• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권5호
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• pp.411-422
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• 2020

With the increasing number of children with inflammatory bowel disease (IBD), very early-onset IBD (VEO-IBD), defined as IBD that is diagnosed or that develops before 6 years of age, has become a field of innovation among pediatric gastroenterologists. Advances in genetic testing have enabled the diagnosis of IBD caused by gene mutations, also known as monogenic or Mendelian disorder-associated IBD (MD-IBD), with approximately 60 causative genes reported to date. The diagnosis of VEO-IBD requires endoscopic and histological evaluations. However, satisfactory small bowel imaging studies may not be feasible in this small population. Both genetic and immunological approaches are necessary for the diagnosis of MD-IBD, which can differ among countries according to the available resources. As a result of the use of targeted gene panels covered by the national health insurance and the nationwide research project investigating inborn errors of immunity, an efficient approach for the diagnosis of MD-IBD has been developed in Japan. Proper management of VEO-IBD by pediatric gastroenterologists constitutes a challenge. Some MD-IBDs can be curable by allogenic hematopoietic stem cell transplantation. With an understanding of the affected gene functions, targeted therapies are being developed. Social and psychological support systems for both children and their families should also be provided to improve their quality of life. Multidisciplinary team care would contribute to early diagnosis, proper therapeutic interventions, and improved quality of life in patients and their families.

• 한국태양에너지학회 논문집
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• 제32권2호
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• pp.11-18
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• 2012

Diesel fuel is expensive because transportation to remote areas adds extra cost, and it causes air pollution by engine exhaust. Providing a feasible economical and environmental solution to diesel generators is important. A hybrid system of renewable plants and diesel generators can benefit islands or other isolated communities and increase fuel savings. Renewable energy is, however, a natural source that produces a fluctuating power output. In this paper, hybrid power system of the marado lighthouse is proposed to supply stable power in the stand-alone hybrid power system. The proposed hybrid power system consists of the diesel generator, wind turbine, photovoltaic, fuel cell, and battery bank. To decrease the carbon emissions and find the optimization, the cost analysis of hybrid system is simulated using HOMER program and the optimized hybrid power system is designed.

• Journal of Ship and Ocean Technology
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• 제8권2호
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• pp.41-60
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• 2004

Ship design process requires lots of complicated analyses for determining a large number of design variables. Due to its complexity, the process is divided into several tractable designs or analysis problems. The interdependent relationship requires repetitive works. This paper employs collaborative optimization (CO), one of the multidisciplinary design optimization (MDO) techniques, for treating such complex relationship. CO guarantees disciplinary autonomy while maintaining interdisciplinary compatibility due to its bi-level optimization structure. However, the considerably increased computational time and the slow convergence have been reported as its drawbacks. This paper proposes the use of an approximation model in place of the disciplinary optimization in the system-level optimization. Neural network classification is employed as a classifier to determine whether a design point is feasible or not. Kriging is also combined with the classification to make up for the weakness that the classification cannot estimate the degree of infeasibility. For the purpose of enhancing the accuracy of a predicted optimum and reducing the required number of disciplinary optimizations, an approximation management framework is also employed in the system-level optimization.

• Archives of Plastic Surgery
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• 제49권3호
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• pp.369-372
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• 2022

Reduction mammaplasty is the gold standard treatment for gigantomastia. We report one female patient with juvenile gigantomastia associated with severe pulmonary hypertension where her pulmonary pressure decreased significantly after the surgery, improving her quality of life. A 22-year-old female patient with gigantomastia since 10 years old, tricuspid regurgitation, and pulmonary thromboembolism antecedent was admitted to the emergency department. Her oxygen saturation was 89%. Acute heart failure management was initiated. An echocardiogram reported left ventricle ejection fraction (LVEF) of 70% with severe right heart dilation, contractile dysfunction, and arterial pulmonary pressure (PASP) of 110 mm Hg. A multidisciplinary team considered gigantomastia could generate a restrictive pattern, so a Thorek reduction mammoplasty with Wise pattern was performed. Presurgical measurements were: sternal notch to nipple-areola complex, right 59 cm, left 56 cm. Three days after surgery, the patient could breathe without oxygen support. In the outpatient follow-up, patient referred reduction of her respiratory symptoms and marked improvement in her quality of life. Six months after surgery, a control echocardiogram showed a LVEF of 62% and PASP of 85 mm Hg. Pulmonary hypertension may be present in patients with gigantomastia. Reduction mammoplasty may be a feasible alternative to improve the cardiac signs and symptoms in patients with medical refractory management.

