• Korean Journal of Crystallography
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• v.18 no.1_2
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• pp.10-15
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• 2007

UDP-N-acetylglucosamine enolpyruvyl transferase (MurA; EC 2.5.1.7) catalyzes the first committed step of peptidoglycan biosynthesis in bacteria, i.e., transfer of enolpyruvate from phosphoenolpyruvate to UDP-N-acetyl-glucosamine. Because the crystallization condition contained a high concentration of ammonium sulfate, our inhibitor binding studies were not successful. Therefore, we employed a docking approach to investigate the inhibitor binding. Our results will be useful in structure-based design of specific inhibitors of MurA for antibacterial discovery.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2000.05a
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• pp.147-151
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• 2000

This paper presents an analysis of a slot on the broad wall of a rectangular waveguide using the 3D FDTD method. In order to reduce the reflection loss, Mur's 2nd absorbing boundary condition is used. To realize the optimum design by FDTD, the effects of time step, excitation aperture size, analysis region and excitation position in model are derived. The analysis results are compared with the experimental results and they show a good agreement with each other.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.2 no.4
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• pp.653-660
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• 1998

The purpose of this paper is to analyze the electromagnetic field characteristics of microstrip array antenna with the FDTD(finite difference-time domain method). Finite difference equations of Maxwell's equations are defined in rectangular coordinate systems. To simulate the unbounded problem like a free space, the Mur's absorbing boundary condition is also used. After modeling the microstrip array antenna with the grid structure, the transient response of the field distribution is depicted in the time domain.

• Journal of the Korean Institute of Telematics and Electronics D
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• v.34D no.10
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• pp.60-67
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• 1997

This paper presents a 3-D finite difference time domain (FDTD) method used for indoor propagation simulations where the electromagnetic wav eis uniformly excited on th eone of the wall in a building and affected by an indoor obstacles. In cases of simulation and measurement, the frequency of 851 MHz is used. The conductivities of walls, floor, ceiling and indoor obstacles are measured and used for simulations. These simulations are carried out using different boundary condition such as mur's absorbing boundary condition (ABC) and perfectly matched layer (PML) technique. The PML technique is found to be well-suited to this analysis because of it's smaller computational domain than mur's ABC. The measured signal strengths are compared to simulated values with good agreement.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.21 no.11
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• pp.2954-2965
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• 1996

In this paper, the electromagnetic field characteristics of leaky caxial cable are anlyzed by using the finite difference-time domain(FDTD) technique. Finite difference equations of Maxwell's equations are definedin cylindrical coordinate systems. To simulate the open boundary problem like a free space, the Mur's Absorbing Boundary condition(Mur-ABC) is also used. After modeling the leaky coaxial cable with the three dimensional grid structure, the transient response of the field distribution and the current distribution, the field pattern, the coupling effect are depicted in the time domain.

• 월간산업보건
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• s.264
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• pp.46-52
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• 2010

• Journal of the Korea Institute of Information and Communication Engineering
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• v.2 no.2
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• pp.197-205
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• 1998

The purpose of this paper is to analyze the electromagnetic field characteristics of array antenna with the finite difference-time domain algorithm. Finite difference equations of Maxwell's equations are defined in cylindrical coordinate systems. To simulate the unbounded problem like a free space, the Mur's absorbing boundary condition is also used. After modeling the array antenna with the grid structure, the transient response of the field distribution is depicted in the time domain.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.9 no.5
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• pp.678-686
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• 1998

This paper describes an anisotropic perfectly matched layer (APML) for mesh truncation of the Finite Difference Time Domain(FDTD) method. The APML method can classified by a split type and an unsplit type, in case of the split type be made up 12 equations or 8 equations largely, and in case of the unsplit type be made of 6 equations. Therefore the latter is more simple as compare with the former. For the APML method presented in this paper is the latter, is directly derived from the time domain equations of Maxwell and extend to the three dimensional problem for the method suggested by Chen. Especially, in the edge and corner parts except the planes, the APML method effectively treated as compound with the Chen's method and Gedney's method newly. The results of the numerical method in this paper show the radiation patterns and the time responses of electromagnetic fields of the wire antennas according to wavelengths and the APML results are compared with Mur's first order absorbing boundary condition and Kraus's analytical results. Eventually, Mur's first order condition have many errors at the edge and corner. On the other hand, in comparison with Kraus's analytical results, it is quite good agreement, and the validity of present method is confirmed.

• Journal of Broadcast Engineering
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• v.2 no.1
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• pp.1-7
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• 1997

In this paper, a microstrip patch antenna was analyzed by using FDTD method. Firstly, the electric field in the microstrip patch antenna was obtained by approximating a Maxwell's equation to a finite difference equation by means of Yee's algorithm. In this case, Mur's 1st approximation and dispersive boundary condition(BBC) were applied to an absorbing boundary condition. We also analyzed a single microstrip patch antenna by using the FDTD method, then calculating the propagative process in the wave of a return loss. Also, as the result that FDTD was applied to 2-array antenna designed to increase the gain of antenna, the measured results was in relatively good accordance with the values calculated by the FDTD method. The calculated impedance, return loss and VSWR were comparatively good. And these results were In relatively good accordance with the measured values.

• Molecules and Cells
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• v.19 no.3
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• pp.398-401
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• 2005

The bacterial enzyme UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes the first committed step of peptidoglycan biosynthesis, i.e., transfer of enolpyruvate from phosphoenolpyruvate to UDP-N-acetyl-glucosamine. We have overexpressed the enzyme from Haemophilus influenzae in Escherichia coli and crystallized it in the apo-form, as well as in a complex with UDP-N-acetylglucosamine and fosfomycin using ammonium sulfate as the precipitant. X-ray diffraction data from a crystal of the apo-form were collected to $2.8{\AA}$ resolution at 293 K. The crystal quality was improved by co-crystallization with UDP-N-acetylglucosamine and fosfomycin. X-ray data to $2.2{\AA}$ have been collected at 100 K from a flash-frozen crystal of the complex. The complex crystals belong to the orthorhombic space group I222 (or $I2_12_12_1$) with unit-cell parameters of a = 63.7, b = 124.5, and $c=126.3{\AA}$. Assuming a monomer of the recombinant enzyme in the crystallographic asymmetric unit, the calculated Matthews parameter ($V_M$) is $2.71{\AA}^3Da^{-1}$ and solvent content is 54.6%.