• Molecules and Cells
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• v.41 no.7
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• pp.653-664
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• 2018

The RNA-binding protein tristetraprolin (TTP) binds to adenosine-uridine AU-rich elements in the 3'-untranslated region of messenger RNAs and facilitates rapid degradation of the target mRNAs. Therefore, it regulates the expression of multiple cancer and immunity-associated transcripts. Furthermore, a lack of TTP in cancer cells influences cancer progression and predicts poor survival. Although the functions of TTP on cancer cells have previously been researched, the mechanism of TTP on the interaction between cancer cells with their micro-environment remains undiscovered. In this study, we admed to determine the role of cancer cell TTP during the interaction between tumor and immune cells, specifically regulatory T cells (Tregs). We evaluate the capability of TTP to modulate the antitumor immunity of GC and explored the underlying mechanism. The overexpression of TTP in GC cells dramatically increased peripheral blood mononuclear lymphocyte (PBML) -mediated cytotoxicity against GC cells. Increased cytotoxicity against TTP-overexpressed GC cells by PBMLs was determined by Treg development and infiltration. Surprisingly, we found the stabilization of programmed death-ligand 1 (PD-L1) mRNA was declining while TTP was elevated. The PD-L1 protein level was reduced in TTP-abundant GC cells. PD-L1 gas been found to play a pivotal role in Treg development and functional maintenance in immune system. Taken together, our results suggest the overexpression of TTP in GC cells not only affects cell survival and apoptosis but also increases PBMLs -mediated cytotoxicity against GC cells to decelerate tumor progression. Moreover, we identified PD-L1 as a critical TTP-regulated factor that contributes to inhibiting antitumor immunity.

• 재활복지
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• v.22 no.1
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• pp.27-49
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• 2018

The purpose of this study was to analyze the relationship between social interaction, role acquisition, and self-identity of people with physical disabilities participating in daily sports. In order to accomplish the purpose of this study, people with physical disabilities residing in Busan, Gyeongnam, and Gyeongbuk were set as a population. Among them, 384 people with physical disabilities participating in daily sports were sampled using convenience sampling. Data were analyzed by frequency analysis, exploratory factor analysis, reliability analysis, multiple regression analysis, and simple regression analysis using the SPSS 23.0 program. The results were as follows. As a result of analyzing the effects of participation level of daily sports for people with physical disabilities on social interaction, role acquisition, and self-identity, first, participation period had a significant effect on ego-identity. Second, participation time did not have a statistically significant effect on social interaction, role acquisition, and self-identity. Third, participation frequency had a significant effect on social interaction, role acquisition, and self-identity. In addition, social interaction, role acquisition, and self-identity showed a statistically significant correlation with positive effects as a result of analyzing the relationship between social interaction, role acquisition, and self-identity.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.657-665
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• 2023

Purpose : The purpose of this study is to examine the mediating effect of self-efficacy in the relationship between sense of calling and service quality of personal assistants for people with disabilities. The subjects of this study were personal assistants for people with disabilities belonging to four disability activity support organizations in K-city, Gyeongsangnam-do, and a total of 308 questionnaires were used for the final analysis. The dsta were collected from March 13, 2023 to to April 28, 2023. The collected data were analyzed by frequency analysis, Pearson's coefficents, Baron & Kenny multiple regression analysis using SPSS WIN 24.0. The results of this study are as follows. First, as a result of analyzing the correlation between sense of calling, self-efficacy, and service quality of personal assistants for people with disabilities, it was found that there was a positive correlation in all sub-variables. Second, in the relationship between sense of calling and service quality, self-efficacy was found to have a partial mediating effect. And self-efficacy was found to have a partial mediating effect in the relationship between prosocial orientation, which are sub-factors of sense of calling, and service quality. These results suggest that it is necessary to increase sense of calling and self-efficacy in order to improve the service quality of personal assistants for people with disabilities, and suggestions are made.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.19 no.2
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• pp.179-189
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• 2012

