• 한국통신학회논문지
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• 제21권5호
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• pp.1332-1344
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• 1996

This paper presents a pipelined floating point multiplier(FMUL) for superscalar microprocessors that conbines radix-16 recoding scheme based on signed-digit(SD) number system and new rouding and normalization scheme. The new rounding and normalization scheme enable the FMUL to compute sticky bit in parallel with multiple operation and elminate timing delay due to post-normalization. By expoliting SD radix-16 recoding scheme, we can achieves further reduction of silicon area and computation time. The FMUL can execute signle-precision or double-precision floating-point multiply operation through three-stage pipelined datapath and support IEEE standard 754. The algorithm andstructure of the designed multiplier have been successfully verified through Verilog HOL modeling and simulation.

• 한국정보과학회논문지:소프트웨어및응용
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• 제28권12호
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• pp.875-884
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• 2001

자기 구성지도는 데이타 시각화, 위상보존 매핑 등의 분야에서 널리 사용되고 있지만. 학습이 되기 전에 위상을 미리 고정시켜야 하기 때문에 실제 문제에 적용하기 어렵다는 것과 클러스터링 능력에 비해 분류율이 낮다는 결점이 있다. 이를 해결하기 위해서 자기구성 지도의 출력 노드를 동적으로 분화하고 분화된 노드를 파습하는 동적 위상보존 사기구성 지도를 제안하고, 이를 다중 결합함으로써 분류율을 향상 시켰다. 동적 위상보존 자기구성 지도의 결함 방법으로는 자기구성 지도의 K개 노드가 출격을 내도록하는 K-Winner 방법 및 K-Winner+ 가중치 방법이 제안되었는데, 이는 다수결 투표, 가중치, BKS, Byayesian, Borda, Condorect, 신뢰값 합산 등의 기존 결합 방법보다도 우수한 결과를 나타내었다. 동적 위상보존 자기 구성 지도를 통해서 위상을 고정 시켜야 하는 결점을 해결할 수 있었고. 서로 다른 특징으로 학습된 동적 위상보존 자기구성 지도들을 결합하여 분류 능력을 향상시킬 수 있었다. 필기 숫자데이타로. 실험한 결과, 제안한 방법이 자기구성 지도의 결점을 효과적으로 해결하여 98.1% 의 높은 인식률을 보였다.

• Archives of Plastic Surgery
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• 제49권1호
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• pp.61-69
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• 2022

Background Single free flaps are a commonly used reconstructive method for multiple soft tissue defects in digits. We analyzed the flap size, division timing, and degree of necrosis in cases with various types of flap division. Methods We conducted a retrospective review of the medical charts of patients who had undergone single free flap reconstruction for multiple soft tissue defects across their digits from 2011 to 2020. The flap types included were the lateral arm free flap, venous forearm free flap, thenar free flap, hypothenar free flap, anterolateral thigh free flap, medial plantar free flap, and second toe pulp free flap. Flap size, anastomosed vessels, division timing, and occurrence of flap necrosis were retrospectively investigated and then analyzed using the t-test. Results In total, 75 patients were included in the analysis. The success rate of the free flaps was 97.3%. All flaps were successfully divided after at least 17 days, with a mean of 47.17 days (range, 17-243 days) for large flaps and 42.81 days (range, 20-130 days) for the medium and small flaps (P=0.596). The mean area of flap necrosis was 2.38% in the large flaps and 2.58% in the medium and small flaps (P=0.935). Severe necrosis of the divided flap developed in two patients who had undergone flap division at week 6 and week 34. Conclusions In cases where blood flow to the flap has been stable for more than 3 weeks, flap division can be safely attempted regardless of the flap size.

