• Journal of Korean Physical Therapy Science
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• v.11 no.1
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• pp.20-27
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• 2004

It is widely accepted that smooth muscle contraction is triggered by intracellular $Ca^{2+}$ ($[Ca^{2+}]_i$) released from intracellular $Ca^{2+}$ stores such as sarcoplasmic reticulum (SR) and from the extracellular space, The increased $[Ca^{2+}]_i$ can phosphorylate the 20-kDa myosin light chain ($MLC_{20}$) by activating MLC kinase (MLCK), and this initiates smooth muscle contraction. In addition to the $[Ca^{2+}]_i$-MLCK-tension pathway, a number of intracellular signal molecules, including mitogen-activated protein kinase (MAPK), protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K), and Rho-associated coiled coil-forming protein kinase (ROCK), play important roles in the regulation of smooth muscle contraction. However, the mechanisms regulating contraction of caldesmon (CaD), actin-binding protein, are not entirely elucidated in the presence of $Ca^{2+}$. It is known that CaD tightly interacts with actin and inhibits actomyosin ATPase activity. Therefore, the purpose of the present study was to investigate the roles of $Ca^{2+}$-dependent CaD in smooth muscle contraction. Endothelin-1 (ET-1), G-protein coupled receptor agonist and vasoconstrictor, increased both vascular smooth contraction and phosphorylation of CaD in the presence of $Ca^{2+}$. These results suggest that ET-1 induces contraction and phosphorylation of CaD in rat aortic smooth muscle, which may he mediated by the increase of $[Ca^{2+}]_i$.

• Journal of Korean Physical Therapy Science
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• v.31 no.2
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• pp.30-40
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• 2024

Background: The purpose of this study is to identify the difference in muscle activity and muscle contraction onset time according to a LLD and object weight When subjects performed a lifting task. Design: Repeated measure design Methods: 15 male adults participated in this study. When subjects performed a lifting task, we measured a difference of muscle activity and muscle contraction onset time in the rectus abdominis(RA), the erector spinae(ES), and the rectus femoris(RF) between both legs using the surface electromyogram (Telemyo DTS, Noraxon Inc., USA). When subjects performed a lifting task, the weight of the object was set to 0% kg, 10% kg, and 20% kg of the subject's body weight, excluding the weight of the box. Results: The difference in muscle activity in the RA, the ES, and the RF between both legs when lifting an object was larger in LLD condition than in non-LLD condition(p<0.05). In all of muscles, the difference of contraction onset time was generally increased as the object's weight increased. Specially, the difference in muscle contraction onset time in the RA, the ES between both legs was larger in the LLD condition than in the non-LLD condition(p<0.05). Conclusion: This study suggests that LLD affects the muscle activity and muscle contraction onset time during lifting objects. It can be used as data to prevent joint damage and muscle due to the LLD during work and movements of daily living.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.14 no.10
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• pp.2317-2323
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• 2010

When the muscle is contracted by continuous and same, the force takes fatigue and stiffness. The aim of this study was to know how the fatigue and muscle stiffness change during an isometric contraction. Surface Electro myography(EMG) signal monitoring system and ultrasonic transducer set up the same muscle stem, subjects contract his right femoris muscle by submaximal isometric contraction(50% of MVC) until exhaustion. Before and after the test, muscle stiffness was measured and EMG was measured during the contraction. As time goes by, muscle fatigue was increased. and the stiffness was shown strongly after the contraction. These results show if the muscle becomes more and more fatigued, the circulation of muscle is delayed although the contraction doesn't happen. So muscle stiffness is increased.