Purpose: The purpose of this study was to identify the effects of eating habits, activities of daily living and health behaviors on oral health related-quality of life in elders. Methods: The sample consisted of 246 people 65 years or older. Data were analyzed using frequency, percentage, average standard deviation, t-test, ANOVA, Scheff$\acute{e}$, Pearson Correlation Analysis and Hierarchical Multiple Regression. Results: The control variables such as gender, presence of a spouse, subjective health status, presence of chronic disease and existing number of teeth explained 14% (F=7.76, p<.001) of variance in oral health related-quality of life. The control variables, eating habits, activities of daily living and health behaviors collectively explained 20% of variance in oral health related quality of life. Conclusions: The factors that influence oral health related quality of life were presence of spouse presence factor, existing number of teeth and health behavior. Therefore, oral health related quality of life of elders requires the development of programs to boost the quality of life, and help the elderly people to maintain existing number of teeth by focusing on the variety of characteristics.

• Research in Community and Public Health Nursing
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• v.28 no.3
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• pp.251-259
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• 2017

Purpose: This study aims to examine the influence of vitamin D and calcium on depression and cognitive function of the elderly living alone in a city. Methods: The participants were registered in eight senior centers in S city and they had lived alone. Data were collected between November 28, 2014 and March 7, 2015. A total of 155 people participated in data collection to measure the serum vitamin D, the serum calcium, depression, and cognitive function. The data were analyzed with t-test, ANOVA, Pearson's correlation and multiple regression analysis. Results: There were significant differences in depression according to gender and perceptions of health status. Depression correlated significantly with the serum calcium and perceptions of health status, and a stepwise regression analysis showed that the perceptions of health status were significant. There were significant differences in cognitive function according to education level and age. Cognitive function correlated significantly with the serum vitamin D and a stepwise regression analysis showed that education level and age were significant. Conclusion: Consequently, elderly people with poor perceptions of their health status need a depressive intervention program and those with a higher age and lower level of education need a cognitive function intervention program.

• Research in Community and Public Health Nursing
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• v.28 no.3
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• pp.313-323
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• 2017

Purpose: The purpose of this study is to investigate factors affecting social problem-solving ability of alcohol-dependent patients with a focus on gender differences. Methods: Participants were 250 alcohol-dependent people(men 140, women 110) who were living in B, G and Y cities. Data were collected from January 10 to March 31, 2017 using self-report questionnaires. Abstinence self-efficacy, alcohol insight, unconditional self-acceptance, and social problem-solving ability were investigated. For data analysis, t-test, one-way ANOVA, Pearson correlation coefficients and multiple regression were employed. Results: Factors influencing social problem-solving ability for men were unconditional self-acceptance and age. The explanatory power was 28%. Factors influencing social problem-solving ability for women were unconditional self-acceptance, stress, religiousness, age, occupation and abstinence self-efficacy and the explanatory power was 72%. Unconditional self-acceptance and age were significant variables of social problem-solving ability in both men and women. Stress, occupation, religiousness and abstinence self-efficacy were significantly associated with social problem-solving ability in women but not in men. Conclusion: The results suggest that it is necessary to consider gender characteristics in order to develop effective management programs for social problem-solving ability in alcohol-dependent people.

• Research in Community and Public Health Nursing
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• v.21 no.4
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• pp.502-511
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• 2010

Purpose: The purpose of this study was to investigate the influencing factors of influenza vaccination in the elderly participating in lifetime transitional health examination. Methods: This study was a secondary analysis of data collected from lifetime transitional health examination (for 66-year-old people) conducted by the National Health Insurance Corporation (NHIC) from January 1 to December 31, 2008. Questionnaires were received from NHIC to obtain information regarding gender, chronic diseases, health-related behaviors, and ADL. A total of 255,333 participants who responded all the questions in the questionnaire were included in the analysis. Collected data were analyzed by descriptive statistics, ${\chi}^2$ test, and multiple logistic regression. Results: The influenza vaccine coverage rate in 66-year-old people was 66.1%. The influenza vaccine coverage rate was higher in female elders and those with hypertension, diabetes, heart disease or past smoking, and lower in those with stroke, current smoking, drinking, no-exercise or ADL-dependency. Conclusion: Strategies for improving the influenza vaccination coverage rate in the elderly are needed. The strategies should give priority to the elderly with current smoking, drinking, and no-exercise, and home visiting programs are needed for the elderly with stroke and ADL-dependency.

