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http://dx.doi.org/10.7314/APJCP.2012.13.8.3561

Calcium Sensing Receptor Modulation for Cancer Therapy  

Sarkar, Puja (IGNOU-I2IT Centre of Excellence for Advanced Education and Research)
Kumar, Sudhir (IGNOU-I2IT Centre of Excellence for Advanced Education and Research)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.8, 2012 , pp. 3561-3568 More about this Journal
Abstract
The calcium sensing receptor (CaSR) is a member of the largest family of cell surface receptors, the G protein-coupled receptors involved in calcium homeostasis. The role of the CaSR in neoplasia appears to be homeostatic; loss of normal CaSR-induced response to extracellular calcium is observed in cancers of the colon and ovary, while increased release of PTHrP is observed in cancers of the breast, prostate and Leydig cells. Currently CaSR can be considered as a molecule that can either promote or prevent tumor growth depending on the type of cancer. Therefore, recognition of the multifaceted role of CaSR in gliomas and other malignant tumors in general is fundamental to elucidating the mechanisms of tumor progression and the development of novel therapeutic agents. Emphasis should be placed on development of drug-targeting methods to modulate CaSR activity in cancer cells.
Keywords
CaSR; GPCR; metastasis; PTHrP; homeostasis; cancer cells;
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1 Ray K, Hauschild BC, Steinbach PJ, et al (1999). Identification of the cysteine residues in the amino-terminal extracellular domain of the human $Ca(^{2+})$ receptor critical for dimerization. Implications for function of monomeric $Ca(^{2+})$ receptor. J Biol Chem, 274, 27642-0.   DOI
2 Rey O, Chang W, Bikle D, et al (2012). Negative cross-talk between calcium-sensing receptor and beta-catenin signaling systems in colonic epithelium. J Biol Chem, 287, 1158-7.   DOI
3 Rodland KD (2004). The role of the calcium-sensing receptor in cancer. Cell Calcium, 35, 291-5.   DOI
4 Roodman GD (2001). Biology of osteoclast activation in cancer. J Clin Oncol, 19, 3562-1.   DOI
5 Roodman GD (2004). Mechanisms of bone metastasis. N Engl J Med, 350, 1655-4.   DOI
6 Rozengurt, E (2007). Mitogenic signaling pathways induced by G protein-coupled receptors. J Cell Physiol, 213, 589-602.   DOI
7 Ruat M, Molliver ME, Snowman AM, Snyder SH (1995). Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals. Proc Natl Acad Sci U S A, 92, 3161-5.   DOI
8 Saidak Z, Mentaverri R, Brown EM (2009). The role of the calcium-sensing receptor in the development and progression of cancer. Endocr Rev, 30, 178-5.   DOI
9 Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Brown EM (2001). $Ca(^{2+})$-sensing receptor expression and PTHrP secretion in PC-3 human prostate cancer cells. Am J Physiol Endocrinol Metab, 281, 1267-4.   DOI
10 Sanders JL, Chattopadhyay N, Kifor O, et al (2000). Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. Endocrinology, 141, 4357-4.   DOI
11 Saxena H, Deshpande DA, Tiegs BC, et al (2012). The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH. Br J Pharmacol, 166, 981-0.   DOI
12 Schneider A, Kalikin LM, Mattos AC, et al (2005). Bone turnover mediates preferential localization of prostate cancer in the skeleton. Endocrinology, 146, 1727-6.   DOI
13 Sellers TA, Bazyk AE, Bostick RM, et al (1998). Diet and risk of colon cancer in a large prospective study of older women: an analysis stratified on family history (Iowa, United States). CCC, 9, 357-7.
14 Squires PE, Harris TE, Persaud SJ, et al (2000). The extracellular calcium-sensing receptor on human beta-cells negatively modulates insulin secretion. Diabetes, 49, 409-7.   DOI
15 Sun YX, Schneider A, Jung Y, et al (2005). Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo. J Bone Miner Res, 20, 318-9.
