1 |
Perez VI, Bokov A, Van Remmen H et al (2009) Is the oxidative stress theory of aging dead? Biochim Biophys Acta 1790, 1005-1014
DOI
|
2 |
Fabrizio P, Liou LL, Moy VN et al (2003) SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics 163, 35-46
DOI
|
3 |
Cabreiro F, Ackerman D, Doonan R et al (2011) Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med 51, 1575-1582
DOI
|
4 |
Melov S, Ravenscroft J, Malik S et al (2000) Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics. Science 289, 1567-1569
DOI
|
5 |
Curtis C, Landis GN, Folk D et al (2007) Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophilareveals a species-general network of aging and metabolic genes. Genome Biol 8, R262
DOI
|
6 |
Sun J, Folk D, Bradley TJ, Tower J (2002) Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics 161, 661-672
DOI
|
7 |
Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL (1998) Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat Genet 19, 171-174
DOI
|
8 |
Schriner SE, Linford NJ, Martin GM et al (2005) Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308, 1909-1911
DOI
|
9 |
Bua E, Johnson J, Herbst A et al (2006) Mitochondrial DNA-Deletion Mutations Accumulate Intracellularly to Detrimental Levels in Aged Human Skeletal Muscle Fibers. Am J Hum Genet 79, 469-480
DOI
|
10 |
Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11, 298-300
DOI
|
11 |
Harman D (2009) Origin and evolution of the free radical theory of aging: a brief personal history, 1954-2009. Biogerontology 10, 773
DOI
|
12 |
Harman D (1972) The biologic clock: the mitochondria? J Am Geriatr Soc 20, 145-147
DOI
|
13 |
Yakes FM, Van Houten B (1997) Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci U S A 94, 514-519
DOI
|
14 |
Wallace DC (2005) A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet 39, 359-407
DOI
|
15 |
Lee HY, Choi CS, Birkenfeld AL et al (2010) Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab 12, 668-674
DOI
|
16 |
Brooks AR, Harkins RN, Wang P, Qian HS, Liu P, Rubanyi GM (2004) Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle. J Gene Med 6, 395-404
DOI
|
17 |
Cortopassi GA, Arnheim N (1990) Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res 18, 6927-6933
DOI
|
18 |
Bender A, Krishnan KJ, Morris CM et al (2006) High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 38, 515-517
DOI
|
19 |
Vermulst M, Wanagat J, Kujoth GC et al (2008) DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet 40, 392-394
DOI
|
20 |
Sarsour EH, Kalen AL, Goswami PC (2014) Manganese superoxide dismutase regulates a redox cycle within the cell cycle. Antioxid Redox Signal 20, 1618-1627
DOI
|
21 |
Ristow M (2014) Unraveling the truth about antioxidants: mitohormesis explains ROS-induced health benefits. Nat Med 20, 709-711
DOI
|
22 |
Sun N, Youle RJ, Finkel T (2016) The Mitochondrial Basis of Aging. Mol Cell 61, 654-666
DOI
|
23 |
Shadel GS, Horvath TL (2015) Mitochondrial ROS signaling in organismal homeostasis. Cell 163, 560-569
DOI
|
24 |
Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G (2003) A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-48
DOI
|
25 |
Dillin A, Hsu AL, Arantes-Oliveira N et al (2002) Rates of behavior and aging specified by mitochondrial function during development. Science 298, 2398-2401
DOI
|
26 |
Sullivan LB, Gui DY, Vander Heiden MG (2016) Altered metabolite levels in cancer: implications for tumour biology and cancer therapy. Nat Rev Cancer 16, 680-693
DOI
|
27 |
Kazak L, Reyes A, Holt IJ (2012) Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nat Rev Mol Cell Biol 13, 659-671
DOI
|
28 |
Kang D, Kim SH, Hamasaki N (2007) Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions. Mitochondrion 7, 39-44
DOI
|
29 |
Liu X, Jiang N, Hughes B, Bigras E, Shoubridge E, Hekimi S (2005) Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev 19, 2424-2434
DOI
|
30 |
Frezza C (2017) Mitochondrial metabolites: undercover signalling molecules. Interface Focus 7, 20160100
DOI
|
31 |
