• 한국운동역학회지
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• 제29권3호
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• pp.157-166
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• 2019

Objective: This study examined the effects of stimulating fingertip temperature on the patterns of force sharing and stability properties during multi-finger force production tasks. Method: 9 adult subjects (male: 3, female: 6, age: $26.11{\pm}4.01yrs$, height: $169.22{\pm}5.97cm$, weight: $61.44{\pm}11.27kg$) participated in this study. The experiment consisted of three blocks: 1) maximal voluntary contraction (MVC) task, 2) single-finger ramp task to quantify enslaving (i.e., unintended force production by non-task fingers), and 3) 12 trials of multi-finger steady-state force production task at 20% MVC. There were three temperature conditions including body-temperature (i.e., control condition), $40^{\circ}C$, and $43^{\circ}C$, and the stimulation was given to the index finger only for all experimental conditions. Results: There were no significant differences in the MVC forces, enslaving, and the accuracy of performance during the steady-state task between the conditions. However, the share of stimulated index finger force increased with the index fingertip temperature, while the share of middle finger force decreased. Also, the coefficient of variation of both index and middle finger forces over repetitive trials increased with the index fingertip temperature. Under the framework of the uncontrolled manifold (UCM) hypothesis used to quantify indices of multi-finger synergies (i.e., stability property) stabilizing total force during the steady-state task, the two variance components within the UCM analysis increased together with the fingertip temperature, while no changes in the synergy indices between the conditions. Conclusion: The current results showed that fingertip temperature stimulation only to index finger does not affect to muscle force production capability of multi-finger, independence of individual fingers, and force production accuracy by the involvement of all four fingers. The effect of fingertip temperature on the sharing pattern and force variation may be due to diffuse reflex effects of the induced afferent activity on alpha-motoneuronal pools. However, the unchanged stability properties may be the reflection of the active error compensation strategies by non-stimulated finger actions.

• Nutrition Research and Practice
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• 제13권4호
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• pp.302-309
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• 2019

BACKGOURND/OBJECTIVES: Vascular inflammation is an important feature in the atherosclerotic process. Recent studies report that leaves and branches of Carpinus turczaninowii (C. turczaninowii) have antioxidant capacity and exert anti-inflammatory effects. However, no study has reported the regulatory effect of C. turczaninowii extract on the arterial inflammatory response. This study therefore investigated modulation of the arterial inflammatory response after exposure to C. turczaninowii extract, using human aortic vascular smooth muscle cells (HAoSMCs). MATERIALS/METHODS: Scavenging activity of free radicals, total phenolic content (TPC), cell viability, mRNA expressions, and secreted levels of cytokines were measured in LPS-stimulated (10 ng/mL) HAoSMCs treated with the C. turczaninowii extract. RESULTS: C. turczaninowii extract contains high amounts of TPC ($225.6{\pm}21.0mg$ of gallic acid equivalents/g of the extract), as well as exerts time-and dose-dependent increases in strongly scavenged free radicals (average $14.8{\pm}1.97{\mu}g/mL$ $IC_{50}$ at 40 min). Cell viabilities after exposure to the extracts (1 and $10{\mu}g/mL$) were similar to the viability of non-treated cells. Cytokine mRNA expressions were significantly suppressed by the extracts (1 and $10{\mu}g/mL$) at 6 hours (h) after exposure. Interleukin-6 secretion was dose-dependently suppressed 2 h after incubation with the extract, at $1-10{\mu}g/mL$ in non-stimulated cells, and at 5 and $10{\mu}g/mL$ in LPS-stimulated cells. Similar patterns were also observed at 24 h after incubation with the extract (at $1-10{\mu}g/mL$ in non-stimulated cells, and at $10{\mu}g/mL$ in the LPS-stimulated cells). Soluble intracellular vascular adhesion molecules (sICAM-1) secreted from non-stimulated cells and LPS-stimulated cells were similarly suppressed in a dose-dependent manner after 24 h exposure to the extracts, but not after 2 h. In addition, sICAM-1 concentration after 24 h treatment was positively related to IL-6 levels after 2 h and 24 h exposure (r = 0.418, P = 0.003, and r = 0.524, P < 0.001, respectively). CONCLUSIONS: This study demonstrates that C. turczaninowii modulates the arterial inflammatory response, and indicates the potential to be applied as a therapeutic use for atherosclerosis.