16 Tetsu O, McCormick F (1999). Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature, 398, 422-6.   DOI   ScienceOn
17 Tfelt-Hansen J, Schwarz P, Terwilliger EF, et al (2003). Calciumsensing receptor induces messenger ribonucleic acid of human securin, pituitary tumor transforming gene, in rat testicular cancer. Endocrinology, 144, 5188-3.   DOI
18 Thomsen LL, Miles DW (1998). Role of nitric oxide in tumour progression: lessons from human tumours. Cancer Metastasis Rev, 17, 107-18.   DOI   ScienceOn
19 Tharmalingam S, Daulat AM, Antflick JE, et al (2011). Calciumsensing receptor modulates cell adhesion and migration via integrins. J Biol Chem, 286, 40922-33.   DOI
20 Theman TA, Collins MT (2009). The role of the calcium-sensing receptor in bone biology and pathophysiology. Curr Pharm Biotechnol, 10, 289-01.   DOI
21 VanHouten J, Dann P, McGeoch G, et al (2004). The calciumsensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. J Clin Invest, 113, 598-8.   DOI
22 Ward DT, Riccardi D (2012). New concepts in calcium-sensing receptor pharmacology and signalling. Br J Pharmacol, 165, 35-48.   DOI
23 Wargovich MJ, Jimenez A, McKee K, et al (2000). Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Carcinogenesis, 21, 1149-5.   DOI
24 Wong NA, Pignatelli M (2002). Beta-catenin--a linchpin in colorectal carcinogenesis? Am J Pathol, 160, 389-1.   DOI
25 Wu K, Willett WC, Fuchs CS, et al (2002). Calcium intake and risk of colon cancer in women and men. J Natl Cancer Inst, 94, 437-6.   DOI
26 Yano S, Macleod RJ, Chattopadhyay N, et al (2004). Calciumsensing receptor activation stimulates parathyroid hormonerelated protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation. Bone, 35, 664-2.   DOI   ScienceOn
27 Yin JJ, Pollock CB, Kelly K (2005). Mechanisms of cancer metastasis to the bone. Cell Res, 15, 57-62.   DOI
28 Adams GB, Chabner KT, Alley IR, et al (2006). Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature, 439, 599-3.   DOI   ScienceOn
29 Yin JJ, Selander K, Chirgwin JM, et al (1999). TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest, 103, 197-6.   DOI   ScienceOn
30 Zheng Y, Zhou H, Modzelewski JR, et al (2007). Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone. Cancer Res, 67, 9542-8.   DOI
31 Al-Haddad S, Zhang Z, Leygue E, et al (1999). Psoriasin (S100A7) expression and invasive breast cancer. Am J Pathol, 155, 2057-6.   DOI
32 Arnold A, Kim HG, Gaz RD, et al (1989). Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma. J Clin Invest, 83, 2034-0.   DOI
33 Auersperg N, Edelson MI, Mok SC, Johnson SW, Hamilton TC (1998). The biology of ovarian cancer. Semin Oncol, 25, 281-04.
34 Auersperg N, Maines-Bandiera SL, Dyck HG, Kruk PA (1994). Characterization of cultured human ovarian surface epithelial cells: phenotypic plasticity and premalignant changes. Lab Invest, 71, 510-8.
35 Bhagavathula N, Hanosh AW, Nerusu KC et al (2007). Regulation of E-cadherin and beta-catenin by $Ca^{2+}$ in colon carcinoma is dependent on calcium-sensing receptor expression and function. Int J Cancer, 121, 1455-2.   DOI
36 Bandyopadhyay S, Tfelt-Hansen J, Chattopadhyay N (2010). Diverse roles of extracellular calcium-sensing receptor in the central nervous system. J Neurosci Res, 88, 2073-2.   DOI
37 Barrett PQ, Kojima I, Kojima K, et al (1986). Short term memory in the calcium messenger system. Evidence for a sustained activation of protein kinase C in adrenal glomerulosa cells. Biochem J, 238, 905-2.   DOI
38 Bellahcene A, Castronovo V, Ogbureke KU, Fisher LW, Fedarko NS (2008). Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer. Nat Rev Cancer, 8, 212-26.   DOI
39 Bhagavathula N, Kelley EA, Reddy M, et al (2005). Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signalling in the regulation of growth and differentiation in colon carcinoma. Br J Cancer, 93, 1364-1.   DOI
