• Journal of Advanced Marine Engineering and Technology
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• 제38권10호
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• pp.1217-1224
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• 2014

This paper provides a practical scaling method to solve an old problem for scaling and developing the speed and resistance of a model to full-scale submarine in fully submerged underwater test. In every experimental test in towing tank, water tunnel and wind tunnel, in the first step, the speed of a model should be scaled to the full-scale vessel (ship or submarine). In the second step, the obtained resistance of the model should be developed. For submarine, there are two modes of movement: surface and submerged mode. There is no matter in surface mode because, according to Froude's law, the ratio of speed of the model to the full-scale vessel is proportional to the square root of lengths (length of the model on the length of the vessel). This leads to a reasonable speed and is not so much for the model that is applicable in the laboratory. The main problem is in submerged mode (fully submerged) that there isn't surface wave effect and therefore, Froude's law couldn't be used. Reynold's similarity is actually impossible to implement because it leads to very high speeds of the model that is impossible in a laboratory and inside the water. According to Reynold's similarity, the ratio of speed of the model to the full-scale vessel is proportional to the ratio of the full-scale length to the model length that leads to a too high speed. This paper proves that there is no need for exact Reynold's similarity because after a special Reynolds, resistance coefficient remains constant. Therefore, there is not compulsion for high speeds of the model. For proving this finding, three groups of results are presented: two cases are based on CFD method, and one case is based on the model test in towing tank. All these three results are presented for three different shapes that can show; this finding is independent of the shapes and geometries. For CFD method, Flow Vision software has been used.

• 한국어병학회지
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• 제36권2호
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• pp.277-286
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• 2023

Korean rockfish, Sebastes schlegelii, is a representative bony fish that belongs to the family Scorpaenidae and the order Scorpaeniformes. It has high ecological and economic value and is widely cultivated in many East Asian countries, including South Korea, Japan and China. One of streptococci, Streptococcus iniae, is Gram-positive cocci with a negative reaction for catalase and oxidase. The Korean rockfish shows clinical signs when infected with S. iniae, such as body darkening, bleeding, enlarged kidneys, blurred eyes, abdominal distension, etc., ultimately leading to death. The Korean rockfish causes significant economic losses every year in South Korea due to streptococcosis. In this study, we identified bacteria from the fish using polymerase chain reaction and conducted analyses of hemolytic activity and biochemical tests using API 20 STREP and API ZYM systems. Results of confirming the hemolytic activity (n=4) observed in alpha-type hemolysis (25%), beta-type hemol- ysis (50%), and gamma-type hemolysis (25%) of isolates. The biochemical test results exhibited sig- nificant variation among S. iniae. Additionally, we performed intraperitoneal injection with S. iniae in the fish and analyzed the phylogenetic tree using housekeeping genes of S. iniae, including cpsD, arcC, glnA, groEL, gyrB, mutS, pheT, prkC, rpoB, and tkt, via multilocus sequence typing (MLST). The lethal dose (LD₅₀) showed strong pathogenicity, such as 3.34 × 10 colony-forming unit (CFU)/ml for 23FBStr0601 strain and 7.16 × 10 CFU/ml for 23FBStr0602 strain. 23FBStr0603 strain showed relatively low pathogenicity at 1.73 × 10⁵ CFU/ml. The strains 23FBStr0601 and 23FBStr0602, which showed strong pathogenicity, clustered into one monophyletic group. The 23FBStr0603 strain showed weak pathogenicity and formed a monophyletic group with KCTC 3657.

