• 한국항만경제학회지
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• 제28권3호
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• pp.127-150
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• 2012

해운산업의 일반적 이미지, 경제적 역할, 다면적 역할 등에 대해 일반인을 대상으로 설문 조사를 시행한 결과 해운산업에 대한 일반적 인식과 해운산업의 경제적 역할에 대한 인식은 비교적 긍정적인 것으로 나타났다. 반면 해운산업의 다면적 역할에 대해서는 긍정적 인식과 부정적 인식이 혼재하고 있는 것으로 조사되었다. 또한 직업적 매력도와 고용창출에 해서도 낮은 인식을 보임으로써 해운산업을 개인의 체험 속에서 인식하기보다는 막연하게 남의 일(none of my business)로 인식하고 있음을 보여주었다. 이와 함께 해운산업의 이미지가 방송, 신문 등 언론매체를 통해 형성된 것으로 나타났다. 해운산업에 대한 인식제고의 방안으로 관계적, 상품 및 서비스, 텍스트 접근법 등 3가지 접근법이 논의되었다. 관계적 전략으로 도시민을 위한 해운체험 교육기관의 설립, 일반인 대상 다양한 행사 실시, 해운기념관 설립, 해운산업과 관련한 문화관광 컨텐츠 개발, 해운문화운동을 통한 해운산업 이미지 재창조, 학교교육을 통한 해운관 조성 등이 제시되었다. 상품 및 서비스 전략으로는 해운서비스에 대한 기업브랜드 부여, B2C 서비스의 제공, 해운서비스에 국가이미지 활용, 해운산업의 대외협력사업 참여 등이 논의되었다. 텍스트 전략으로는 B2B 광고의 전개, 해운산업의 국가경제적 다면적 역할 광고, 해운산업과 연관산업의 융합광고, 첨단매체의 활용, 다면적 역할 홍보에 대한 정부의 주도적 역할, 해운산업의 공고 및 홍보를 위한 기금 신설 등이 검토되었다.

• Molecules and Cells
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• 제45권11호
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• pp.781-788
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• 2022

Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes. Here, we focus our review on proline metabolism in neurons, highlighting the role of dysregulated proline metabolism in neuronal dysfunction and consequently neurological and psychiatric disorders. We will discuss the association between genetic and protein function of enzymes in the proline pathway and the development of neurological and psychiatric disorders. We will conclude with a potential mechanism of proline metabolism in neuronal function and mental health.

• 생물정신의학
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• 제22권2호
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• pp.47-54
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• 2015

In the past decade, structural, molecular, and functional changes in glial cells have become a major focus in the search for the neurobiological foundations of schizophrenia. Glial cells, consisting of oligodendrocytes, astrocytes, microglia, and nerve/glial antigen 2-positive cells, constitute a major cell population in the central nervous system. There is accumulating evidence of reduced numbers of oligodendrocytes and altered expression of myelin/oligodendrocyte-related genes that might explain the white matter abnormalities and altered inter- and intra-hemispheric connectivities that are characteristic signs of schizophrenia. Astrocytes play a key role in the synaptic metabolism of neurotransmitters ; thus, astrocyte dysfunction may contribute to certain aspects of altered neurotransmission in schizophrenia. Increased densities of microglial cells and aberrant expression of microglia-related surface markers in schizophrenia suggest that immunological/inflammatory factors are of considerable relevance to the pathophysiology of psychosis. This review describes current evidence for the multifaceted role of glial cells in schizophrenia and discusses efforts to develop glia-directed therapies for the treatment of the disease.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3561-3568
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• 2012

The calcium sensing receptor (CaSR) is a member of the largest family of cell surface receptors, the G protein-coupled receptors involved in calcium homeostasis. The role of the CaSR in neoplasia appears to be homeostatic; loss of normal CaSR-induced response to extracellular calcium is observed in cancers of the colon and ovary, while increased release of PTHrP is observed in cancers of the breast, prostate and Leydig cells. Currently CaSR can be considered as a molecule that can either promote or prevent tumor growth depending on the type of cancer. Therefore, recognition of the multifaceted role of CaSR in gliomas and other malignant tumors in general is fundamental to elucidating the mechanisms of tumor progression and the development of novel therapeutic agents. Emphasis should be placed on development of drug-targeting methods to modulate CaSR activity in cancer cells.

• ETRI Journal
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• 제42권2호
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• pp.196-204
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• 2020

Open-source software development projects are well suited for exploring new ideas and acquiring knowledge from developers outside of the project. In this paper, we examine the impact of external developers on innovation in open-source software development from the perspective of organizational learning theory. We examine the roles of external and internal developers, who "explore" and "exploit," respectively, on the innovation performance of 17 691 open-source software development projects whose data is stored in the GitHub platform. The results indicate that a multifaceted strategy, in which the exploitation successfully supports the exploration, is most effective for their success. The results also indicate that the role of exploration decreases after the release of the software.

• Toxicological Research
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• 제21권3호
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• pp.195-208
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• 2005

Diabetes is a major cause of morbidity and mortality, and associated with a high risk of atherosclerosis, and liver, kidney, nerve and tissue damage. Defective insulin secretion in pancreas and/or insulin resistance in peripheral tissues is a central component of diabetes. It is well established that, regardless of the degree of muscle insulin resistance, glucose levels in diabetic and non-diabetic individuals are determined by the rate of hepatic glucose production. Moreover recently studies using liver-specific insulin receptor knockout mice show the paramount role of the liver in insulin resistance and diabetes. Insulin exerts a multifaceted and highly integrated series of actions via its intracellular signaling systems. The first major section of this review defines the major insulin-mediated signaling pathways including phosphatidylinositol 3-kinase and mitogen activated protein kinases. The second major section of the review presents a summary and evaluation of methods for determination of the role and function of signaling pathways, including methods for determination of kinase phosphorylation, the use of pharmacological inhibitors of kinase and dominant-negative kinase constructs, and the application of new RNA interference methods.