40 Birchmeier W (1995). E-cadherin as a tumor (invasion) suppressor gene. Bioessays, 17, 97-9.   DOI
41 Birchmeier W, Behrens J (1994). Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta, 1198, 11-26.
42 Breitwieser GE (2012). Minireview: The Intimate Link Between Calcium Sensing Receptor Trafficking and Signaling: Implications for Disorders of Calcium Homeostasis. Mol Endocrinol.
43 Brembeck FH, Rosario M,and Birchmeier W. (2006). Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Current Opinion in Genetics & Development, 16, 51-9.   DOI   ScienceOn
44 Chakrabarty S, Radjendirane V, Appelman H, Varani J (2003). Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation. Cancer Res, 63, 67-1.
45 Brown EM, Gamba G, Riccardi D, et al (1993). Cloning and characterization of an extracellular $Ca(^{2+})$-sensing receptor from bovine parathyroid. Nature, 366, 575-0.   DOI
46 Brown EM, MacLeod RJ (2001). Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev, 81, 239-97.   DOI
47 Capiod T, Shuba Y, Skryma R, Prevarskaya N (2007). Calcium signalling and cancer cell growth. Sub-cellular biochemistry, 45, 405-27.   DOI
48 Chakrabarty S, Wang H, Canaff L, et al (2005). Calcium sensing receptor in human colon carcinoma: interaction with $Ca(^{2+})$ and 1,25-dihydroxyvitamin D(3). Cancer Res, 65, 493-8.
49 Chakravarti B, Dwivedi SK, Mithal A, Chattopadhyay N (2009). Calcium-sensing receptor in cancer: good cop or bad cop? Endocrine, 35, 271-84.   DOI
50 Chattopadhyay N (2006). Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy. Am J Physiol Endocrinol Metab, 290, 761-0.   DOI
51 Chattopadhyay N, Mithal A, Brown EM (1996). The calciumsensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism. Endocr Rev, 17, 289-07.
52 Chattopadhyay N, Ye C, Singh DP, et al (1997). Expression of extracellular calcium-sensing receptor by human lens epithelial cells. Biochem Biophys Res Commun, 233, 801-5.   DOI
53 Chikatsu N, Fukumoto S, Takeuchi Y, et al (2000). Cloning and characterization of two promoters for the human calciumsensing receptor (CaSR) and changes of CaSR expression in parathyroid adenomas. J Biol Chem, 275, 7553-7.   DOI
54 Chattopadhyay N, Ye CP, Yamaguchi T, et al (1998). Extracellular calcium-sensing receptor in rat oligodendrocytes: expression and potential role in regulation of cellular proliferation and an outward K+ channel. Glia, 24, 449-8.   DOI
55 Chattopadhyay N, Ye CP, Yamaguchi T, Vassilev PM, Brown EM (1999). Evidence for extracellular calcium-sensing receptor mediated opening of an outward $K^{+}$ channel in a human astrocytoma cell line (U87). Glia, 26, 64-2.   DOI
56 Cheng I, Klingensmith ME, Chattopadhyay N, et al (1998). Identification and localization of the extracellular calciumsensing receptor in human breast. J Clin Endocrinol Metab, 83, 703-7.   DOI
57 Cicek M, Oursler MJ (2006). Breast cancer bone metastasis and current small therapeutics. Cancer Metastasis Rev, 25, 635-4.