• 한국인터넷방송통신학회논문지
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• 제19권1호
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• pp.265-277
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• 2019

본 연구의 목적은 내반슬을 가진 사람에게 무릎의 근전도와 Q-Angle에 탄성 밴드 운동과 런지의 효과를 비교하는 것이다. 연구대상자는 18명의 내반슬을 가진 평범하고 건강한 사람들로 이루어져 있다. 대상자는 탄력 밴드 그룹(인원=9, 남자6명과 여자3명, 나이 : $22.55{\pm}2.05$ 세, 신장 : $169.8{\pm}6.07cm$, 체중 : $66.44{\pm}9.83kg$)과 런지 그룹(인원=9, 남자 7명과 여자 2명, 나이 : $23.88{\pm}1.37$ 세, 신장 : $173.66{\pm}6.72cm$, 체중 : $67.22{\pm}13.30kg$)으로 두 그룹으로 무작위로 나뉘었다. 탄력 밴드운동과 런지는 매주 4 주 동안 실시되었다. 양측 무릎의 Q각이 탄성 밴드 그룹과 런지 그룹에서 실험 전후에 차이를 보이는 결과가 나타났다. 결론 : 결과적으로 두 군에서 두 무릎사이의 거리가 현저하게 감소되었다. 이러한 결과는 탄성 밴드 운동과 런지가 내반슬 변형을 완화 시키는데 효과적인 방법임을 나타내었다.

• 한국산학기술학회논문지
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• 제20권5호
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• pp.267-274
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• 2019

본 연구는 비만관리 교육을 통해 비만에 대한 지식이 선행된 상태에서, 실천한 수중운동 프로그램이 지역사회 비만여성의 신체기능에 미치는 효과를 알아보는데 목적이 있다. 연구대상자는 D광역시 A보건지소의 건강교실에서 참여를 희망한 자로 51세에서 79세의 비만여성 20명이 8주 동안 프로그램에 참여하였다. 비만관리 교육이 포함된 수중운동 프로그램은 주 2회, 20분 동안 비만관리 교육과 60분의 수중운동 프로그램을 포함하여 총 120분으로 구성되었다. 비만관리 교육은 신체활동 실천과 식이섭취 교육에 중점을 두어 실시되었다. 본 연구결과를 통해 8주간의 비만관리 교육을 포함한 수중운동 프로그램 후 비만여성의 복부둘레, 체중, 체질량 지수가 감소되었고(p<.05, p<.001,p<.001), 악력이 증가되어(p<.05), 비만감소와 근력증진에 효과적인 프로그램임을 알 수 있었다. 후속 연구시 연구 대상자의 수를 늘리고, 대조군을 갖춘 실험설계 연구와 대상자가 직접 참여하고 주도하는 참여형 비만관리 수중운동 프로그램으로 개발 할 필요가 있다. 또한, 지속적인 생활습관 개선을 위한 추가적인 전략이 필요함을 제언한다.

• 농촌의학ㆍ지역보건
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• 제44권3호
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• pp.115-123
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• 2019

이 연구는 J시 일부 보건진료소에서 실시한 건강증진프로그램이 농촌여성노인 노쇠정도 확인을 위한 건강상태(지각된 건강상태, 노쇠 점수, 상 하체 유연성, 최대악력, 동적평형검사 Timed Up and Go)에 미치는 효과를 규명하기 위함으로 대한노인병학회에서 개발한 한국형 노쇠측정도구 8개 항목을 통해 보건진료소 관할지역 노인들의 노쇠수준을 파악하고, 농촌 여성노인들의 노쇠수준에 맞는 12주 건강증진프로그램을 적용하였다. 건강증진프로그램(프로그램명: ${\bigcirc}{\bigcirc}$보건진료소와 주민이 함께 만드는 하하호호 백세건강마을 만들기)은 J시 보건진료소 특성화 사업의 한 부분으로 연구자인 보건진료전담공무원이 전문가의 자문을 얻어 농촌여성 노인들에게 적합하도록 수정 보완하여 실시하였다. 연구 결과 노쇠측정도구 8개 항목을 통한 노쇠점수도 실험군이 대조군에 비해서 유의한 차이를 보였는데, 8개 항목 중 주관적인 현재 건강상태와 우울한 감정의 개선이 노쇠점수가 향상에 특히 도움이 되었다. 건강상태 변화로 왼쪽 상체유연성은 실험군이 약 2배(+17cm), 오른쪽 상체유연성은 +11cm, 하체유연성은 실험군이 +6cm 증가하였고, 대조군은 거의 변화가 없어 통계적으로 유의한 차이가 있었다. 노인의 근력평가로 최대악력은 실험군이 약+4kg 증가하였고, 동적 균형 검사(Timed Up and Go test)는 실험군이 3초 빨라지고 대조군은 거의 변화가 없어 통계적으로 유의한 차이가 있었다. 따라서 이 연구에서 실시한 건강증진프로그램이 상 하체 유연성 및 근력, 민첩성 등 운동능력을 향상하는 데 도움이 되었다고 볼 수 있다. 이상의 연구 결과를 바탕으로 의료취약지역 보건 진료소 관할 인구의 평균수명 연장과 고령화로 노쇠한 농촌 노인들의 특성을 반영한 근력강화 및 유연성 운동과 인지개선 활동 등 다양한 건강증진프로그램의 지속적인 개발과 프로그램의 표준화를 통한 확대 적용이 필요하다.