Kim SJ, Xiao J, Wan J, Cohen P, Yen K (2017) Mitochondrially derived peptides as novel regulators of metabolism. J Physiol 595, 6613-6621
DOI
|
32 |
Pinti M, Cevenini E, Nasi M et al (2014) Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for "inflamm-aging". Eur J Immunol 44, 1552-1562
DOI
|
33 |
Furman D, Chang J, Lartigue L et al (2017) Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat Med 23, 174-184
DOI
|
34 |
Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A (2018) Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol 14, 576-590
DOI
|
35 |
Hashimoto Y, Niikura T, Tajima H et al (2001) A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc Natl Acad Sci U S A 98, 6336-6341
DOI
|
36 |
Choudhary C, Weinert BT, Nishida Y, Verdin E, Mann M (2014) The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol 15, 536-550
DOI
|
37 |
Tranah GJ (2011) Mitochondrial-nuclear epistasis: Implications for human aging and longevity. Ageing Res Rev 10, 238-252
DOI
|
38 |
Menzies KJ, Zhang H, Katsyuba E, Auwerx J (2016) Protein acetylation in metabolism-metabolites and cofactors. Nat Rev Endocrinol 12, 43-60
DOI
|
39 |
Sutendra G, Kinnaird A, Dromparis P et al (2014) A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation. Cell 158, 84-97
DOI
|
40 |
Shi L, Tu BP (2015) Acetyl-CoA and the regulation of metabolism: mechanisms and consequences. Curr Opin Cell Biol 33, 125-131
DOI
|
41 |
Xie Z, Dai J, Dai L et al (2012) Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics 11, 100-107
DOI
|
42 |
Benayoun BA, Pollina EA, Brunet A (2015) Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol 16, 593-610
DOI
|
43 |
Schultz MB, Sinclair DA (2016) Why NAD+ Declines during Aging: It's Destroyed. Cell Metab 23, 965-966
DOI
|
44 |
Camacho-Pereira J, Tarrago MG, Chini CCS et al (2016) CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab 23, 1127-1139
DOI
|
45 |
Zarse K, Ristow M (2015) A mitochondrially encoded hormone ameliorates obesity and insulin resistance. Cell Metab 21, 355-356
DOI
|
46 |
Ikonen M, Liu B, Hashimoto Y et al (2003) Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proc Natl Acad Sci U S A 100, 13042-13047
DOI
|
47 |
Guo B, Zhai D, Cabezas E et al (2003) Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature 423, 456-461
DOI
|
48 |
Cobb LJ, Lee C, Xiao J et al (2016) Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging 8, 796-809
DOI
|
49 |
Lee C, Zeng J, Drew BG et al (2015) The mitochondrialderived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab 21, 443-454
DOI
|
50 |
McManus MJ, Picard M, Chen HW et al (2018) Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy. Cell Metab [Epub ahead of print]
|
51 |
Deuse T, Wang D, Stubbendorff M et al (2015) SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts. Cell Stem Cell 16, 33-38
DOI
|
52 |
Betancourt AM, King AL, Fetterman JL et al (2014) Mitochondrial-nuclear genome interactions in non-alcoholic fatty liver disease in mice. Biochemical J 461, 223-232
DOI
|
53 |
Fetterman JL, Zelickson BR, Johnson LW et al (2013) Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload. Biochemical J 455, 157-167
DOI
|
54 |
Raimundo N, Krisko A (2018) Cross-organelle communication at the core of longevity. Aging 10, 15-16
DOI
|
55 |
Rieusset J (2018) The role of endoplasmic reticulummitochondria contact sites in the control of glucose homeostasis: an update. Cell Death Dis 9, 388
DOI
|
56 |
Janikiewicz J, Szymanski J, Malinska D et al (2018) Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics. Cell Death Dis 9, 332
DOI
|
57 |
Wang CH, Chen YF, Wu CY et al (2014) Cisd2 modulates the differentiation and functioning of adipocytes by regulating intracellular Ca2+ homeostasis. Hum Mol Genet 23, 4770-4785
DOI
|
58 |
Rand DM (2017) Fishing for adaptive epistasis using mitonuclear interactions. PLoS Genet 13, e1006662
DOI
|
59 |
Chen YF, Kao CH, Chen YT et al (2009) Cisd2 deficiency drives premature aging and causes mitochondriamediated defects in mice. Genes Dev 23, 1183-1194
DOI
|
60 |
