curve. Results: Kaplan-Meier curve analysis demonstrated that the radiomics scores effectively identified high- and low-risk patients (all P < 0.05). Multivariable Cox analysis showed that the Ann Arbor stage, maximum standardized uptake value (SUVmax), and RadPFS were independent risk factors associated with PFS. Further, β2-microglobulin, Eastern Cooperative Oncology Group performance status score, SUVmax, and RadOS were independent risk factors for OS. The clinical + metabolic + radiomics model exhibited the greatest discriminative ability for both PFS (Harrell's C-index: 0.805 in the validation cohort) and OS (Harrell's C-index: 0.833 in the validation cohort). The time-dependent ROC analysis indicated that the clinical + metabolic + radiomics model had the best predictive performance. Conclusion: The PET/CT-based clinical + metabolic + radiomics model can enhance prognostication among patients with ENKTCL and may be a non-invasive and efficient risk stratification tool for clinical practice.

• 폴리머
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• 제31권2호
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• pp.98-104
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• 2007

다양한 분자량의 폴리스티렌을 벤젠/n-헵탄, 1,4-다이옥산/이소프로판올, 1,4-다이옥산/n-헵탄과 같은 3종류의 혼합용매 계에 녹인 뒤 온도 상승에 따른 사슬의 팽창거동을 Flory $\Theta$온도 이상에서 점성도법으로 측정하였다. 온도 상승에 따라 두 종류의 영역, 즉 고분자 사슬이 팽창하는 영역과 수축하는 영역으로 구별되며, 분자량이 클수록 최대팽창온도가 높게 나타났다. 하나의 혼합용매 계 내에서는 $\tau/\tau_c$ 파라미터로 서로 다른 분자량의 사슬 팽창에 대하여 만능성이 나타나지만 서로 다른 혼합용매 계 사이에서는 각각의 기울기를 보임으로써 만능성이 관찰되지 않았다. 그러나 새로운 실험적 $b^{2/3}\tau/\tau_c$ 파라미터를 도입할 경우 모든 혼합용매 계의 사슬 팽창의 데이터들은 하나의 직선 위에 놓임으로써 만능성은 다시 회복되었다. 여기서 $\tau$는 $(T-\Theta)/\Theta$로 $\tau_c$는 $(\Theta-T_c)/T_c$로 각각 정의되며, $T_c$는 임계용액온도를 의미하며, b는 Schultz-Flory 식에서 $1/T_c$의 $1/M_w^{1/2}$에 대한 유효 기울기이다.

• Communications for Statistical Applications and Methods
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• 제14권1호
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• pp.169-182
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• 2007

Receive operating characteristic (ROC) approach can be employed to rank candidate genes from a microarray experiment, in particular, for the biomarker development with the purpose of population screening of a cancer. In the cancer microarray experiment based on n patients the researcher often wants to compare the tumor tissue with the normal tissue within the same individual using a common reference RNA. Ideally, this experiment produces n pairs of microarray data. However, it is often the case that there are missing values either in the normal or tumor tissue data. Practically, we have $n_1$ pairs of complete observations, $n_2$ "normal only" and $n_3$ "tumor only" data for the microarray. We refer to this data set as a mixed data set. We develop a ROC approach on the mixed data set to rank candidate genes for the biomarker development for the colorectal cancer screening. It turns out that the correlation between two ranks in terms of ROC and t statistics based on the top 50 genes of ROC rank is less than 0.6. This result indicates that employing a right approach of ranking candidate genes for the biomarker development is important for the allocation of resources.

• 한국인쇄학회지
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• 제15권1호
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• pp.71-83
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• 1997

In recent years, various kinds of organic photoreceptors have been used for copy machines based on electrophotography. Most of them are constructed into layered devices in which a photogeneration layer is separated from a charge transport layer. They are usually used with application of negative charges. Organic pigment have received considerable attention with phthalocyanine, squaraine, and azo compounds being used to construct zerograpgic photoreceptors with enhanced long wavelength sensitivity, residual potential and zerograpgic gain of squaraine photoconductor were measured from the photoinduced discharge curve. Most of synthesized squaraine derivative couldn`t use for CGM(charge generation material), but it knew that a part of one was able to use it within the possibility. A few appliance is used it know about dependence on CTM(charge transport material) of squaraine derivative. It could know that experiment`s result is 2.5-bis(4-N-N`-diethylaminophenyl)-1,3,4-oxadiazole(OXD) is the bestproduct.

• 한국물환경학회지
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• 제28권6호
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• pp.819-832
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• 2012

HSPF model based on BASINS was applied for the Hwaseong Reservoir watershed (HRW) to evaluate the feasibility of water quality management. The watershed was divided into 45 sub-basins considering various watershed environment. Streamflow was calibrated based on the measured meteorological data, discharge data of treatment plants and observed streamflow data for 2010 year. Then the model was calibrated against the field measurements of water qualities, including BOD, T-N and T-P. In most cases, there were reasonable agreements between observed and predicted data. The validated model was used to analyze the characterization of pollutant load from study area. As a result, Non-point source pollutant loads during the rainy season was about 66~78% of total loads. In rainy-season, water quality parameters depended on precipitation and pollutant loads patterns, but their concentration were not necessarily high during the rainy season, and showed a decreasing trend with increasing water flow. As another result of evaluation for load duration curves, in order to improve water qualities to the satisfactory level, the watershed managements considering both time-variant and pollution sources must be required in the HRW. Overall, it was found that the model could be used conveniently to assess watershed characteristics and pollutant loads in watershed scale.

• 자원리싸이클링
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• 제13권6호
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• pp.31-36
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• 2004

La-Co원소 치환량에 따른 스트론튬 페라이트의 미세구조효과와 자기특성변화를 연구하였다. La-Co치환된 스트론튬 페라이트는 La원소 치환량 x는 Fe와 Sr의 몰비 n과 Co원소 치환량 y와 x=2ny의 관계식에서, 하소분말의 보자력(Hcj) 값은 Fe와 Sr의 몰비 n=6.0에서 치환량 x=0.3일때 270 kA/m 및 x=0.2일때 240 kA/m 의 값을 나타내었다. La-Co원소가 치환된 스트론튬 페라이트 소결자석의 미세구조는 판상형으로 성장하고, 몰비가 높을수록 결정의 크기는 감소하였다. 이는 하소후 형성된 초기 결정상태에 의하여 결정된 것으로 판단된다. La-Co치환 스트론튬 페라이트의 소결자석의 자기특성은 몰비 n=0.6에서 치환량 x=0.3의 조건으로 제조한 경우, 잔류자속밀도(Br) 415 mT와 보자력(Hcj) 355 kA/m의 특성이 얻어졌으며, 몰비 n=6.0에서 치환량 x=0.2의 조건으로 제조한 경우 잔류자속밀도(Br) 410 mT와 보자력(Hcj)은 370 kA/m의 특성이 얻어졌다. 또한 자기특성곡선의 각성형은 치환량 x=0.2일때 더욱 향상되었다.