58 Coleman RE (1997). Skeletal complications of malignancy. Cancer, 80, 1588-4.   DOI
59 Cumano A and Godin I (2007). Ontogeny of the hematopoietic system. Annu Rev Immunol, 25, 745-85.   DOI
60 Deschenes C, Vezina A, Beaulieu JF, Rivard N (2001). Role of p27(Kip1) in human intestinal cell differentiation. Gastroenterology, 120, 423-38.   DOI
61 Dores MR, Trejo J (2012). Ubiquitination of GPCRs, Functional Implications and Drug Discovery. Mol Pharmacol.
62 Fagotto F, Funayama N, Gluck U, Gumbiner BM (1996). Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus. J Cell Biol, 132, 1105-4.   DOI
63 Drueke TB (2006). Haematopoietic stem cells--role of calciumsensing receptor in bone marrow homing. Nephrol Dial Transplant, 21, 2072-4.   DOI
64 Dvorak-Ewell MM, Chen TH, Liang N, et al (2011). Osteoblast extracellular $Ca^{2+}$ -sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res, 26, 2935-47.   DOI
65 Eaton CL, Coleman RE (2003). Pathophysiology of bone metastases from prostate cancer and the role of bisphosphonates in treatment. Cancer Treatment Reviews, 29, 189-8.   DOI
66 Fukumoto S (1998). [Localization and function of calciumsensing mechanism in bone cells]. Nihon Rinsho, 56, 1419-4.
67 Garland C, Shekelle RB, Barrett-Connor E, et al (1985). Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet, 1, 307-9.
68 Garrett JE, Capuano IV, Hammerland LG, et al (1995). Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs. J Biol Chem, 270, 12919-5.   DOI
69 George GP, Ramesh V, Mittal RD (2011). Impact of total and ionized serum calcium on prostate cancer risk in North Indian men. Asian Pac J Cancer Prev, 12, 1257-0.
70 Greenlee RT, Hill-Harmon MB, Murray T, Thun M (2001). Cancer statistics, 2001. CA: A Cancer J Clinicians, 51, 15-36.   DOI   ScienceOn
71 Hennings H, Holbrook K, Steinert P, Yuspa S (1980a). Growth and differentiation of mouse epidermal cells in culture: effects of extracellular calcium. Curr Probl Dermatol, 10, 3-25.
72 Grill V, Ho P, Body JJ, et al (1991). Parathyroid hormone-related protein: elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer. J Clin Endocrinol Metab, 73, 1309-5.   DOI
73 Gschwind A, Zwick E, Prenzel N, Leserer M, Ullrich A (2001). Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission. Oncogene, 20, 1594-0.   DOI
74 Haylock DN, Nilsson SK (2006). Osteopontin: a bridge between bone and blood. Br J Haematol, 134, 467-4.   DOI
75 Hennings H, Michael D, Cheng C, et al (1980b). Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell, 19, 245-4.   DOI   ScienceOn
76 Hofer AM, Brown EM (2003). Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol, 4, 530-8.   DOI
77 Holmbeck K, Bianco P, Chrysovergis K, Yamada S, Birkedal- Hansen H (2003). MT1-MMP-dependent, apoptotic remodeling of unmineralized cartilage: a critical process in skeletal growth. J Cell Biol, 163, 661-1.   DOI
78 House MG, Kohlmeier L, Chattopadhyay N, et al (1997). Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells. J Bone Miner Res, 12, 1959-70.   DOI
79 Imanishi Y, Nagata Y, Inaba M (2012). Parathyroid Diseases and Animal Models. Frontiers in Endocrinology, 3, 78.
80 Imbriaco M, Larson SM, Yeung HW, et al (1998). A new parameter for measuring metastatic bone involvement by prostate cancer: the Bone Scan Index. Clin Cancer Res, 4, 1765-2.
81 Kampman E, Slattery ML, Caan B, Potter JD (2000). Calcium, vitamin D, sunshine exposure, dairy products and colon cancer risk (United States). CCC , 11, 459-6.