Murley A, Sarsam RD, Toulmay A, Yamada J, Prinz WA, Nunnari J (2015) Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. J Cell Biol 209, 539-548
DOI
|
61 |
Honscher C, Mari M, Auffarth K et al (2014) Cellular metabolism regulates contact sites between vacuoles and mitochondria. Dev Cell 30, 86-94
DOI
|
62 |
Durieux J, Wolff S, Dillin A (2011) The cell-nonautonomous nature of electron transport chain-mediated longevity. Cell 144, 79-91
DOI
|
63 |
Woo DK, Shadel GS (2011) Mitochondrial stress signals revise an old aging theory. Cell 144, 11-12
DOI
|
64 |
Zhang Q, Wu X, Chen P et al (2018) The mitochondrial unfolded protein response is mediated cell-nonautonomously by retromer-dependent Wnt signaling. Cell 174, 870-883.e817
DOI
|
65 |
Shao L-W, Niu R, Liu Y (2016) Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Res 26, 1182-1196
DOI
|
66 |
Stewart JB, Chinnery PF (2015) The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease. Nat Rev Genet 16, 530-542
DOI
|
67 |
Kauppila TES, Kauppila JHK, Larsson NG (2017) Mammalian Mitochondria and Aging: An Update. Cell Metab 25, 57-71
DOI
|
68 |
Owusu-Ansah E, Song W, Perrimon N (2013) Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell 155, 699-712
DOI
|
69 |
Kim KH, Jeong YT, Oh H et al (2012) Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med 19, 83-92
DOI
|
70 |
Berendzen KM, Durieux J, Shao LW et al (2016) Neuroendocrine coordination of mitochondrial stress signaling and proteostasis. Cell 166, 1553-1563.e1510
DOI
|
71 |
da Cunha FM, Torelli NQ, Kowaltowski AJ (2015) Mitochondrial Retrograde Signaling: Triggers, Pathways, and Outcomes. Oxid Med Cell Longev 2015, 482582
|
72 |
Lee C, Kim KH, Cohen P (2016) MOTS-c: a novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med 100, 182-187
DOI
|
73 |
Doonan R, McElwee JJ, Matthijssens F et al (2008) Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev 22, 3236-3241
DOI
|
74 |
Pomatto LCD, Davies KJA (2018) Adaptive homeostasis and the free radical theory of ageing. Free Radic Biol Med 124, 420-430
DOI
|
75 |
Unlu ES, Koc A (2007) Effects of deleting mitochondrial antioxidant genes on life span. Ann N Y Acad Sci 1100, 505-509
DOI
|
76 |
Longo VD, Gralla EB, Valentine JS (1996) Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae Mitochondrial production of toxic oxygen species in vivo. J Biol Chem 271, 12275-12280
DOI
|
77 |
Kirby K, Hu J, Hilliker AJ, Phillips JP (2002) RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress. Proc Natl Acad Sci U S A 99, 16162-16167
DOI
|
78 |
Martin I, Jones MA, Rhodenizer D et al (2009) Sod2 knockdown in the musculature has whole-organism consequences in Drosophila. Free Radic Biol Med 47, 803-813
DOI
|
79 |
Duttaroy A, Paul A, Kundu M, Belton A (2003) A Sod2 null mutation confers severely reduced adult life span in Drosophila. Genetics 165, 2295-2299
DOI
|
80 |
Wicks S, Bain N, Duttaroy A, Hilliker AJ, Phillips JP (2009) Hypoxia rescues early mortality conferred by superoxide dismutase deficiency. Free Radic Biol Med 46, 176-181
DOI
|
81 |
Kennedy SR, Salk JJ, Schmitt MW, Loeb LA (2013) Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet 9, e1003794
DOI
|
82 |
Cooke MS, Evans MD, Dizdaroglu M, Lunec J (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17, 1195-1214
DOI
|
83 |
Vermulst M, Bielas JH, Kujoth GC (2007) Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet 39, 540-543
DOI
|
84 |
Ameur A, Stewart JB, Freyer C et al (2011) Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins. PLoS Genet 7, e1002028
DOI
|
85 |
Trifunovic A, Hansson A, Wredenberg A et al (2005) Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci U S A 102, 17993-17998
DOI
|
86 |
Trifunovic A, Wredenberg A, Falkenberg M et al (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429, 417-423
DOI
|
87 |
Edgar D, Shabalina I, Camara Y et al (2009) Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice. Cell Metab 10, 131-138
DOI
|
88 |
Kujoth GC, Hiona A, Pugh TD et al (2005) Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging. Science 309, 481-484