• 수면정신생리
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• 제12권2호
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• pp.122-132
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• 2005

배 경：본 연구에서는 청년기 기면병 환자의 인지기능 변화를 평가하고자 하였다. 청년기 기면병 환자의 인지기능과 수면 증상과의 관계도 관찰하였다. 방 법：17세 이상 35세 이하의 기면병 환자 18명과 정상대조군 18명을 모집하여 연구를 시행하였다. 탈력발작이 있고, HLA $DQB_1$ *0602 양성인 경우만을 기면병 대상군으로 하였다. 기면병 대상군과 정상대조군에게 13종의 신경심리검사(Wisconsin 카드분류, Trail making, Stroop, Ruff, 청각순차합산, 바꿔쓰기, 숫자 외우기, 공간 외우기, Rey 기억력, California 언어학습, 통제단어연상, Boston 이름대기, 굽은 막대 검사)를 시행하여 양군을 비교하였다. 그리고, 기면병 대상군의 신경심리검사 결과와 Epworth 졸음증 척도, Ullanlinna 기면병 척도, 야간수면다원검사 및 입면 잠복시간 반복검사 결과 사이의 상관관계를 분석하였다. 결 과：기면병 대상군은 정상 대조군에 비해 2.0초 간격과 2.4초 간격의 청각순차합산, 바꿔쓰기, 공간 외우기 정방향 검사에서 수행능력이 저조하였다(t=3.86, p<0.001；t=-2.47, p=0.02；t=-3.95, p<0.001；t=-2.22, p=0.03). 다른 신경심리검사에서는 양 군간에 유의한 차이가 없었다. 기면병 대상군에서 저하된 신경심리검사 결과는 Epworth 졸음증 척도나 Ullanlinna 기면병 척도와 유의한 상관관계가 없었으며, 야간수면다원검사나 입면잠복시간 반복검사와도 유의한 상관관계가 없었다. 결 론：본 연구에서 기면병 환자군의 주의력이 저하되어 있음을 관찰하였다. 그러나 주의력 저하는 주간 졸음증과 유의한 상관을 보이지 않았다. 따라서 기면병 환자의 주의력 저하는 주간 졸음증의 개선만으로 호전시킬 수 없다는 점을 시사한다.

• ETRI Journal
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• 제33권5호
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• pp.695-703
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• 2011

The number of adders and critical paths in a multiplier block of a multiple constant multiplication based implementation of a finite impulse response (FIR) filter can be minimized through common subexpression elimination (CSE) techniques. A two-bit common subexpression (CS) can be located recursively in a noncanonic sign digit (CSD) representation of the filter coefficients. An efficient algorithm is presented in this paper to improve the elimination of a CS from the multiplier block of an FIR filter so that it can be realized with fewer adders and low logical depth as compared to the existing CSE methods in the literature. Vinod and others claimed the highest reduction in the number of logical operators (LOs) without increasing the logic depth (LD) requirement. Using the design examples given by Vinod and others, we compare the average reduction in LOs and LDs achieved by our algorithm. Our algorithm shows average LO improvements of 30.8%, 5.5%, and 22.5% with a comparative LD requirement over that of Vinod and others for three design examples. Improvement increases as the filter order increases, and for the highest filter order and lowest coefficient width, the LO improvements are 70.3%, 75.3%, and 72.2% for the three design examples.

• 한국정보통신학회논문지
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• 제12권11호
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• pp.2039-2044
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• 2008

FIR 필터, DCT, FFT와 같은 디지털 신호처리 응용에서 다중 고정 계수 곱셈의 효율적인 하드웨어 구현문제에 자주 접하게 된다. 고정계수 곱셈기 설계에서 공통 하위식 제거 알고리즘은 면적과 전력소모를 상당히 개선시킬 수 있는 방법을 제공한다. 본 논문에서는 CSD 계수에서 빈번히 나타나는 두 공통 하위식($10{\bar{1}}$, 101)의 덧셈을 수행하는 전용덧셈기 설계 방법을 제안한다. 제안한 방법을 radix-24 FFT 구조의 고정계수 곱셈블록에 적용한 실험에서 제안한 방법의 면적, 지연시간, 전력소비는 기존방법 보다 각각 21%, 11%, 12% 정도 향상됨을 보인다.

• Journal of Medicine and Life Science
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• 제15권2호
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• pp.89-94
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• 2018

Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is inherited microangiopathy caused by mutations in the Notch3 gene. Typical findings from brain magnetic resonance imaging (MRI) include subcortical lacunes, extensive white matter change and cerebral microbleeds(CMBs). CMBs are indicative of bleeding-prone microangiopathy. Despite some studies investigating the association between lacunes and cognitive dysfunction in CADASIL, few studies have examined the relationship between cognitive dysfunction and CMBs. We sought to assess whether CMBs are associated with cognitive dysfunction in CADASIL. This study enrolled 83 consecutive patients with CADASIL between April 2012 and January 2014. Their degree of cognitive dysfunction was assessed by the Korean version of the CERAD neuropsychological assessment battery, digit span test, and the Stroop test. A 3.0-T MRI was used to obtain T1-weighted, fluid-attenuated inversion recovery, and susceptibility weighted images. In multiple logistic regression analysis, the grade of CMBs influenced tests of memory dysfunction (p=0.003). Three or more lacunes correlated with dysfunction in the executive domain (p=0.013) and attention domain (p=0.005). White matter hyperintensity (WMH) was an independent predictor of executive dysfunction (p=0.001). These findings suggest that in addition to lacunes, CMBs and WMHs may be useful imaging markers to associated with cognitive dysfunction in CADASIL.

• 문화기술의 융합
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• 제3권4호
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• pp.165-169
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• 2017

CNN(Convolutional Nerual Network)는 기계학습 알고리즘 중에서도 이미지의 인식과 분류에 뛰어난 성능을 보이는 알고리즘 중 하나이다. CNN의 경우 간단하지만 많은 연산량을 가지고 있어 많은 시간이 소요된다. 따라서 본 논문에서는 CNN 수행과정에서 많은 처리시간이 소모되는 convolution layer와 pooling layer, fully connected layer의 연산수행을 SIMT(Single Instruction Multiple Thread)구조의 GPGPU(General-Purpose computing on Graphics Processing Units)를 통하여 병렬로 연산처리를 수행했다. 또한 convolution layer의 출력을 저장하지 않고 pooling layer의 입력으로 바로 사용함으로 메모리 접근횟수를 줄여 성능 향상을 기대했다. 본 논문에서는 이 실험검증을 위하여 MNIST 데이터 셋을 사용하였고 이를 통하여 제안하는 CNN 구조가 기존의 구조보다 12.38% 더 좋은 성능을 보임을 확인했다.

• 대한조현병학회지
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• 제20권1호
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• pp.15-22
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• 2017

Objectives : It has been shown that early intervention is crucial for favorable outcome in patients with schizophrenia. However, development of biomarkers for predicting prognosis of psychotic disorder still requires more research. In this study, we aimed to investigate whether baseline mismatch negativity (MMN) predict prognosis in patients with first episode psychosis (FEP). Methods : Twenty-four patients with FEP and matched healthy controls (HCs) were examined with MMN at baseline, and their clinical status were re-assessed after 1 year. Repeated-measures analysis of variance was performed to compare baseline MMN between the two groups. Multiple regression analysis was used to identify factors predicting prognosis in FEP patients during the follow-up period. Results : MMN amplitudes at baseline were significantly reduced in patients with FEP compared to healthy controls. In the multiple regression analysis, baseline MMN amplitude significantly predicted later improvement of performances on digit span and delayed recall of California Verbal Learning Test. However, baseline MMN did not predicted improvement of clinical symptoms. Conclusion : These results indicate that MMN may be a possible predictor of improvement in cognitive functioning in patients with FEP. Future study with larger sample and longer follow-up period would be needed to confirm the findings of the current study.

• 생물정신의학
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• 제24권3호
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• pp.142-148
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• 2017

Objectives The ratio of second to fourth digit length (2D : 4D) could be a potential epigenetic marker of sexual dimorphism reflecting prenatal testosterone exposure. Testosterone is known to affect the development of the brain through an epigenetic mechanism. The purpose of this study was to investigate the effects of exposure to fetal testosterone on the metabolic syndrome based on 2D : 4D of schizophrenia patients and the relationship with the age of onset of schizophrenia. Methods A total of 214 schizophrenia patients participated in this study. The participant's physical and blood tests were performed according to the American National Cholesterol Education Program's Third Amendment of the Metabolic Syndrome Diagnostic Criteria, and the 2D : 4D was measured by the method designed by McFadden. Data were statistically analyzed by t-test, Pearson's correlation analysis and multiple regression model analysis. Results 2D : 4D was significantly higher in female than male in both hands, and there was a statistically significant negative correlation between 2D : 4D and the age of onset of schizophrenia in male. However, 2D : 4D did not show statistically significant correlation with metabolic factors. Conclusions Fetal testosterone suggests the possibility of affecting the age of onset of schizophrenia through the epigenetic mechanism, but there is no clear relationship with metabolic factors.