82 Kingsley LA, Fournier PG, Chirgwin JM, Guise TA (2007). Molecular biology of bone metastasis. Mol Cancer Ther, 6, 2609-7.   DOI
83 Koeneman KS, Yeung F, Chung LW (1999). Osteomimetic properties of prostate cancer cells: a hypothesis supporting the predilection of prostate cancer metastasis and growth in the bone environment. Prostate, 39, 246-61.   DOI
84 Kuroda S, Fukata M, Nakagawa M, et al (1998). Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. Science, 281, 832-5.   DOI
85 Lala PK, Chakraborty C (2001). Role of nitric oxide in carcinogenesis and tumour progression. The lancet oncol, 2, 149-6.   DOI   ScienceOn
86 Lamprecht SA, Lipkin M (2003). Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat Rev Cancer, 3, 601-14.   DOI
87 Le Gall C, Bellahcene A, Bonnelye E, et al (2007). A cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden. Cancer Res, 67, 9894-2.   DOI
88 Liao J, Schneider A, Datta NS, McCauley LK (2006). Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis. Cancer Res, 66, 9065-3.   DOI
89 Lipkin M (1999). Preclinical and early human studies of calcium and colon cancer prevention. Ann N Y Acad Sci, 889, 120-7.   DOI
90 Liu J, Lv F, Sun W, et al (2011). The abnormal phenotypes of cartilage and bone in calcium-sensing receptor deficient mice are dependent on the actions of calcium, phosphorus, and PTH. PLoS Genet, 7, 1002294.
91 Mamillapalli R, VanHouten J, Zawalich W, Wysolmerski J (2008). Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells. J Biol Chem, 283, 24435-47.   DOI
92 McNeil SE, Hobson SA, Nipper V, Rodland KD (1998). Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium. J Biol Chem, 273, 1114-0.   DOI
93 Moon RT, Brown JD, Yang-Snyder JA, Miller JR (1997). Structurally related receptors and antagonists compete for secreted Wnt ligands. Cell, 88, 725-8.   DOI
94 Morin PJ (1999). beta-catenin signaling and cancer. Bioessays, 21, 1021-0.   DOI   ScienceOn
95 Morony S, Capparelli C, Sarosi I, et al (2001). Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis. Cancer Res, 61, 4432-6.
96 Motokura T, Bloom T, Kim HG, et al (1991). A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature, 350, 512-5.   DOI
97 Neudert M, Fischer C, Krempien B, et al (2003). Site-specific human breast cancer (MDA-MB-231) metastases in nude rats: model characterisation and in vivo effects of ibandronate on tumour growth. Int J Cancer, 107, 468-7.   DOI
98 Nilsson SK, Johnston HM, Coverdale JA (2001). Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches. Blood, 97, 2293-9.   DOI
99 Oka H, Shiozaki H, Kobayashi K, et al (1993). Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res, 53, 1696-1.
100 Nilsson SK, Johnston HM, Whitty GA, et al (2005). Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood, 106, 1232-9.   DOI   ScienceOn
101 Parkinson IH, Fazzalari NL (2003). Interrelationships between structural parameters of cancellous bone reveal accelerated structural change at low bone volume. J Bone Miner Res, 18, 2200-5.   DOI
102 Pignatelli M, Ansari TW, Gunter P, et al (1994). Loss of membranous E-cadherin expression in pancreatic cancer: correlation with lymph node metastasis, high grade, and advanced stage. J Pathol, 174, 243-8.   DOI   ScienceOn
103 Pin JP, Galvez T, Prezeau L (2003). Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol Ther, 98, 325-54.   DOI
104 Polyak K, Hamilton SR, Vogelstein B, Kinzler KW. (1996). Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia. Am J Pathol, 149, 381-7.
105 Prenzel N, Zwick E, Daub H, et al (1999). EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature, 402, 884-8.   DOI
106 Quaroni A, Tian JQ, Seth P, Ap Rhys C (2000). p27(Kip1) is an inducer of intestinal epithelial cell differentiation. Am J Physiol Cell Physiol, 279, 1045-57.
107 Ray JM, Squires PE, Curtis SB, Meloche MR, Buchan AM. (1997). Expression of the calcium-sensing receptor on human antral gastrin cells in culture. J Clin Invest, 99, 2328-3.   DOI