DOI
|
89 |
Logan A, Shabalina IG, Prime TA et al (2014) In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice. Aging Cell 13, 765-768
DOI
|
90 |
DeBalsi KL, Hoff KE, Copeland WC (2017) Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases. Ageing Res Rev 33, 89-104
DOI
|
91 |
Rando TA, Chang HY (2012) Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell 148, 46-57
DOI
|
92 |
Zarse K, Schmeisser S, Groth M et al (2012) Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab 15, 451-465
DOI
|
93 |
Lee SJ, Hwang AB, Kenyon C (2010) Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol 20, 2131-2136
DOI
|
94 |
Munoz-Najar U, Sedivy JM (2011) Epigenetic control of aging. Antioxid Redox Signal 14, 241-259
DOI
|
95 |
Schroeder EA, Raimundo N, Shadel GS (2013) Epigenetic silencing mediates mitochondria stressinduced longevity. Cell Metab 17, 954-964
DOI
|
96 |
Shpilka T, Haynes CM (2018) The mitochondrial UPR: mechanisms, physiological functions and implications in ageing. Nat Rev Mol Cell Biol 19, 109-120
DOI
|
97 |
Wong W (2018) Going nuclear with stress. Science Signaling 11, eaav4285
DOI
|
98 |
Lee C, Kim KH, Cohen P (2016) MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med 100, 182-187
DOI
|
99 |
Kim KH, Son JM, Benayoun BA, Lee C (2018) The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab 28, 516-524
DOI
|
100 |
Mangalhara KC, Shadel GS (2018) A Mitochondrial-Derived Peptide Exercises the Nuclear Option. Cell Metab 28, 330-331
DOI
|
101 |
Pickles S, Vigie P, Youle RJ (2018) Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance. Curr Biol 28, R170-R185
DOI
|
102 |
Lee SR, Han J (2017) Mitochondrial nucleoid: shield and switch of the mitochondrial genome. Oxid Med Cell Longev 2017 [Epub ahead of print]
|
103 |
Chen H, Vermulst M, Wang YE et al (2010) Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations. Cell 141, 280-289
DOI
|
104 |
Prevost CT, Peris N, Seger C et al (2018) The influence of mitochondrial dynamics on mitochondrial genome stability. Curr Genet 64, 199-214
DOI
|
105 |
Felkai S, Ewbank JJ, Lemieux J, Labbe JC, Brown GG, Hekimi S (1999) CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. EMBO J 18, 1783-1792
DOI
|
106 |
Nargund AM, Fiorese CJ, Pellegrino MW, Deng P, Haynes CM (2015) Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR mt. Mol Cell 58, 123-133
DOI
|
107 |
Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, Haynes CM (2012) Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science 337, 587-590
DOI
|
108 |
Tian Y, Garcia G, Bian Q et al (2016) Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR(mt). Cell 165, 1197-1208
DOI
|
109 |
Mouchiroud L, Houtkooper RH, Moullan N et al (2013) The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 154, 430-441
DOI
|
110 |
Gomes AP, Price NL, Ling AJ et al (2013) Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 155, 1624-1638
DOI
|
111 |
Yoshino J, Mills KF, Yoon MJ, Imai S (2011) Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice. Cell Metab 14, 528-536
DOI
|
112 |
Quiros PM, Mottis A, Auwerx J (2016) Mitonuclear communication in homeostasis and stress. Nat Rev Mol Cell Biol 17, 213-226
DOI
|
113 |
Mammucari C, Gherardi G, Zamparo I et al (2015) The mitochondrial calcium uniporter controls skeletal muscle trophism in vivo. Cell Rep 10, 1269-1279
DOI
|
114 |
Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A (2018) Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol 14, 576-590
DOI
|
115 |
Davis BK, Wen H, Ting JP (2011) The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol 29, 707-735
DOI
|
116 |
Wenceslau CF, McCarthy CG, Szasz T et al (2014) Mitochondrial damage-associated molecular patterns and vascular function. Eur Heart J 35, 1172-1177
DOI
|
117 |
Zhang Q, Raoof M, Chen Y et al (2010) Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464, 104-107
DOI
|
118 |
Fuku N, Pareja-Galeano H, Zempo H et al (2015) The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity? Aging Cell 14, 921-923
