• Title/Summary/Keyword: Multicomponent synthesis

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One-Pot Multicomponent Synthetic Route for New Quinolidinyl 2,4-Thiazolidinediones

  • Mali, Jyotirling R.;Bhosle, Manisha R.;Mahalle, Shital R.;Mane, Ramrao A.
    • Bulletin of the Korean Chemical Society
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    • v.31 no.7
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    • pp.1859-1862
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    • 2010
  • A convenient one-pot condensation route has been developed for obtaining 5-[(2-(piperidin-1-yl) quinolin-3-yl) methylene]-2,4-thiazolidinediones using multicomponents, 2-chloro-3-formyl quinolines, piperidine, 2,4-thiazolidinedione and safer medium/mediator, polyethylene glycol-400.

Facile and Convenient Synthesis and Characterization of Novel Schiff Bases Involving Heterocyclic Ring through One Pot Multicomponent Reactions under Mild Conditions (온화한 반응조건에서 One Pot 다성분 반응을 통해 이종원자고리를 포함한 새로운 시프염기의 쉽고 편리한 합성 및 특성)

An Efficient Synthesis of α-Amino-δ-valerolactones by the Ugi Five-Center Three-Component Reaction

  • Kim, Young-Bae;Park, Soo-Jung;Geum, Gyo-Chang;Jang, Min-Seok;Kang, Soon-Bang;Lee, Duck-Hyung;Kim, You-Seung
    • Bulletin of the Korean Chemical Society
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    • v.23 no.9
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    • pp.1277-1320
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    • 2002
  • A novel approach to ${\alpha}-amino-{\delta}-valerolactone$ derivatives 8 by the intramolecular Ugi five-center three-component reaction (U-5C-3CR) using the multifunctional starting material, L-pentahomoserine 5 is described.

CuI Nanoparticles as New, Efficient and Reusable Catalyst for the One-pot Synthesis of 1,4-Dihydropyridines

  • Safaei-Ghomi, Javad;Ziarati, Abolfazl;Teymuri, Raheleh
    • Bulletin of the Korean Chemical Society
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    • v.33 no.8
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    • pp.2679-2682
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    • 2012
  • A simple one-pot synthesis of two derivatives of 1,4-dihydropyridines has been described under reflux conditions using copper iodide nanoparticles (CuI NPs) as a catalyst in high yields. This method demonstrated four-component coupling reactions of aldehydes and ammonium acetate via two pathways. In one route, the reaction was performed using 2 eq ethyl acetoacetate while in the other one 1 eq ethyl acetoacetate and 1 eq malononitrile were used. The CuI NPs was reused and recycled without any loss of activity and product yield. It is noteworthy to state that wide range of the 1,4-dihydropyridines have attracted large interest due to pharmacological and biological activities.

One-Pot and Green Procedure for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-(thio)ones Using ZnO Nanoparticles as a Solid Acid Catalyst

  • Hassanpour, Akbar;Abolhasani, Jafar;Khanmiri, Rahim Hosseinzadeh
    • Journal of the Korean Chemical Society
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    • v.58 no.5
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    • pp.445-449
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    • 2014
  • A convenient and efficient method has been developed for the one-pot synthesis of dihydropyrimidinones (DHPMs) compounds. Dihydropyrimidinone derivatives were synthesized in good yields using ethyl acetoacetate, aldehyde (aromatic and aliphatic) and urea or thiourea in the presence of ZnO nanoparticles as a catalyst in $H_2O$ as solvent at $80^{\circ}C$. This green chemistry procedure applied to the Biginelli reaction using ZnO nanoparticles as catalyst and illustrated as a rapid preparation of DHPMs in water as solvent. The products were identified by physical data (mp) by comparison with those reported in the literatures.

Brønsted Acidic Ionic Liquids as Efficient Catalysts for Clean Synthesis of Carbamatoalkyl Naphthols

  • Tavakoli-Hoseini, Niloofar;Heravi, Majid M.;Bamoharram, Fatemeh F.;Davoodnia, Abolghasem
    • Bulletin of the Korean Chemical Society
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    • v.32 no.3
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    • pp.787-792
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    • 2011
  • Under mild conditions and without any additional organic solvent, synthesis of carbamatoalkyl naphthols could be carried out in the present of two halogen-free Br${\phi}$nsted acidic ionic liquids, 3-methyl-1-(4-sulfonic acid)butylimidazolium hydrogen sulfate and N-(4-sulfonic acid)butylpyridinium hydrogen sulfate. A wide range of aromatic aldehydes easily undergo condensation with $\beta$-naphthol and methyl or benzyl carbamate to afford the desired products of good purity in excellent yields. The present methodology offers several advantages such as a simple procedure with an easy work-up, short reaction times, and excellent yields. The catalysts could be recycled and reused for several times without substantial reduction in their catalytic activities.