• Biomolecules & Therapeutics
• /
• v.20 no.3
• /
• pp.346-351
• /
• 2012

Cells show various stress signs when they are challenged with severe physiological problems. Majority of such cellular stresses are conveyed to endoplasmic reticulum (ER) and unfolded protein response (UPR) serves as typical defense mechanism against ER stress. This study investigated an interaction between ER stress agents using macropage cell line Raw 264.7. When activated by lipopolysaccharide (LPS), the cell lines showed typical indicators of ER stress. Along with molecular chaperones, the activation process leads to the production of additional inflammatory mediators. Following activation, the macrophage cell line was further treated with TUN and characterized in terms of chaperone expression and cytokine secretion. When treated with TUN, the activated macrophage cell leads to increased secretion of IL-6 although expression of ER stress markers, GRP94 and GRP78 increased. The secretion of cytokines continued until the addition of BFA which inhibits protein targeting from ER to Golgi. However, secretion of cytokines was ceased upon dual treatments with BFA and TG. This result strongly implies that cells may differently deal with various polypeptides depending on the urgency in cellular function under ER stress. Considering IL-6 is one of the most important signal molecules in macrophage, the molecule might be able to circumvent ER stress and UPR to reach its targeting site.

• The Journal of Korean Academic Society of Nursing Education
• /
• v.25 no.1
• /
• pp.125-135
• /
• 2019

Purpose: This study was conducted to determine the mediator effect of social support in the association between stress for college life and depression among nursing students. Methods: The participants of the study were 201 university students in A and C cities. Self-report questionnaires were used to measure the variables. In the data analysis, the SPSSWIN 25.0 program was utilized for descriptive statistics, Pearson's correlation, Sobel test and multiple regression analysis. Results: Mean scores of stress for college life, depression and social support were 2.56, 4.12 and 0.61, respectively. Stress for college life and depression showed a significant positive correlation (r=.60, p<.001), while depression and social support showed a significant negative correlation (r=-.46, p<.001). Lastly, stress for college life and social support showed a significant negative correlation (r=-.55, p<.001). The analysis of the mediator effect of social support in the association between stress for college life and depression showed that social support had a significant mediator effect. Conclusion: Among nursing students, social support may be a mediator in the association between stress for college life and depression. Therefore, strategies for nursing intervention to improve social support should be developed for nursing students.

• Journal of Technologic Dentistry
• /
• v.40 no.4
• /
• pp.249-259
• /
• 2018

Purpose: This study aimed to investigate the relationship between dental technology students' life stress and smartphone addiction in order to detect smartphone over-users early, prevent them from getting addicted, and obtain basic data for creating a positive environment for academic achievement by using smartphone in a right way. Methods: The subjects of this study were university students at D University and G University in Daejeon Metropolitan City and Gangwon-do. A questionnaire survey was conducted to the subjects who understood the purpose of this study and participated in it from March 1 to June 10, 2018, and 243 were finally analyzed except 24 questionnaires without sufficient answers. Results: As a result of multiple regression analysis with variables, which were significant in univariate analysis, as independent variables, there were gender and smartphone dependency as general characteristics affecting the degree of smartphone addiction, and family relations and future problems among stress sub-factors were selected as significant variables. Conclusion : In the case of college students, they choose the smartphone as the easiest way to relieve stress because they lack the time and space to actually release stress. Therefore, club activities or on-campus and extra-curricular activities are recommended, and it needs to seek a way to get rid of stress by solving the cause of stress through counseling.

• International Journal of Advanced Culture Technology
• /
• v.7 no.2
• /
• pp.201-208
• /
• 2019

The purpose of this study was to investigate the effect of type of values on coping stress through communication ability. The data for the study were collected from February 1 to 15, 2019, and the participants were collected through online questionnaires in the twenties who voluntarily participated in the study. The final data used in this study were 324. The research method was cross - sectional questionnaire survey. The analysis was done using SPSS 18.0, descriptive statistics, Pearson correlation, multiple regression and median effect analysis. A total of 324 people participated in the study, 38% of men and 62% of women were female. The results of this study showed that the collectivism values were positively correlated with individualism values (r = .224, p<0.01), emotional stress coping style (r = .266, p <), And emotion - centered stress coping was correlated with problem - oriented stress coping (r = .369, p <0.01). Those who had a collectivist value had a significant influence on the type of problem - centered stress coping(${\beta}=.271$, p<0.01), and the communication ability showed a perfect mediating effect($R^2=.310$,${\beta}=.113$, p>0.05). According to the results of this study, stress coping in the twenties suggests a program that fosters individualized communication ability.

