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http://dx.doi.org/10.14348/molcells.2022.0115

Proline Metabolism in Neurological and Psychiatric Disorders  

Yao, Yuxiao (The Fifth Affiliated Hospital of Guangzhou Medical University)
Han, Weiping (Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR))
Publication Information
Molecules and Cells / v.45, no.11, 2022 , pp. 781-788 More about this Journal
Abstract
Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes. Here, we focus our review on proline metabolism in neurons, highlighting the role of dysregulated proline metabolism in neuronal dysfunction and consequently neurological and psychiatric disorders. We will discuss the association between genetic and protein function of enzymes in the proline pathway and the development of neurological and psychiatric disorders. We will conclude with a potential mechanism of proline metabolism in neuronal function and mental health.
Keywords
cell metabolism; neurological disease; neuron; proline; psychiatric disease;
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