Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.05a
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- Pages.153-153
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- 2001
ACTIVATION OF NF-$\textsc{k}$ B AND INDUCTION OF CYCLOOXYGENASE-2 BY NITRIC OXIDE IN MOUSE SKIN
- Cha, Hyun-Ho (College of Pharmacy, Seoul National University) ;
- Chun, Kyung-Soo (College of Pharmacy, Seoul National University) ;
- Kim, Hee-Kyung (College of Dentistry, Yonsei University) ;
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Park, Kwang-Kyun
(College of Dentistry, Yonsei University)
;
- Byeongwoo Ahn (Korea Food and Drug Administration) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University)
- Published : 2001.05.01
Abstract
Nitric oxide (NO) has multifaceted roles in carcinogenesis. Besides acting as an initiator, NO may also playa role in the promotional stage of tumorigenesis or neoplastic transformation. In line with this notion, our previous studies have revealed that the tumor promotor phorbol ester induces expression of inducible nitric oxide synthase (iNOS) and NO production in mouse skin.(omitted)
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