• Earthquakes and Structures
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• 제8권6호
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• pp.1363-1386
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• 2015

The October 23 2011 Van Earthquake is studied from an earthquake engineering point of view. Strong ground motion processing was performed to investigate features of the earthquake source, forward directivity effects during the rupture process as well as local site effects. Strong motion characteristics were investigated in terms of peak ground motion and spectral acceleration values. Directiviy effects were discussed in detail via elastic response spectra and wide band spectograms to see the high frequency energy distributions. Source parameters and slip distribution results of the earthquake which had been proposed by different researchers were summarized. Influence of the source parameters on structural response were shown by comparing elastic response spectra of Muradiye synthetic records which were performed by broadband strong motion simulations of the earthquake. It has been emphasized that characteristics of the earthquake rupture dynamics and their effects on structural design might be investigated from a multidisciplinary point of view. Seismotectonic calculations (e.g., slip pattern, rupture velocity) may be extended relating different engineering parameters (e.g., interstorey drifts, spectral accelerations) across different disciplines while using code based seismic design approaches. Current state of the art building codes still far from fully reflecting earthquake source related parameters into design rules. Some of those deficiencies and recent efforts to overcome these problems were also mentioned. Next generation ground motion prediction equations (GMPEs) may be incorporated with certain site categories for site effects. Likewise in the 2011 Van Earthquake, Reverse/Oblique earthquakes indicate that GMPEs need to be feasible to a wider range of magnitudes and distances in engineering practice. Due to the reverse faulting with large slip and dip angles, vertical displacements along with directivity and fault normal effects might significantly affect the engineering structures. Main reason of excessive damage in the town of Erciş can be attributed to these factors. Such effects should be considered in advance through the establishment of vertical design spectra and effects might be incorporated in the available GMPEs.

• 국제교류와 융합교육
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• 제3권2호
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• pp.1-27
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• 2023

본 연구는 P 대학교의 일반대학원 교육학과의 현황과 문제점을 분석하여 일반대학원으로서의 교육학과의 발전방안을 탐색하는 것이다. 이를 위해 P 대학의 일반대학원 교육학과 수업에서 석박사 재학생들의 토의토론을 중심으로 일반대학원 교육학과의 발전 방향에 대한 선행연구와 P 대학의 일반대학원 교육학과의 운영 현황과 특이점 등을 종합적으로 분석하여 해당 대학 교육학과의 발전방안을 모색하였다. 연구 결과는 첫째, 구성원들의 비전 공유를 위해 일반대학원으로서의 교육학과의 목표와 정체성을 재정립할 필요가 있다. 둘째, 융·복합적 교육 문제해결에 적합하도록 학사 구조와 석·박사과정의 운영 체제의 변화를 고려할 필요가 있다. 셋째, 실제적 연구와 실천을 위하여 공동 연구와 공동 지도 및 프로젝트 내실화를 도모할 필요가 있다. 넷째, 구성원 간 개방적 네트워크와 국제화 및 실효성 높은 교육을 위한 대학원의 인적 및 물적 환경을 구축할 필요가 있다. 본 연구에서 도출한 발전방안들은 개별적으로 수행될 수 있는 것이 아니며, 교육학과의 체제 및 지원에 영향을 미치는 다양한 요소들 유기적인 관계를 고려하여 접근할 필요가 있다. 또한 일반대학원으로서의 교육학과의 발전을 위해서는 개별 구성원 또는 공동체적 차원에서 지속적인 노력을 이어가야 할 것이다.