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http://dx.doi.org/10.5012/jkcs.2014.58.5.445

One-Pot and Green Procedure for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-(thio)ones Using ZnO Nanoparticles as a Solid Acid Catalyst  

Hassanpour, Akbar (Department of Chemistry, Marand branch, Islamic Azad university)
Abolhasani, Jafar (Department of Chemistry, Tabriz branch, Islamic Azad university)
Khanmiri, Rahim Hosseinzadeh (Department of Chemistry, Shahid Beheshti University)
Publication Information
Journal of the Korean Chemical Society / v.58, no.5, 2014 , pp. 445-449 More about this Journal
Abstract
A convenient and efficient method has been developed for the one-pot synthesis of dihydropyrimidinones (DHPMs) compounds. Dihydropyrimidinone derivatives were synthesized in good yields using ethyl acetoacetate, aldehyde (aromatic and aliphatic) and urea or thiourea in the presence of ZnO nanoparticles as a catalyst in $H_2O$ as solvent at $80^{\circ}C$. This green chemistry procedure applied to the Biginelli reaction using ZnO nanoparticles as catalyst and illustrated as a rapid preparation of DHPMs in water as solvent. The products were identified by physical data (mp) by comparison with those reported in the literatures.
Keywords
Biginelli reaction; Multicomponent reaction; ZnO nanoparticles; Dihydropyrimidinone;
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