• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.3
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• pp.104-116
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• 2021

In order to reduce the social and economic costs due to the increase in dementia patients, which is a representative senile disease in an aging society, it will be important to prevent dementia and to detect and treat early in high-risk groups. This study reported the results of treatment for the elderly with high risk of dementia and depression who received Korean medicine (KM) treatment in 9 KM clinics. Medical charts were surveyed on 116 patients with high risk of dementia and depression who received KM treatment at 9 KM clinics in Gangseo-gu from September 1, 2020 to December 31, 2020. The majority of the patients were female(76.72%), the average age was 71.66±7.18 years old, and the average education level was 8.96±3.91 years. The average treatment period was 61.47±10.30 days, the average number of treatments was 15.38±1.06 times, and both acupuncture and herbal medicine were administered. After receiving KM treatment, cognitive assessment scores such as MMSE-DS and MoCA-K, depression-related GDSSF-K score, dementia knowledge, attitude, and preventive behavior, blood debilitation scale, and GQOL-D score were improved compared to before. There was no specific adverse reaction except that one patient with elevated AST and ALT levels was observed. This study showed improvement in cognitive function, depression, dementia-related scale, and quality of life in high-risk groups for dementia and depression over 60 years old who received KM treatment. More systematic and large-scale planned clinical studies will be needed.

• 한국노년학
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• v.38 no.3
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• pp.627-643
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• 2018

This study aims to analyze gender differences in the prevalence of and risk factors for self-neglect among the elderly in South Korea. In order to investigate the differences between male and female elderly group, we compared 793 elderly men and 1,089 women from the data "Research on the Healthy Aging and Well-being of the Elderly" conducted in 2018. First, t-test and ${\chi}^2$-test and multiple regression analysis identified that gender differences in the prevalence of elder self-neglect was not statistically significant. Second, There are differences in risk factors affecting self-neglect between genders. age and class(perception) are the factors only affecting men. Income(monthly), having-religion, living-alone, satisfaction with life, social network are the ones only affecting women. Third, the risk factors for both men and women are depression and social support(public support). It is notable that we verify the empirical evidence supporting the hypothesis that risk factors for elder self-neglect may exist differently according to gender. In particular, gender characteristics revealed in this study can be reasonably explained through exchange theory and feminist theory. Therefore, we emphasize that the policy approach should be done depending on the gender of the elderly, and that the social safety net more paying attention to the depression of the elderly should be strengthened.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.3
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• pp.544-552
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• 2019

The purpose of this study was to find concrete measures to improve the subjective health level, happiness and quality of life of the elderly according to economic level and to propose social and policy alternatives accordingly. As a research method, 63,929 elderly people aged 65 or older were surveyed using the Community Health Survey (Indicator Bank) _v09, and the frequency of health use by economic level, subjective health level, euphoria and quality of life Analysis and Chi square analysis and independent t-test. Multi variate logistic regression analysis was performed with subjective health level as a dependent variable and multiple linear regression analysis was performed to determine the factors affecting euphoria and quality of life. The results of the study are as follows. In the case of recipients, medical use was lower than that of non-recipients, lower education level, female age of 75 years or older, and less stress, In case of present or past recipients, the result of non - receipt increased as the subjective health level was worse, and the non - recipient had higher euphoria and quality of life. As a result, there is a need for alternatives to increase opportunities for medical use among the recipients, with particular attention being paid to women and elderly people over 75 years old. It is expected to be used as a basic data to effectively improve the health promotion, happiness and quality of life of the elderly people of low income group.

• Journal of Life Science
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• v.28 no.12
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• pp.1397-1405
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• 2018