• Journal of Korean Public Health Nursing
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• v.30 no.1
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• pp.136-148
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• 2016

Purpose: Patterns of traditional medicine (TM) utilization vary depending on culture, historical significance, and regulations. We seek to understand how socio-demographic factors are related to TM use in Korea. Methods: The longitudinal cohort survey data of the Korea Health Panel (2008-2012) were used for the analysis. Information on TM included questions on 4 types of TM therapies used in South Korea (e.g., acupuncture, moxibustion and cupping, herbal therapies, and massage using hand). To adjust clustering across multiple observations per individual, individual random effects were used in the multivariate analysis. All analyses were performed using Stata 11.0. Results: A majority of Koreans (60%) used WM only during a year, and few people used TM only. Among TM users, most (93%) used it along with WM and 8% used TM only. Our regression analysis showed that female, age 34-64, low-educated, and sicker people were more likely to use TM. Conclusion: This study provides evidence on the relationship between TM utilization and socio-demographic factors.

• Environmental Analysis Health and Toxicology
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• v.29
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• pp.13.1-13.11
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• 2014

Objectives This study examined variations in the perceptions of dioxin risk among social groups defined by geographical living location, environmental education, and occupation. Dioxin risk perceptions were analyzed according to values, risk awareness, knowledge, and behavioral preferences. Methods A quasi-experimental survey was designed and conducted on individuals from seven experimental groups in Jeonju city, South Korea, including: people living near incineration facilities; people living far from incineration facilities; governmental experts; non-governmental organization members; office workers in developmental institutes or banks; students who were enrolled in environmental-related classes; and students who were enrolled in business-related classes. Results The results show variations among groups in values, awareness and behavioral preferences. Particular attention should be given to the result that groups with higher connectedness-to-nature values show higher willingness-to-act (WTA) for risk reduction. Result s can be summarized as follows. First, awareness is associated with one's geographical setting. Second, values and WTA behaviors are related to one's environmental-related education and occupation. Third, values are significantly related to WTA behaviors. Conclusions Different cultures, in terms of values or worldview, among groups influence their perceptions of dioxin risk and choices of risk reduction behaviors. It is important to consider values in communicating complicated long-term risk management involving public participation. Further research should be continuously conducted on the effects of multiple dimensions of values on one's WTA for risk reduction behaviors.

• Asian Journal for Public Opinion Research
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• v.8 no.3
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• pp.180-196
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• 2020

This paper considers Japanese political interviews to integrate conversation and facial expression analysis. The behaviors of political leaders will be disclosed by analyzing questions and responses by using the turn-taking system in conversation analysis. Additionally, audiences who cannot understand verbal expressions alone will understand the psychology of political leaders by analyzing their facial expressions. Integral analyses promote understanding of the types of facial and verbal expressions of politicians and their effect on public opinion. Politicians have unique techniques to convince people. If people do not know these techniques and ways of various expressions, they will become confused, and politics may fall into populism as a result. To avoid this, a complete understanding of verbal and non-verbal behaviors is needed. This paper presents two analyses. The first analysis is a qualitative analysis that deals with Prime Minister Shinzō Abe and shows that differences between words and happy facial expressions occur. That result indicates that Abe expresses disgusted facial expressions when faced with the same question from an interviewer. The second is a quantitative multiple regression analysis where the dependent variables are six facial expressions: happy, sad, angry, surprised, scared, and disgusted. The independent variable is when politicians have a threat to face. Political interviews that directly inform audiences are used as a tool by politicians. Those interviews play an important role in modelling public opinion. The audience watches political interviews, and these mold support to the party. Watching political interviews contributes to the decision to support the political party when they vote in a coming election.