• 전자공학회논문지S
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• 제36S권12호
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• pp.20-26
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• 1999

본 논문에서는 신호 부공간을 이용하여 표적들의 방위각 이노베이션을 구함으로써, 별도의 데이터연관 기법이 필요 없으며 간단한 구조의 효율적인 다중표적 방위각 추적 알고리즘을 제안하였다. 신호 부공간은 PAST와 같은 신호 부공간 추적 알고리즘을 이용하여 추정된다. 추정된 신호 부공간과 방위각 이노베이션이 만족시키는 비선형 행렬방정식을 유도하고, 이를 Taylor 급수 전개하여 선형근사화 한다. 이렇게 선형근사화하여 얻은 선형 행렬방정식으로부터 최소제곱법을 이용하여 방위각 이노베이션을 구한다. 다양한 컴퓨터 시뮬레이션을 통하여 제안한 알고리즘의 효율적이고 우수한 성능을 확인하였다.

• Journal of Biosystems Engineering
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• 제39권2호
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• pp.111-114
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• 2014

Purpose: This review aims to introduce aptamers and the methods of its development to improve the sensitivity and selectivity to target bacteria. In this review, we have highlighted current developments and directions in the pathogen detection based on aptamers. Background: Aptamers, the specific nucleic acid sequences, can bind to targets with high affinity and specificity. Some of researches on the use of aptamers for the detection of pathogen have been reported in recent years. Aptamers have more applicability than antibodies for the development of pathogen detection using biosensor; such as easy to synthesis and labeling, lack of immunogenicity, and a low cost of production. However, only few reports on the development and use of aptamers for the detection of pathogen have been published. Review: Aptamers specific to pathogen are obtained by whole-cell systematic evolution of ligands by exponential enrichment (SELEX) process. SELEX process is composed of screening random oligonucleotide bound with target cells, multiple separation and amplification of nucleic acids, final identification of the best sequences. For improving those affinity and selectivity to target bacteria, optimization of multiple separating process to remove unbounded oligonucleotides from aptamer candidates and sorting process by flow cytometry are required.

• BMB Reports
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• 제41권12호
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• pp.833-839
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• 2008

Angiogenesis in tumors is driven by multiple growth factors that activate receptor tyrosine kinases. An important driving force of angiogenesis in solid tumors is signaling through vascular endothelial growth factor (VEGF) and its receptors (VEGFRs). Angiogenesis inhibitors that target this signaling pathway are now in widespread use for the treatment of cancer. However, when used alone, inhibitors of VEGF/VEGFR signaling do not destroy all blood vessels in tumors and do not slow the growth of most human cancers. VEGF/VEGFR signaling inhibitors are, therefore, used in combination with chemotherapeutic agents or radiation therapy. Additional targets for inhibiting angiogenesis would be useful for more efficacious treatment of cancer. One promising target is the signaling pathway of hepatocyte growth factor (HGF) and its receptor (HGFR, also known as c-Met), which plays important roles in angiogenesis and tumor growth. Inhibitors of this signaling pathway have been shown to inhibit angiogenesis in multiple in vitro and in vivo models. The HGF/c-Met signaling pathway is now recognized as a promising target in cancer by inhibiting angiogenesis, tumor growth, invasion, and metastasis.

• BMB Reports
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• 제51권3호
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• pp.119-125
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• 2018

The Hippo pathway plays prominent and widespread roles in various forms of human carcinogenesis. Specifically, the Yes-associated protein (YAP), a downstream effector of the Hippo pathway, can lead to excessive cell proliferation and the inhibition of apoptosis, resulting in tumorigenesis. It was reported that the YAP is strongly elevated in multiple types of human malignancies such as breast, lung, small intestine, colon, and liver cancers. Recent work indicates that, surprisingly, Hippo signaling components' (SAV1, MST1/2, Lats1/2) mutations are virtually absent in human cancer, rendering this signaling an unlikely candidate to explain the vigorous activation of the YAP in most, if not all human tumors and an activated YAP promotes the resistance to RAF-, MAPK/ERK Kinase (MEK)-, and Epidermal growth factor receptor (EGFR)-targeted inhibitor therapy. The analysis of YAP expressions can facilitate the identification of patients who respond better to an anti-cancer drug treatment comprising RAF-, MEK-, and EGFR-targeted inhibitors. The prominence of YAP for those aspects of cancer biology denotes that these factors are ideal targets for the development of anti-cancer medications. Therefore, our report strongly indicates that the YAP is of potential prognostic utility and druggability in various human cancers.

• BMB Reports
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• 제51권3호
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• pp.143-150
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• 2018

The Hippo signaling pathway plays an essential role in adult tissue homeostasis and organ size control. Abnormal regulation of Hippo signaling can be a cause for multiple types of human cancers. Since the awareness of the importance of the Hippo signaling in a wide range of biological fields has been continually grown, it is also understood that a thorough and well-rounded comprehension of the precise dynamics could provide fundamental insights for therapeutic applications. Several components in the Hippo signaling pathway are known to be targeted for proteasomal degradation via ubiquitination by E3 ligases. ${\beta}-TrCP$ is a well-known E3 ligase of YAP/TAZ, which leads to the reduction of YAP/TAZ levels. The Hippo signaling pathway can also be inhibited by the E3 ligases (such as ITCH) which target LATS1/2 for degradation. Regulation via ubiquitination involves not only complex network of E3 ligases but also deubiquitinating enzymes (DUBs), which remove ubiquitin from its targets. Interestingly, non-degradative ubiquitin modifications are also known to play important roles in the regulation of Hippo signaling. Although there has been much advanced progress in the investigation of ubiquitin modifications acting as regulators of the Hippo signaling pathway, research done to date still remains inadequate due to the sheer complexity and diversity of the subject. Herein, we review and discuss recent developments that implicate ubiquitin-mediated regulatory mechanisms at multiple steps of the Hippo signaling pathway.