Mitochondria have multiple functions in cells: providing chemical energy, storing cellular $Ca^{2+}$, generating reactive oxygen species, and regulating apoptosis. Through these functions, mitochondria are also involved in the maintenance, proliferation, and differentiation of stem/progenitor cells. In the brain, the subventricular zone (SVZ) is one of the neurogenic regions that contains neural stem cells (NSCs) throughout a lifetime. However, reports on the role of mitochondria in SVZ NSCs are scarce. Here, we show that rotenone, a complex I inhibitor of mitochondria, inhibits the proliferation and differentiation of SVZ NSCs in different ways. In proliferating NSCs, rotenone decreases mitosis as measured through phosphorylated histone H3 detection; moreover, apoptosis is not induced by rotenone at 50 nM. In differentiating NSCs, rotenone blocks neurogenesis and oligodendrogenesis while glial fibrillary acidic protein-positive astrocytes are not affected. Interestingly, in this study there were more cells in the differentiating NSCs treated with rotenone for 4-6 days than in the vehicle control group which was a different effect from the reduced number of cells in the proliferating NSCs. We examined both apoptosis and mitosis and found that rotenone decreased apoptosis as detected by staining cleaved caspase-3 but did not affect mitosis. Our results suggest that functional mitochondria are necessary in both the proliferation and differentiation of SVZ NSCs. Furthermore, mitochondria might be involved in the mitosis and apoptosis that occur during those processes.

• Korean Journal of Ecology and Environment
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• v.52 no.3
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• pp.221-230
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• 2019

Barbel steed (Hemibarbus labeo) is a small freshwater fish species as semi-bottom dwellers distributed in eastern Asia. We carried out characterization of the cytochrome c oxidase subunit I (COI) gene from the mitochondrial DNA of H. labeo in the Sumjin River to identify the phylogenetic location of H. labeo in the genus Hemibarbus and Cyprinidae. Multiple alignment of the 577 bp COI sequence revealed high sequence homology (99~100%) between Seomjin River H. labeo. The nucleotide sequence similarity between H. labeo (HD1) and H. mylodon was 88.91% and that of H. longirostis was 88.81% among the three species found in Korea. In addition, the nucleotide sequence similarities of H. maculatus, H. meditus, H. umbrifer and H. barbus showed 98.97%, 97.20%, 96.87% and 98.85%, respectively. Phylogenetic analysis on seven species of the genus Hemibarbus showed that the H. labeo collected in this study formed two clades. One of which consisted of Hadong, Imsil, Kangjin. The other one formed a step with HD2, HD8 and HD9 of Hadong and the H. labeo reported in Busan, Asan and Seoul, Korea. Phylogenetic position of the H. labeo among Cyprinidae showed 0.143 for the evolutionary distance from Zacco platypus and 0.006 for the H. maculatus. In addition, the genetic position of the H. labeo among 28 species of Cyprinidae was found to be located in Group I, including Gobioninae fishes. The results of this study will provide key genetic information for the taxonomic comparison in Cyprinidae and study of model fish for pollution monitoring in freshwater environments.

• The Journal of the Korea Contents Association
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• v.19 no.9
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• pp.666-673
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• 2019

In the immersive virtual reality environment, we can select and manipulate various virtual objects. in order to select a virtual object, we generally use Ray-casting method that fires a virtual line in user's view and selects an object when the line and the object match, or Cone-casting method that is widely used to select multiple objects at the same time. However, since the virtual objects used in CAD are composed of small and complex objects in detail, when selecting an object in the user's view by existing methods, there occurs a ambiguity problem that needs additional realignment operation even though an object is selected as a group. in this paper, even if a virtual object is composed of several small virtual objects, it calculates the spatial and logical relationship among objects and expands or shrinks desired objects, so that the user can quickly and accurately select a desired object. in order to evaluate the proposed method, performance comparison were performed using Our and Ray-Casting and Cone-Casting methods. Experimental results show that the proposed method has the fastest speed and the highest accuracy when selecting the desired objects.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.12
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• pp.404-415
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• 2018

This descriptive research investigates the knowledge of and attitude toward HIV/AIDS among individuals in their 20s to 40s. This study also analyzes the results of the 2011 and 2013 community health surveys to identify the factors influencing their knowledge and attitude. The study subjects were 20 to 49 years old, and the final analysis included 182,315 subjects. The collected data were analyzed through t-tests, ANOVA, correlational analysis, and multiple regression analysis. The survey results showed a high level of knowledge of HIV/AIDS, with 69.4% correct answers. Most individuals lacked knowledge regarding routes of infection, and those in their 20s had the lowest percentage of correct answers. As for attitude toward HIV/AIDS, 44.3% showed a negative attitude. The scores for knowledge and attitude toward HIV/AIDS were higher among males, unmarried individuals, individuals with a higher income, individuals with a higher level of education, individuals working in agriculture, forestry, or fishery, managers, professions that were not homemakers/unemployed, and professional soldiers. A positive correlation (r=0.27, p<0.001) was observed between knowledge and attitude. The factors influencing AIDS knowledge and attitude were gender, marital status, income level, occupation, and education level. This study confirmed that there is a difference by age group. As such, educational programs customized by age and other characteristics are expected to be more effective in enhancing knowledge and in developing a more positive attitude towards HIV/AIDS.