• Journal of Biomedical Engineering Research
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• v.10 no.2
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• pp.109-111
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• 1989

An electrical stimulator was designed to induce locomotion for paraplegic patients caused by central nervous system injury. Optimal stimulus parameters, which can minimize muscle fatigue and can achieve effective muscle contraction were determined in slow and fast muscles in Sprague-Dawley rats. Stimulus patterns of our stimulator were designed to simulate electromyographic activity monitored during locomotion of normal subjects. Muscle types of the lower extremity were classified according to their mechanical property of contraction, which are slow muscle (msoleus m.) and fast muscle (medial gastrocneminus m., rectus femoris m., vastus lateralis m.). Optimal parameters of electrical stimulation for slow muscles were 20 Hz, 0.2 ms square pulse. For fast muscle, 40 Hz, 0.3 ms square pulse was optimal to produce repeated contraction. Higher stimulus intensity was required when synergistic muscles were stimulated simultaneously than when they were stimulated individually. Electrical stimulation for each muscle was designed to generate bipedal locomotion, so that individual muscles alternate contraction and relaxation to simulate stance and swing phases. Portable electrical stimulator with 16 channels built in microprocessor was constructed and applied to paraplegic patients due to lumbar cord injury. The electrical stimulator restored partially gait function in paraplegic patients.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.6 no.1
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• pp.59-65
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• 2012

In this study, muscle fatigue of biceps and triceps during isometric exercise depending on concentric contraction and eccentric contraction was evaluated using EMG. 12 healthy male volunteers was performed concentric exercise and eccentric exercise by maximum flection and extension of elbow joint. Integrated EMG (IEMG) in time domain and mean power frequency (MNF) in frequency domain were calculated. MNF of the biceps and triceps was decreased, whereas IEMG was increased during concentric contraction and eccentric contraction. But muscle fatigue index appeared higher at region of stretched muscle length. in this result, muscle fatigue occurs at both biceps and triceps muscle during concentric and eccentric exercise, and muscle fatigue was affected by muscle contraction and extension.

• Korean Journal of Veterinary Research
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• v.34 no.3
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• pp.471-478
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• 1994

Effects of histamine on the ruminal smooth muscle motility of cattle were investigated in the longitudinal and circular smooth muscle strips. In order to these experiments, specimens were obtained from 35 korean native cattles, 3-4 years old, in Kwang-ju area slaughterhouse. Smooth muscle strips of rumen were made from sample, and then measured the isometric contraction with physiograph in $37{^{\circ}C}$ organ bath. The results were as follows : 1. Histamine caused two different types of response(a contraction or a relaxation) on the smooth muscle of cattle rumen. These responses increased in dose dependant manner. 2. Pyrilamine($H_1$-receptor antagonist) completely blocked contraction in all the preparation and converted the response into relaxation. 3. Cimetidine($H_2$-receptor antagonist) completely blocked relaxation in all the preparation and converted the response into contraction. 4. The contraction induced by histamine($10^{-3}M$) was not Mocked by cholinergic, adrenergic blocker or hexamethonium. 5. The contraction induced by histamine($10^{-3}M$) was markedly inhibited in the $Ca^{2+}$ free(or EDTA 2Na) Kreb's solution and by verapamil.

• PNF and Movement
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• v.20 no.3
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• pp.331-340
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• 2022

Purpose: Thisstudy aimed to identify the effect of varying the expansibility of elastic tape on the onset time of muscle contraction during neck extension for forward head posture syndrome. Methods: Forty-five young adults with forward head posture syndrome volunteered to participate and were randomly assigned to one of three groups according to the expansibility of the elastic tape (25%, 50%, 75%). The onset time of muscle contraction for the neck extensor during neck extension was measured using an electromyographic system (Free EMG, BTS, Italy). Multivariate analysis of variance was employed to determine the effect of different expansibilities of elastic tape on the onset time of muscle contraction during neck extension for forward head posture syndrome. When there was a statistically significant difference by MANOVA, Scheffe was used as a post-hoc test. The level of significance was set at α=0.05. Results: In the comparison of the onset time of muscle contraction of varying elastic tape expansibilities and measurement times, there was a significant difference between the groups (Lt. UT, Lt. SCM, Rt. SCM) (p < 0.05), but there was no significant difference in the interaction between the measurement time and the group, between the measurement time (p > 0.05). Conclusion: In the neck extension, 75% of the tape extensibility in the Lt. UT and both SCM shortened the muscle contraction onset time.