• 한국정보통신학회논문지
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• 제7권8호
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• pp.1802-1808
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• 2003

본 논문은 자동 보행자 추적 시스템에 필요한 배경 이미지를 추출하는 방법과 추출되어진 배경 이미지를 이용하여 보행자를 탐지하고 적응적 신경망을 이용하여 보행자의 이동 궤적을 추적하는 시스템을 구현하였다. 본 논문은 고스트(ghost) 현상을 극복하기 위하여 모자이크 배경 이미지 추출 법으로 배경 이미지를 추출하였으며, 보행자의 탐지에 차영상 분석법을 기반으로 하여 보행자를 탐지하였다. ART2 네트워크는 프레임에 존재하는 이동 물체의 중심점을 탐지할 수 있다. 그리고, 이전 프레임에서 탐지되어진 물체의 정보를 이용하여 물체의 이동궤적을 추적할 수 있다. 제안하는 방법으로 실험한 결과 비강체(non­rigid)형태 운동을 하는 보행자를 탐지하고 그 궤적 추적에 대한 실시간 시스템 구성의 가능성에 대하여 알 수 있었다.

• 한국초전도ㆍ저온공학회논문지
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• 제23권4호
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• pp.56-60
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• 2021

The microwave Radar used for special purposes in the past is being applied in various areas due to the technological advancement and cost reduction, and is particularly applied to autonomous driving in the automobile field. The FMCW (Frequency Modulated Continuous Wave) Radar can acquire level information of liquid in vessel based on the beat frequency obtained by continuously transmitting and receiving signals by modulating the frequency over time. However, for cryogenic fluids with small impedance differences between liquid medium and gas medium, such as liquid nitrogen and liquid hydrogen, it is difficult to apply a typical Radar-based level meter. In this study, we develop an 80 GHz FMCW Radar for level measurement of cryogenic fluids with small impedance differences between media and analyze its characteristics. Here, because of the low intrinsic impedance difference, most of the transmitted signal passes through the liquid nitrogen interface and is reflected at the bottom of the vessel. To solve this problem, a radar measurement algorithm was designed to detect multiple targets and separate the distance signal to the bottom of the vessel in order to estimate the precise position on the liquid nitrogen interface. Thereafter, performance verification experiments were performed according to the liquid nitrogen level using the developed radar level meter.

• BMB Reports
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• 제50권11호
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• pp.535-536
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• 2017

A novel approach has been used to identify functional interactions relevant to human disease. Using high-throughput human-yeast genetic interaction screens, a first draft of disease interactome was obtained. This was achieved by first searching for candidate human disease genes that confer toxicity in yeast, and second, identifying modulators of toxicity. This study found potentially disease-relevant interactions by analyzing the network of functional interactions and focusing on genes implicated in amyotrophic lateral sclerosis (ALS), for example. In the subsequent proof-of-concept study focused on ALS, similar functional relationships between a specific kinase and ALS-associated genes were observed in mammalian cells and zebrafish, supporting findings in human-yeast genetic interaction screens. Results of combined analyses highlighted MAP2K5 kinase as a potential therapeutic target in ALS.

• 한국군사과학기술학회지
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• 제21권5호
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• pp.684-696
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• 2018

The mission in missile systems can be conducted with multiple phases according to the characteristics of the systems and the targets. The safeguarded multi-phase mission includes a safeguarded phase before launch for considering the safety of operators in unexpected squib activation. However, the safeguard function should be disabled after launch to complete the mission. Therefore, the squib system needs to be selectively activated according to the phases. This paper presents a selective squib activation and check circuit design for safeguarded multi-phase missions in missile systems. The presented circuit design was implemented with various electronic components including a field-programmable gate array(FPGA). Its functions and performance were validated by both many ground tests and several flight tests.

• 천문학회보
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• 제38권2호
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• pp.43.1-43.1
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• 2013

We report the preliminary results of our GMVA(Global mm VLBI Array) observation at the frequency of 86 GHz. Observation were made in the dual polarization mode (LCP and RCP), to produce the polarimetric maps with the maximum angular resolution which the array is capable of. We aim to link the source-integrated AGN polarization properties with the polarized spatial source structure, by mapping the polarized "fine structure" of the target AGN. We selected 2 targets, 0954+658 and 0716+714, which (1) have been observed multiple times by the PdBI polarimetric monitoring program; (2) have sufficient integrated fluxes ($S_{90GHz}$ > 1 Jy) ; (3) are close enough to resolve the source structure < 1 pc with given angular resolution ; and (4) are located at high northern declination for good UV coverages. As preliminary results, we present LL and RR polarized images of each target with the maximum angular resolution of ${\sim}60{\mu}as$. Extended structures, probably the jet outflows, are discovered in both sources.