• Journal of Life Science
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• v.31 no.2
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• pp.237-247
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• 2021

Immune responses in the central nervous system (CNS) function as the host's defense system against pathogens and usually help with repair and regeneration. However, chronic and exaggerated neuroinflammation is detrimental and may create neuronal damage in many cases. The NOD-, LRR-, and pyrin domain―containing 3 (NLRP3) inflammasome, a kind of NOD-like receptor, is a cytosolic multiprotein complex that consists of sensors (NLRP3), adaptors (apoptosis-associated speck like protein containing a caspase recruitment domain, ASC) and effectors (caspase 1). It can detect a broad range of microbial pathogens along with foreign and host-derived danger signals, resulting in the assembly and activation of the NLRP3 inflammasome. Upon activation, NLRP3 inflammasome leads to caspase 1-dependent secretion of the pro-inflammatory cytokines IL-1β and IL-18, as well as to gasdermin D-mediated pyroptotic cell death. NLRP3 inflammasome is highly expressed in CNS-resident cell types, including microglia and astrocytes, and growing evidence suggests that NLRP3 inflammasome is a crucial player in the pathophysiology of several neuroinflammatory and psychiatric diseases, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, traumatic brain injury, amyotrophic lateral sclerosis, and major depressive disorder. Thus, this review describes the molecular mechanisms of NLRP3 inflammasome activation and its crucial roles in the pathogenesis of neurological disorders.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.2
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• pp.139-145
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• 2021

Plant-derived exosome-like nanovesicles (PELNs) are known to include various biological activities and possess high biocompatibility. Because PELNs can influence immune responses, cell differentiation, and proliferation regulation, they can be applied in multiple industries. However, the studies on the skin physiological of exosome-like nanovesicles derived from plant callus are insignificant compared to nanovesicles derived from mammalian cells. In this study, callus was induced from apple fruit (Malus domestica), and exosome-like nanovesicles (ACELNs) were isolated for improving skin barrier and anti-aging. The yield of ACELNs was 6.42 × 10⁹ particles/mL, and the particle size was ranged from 100 to 200 nm. HDF cells and HaCaT cells were concentration-dependent, increased in cell, and decreased in cytotoxicity. The cornified envelope formation was significantly increased compared to the control group. The COL1A1 expression and the FBN1 expression in HDF cells were increased. In addition, the ACELNs promoted collagen biosynthesis in UVA-irradiated HDF cells. These results might be considered as potential materials that could improve skin barrier and prevent skin aging.

• Journal of Digital Convergence
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• v.19 no.7
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• pp.237-243
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• 2021

This study was attempted to identify the difference between nursing competencies and major satisfaction before and after the first clinical practice of nursing college students and use it as basic data for efficient clinical practice education. Data collection by single group pre- and post-design was conducted from February 18 to April 23, 2019 for 201 nursing college students before and after clinical practice for 8 weeks. The collected data were analyzed by frequency, paried t-test, and Pearson's Correlation, Multiple Regression using SPSS/Win 23.0. As a result of the study, Nursing competency increased after the first clinical practice than before, but it was not significant(t=-1.73, p=.084). Among the sub-factors of nursing competency, educational ability(t=-1.97, p=.050) and ethical practical ability(t=-209, p=.038) was found to increase significantly. Major satisfaction was significantly increased after clinical practice than before(t=-2.45, p=.015). After clinical practice, it was found that general satisfaction, relationship satisfaction, and recognition satisfaction which are sub-factors of major satisfaction, had a positive correlation with nursing competency. As a result of analyzing the impact on nursing competency, it was found that recognition satisfaction explains nursing competency as 9.9%. Therefore, it is necessary to reorganize the clinical practice curriculum that can improve nursing competency, develop a program that can improve major satisfaction, and verify the effectiveness.