• Korean Journal of Childcare and Education
• /
• v.16 no.6
• /
• pp.89-104
• /
• 2020

Objective: The purpose of this study was to examine the effects of maternal parenting stress and mother's ego-resilience on mother-child attachment. More specially, mother-child attachment for higher grade elementary school children was examined according to the internal working model. Methods: Participants were 190 mothers of fourth and fifth grade elementary school children. The Maternal Parenting Stress Scale(Shin, 1997), the Scales of Ego-resilience(Yoo & Shim, 2002), and Inventory of Parent Attachment(Yang, 2006) were used to measure variables. Collected data were analyzed by descriptive statistics, t-test, correlation analysis and multiple regression analysis. Results: The major findings were summarized as follows: First, there were no differences between mother-child attachment according to children's gender. Second, mother-child attachment was negatively correlated with maternal parenting stress and positively correlated with ego-resilience. Next, maternal parenting stress_interaction and ego-resilience explained mother-child attachment_trust. Last, maternal stress_interaction explained mother-child attachment_isolation. Conclusion/Implications: In conclusion, the study results showed that maternal parenting stress and ego-resilience influenced mother-child attachment. based on the results, the implications of this study were discussed.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.15 no.1
• /
• pp.323-330
• /
• 2014

This study was done to identify the relationship of Major satisfaction, employment stress, depression and to identify the factors influencing depression for 196 College Students who agreed to participate in the study. Date were analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation coefficients and multiple regression with SPSS 18.0. A negative correlation was found between major satisfaction and depression, positive correlation was found between employment stress and depression. The predicting factors for depression were major satisfaction and employment stress. Those factors accounted for 26.0% of depression. The fallow-up survey about various factors influencing college student's depression is needed and prevent depression program for developing depression are controled.

• Journal of Digital Convergence
• /
• v.16 no.9
• /
• pp.187-195
• /
• 2018

The purpose of this study is to measure quality of sleep (PSQI) and to investigate the affecting factors according to sex in college students. The participants in this study were 214 students from 4 universities. The data were analyzed by t-test, chi-square test and multiple regression using SPSS/WIN 24.0 program. The mean score of quality of sleep was 2.83, for male students are 2.70 and female students 3.06. In multiple regression analysis, physical stress, psychological stress and exercise were significant predictors and explained 25.4% of quality of sleep for male students. In female students, physical stress, psychological stress and drinking were significant predictors and explained 39.2% of quality of sleep. It is necessary to develop and apply education and counseling that can solve factors affecting the quality of sleep of college students.

• Journal of the Korea Convergence Society
• /
• v.7 no.6
• /
• pp.89-97
• /
• 2016

The purposes of this study was to identify the significant predictors of depression. The data were collected using questionnaire from the sample of 114 middle-aged women and 125 middle-aged men. The data were collected through self-report questionnaires, which were constructed to include stress, self-esteem, and depression. Data were analyzed using frequencies, means, $X^2$-test, Analysis of Covariance, Pearson's correlation coefficients, and multiple regression analysis with SPSS 18.0. The significant predictors of depression for middle-aged women were stress(${\beta}=.387$, p<.001), self-esteem(${\beta}=-.249$, p<.05), health perception(${\beta}=-.191$, p<.05), explaining 43.1% of the variance in depression. The significant predictors of depression for middle-aged men were self-esteem(${\beta}=-.429$, p<.001), stress(${\beta}=.322$, p<.001), explaining 56.0% of the variance in depression.

• Korean Journal of Occupational Health Nursing
• /
• v.26 no.3
• /
• pp.172-183
• /
• 2017

Purpose: This study was conducted to investigate factors affecting the job embeddedness of workers in the manufacturing industry. Methods: The survey was conducted on 261 workers of the manufacturing industry in P city and Y city with the help of a structured self-report questionnaire, administered between June 10 and June 30, 2017. Data were analyzed using descriptive statistics, a t-test, ANOVA, a $Scheff{\acute{e}}s$ test, Pearson's correlation coefficients, and stepwise multiple regression. Results: There were significant differences in job embeddedness according to educational level, marital status, jobs and types of employment, satisfaction with salary, stress level, and the perceived health status of the subjects. There were significant positive correlations between role clarity of job demands (r=.45), leader member exchange (r=.48), recovery experience from job stress (r=.27), and job embeddedness. From the multiple regression analysis, the most significant factors affecting job embeddedness were found to be leader member exchange (${\beta}=.43$), recovery experience from job stress (${\beta}=.22$), and job demand (${\beta}=.15$). These variables explained 35.0% of the total variance in job embeddedness. Conclusion: In order to increase job embeddedness of workers in the manufacturing industry, it is necessary to prepare measures to increase job demand, leader member exchange, and recovery experience from job stress.

• Korean Journal of Occupational Health Nursing
• /
• v.26 no.3
• /
• pp.142-150
• /
• 2017

Purpose: The purpose of this descriptive, cross-sectional study was to identify the factors affecting health-related quality of life by examining the relationships among posttraumatic stress, health-related work limitations, and family support in firefighters. Methods: The data were collected from 390 firefighters working in four fire stations located in the G district using self-report questionnaires. The collected data were analyzed using descriptive statistics, t-test, one-way ANOVA along with the $Scheff{\acute{e}}$ test, and multiple regression. Results: As per the results of multiple regression analysis, the factors affecting health-related quality of life in firefighters were posttraumatic stress, health-related work limitations, and family support. This model explained 31% of the variance in health-related quality of life (F=30.03, p<.001). Conclusion: Considering the findings of this study, there is a need to reduce posttraumatic stress and health-related work limitations and develop family support toward firefighters.