• 대한물리치료과학회지
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• 제28권2호
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• pp.57-64
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• 2021

Background: During squat exercises, Ankle joint stability during squat movement transfers forces produced by unstable supports or various loads to the leg joints and trunk, reducing the risk of injury; therefore, a reference is needed for correct ankle joint posture during squat exercises. The purpose of this study was to examine the effect of ankle joint stability on quadriceps femoris and hamstring activation during squat exercises. Design: Quasi-experiment one group pretest-posttest design. Methods: The participants in this study were 20 volunteers who performed squat exercises with and without kinesiology tape. We measured quadriceps femoris and hamstring activation using surface electromyography. The ankle joint was stabilized with kinesiology tape using the ankle balance taping (ABT) method. A paired t-test was performed to compare differences between taping conditions. Results: Vastus medialis and vastus lateralis activation were greater following squat exercises with kinesiology tape than without; however, the difference was not significant. Medial and lateral hamstring activation was not significantly different between taping conditions. Conclusion: Although it is difficult to maintain stability using kinesiology tape alone, ankle joint stability is believed to affect quadriceps femoris muscle activity, which increases the effectiveness of the squat exercise.

• Journal of Ginseng Research
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• 제45권3호
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• pp.390-400
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• 2021

Background: We recently showed that gintonin, an active ginseng ingredient, exhibits antibrain neurodegenerative disease effects including multiple target mechanisms such as antioxidative stress and antiinflammation via the lysophosphatidic acid (LPA) receptors. Amyotrophic lateral sclerosis (ALS) is a spinal disease characterized by neurodegenerative changes in motor neurons with subsequent skeletal muscle paralysis and death. However, pathophysiological mechanisms of ALS are still elusive, and therapeutic drugs have not yet been developed. We investigate the putative alleviating effects of gintonin in ALS. Methods: The G93A-SOD1 transgenic mouse ALS model was used. Gintonin (50 or 100 mg/kg/day, p.o.) administration started from week seven. We performed histological analyses, immunoblot assays, and behavioral tests. Results: Gintonin extended mouse survival and relieved motor dysfunctions. Histological analyses of spinal cords revealed that gintonin increased the survival of motor neurons, expression of brain-derived neurotrophic factors, choline acetyltransferase, NeuN, and Nissl bodies compared with the vehicle control. Gintonin attenuated elevated spinal NAD(P) quinone oxidoreductase 1 expression and decreased oxidative stress-related ferritin, ionized calcium-binding adapter molecule 1-immunoreactive microglia, S100β-immunoreactive astrocyte, and Olig2-immunoreactive oligodendrocytes compared with the control vehicle. Interestingly, we found that the spinal LPA1 receptor level was decreased, whereas gintonin treatment restored decreased LPA1 receptor expression levels in the G93A-SOD1 transgenic mouse, thereby attenuating neurological symptoms and histological deficits. Conclusion: Gintonin-mediated symptomatic improvements of ALS might be associated with the attenuations of neuronal loss and oxidative stress via the spinal LPA1 receptor regulations. The present results suggest that the spinal LPA1 receptor is engaged in ALS, and gintonin may be useful for relieving ALS symptoms.

