• IMMUNE NETWORK
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• v.13 no.5
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• pp.184-193
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• 2013

Co-signaling molecules are surface glycoproteins that positively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T cell receptor (TCR) signaling. In the past 10 years, the field of co-signaling research has been advanced by the understanding of underlying mechanisms of the immune modulation led by newly identified co-signaling molecules and the successful preclinical and clinical trials targeting co-inhibitory molecules called immune checkpoints in the treatment of autoimmune diseases and cancers. In this review, we briefly describe the characteristics of well-known B7 co-signaling family members regarding the expression, functions and therapeutic implications and to introduce newly identified B7 members such as B7-H5, B7-H6, and B7-H7.

• Journal of Korean Society for Quality Management
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• v.38 no.4
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• pp.580-586
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• 2010

Performance variations in mixture products such as medicine, food, and chemicals can be caused by their own subcomponents. For instance, a discharge capacity of a lithium-ion battery depends upon the mixture ratio of ethylene, dimethyle, and ethyle-methyle, all of which are subcomponents of an electrolyte solution in the battery. Thus it is crucial to determine tolerances of the mixture ratio in order to maintain the product quality at a desired level. This paper is concerned with the tolerance design of the mixture ratio. In particular, minimizing variance around the mixture ratio is adopted as a decision criterion in this paper. An illustrative example with multiple quality characteristics is given as well.

• Journal of Welding and Joining
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• v.23 no.3
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• pp.68-75
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• 2005

The fatigue life of welded joints is associated with crack initiation and propagation life. Theses cannot be easily separated, since the definition of crack initiation is vague due to the initiation of multiple cracks that are distributed randomly along the weld toes. In this paper a method involving a notch strain and fracture mechanical approach, which considers the characteristics of welded joints, e.g. welding residual stress and statistical characteristics of multiple cracks, is proposed, in an attempt to reasonably estimate these fatigue lives. The fatigue crack initiation life was evaluated statistically, e.g. the probability of failure occurrence in 2.3, 50 and $97.7\%$, in which the cyclic response of the local stress/strain hi the vicinity of the weld toes and notch factors derived by the irregular shape of the weld bead are taken into account. The fatigue crack propagation life was simulated by using Monte-Carlo method in consideration of the Ad-factor and the mechanical behavior of mutual interaction/coalescence between two adjacent cracks. The estimated total fatigue life, $(N_T)_{P50\%}$, as a sum of crack initiation and propagation life under the probability of failure occurrence in $50\%$ showed a good agreement with the experimental results. The developed technique for fatigue lift estimation enables to provide a quantitative proportion of crack initiation and propagation life in the total fatigue life due to the nominal stress range, ${\Delta}S$.

• Journal of Korean Institute of Industrial Engineers
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• v.22 no.4
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• pp.633-649
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• 1996

An interactive multicriteria method, which is called the Modified Pairwise Comparison Stochastic Cutting Plane (MPCSCP) method, is proposed for determining the best levels of the integer decision variables needed to optimize a stochastic computer simulation with multiple response functions. MPCSCP combines good features from interactive tradeoff cutting plane methods and response surface methodologies. The proposed method uses a simple pairwise man-machine interaction and searches an integer space uniformly by using the experimental design which evaluates the decision space centering around an integer center point. The characteristics of the proposed method are investigated through an extensive computational study. The parameter configurations examined in the study are (1) variability of the sampling errors, (2) the size of experimental design, (3) the relaxation of cutting planes, and (4) the levels of decision maker's inconsistency.

• Journal of the Korean institute of surface engineering
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• v.49 no.2
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• pp.119-124
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• 2016

Plasma electrolytic oxidation (PEO) is a promising coating process to produce ceramic oxide on valve metals such as Al, Mg and Ti. The PEO coating is carried out with a dilute alkaline electrolyte solution using a similar technique to conventional anodizing. The coating process involves multiple process parameters which can influence the surface properties of the resultant coating, including power mode, electrolyte solution, substrate, and process time. In this study, ceramic oxide coatings were prepared on commercial Al alloy in electrolytes with different KOH concentrations (0.5 ~ 4 g/L) by plasma electrolytic oxidation. Microstructural and electrochemical characterization were conducted to investigate the effects of electrolyte concentration on the microstructure and electrochemical characteristics of PEO coating. It was revealed that KOH concentration exert a great influence not only on voltage-time responses during PEO process but also on surface morphology of the coating. In the voltage-time response, the dielectric breakdown voltage tended to decrease with increasing KOH concentration, possibly due to difference in solution conductivity. The surface morphology was pancake-like with lower KOH concentration, while a mixed form of reticulate and pancake structures was observed for higher KOH concentration. The KOH concentration was found to have little effect on the electrochemical characteristics of coating, although PEO treatment improved the corrosion resistance of the substrate material significantly.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.40.1-40.1
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• 2020