DOI
|
119 |
Muzumdar RH, Huffman DM, Atzmon G et al (2009) Humanin: a novel central regulator of peripheral insulin action. PLoS One 4, e6334
DOI
|
120 |
Lee C, Wan J, Miyazaki B et al (2014) IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell 13, 958-961
DOI
|
121 |
Zempo H, Fuku N, Nishida Y et al (2016) Relation between type 2 diabetes and m. 1382 A> C polymorphism which occurs amino acid replacement (K14Q) of mitochondria-derived MOTS-c. FASEB J 30, 956.1
|
122 |
Price NL, Gomes AP, Ling AJ et al (2012) SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 15, 675-690
DOI
|
123 |
Canto C, Gerhart-Hines Z, Feige JN et al (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458, 1056-1060
DOI
|
124 |
Dunham-Snary KJ, Ballinger SW (2015) GENETICS. Mitochondrial-nuclear DNA mismatch matters. Science 349, 1449-1450
DOI
|
125 |
Santos MJ, Quintanilla RA, Toro A et al (2005) Peroxisomal proliferation protects from -amyloid neurodegeneration. J Biol Chem 280, 41057-41068
DOI
|
126 |
Titorenko VI, Terlecky SR (2011) Peroxisome metabolism and cellular aging. Traffic 12, 252-259
DOI
|
127 |
Sebastian D, Palacin M, Zorzano A (2017) Mitochondrial dynamics: coupling mitochondrial fitness with healthy aging. Trends Mol Med 23, 201-215
DOI
|
128 |
Koepke JI, Nakrieko KA, Wood CS et al (2007) Restoration of peroxisomal catalase import in a model of human cellular aging. Traffic 8, 1590-1600
DOI
|
129 |
Nell HJ, Au JL, Giordano CR et al (2017) Targeted Antioxidant, Catalase-SKL, Reduces Beta-Amyloid Toxicity in the Rat Brain. Brain Pathol 27, 86-94
DOI
|
130 |
Yoboue ED, Sitia R, Simmen T (2018) Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages. Cell Death Dis 9, 331
DOI
|
131 |
Carmona-Gutierrez D, Hughes AL, Madeo F, Ruckenstuhl C (2016) The crucial impact of lysosomes in aging and longevity. Ageing Res Rev 32, 2-12
DOI
|
132 |
Soto-Heredero G, Baixauli F, Mittelbrunn M (2017) Interorganelle communication between mitochondria and the endolysosomal system. Front Cell Dev Biol 5, 95
DOI
|
133 |
Linnane AW, Marzuki S, Ozawa T, Tanaka M (1989) Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1, 642-645
|
134 |
Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M et al (2011) Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med 3, 70ra13
DOI
|
135 |
Cortopassi GA, Arnheim N (1990) Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res 18, 6927-6933
DOI
|
136 |
Piko L, Hougham AJ, Bulpitt KJ (1988) Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions/additions with aging. Mech Ageing Dev 43, 279-293
DOI
|
137 |
Larsson NG (2010) Somatic mitochondrial DNA mutations in mammalian aging. Annu Rev Biochem 79, 683-706
DOI
|
138 |
Payne BA, Wilson IJ, Yu-Wai-Man P et al (2013) Universal heteroplasmy of human mitochondrial DNA. Hum Mol Genet 22, 384-390
DOI
|
139 |
Khrapko K, Vijg J (2009) Mitochondrial DNA mutations and aging: devils in the details? Trends Genet 25, 91-98
DOI
|
140 |
Rossignol R, Faustin B, Rocher C, Malgat M, Mazat JP, Letellier T (2003) Mitochondrial threshold effects. Biochem J 370, 751-762
DOI
|
141 |
Bachar AR, Scheffer L, Schroeder AS et al (2010) Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress. Cardiovasc Res 88, 360-366
DOI
|
142 |
Imai S-I, Guarente L (2016) It takes two to tango: NAD+ and sirtuins in aging/longevity control. NPJ Aging Mech Dis 2, 16017
DOI
|
143 |
Grazioli S, Pugin J (2018) Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases. Front Immunol 9, 832
DOI
|
144 |
Hughes AL, Gottschling DE (2012) An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature 492, 261-265
DOI
|
145 |
Elbaz-Alon Y, Rosenfeld-Gur E, Shinder V, Futerman AH, Geiger T, Schuldiner M (2014) A dynamic interface between vacuoles and mitochondria in yeast. Dev Cell 30, 95-102
DOI
|
146 |
Klecker T, Westermann B (2014) Mitochondria Are Clamped to Vacuoles for Lipid Transport. Dev Cell 30, 1-2
DOI
|
147 |
Cobb LJ, Lee C, Xiao J et al (2016) Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging 8, 796-809
DOI
|