• Asian-Australasian Journal of Animal Sciences
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• 제29권1호
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• pp.36-42
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• 2016

Milk-related traits (milk yield, fat and protein) have been crucial to selection of Holstein. It is essential to find the current selection trends of Holstein. Despite this, uncovering the current trends of selection have been ignored in previous studies. We suggest a new formula to detect the current selection trends based on single nucleotide polymorphisms (SNP). This suggestion is based on the best linear unbiased prediction (BLUP) and the Fisher's fundamental theorem of natural selection both of which are trait-dependent. Fisher's theorem links the additive genetic variance to the selection coefficient. For Holstein milk production traits, we estimated the additive genetic variance using SNP effect from BLUP and selection coefficients based on genetic variance to search highly selective SNPs. Through these processes, we identified significantly selective SNPs. The number of genes containing highly selective SNPs with p-value <0.01 (nearly top 1% SNPs) in all traits and p-value <0.001 (nearly top 0.1%) in any traits was 14. They are phosphodiesterase 4B (PDE4B), serine/threonine kinase 40 (STK40), collagen, type XI, alpha 1 (COL11A1), ephrin-A1 (EFNA1), netrin 4 (NTN4), neuron specific gene family member 1 (NSG1), estrogen receptor 1 (ESR1), neurexin 3 (NRXN3), spectrin, beta, non-erythrocytic 1 (SPTBN1), ADP-ribosylation factor interacting protein 1 (ARFIP1), mutL homolog 1 (MLH1), transmembrane channel-like 7 (TMC7), carboxypeptidase X, member 2 (CPXM2) and ADAM metallopeptidase domain 12 (ADAM12). These genes may be important for future artificial selection trends. Also, we found that the SNP effect predicted from BLUP was the key factor to determine the expected current selection coefficient of SNP. Under Hardy-Weinberg equilibrium of SNP markers in current generation, the selection coefficient is equivalent to $2^*SNP$ effect.

• BMB Reports
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• 제57권3호
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• pp.161-166
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• 2024

Aberrant DNA methylation plays a critical role in the development and progression of colorectal cancer (CRC), which has high incidence and mortality rates in Korea. Various CRC-associated methylation markers for cancer diagnosis and prognosis have been developed; however, they have not been validated for Korean patients owing to the lack of comprehensive clinical and methylome data. Here, we obtained reliable methylation profiles for 228 tumor, 103 adjacent normal, and two unmatched normal colon tissues from Korean patients with CRC using an Illumina Infinium EPIC array; the data were corrected for biological and experiment biases. A comparative methylome analysis confirmed the previous findings that hypermethylated positions in the tumor were highly enriched in CpG island and promoter, 5' untranslated, and first exon regions. However, hypomethylated positions were enriched in the open-sea regions considerably distant from CpG islands. After applying a CpG island methylator phenotype (CIMP) to the methylome data of tumor samples to stratify the CRC patients, we consolidated the previously established clinicopathological findings that the tumors with high CIMP signatures were significantly enriched in the right colon. The results showed a higher prevalence of microsatellite instability status and MLH1 methylation in tumors with high CMP signatures than in those with low or non-CIMP signatures. Therefore, our methylome analysis and dataset provide insights into applying CRC-associated methylation markers for Korean patients regarding cancer diagnosis and prognosis.

• 방사성폐기물학회지
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• 제4권1호
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• pp.87-93
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• 2006

제2차 전력수급기본계획에 의거 2017년까지 계획된 원자로만을 대상으로 심지층 처분시스템 설계 시 필요한 국내 사용후핵연료의 발생량, 제원적 특징, 초기농축도 및 방출연소도 등에 대하여 현재 및 미래 현황을 파악하고 예측하였다. 2057년까지 PWR 및 CANDU 사용후핵연료 발생량은 각각 20,500 및 14,800 MTU로 나타났다. 초기 농축도에 대해서는 4.5 wt.% 이하를 갖는 사용후핵연료가 96.5%를 차지하는 것으로 나타났다. 사용후핵연료의 평균 방출연소도는 90년대 후반에는 36 GWD/MUT 전도, 2000년대 초반에는 40 GWD/MTU를 나타냈으며, 2000년대 중 후반부터는 45 GWD/MTU가 될 것으로 나타났다. 광범위한 분석 및 예측 결과, 총 처분물량을 대표할 수 있는 가상적인 기준 사용후핵 연료는 16 6 한국표준형연료, 단면적 $21.4cm\times21.4cm$, 길이 453cm, 무게 672 kg, 초기 농축도 4.5 wt.%, 방출연소도 55 GWD/MTU로 나타났다.