• 부모자녀건강학회지
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• 제3권2호
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• pp.81-93
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• 2000

The role of the neonatal nurse specialist has been well established over the past decade and now reform in 21st century. Neonatal nurse specialists responsibilities in caring for critically and long-term chronically ill infants and their families are very important. Neonatal nurse specialists have a two fold responsibility in caring for these infants. First, through acquiring advanced practice education in complex neonatal care and diagnostic skills, neonatal nurse specialists meet the physiologic needs of the infant. Second, neonatal nurse specialists provide a more holistic approach to their care through evaluating the family in treatment plans and involving the family in discharge planning for the infant. In some institutions, neonatal nurse specialists are directly involved in institutional and/or home follow-up care and case management also. It is the neonatal nurse specialists responsibility to function collaboratively with the multidisciplinary team in managing critically or chronically ill infants from admission to discharge. The role of the neonatal nurse specialist case manager can be described as one that focuses on individualized care of the infant, while providing continuity of care to both the infant and family. The neonatal nurse specialist's role will vary depending on the neonatal intensive care unit(NICU). Therefore, the multidisciplinary collaborative approach to long-term management of infants in the NICU is extremely important to provide successful transition to home or to long-term rehabilitative care facilities because care for the chronically ill infant is complex and multifaceted. I suggest the role of neonatal nurse specialist in 21st century are as follows. 1. Diagnostic/patient assessment 2. Management of patient health/illness 3. Administering/monitoring therapeutic interventions and regimens 4. Monitoring/ensuring quality of health care practices 5. Organization and work role 6. Helping role 7. Teaching/coaching role 8. Management of rapidly changing situations 9. Consulting role The advanced practice nursing model of care delivered by neonatal nurse specialist's in the NICU incorporates medical and nursing role functions and emphasizes holism, caring, and a health perspective for critically and chronically ill neonates and their families.

• Genomics & Informatics
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• 제21권2호
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• pp.23.1-23.9
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• 2023

The mammalian sirtuin family, consisting of SIRT1-SIRT7, plays a vital role in various biological processes, including cancer, diabetes, neurodegeneration, cardiovascular disease, cellular metabolism, and cellular homeostasis maintenance. Due to their involvement in these biological processes, modulating sirtuin activity seems promising to impact immuneand aging-related diseases, as well as cancer pathways. However, more understanding is required regarding the safety and efficacy of sirtuin-targeted therapies due to the complex regulatory mechanisms that govern their activity, particularly in the context of multiple targets. In this study, the interaction landscape of the sirtuin family was analyzed using a systems biology approach. A sirtuin protein-protein interaction network was built using the Cytoscape platform and analyzed using the NetworkAnalyzer and stringApp plugins. The result revealed the sirtuin family's association with numerous proteins that play diverse roles, suggesting a complex interplay between sirtuins and other proteins. Based on network topological and functional analysis, SIRT1 was identified as the most prominent among sirtuin family members, demonstrating that 25 of its protein partners are involved in cancer, 22 in innate immune response, and 29 in aging, with some being linked to a combination of two or more pathways. This study lays the foundation for the development of novel therapies that can target sirtuins with precision and efficacy. By illustrating the various interactions among the proteins in the sirtuin family, we have revealed the multifaceted roles of SIRT1 and provided a framework for their possible roles to be precisely understood, manipulated, and translated into therapeutics in the future.

• 디지털융복합연구
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• 제19권3호
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• pp.353-361
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• 2021

고령화 사회에서 건강과 웰빙에 대한 요구 수준이 높아짐에 따라 의료 환경에서는 다양한 이해관계자가 얽힌 복잡한 문제가 발생한다. 본 논문의 목적은 여러 분야의 전문가들이 의료 환경에서 공동의 목표를 달성하기 위하여 협업하는 상황에서 디자이너의 역할과 능력을 알아내는 것이다. 학제간 접근법을 도입한 헬스케어 디자인 프로젝트에서의 효과적인 방법과 프로세스를 파악하기 위해 사례 연구를 진행하였다. 결과는 세 가지 연구 질문을 기반으로 프로세스 퍼실리테이션, 관계 관리, 시각화, 상상력과 같은 디자이너의 다면적인 역할을 분석하였다.

• Tuberculosis and Respiratory Diseases
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• 제79권4호
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• pp.207-213
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• 2016

Chronic obstructive pulmonary disease (COPD) encompasses several clinical syndromes, most notably emphysema and chronic bronchitis. Most of the current treatments fail to attenuate severity and progression of the disease, thereby requiring better mechanistic understandings of pathogenesis to develop disease-modifying therapeutics. A number of theories on COPD pathogenesis have been promulgated wherein an increase in protease burden from chronic inflammation, exaggerated production of reactive oxygen species and the resulting oxidant injury, or superfluous cell death responses caused by enhanced cellular injury/damage were proposed as the culprit. These hypotheses are not mutually exclusive and together likely represent the multifaceted biological processes involved in COPD pathogenesis. Recent studies demonstrate that mitochondria are involved in innate immune signaling that plays important roles in cigarette smoke-induced inflammasome activation, pulmonary inflammation and tissue remodeling responses. These responses are reviewed herein and synthesized into a view of COPD pathogenesis whereby mitochondria play a central role.