• The Korean Journal of Physiology
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• v.24 no.2
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• pp.353-362
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• 1990

Fluoride (F-), a known stimulator of G-protein, induced strong contraction in rabbit trachealis muscle. $AlCl_3\;(5{\sim}20\;{\mu}M)$, which is required for G-protein stimulation by $F^-$, potentiated the contractile response to $F^-$. $Ca^{2+}-removal$ and verapamil, a calcium channel blocker, inhibited the fluoroaluminate-induced contraction. Fluoroaluminate increased $^{45}Ca$ influx in the absence and presence of verapamil. In heparin-loaded muscle high $K^+-induced$ contraction was not affected, but acetylcholine and fluoroaluminate-induced contractions were inhibited. The fluoroaluminate-induced contraction was partially relaxed by isoproterenol, a stimulator of adenylate cyclase. Pertussis toxin partially inhibited fluoroaluminate-induced contraction and potentiated isoproterenol-induced relaxation in the presence of fluoroaluminate, but had no effect on acetylcholine-induced contraction and the isoproterenol-induced relaxation in the presence of acetylcholine. These results suggest that fluoroaluminate has the ability to stimulate at least two putative G-proteins in rabbit trachealis muscle; One causes $Ca^{2+}$ influx through the potential-operated $Ca^{2+}$ channel and the other induces intracellular $Ca^{2+}$ release by the increase of inositol-1, 4, 5-triphosphate.

• Journal of the Korean Society of Physical Medicine
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• v.11 no.4
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• pp.139-146
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• 2016

PURPOSE: The purpose of this study was to determine the effect of craniocervical flexion exercise with masticatory muscle contraction in patients with neck pain. Patients with neck pain also experience muscle weakness and limitation of activities of daily living. Craniocervical flexion exercise with masticatory muscle contraction may increase the thickness of the deep cervical flexor muscles, thereby reducing pain and limitations on activities of daily living. METHODS: Twenty-six volunteers participated in this study. The subjects were randomly divided into an experimental group (n=13) and a control group (n=13). Both groups performed craniocervical flexion exercise using a pressure biofeedback unit; the experimental group performed craniocervical flexion exercise with masticatory muscle contraction for 20 minutes, 3 times a week for 4 weeks. Assessment tools included ultrasonography for measurement of muscle thickness and the Neck Disability Index for the level of pain and function. RESULTS: The rate of change in muscle thickness in both groups significantly increased (p<.05), with a significantly greater increase in the experimental group than in the control group (p<.05). The Neck Disability Index score significantly improved (p<.05) in both groups, with significantly greater improvement in the experimental group compared with the control group (p<.05). CONCLUSION: These results suggest that craniocervical flexion exercise with masticatory muscle contraction can be effective in increasing muscle thickness and improving the Neck Disability Index score in patients with neck pain.

• PNF and Movement
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• v.13 no.1
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• pp.1-7
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• 2015

Purpose: This study aimed to examine the activity of the shoulder flexor and extensor when hold-relax and contraction-relax techniques were applied with shoulder joint flexion. Methods: The subjects of this study were 15 healthy women. With the shoulder joint flexion at $0^{\circ}$ and $90^{\circ}$, hold-relax and contraction-relax techniques were applied for the same submaximal resistance to measure the activities of the deltoid muscle anterior fiber, deltoid muscle posterior fiber, pectoralis major fiber, and latissimus dorsi muscle with surface electromyography. An independent t-test was conducted in order to compare activities of each muscle according to the two techniques. Results: When the hold-relax and contraction-relax techniques were applied with the shoulder joint flexion at $0^{\circ}$, the activities of the shoulder flexor and extensor were not significantly different, but the activity of the flexor was higher when the contraction-relax technique was applied than when the hold-relax technique was applied. When the hold-relax and contraction-relax techniques were applied with the shoulder joint flexed at $90^{\circ}$, the activities of the shoulder flexor and extensor were not significantly different, but the activity of the extensor was relatively higher than when the flexor was at $0^{\circ}$ Conclusion: When the hold-relax and contraction-relax techniques were applied with the shoulder joint flexion at $0^{\circ}$, the activities of the shoulder flexor and extensor were not significantly different, but the activity of the flexor was higher when the contraction-relax technique was applied than when the hold-relax technique was applied. When the hold-relax and contraction-relax techniques were applied with the shoulder joint flexed at $90^{\circ}$, the activities of the shoulder flexor and extensor were not significantly different, but the activity of the extensor was relatively higher than when the flexor was at $0^{\circ}$.