• 대한본초학회지
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• 제28권4호
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• pp.83-92
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• 2013

Objectives : Lespedeza Cuneata has been used to treat leukorrhea, asthma, stomach pain, diarrhea, acute mastitis, in Korean traditional medicine. According to recent studies, Lespedeza Cuneata has antioxidation, hypoglycemia, cell protective, insulin secretion, whitening, corpora cavernosa smooth muscle relaxation and antimicrobial activities, but it has been rarely conducted to evaluate the immuno-biological activity. The present study was examined to evaluate the anti-inflammatory effects of the Lespedeza Cuneata MeOH extract (LCE) in vivo and in vitro. Methods : In vitro, inflammatory mediators, such as cytokines, nitric oxide and prostaglandin $E_2$ were detected after the addition of LPS with or without LCE in Raw 264.7 macrophage cell line. In vivo, anti-edema effect of LCE was determined in the carrageenan-induced paw edema model in rats. Results : In vitro assay, LCE decreased release of nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) via suppression of iNOS and COX-2 expression. LCE inhibited the phosphorylation of $I{\kappa}B$ indicating the suppression of NF-${\kappa}B$ pathway. In vivo assay, LCE significantly inhibited the formation of paw edema induced by carrageenan injection in rats. LCE effectively inhibited increases of hind paw skin thickness and inflammatory cell infilterations. Conclusion : These findings demonstrate that LCE has inhibitory effect on inflammatory mediators in LPS-activated Raw 264.7 cells and on paw edema in carrageenan-stimulated rats, showing the possibility of anti-inflammatory use of Lespedeza Cuneata.

• 한국축산식품학회지
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• 제42권5호
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• pp.816-832
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• 2022

To evaluate the effects of early postmortem vacuum packaging (VP) on meat quality during postmortem chilled storage, hot-boned lamb was vacuum-packaged at 1, 6, 12, 24, and 48 h postmortem and stored around 2℃ until 168 h postmortem, with lamb packaged in plastic wrap as the control (aerobic packaging). Intramuscular pH decline was delayed when lamb was vacuum packaged at 1, 6, and 12 h postmortem (p<0.05). The lamb vacuum-packaged at 1 h postmortem (VP-1h group) had significantly lower shear force values and purge losses accompanied by lower free thiol group values than other treatments during postmortem storage and was also higher in extractable calpain-1 activity by 6 h postmortem (p<0.05). Free thiol group concentrations were significantly higher after VP at 6 and 12 h postmortem (p<0.05). Packaging lamb under vacuum very early postmortem produced the lowest shear force and purge loss, likely by slowing heat loss and muscle temperature decline, implying that lamb quality is improved by VP when applied very early postmortem. This was at the expense of protein oxidation, which was unrelated to other meat quality measurements, most likely because potential contracture during hot boning confounded its impact. Further research is required to understand the implications of the interaction between protein oxidation, VP, and hot boning on the acceptability of lamb.

• Journal of Nutrition and Health
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• 제55권4호
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• pp.430-440
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• 2022

셀레늄은 산화스트레스 방어 기능으로 인체의 면역기능 유지에 필수적 역할을 하고, 세포의 항산화기능, 면역기능, 갑상선호르몬 조절, 약물이나 중금속 위해에 대한 방어, 만성질환의 위험 감소에 필수 역할을 하는 미량무기질이다. 셀레늄 섭취의 부족은 암, 심혈관질환, 당뇨병, 신경질환, 골관절 및 근육괴사와 약화, 갑상선질환, 염증성 질환 등 다양한 만성적 질환의 위험을 높인다. 본 논문은 2020 한국인 영양소 섭취기준에서 셀레늄의 제정과 개정 근거 기준에 대해 설명하고, 셀레늄 데이터베이스의 현황과 향후 2025 한국인 영양소 섭취기준 설정을 위한 필요 연구에 대해 논의하였다. 셀레늄의 2020 한국인 영양소 섭취기준은 2015년에 이어 혈장 셀레노프로테인 P 수준이 최대가 되는 셀레늄의 평균필요량을 지표로 사용하였고, 중국인 대상의 보고치에 한국인의 기준체중과 변이계수를 적용하는 방법이 적용되었으며, 2015년에 비해 참고체중치의 변경에 따라 성별, 연령별 셀레늄 섭취기준에서 약간의 개정이 있었다. 향후 셀레늄 섭취기준 설정의 발전을 위해서는 1) 한국인 대상의 혈장 셀레노프로테인 P의 최대수준을 나타내는 셀레늄 섭취량을 파악하기 위한 셀레늄 중재연구가 필요하고, 2) 셀레늄 섭취량 판정의 정확성을 높이기 위한 영양평가 프로그램내 식품 셀레늄 데이터베이스의 검토와 식품의 셀레늄 함량 분석을 확대해야 하며, 3) 국민의 셀레늄 섭취와 체내 생물학적 지표와의 관계를 건강한 일반인뿐만 아니라 질환자 및 운동선수와 같은 특수 환경의 대상자들로 확대하는 연구가 요구된다.