• 한국독성학회:학술대회논문집
• /
• 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
• /
• pp.153-153
• /
• 2001

Nitric oxide (NO) has multifaceted roles in carcinogenesis. Besides acting as an initiator, NO may also playa role in the promotional stage of tumorigenesis or neoplastic transformation. In line with this notion, our previous studies have revealed that the tumor promotor phorbol ester induces expression of inducible nitric oxide synthase (iNOS) and NO production in mouse skin.(omitted)

• International Journal of Quality Innovation
• /
• 제9권1호
• /
• pp.134-152
• /
• 2008

Almost every country around the world has been focusing on food safety in intense and multifaceted ways. The use of Hazard Analysis Critical Control Points (HACCP) is widely accepted as a food safety management system. This paper investigates the success factors of HACCP practices with reference to the domains of food production, processing and delivery. A literature review of food safety and management articles was conducted. Using the keywords search, the online Emerald Database was used and a total of 102 journal articles were identified between 1994 and 2007. The study examined a list of 20 success factors. Results show that 'food regulations,' 'role of the industry,' 'government policies and interventions,' 'training on food safety and hygiene,' and 'food contamination and/or poisoning' share the spotlight as being the most critical factors for HACCP practices in organisations. Future research could investigate a holistic paradigm that incorporates the success factors and aligns HACCP measures for attaining safety performance goals.

• 반도체디스플레이기술학회지
• /
• 제21권1호
• /
• pp.1-4
• /
• 2022

As computers can express and utilize information in a semantic dimension different from the real world, humans have opened the door to the digital world and have played a pivotal role in the transformation of the human habitual environment. Using metaverse, it can be possible to predict concepts such as virtual currency, artificial intelligence, and virtual reality, which have now become possible for practical systemic visualization. In order to implement the metaverse in the realm of technology, it requires not only a multifaceted discussion on the platform, but also research on an architect that can include the intrinsic complexity of the metaverse. In this paper, we discuss the architecture for an open metaverse platform based on convergence wrapping that can converge various contents into one space, and propose a comprehensive platform design.

• International Journal of Computer Science & Network Security
• /
• 제22권11호
• /
• pp.192-198
• /
• 2022

The article is devoted to current problems of the concept leadership. The essence of the concept of "leadership" is considered and leadership theories. The authors of the article conducted a multifaceted analysis of leadership theories, analyzed the factors of their formation and identified their relationship. Also, the reasons for the difference and connection between leadership and leadership. Styles were presented leadership and their role in building effective leadership. To form the basis of effective leadership was compared to the main criteria inherent in this theories. The following research methods were used in the work: theoretical (analysis of regulatory documents and scientific literature on the problem under study, comparison, generalization, modeling), empirical (diagnostics of the level of formation of managerial competencies of students of the system, questioning, observation, peer review, comparative qualitative and quantitative analysis of diagnostic results the level of formation of managerial competencies).

• International Journal of Advanced Culture Technology
• /
• 제11권3호
• /
• pp.94-98
• /
• 2023

This study analyzes the combat case involving military drones during the Azerbaijan-Armenian War, which erupted on September 27, 2020. The background of the war revealed that Azerbaijan extensively and aggressively employed offensive drones, which played a decisive role in reshaping the dynamics of the battlefield. Despite Azerbaijan's GDP of $4.639, which corresponds to the level of a developing country, and its 64th rank in global military strength, the country boldly allocated a significant portion of its budget to develop its drone capabilities in preparation for the war. As a result, Azerbaijan effectively utilized offensive drones acquired from Turkey and Israel to neutralize hundreds of tanks, armored vehicles, artillery units, and air defense systems. The purpose of this study is to examine this context and explore how our Korean military organization can enhance its combat capabilities by developing a drone combat system, thereby enabling an effective response posture against multifaceted threats.

• 한국간호교육학회지
• /
• 제18권3호
• /
• pp.486-498
• /
• 2012

Purpose: The purpose of the study was to understand and describe the team manager's experience in relation to the team system in the hospital organization. Methods: In-depth individual interviews for collection of data were conducted from October to November 2011. Participants were chosen purposely among team managers who had worked as team managers under the team manager system in Seoul for more than three years. Content of all interviews was recorded and transcribed according to information collected by interviewers. Data were analyzed using Colaizzi's analysis. Results: Six categories were derived from the analysis: 1) Strengthening of team manager's authority; 2) Sharing of multifaceted leadership role; 3) Demonstrating people-oriented leadership; 4) Complete interpersonal relationship and communication; 5) Self-empowering with web-like plans and practices; and 6) Going through rigorous commitment for team performance. Conclusion: Results of the study demonstrate various positive factors in association with the team system in spite of the short period of time since its introduction in the hospital organization; however, some negative aspects of the team system need to be reevaluated.