The Korea Astronomy and Space Science Institute is participating as a South Korean partner in the Commercial Lunar Payload Services (CLPS)of NASA. In response, the Korea Astronomy and Space Science Institute is currently conducting basic research for the development of four candidate instrument payloads. The magnetic field instrument is one of them and it's scientific mission objective is the moon's surface magnetic field investigation. Therefore, the development requirement of the lunar surface magnetic field instrument were derived and the initial conceptual design was started. The magnetic field instrument has a 1.2 meter boom which has two three-axis fluxgate magnetometer sensors and one gyro sensor to get a attitude information of the boom. The concept of measuring the lunar surface magnetic field will carry out using multiple sensors by placing semiconductor type magnetic field sensors inside the electric box including boom mounted fluxgate sensors. In order to overcome the very short development period, we will use the KPLO (Korean Lunar Pathfinder Orbiter) magnetometer design and parts to improve reliabilities for this instrument. In this presentation, we introduce the instrument requirements and conceptual design for the Lunar surface magnetic field instruments.

• Journal of the Korean Wood Science and Technology
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• v.38 no.3
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• pp.191-198
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• 2010

This research was performed to investigate the effect of hydrogen peroxide on the stain removal in japanese hackberry. Response surface method (RSM) was used to optimize the bleaching conditions such as reaction temperature, reaction time and the concentration of hydrogen peroxide. Fifteen different bleaching conditions were selected according to $2^3$ factorial central composite design (CCD). The bleaching effect were evaluated by lightness differences of wood surface before and after the bleaching. The RSM model was determined and its $R^2$ values were 0.93, showing it well represented the bleaching effect. The most affecting factor on the stain removal was the concentration of hydrogen peroxide, followed by reaction time and reaction temperature. Second degree of concentration was proved to have an effect on the bleaching. Bleaching rates above 3% concentrations of hydrogen peroxide were tended to be slightly decreased, and low bleaching effect was found at $20^{\circ}C$. The determined RSM model may offer very practical ways to obtain the desired levels of bleaching because it offers multiple solutions.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2552-2557
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• 2007

Shape optimization of an internal cooling passage with staggered dimples on single surface is performed and performances of surrogates are evaluated in this paper. Optimizations are performed so that turbulent heat transfer can be enhanced compromising with pressure loss due to friction. The three-dimensional governing differential equations have been solved to find the overall Nusselt number and friction factor which are related to the objective functions of this problem. Three design variables were selected among the dimensionless geometric variables. Basic surrogate models such as second order polynomial response surface approximation (RSA), Kriging meta-modeling technique, radial basis neural network (RBNN), and derived press based averaged (PBA) surrogate model are constructed. The optimal points are searched from the above constructed surrogates by sequential quadratic programming (SQP). It is shown that use of multiple surrogates can increase the robustness in prediction of better design with minimum computational cost.

• Journal of Ocean Engineering and Technology
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• v.11 no.1
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• pp.74-83
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• 1997

This study is to develop a practical calculation method of hydrodynamic force and motion response on very large floating structures of multiple legs. To investigate the effecr of hydrodynamic interfaction and of free surface on the reaponses of very large floating structures in regular waves, four kind of models are considered, ie. 1, 4, 64, 21248 column with footing. Based upon the results of this study, it is found that the middle parts of very large floating structures have small diffration effects. Therefore only out side parts are used to determine the hydrodynamic forcea for taking into account the effects of interaction.

• The Korean Journal of Applied Statistics
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• v.24 no.2
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• pp.411-424
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• 2011

The studies of congruence in organizational research have explored the concepts such as person-job fit person-organization fit, or person-environment fit. The relevant studies dealt with the fit level as an important influencing factor on the performance. In particular, researchers have agreed that employees can be motivated by the high level fit of person-organization. However, few research developing an alternative methodological approach has been done. For the purpose mentioned above the statistics like D, |D| or $D^2$ and the Q values such as Q(the correlation between two sets of interval measures) or $Q_r$(the correlation between two rankings) have been conventionally adopted in spite of numerous methodological problems. In general, these traditional indices such as difference scores, or Q values, are nondirectional and add an extra weight to differences of lager magnitude. Therefore, Edwards (1993) introduced the polynomial regression and the response surface analysis to overcome flaws with conventional approaches. However, the method-ological approaches did not reflect the profile characteristics of person-organizational value fit and wouldn't be a proper solution for the fit level of person-organization value maximizing performance. Hence, this paper investigates alternative methodological approaches, the multivariate polynomial regression and the multiple response surface analysis, to avoid the problems issued from conventional ways.