• BMB Reports
• /
• 제52권1호
• /
• pp.13-23
• /
• 2019

Aging is accompanied by a time-dependent progressive deterioration of multiple factors of the cellular system. The past several decades have witnessed major leaps in our understanding of the biological mechanisms of aging using dietary, genetic, pharmacological, and physical interventions. Metabolic processes, including nutrient sensing pathways and mitochondrial function, have emerged as prominent regulators of aging. Mitochondria have been considered to play a key role largely due to their production of reactive oxygen species (ROS), resulting in DNA damage that accumulates over time and ultimately causes cellular failure. This theory, known as the mitochondrial free radical theory of aging (MFRTA), was favored by the aging field, but increasing inconsistent evidence has led to criticism and rejection of this idea. However, MFRTA should not be hastily rejected in its entirety because we now understand that ROS is not simply an undesired toxic metabolic byproduct, but also an important signaling molecule that is vital to cellular fitness. Notably, mitochondrial function, a term traditionally referred to bioenergetics and apoptosis, has since expanded considerably. It encompasses numerous other key biological processes, including the following: (i) complex metabolic processes, (ii) intracellular and endocrine signaling/communication, and (iii) immunity/inflammation. Here, we will discuss shortcomings of previous concepts regarding mitochondria in aging and their emerging roles based on recent advances. We will also discuss how the mitochondrial genome integrates with major theories on the evolution of aging.

• 보건의료산업학회지
• /
• 제13권3호
• /
• pp.53-65
• /
• 2019

Objectives: This descriptive survey study aimed to identify factors that affect job satisfaction among nurses working in integrated nursing care service wards and to explore measures to increase job satisfaction among these nurses. Methods: Data were collected between July 20 and August 3, 2018 from nurses working in integrated nursing care service wards in Busan and Changwon city, in Korea. Data were analyzed with SPSS/WIN 23.0 software(IBM corp., Armonk, NY, USA). Results: Factors affecting job satisfaction among nurses working in integrated nursing care service wards were identified as follows: professional self-concept (${\beta}=.32$, p=.003), which is a subdomain of nursing professionalism, and nursing foundations for quality care (${\beta}=.30$, p=.001), which is a subdomain of nursing work environment. The model had an explanatory power of 54.7%. Conclusions: Nursing professionalism should be strongly established among nurses, as nurses are key players in a health system that allows stable and expanded operations of integrated nursing care. Intervention measures that create a better work environment for nurses should also be implemented. Furthermore, it is necessary to develop systematic strategies and multifaceted efforts to increase nurses' job satisfaction in integrated nursing care service wards.

• BMB Reports
• /
• 제56권6호
• /
• pp.341-346
• /
• 2023

Acute myocardial infarction (AMI) is a multifaceted syndrome influenced by the functions of various extrinsic and intrinsic pathways and pathological processes, which can be detected in circulation using biomarkers. In this study, we investigated the secretome protein profile of induced-hypertrophy cardiomyocytes to identify next-generation biomarkers for AMI diagnosis and management. Hypertrophy was successfully induced in immortalized human cardiomyocytes (T0445) by 200 nM ET-1 and 1 μM Ang II. The protein profiles of hypertrophied cardiomyocyte secretomes were analyzed by nano-liquid chromatography with tandem mass spectrometry and differentially expressed proteins that have been identified by Ingenuity Pathway Analysis. The levels of 32 proteins increased significantly (>1.4 fold), whereas 17 proteins (<0.5 fold) showed a rapid decrease in expression. Proteomic analysis showed significant upregulation of six 14-3-3 protein isoforms in hypertrophied cardiomyocytes compared to those in control cells. Multi-reaction monitoring results of human plasma samples showed that 14-3-3 protein-zeta levels were significantly elevated in patients with AMI compared to those of healthy controls. These findings elucidated the role of 14-3-3 protein-zeta in cardiac hypertrophy and cardiovascular disorders and demonstrated its potential as a novel biomarker and therapeutic strategy.

• Acta Via Serica
• /
• 제9권1호
• /
• pp.67-90
• /
• 2024

India, Southeast Asia in general, and Siam in particular share a long history of cultural and commercial relations. Located in each other's extended neighbourhood, India and Thailand have a shared maritime boundary in the Andaman Sea. Situated in the strategic position, midway between West Asia on the one hand and East Asia on the other, India and Siam combined played a significant role in the maritime transactions in Asia and beyond. The geographical proximity between India and Siam led to multifaceted maritime interactions and exchanges. Siam was in the Indian sphere of cultural, religious, philosophical, technical, and linguistic influence much before the Common Era. The cultural and mercantile networks between India and Siam are well-attested by archaeological and literary sources. The archaeological findings in Siam and other Southeast Asian countries have revealed the dynamic trade and cultural exchange between India and Southeast Asia since the pre-Common Era. The Takola (modern Takua Pa) area served as a more suitable landing place for Indian merchants and there existed the settlement of the Indian mercantile community. Ligor (Nakhon Si Thammarat), Jaya (Chaiya), Patalung (Phatalung), U Thong, Ban Don Tha Pet, Ban U Taphao, Khao Sam Kaeo, and many other sites in Siam have brought to light a large variety of objects which demonstrate that ancient Siam had close mercantile contact with India as well as the Mediterranean world and China. The paper discusses in detail the cultural and trade links between India and Siam and their impact on the Maritime Silk Road.