• Molecules and Cells
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• 제44권8호
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• pp.569-579
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• 2021

Cyclase-associated protein 2 (CAP2) has been addressed as a candidate biomarker in various cancer types. Previously, we have shown that CAP2 is expressed during multi-step hepatocarcinogenesis; however, its underlying mechanisms in liver cancer cells are not fully elucidated yet. Here, we demonstrated that endoplasmic reticulum (ER) stress induced CAP2 expression, and which promoted migration and invasion of liver cancer cells. We also found that the ER stress-induced CAP2 expression is mediated through activation of protein kinase C epsilon (PKCε) and the promotor binding of activating transcription factor 2 (ATF2). In addition, we further demonstrated that CAP2 expression promoted epithelial-mesenchymal transition (EMT) through activation of Rac1 and ERK. In conclusion, we suggest that ER stress induces CAP2 expression promoting EMT in liver cancer cells. Our results shed light on the novel functions of CAP2 in the metastatic process of liver cancer cells.

• Journal of Welding and Joining
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• 제34권4호
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• pp.28-33
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• 2016

The purpose of this study is to evaluate the redistribution of transverse residual stress in the multi-pass FCA butt weld of YP47 in the hatch coaming top plate of ultra large size containership under the tensile cyclic load. In order to do it, the configuration of modified H type specimen including restraint length was first designed to simulate the restraint condition of the butt weld in hatch coaming top plate. FE analysis procedure for evaluating the transverse residual stress was verified by comparing the calculated mean and surface residual stresses with the measured results in the test specimen. After that, the effect of the cyclic load on the redistribution of transverse residual stress was evaluated by comprehensive FEA. From the results, it was found that although the maximum transverse residual stress decreased with an increase in the applied maximum load, the effect of the cyclic load on the mean residual stress is small enough to be negligible. It is because the maximum stress of the ship corresponding to the probability of 10E-8 is less than 70% of yield stress of the weld.

• 한국가족복지학
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• 제23권4호
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• pp.595-611
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• 2018

The purpose of this study was to examine the moderating effects of interpersonal competence on the effects of academic stress on happiness of adolescents. For this research a survey on academic stress, interpersonal competence, and happiness was conducted with a total 487 high school students living in Daegu city. The collected data was statically processed by using SPSS 20.0 according to frequency, descriptive statistics, and multi regression analysis. The main results can be summarized as follow. First, Academic stress affected the adolescents' happiness. The higher the level of academic stress was, the smaller the adolescent's happiness. second, between academic stress and happiness, conflict management and disclosing personal information played a moderating role to reducing the academic stress. That is, it was confirmed that interpersonal competence played a moderating role on the effect that academic stress had on adolescent happiness. In conclusion, this study can be practically applied as basic information to increase happiness on adolescents. In addition, the results provided valuable insights for developing program the intervene for adolescents' happiness.

• Journal of Welding and Joining
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• 제15권4호
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• pp.70-77
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• 1997

Welding is one of the most important and popular joining techniques employed in structures. In spite of, weld designs depend on the rules and regulations. Moreover, the study to optimize a shape of welding joint not may be sufficient and systematic on the theoretical and experimental sides. Therefore, in this study, a computer program based on thermal elasto plastic theory is developed for optimizing(minimizing) shape of weld joints. By the results, study is made on the characteristics of the distributions of welding residual stresses and plastic strains, and their production mechanisms. Also, Various kinds of tests are carried out to find out mechanical characteristics due to shape of weld joints. As a result of this optimization(minimization) of weld joints, the productivity and the reliability will be improved.

• Journal of Welding and Joining
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• 제13권1호
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• pp.138-144
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• 1995

Recently, as the industrial structure tends to become large, the thickness of structural plate becomes thicker. Therefore, the thicker the plate of welded structure is, the larger the shape of welded joint. The effect of large heat input makes large heat affected zone(HAZ). These bring to complict welding residual stress and to weaken material, which may cause extremely harm to the safety of structures. Nevertheless, welding is design is regulated by the KS, JIS or standard in the resister of shipping such as KR, ABS or LR. However, these rules are based on rather experimental than theoretical. In this study, the computer program of heat conduction, considering un-steady state and quasi-steady state, is developed for optimizing(minimizing) a shape of welded joint. The characteristics of heat on the welded joints with various shapes are clarified by the results of the analyses.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2014년도 춘계학술대회 논문집
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• pp.588-595
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• 2014

In this paper, analysis of the vibration Characteristic for the Mine Detectable Test Platform is described. The test platform system is the multi-sensor mine detectable vehicle. This multi-sensor mine detectable unit is more efficient detection performance than other conventional methods. The test platform system has five subsystems, the UWB(Ultra Wide Band) sensor scanner, the MD(Metal Detector) sensor scanner, the neutron sensor scanner, and the detectable vehicle. We perform the vibration tests for the test platform and analyze the vibration characteristic, such as the max displacement, the max deformation and the max Von-Misses Stress.

• Computers and Concrete
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• 제7권4호
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• pp.303-315
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• 2010

In this paper, we present a new finite Timoshenko beam element with a model for ultimate load computation of reinforced concrete frames. The proposed model combines the descriptions of the diffuse plastic failure in the beam-column followed by the creation of plastic hinges due to the failure or collapse of the concrete and or the re-bars. A modified multi-scale analysis is performed in order to identify the parameters for stress-resultant-based macro model, which is used to described the behavior of the Timoshenko beam element. The micro-scale is described by using the multi-fiber elements with embedded strain discontinuities in mode 1, which would typically be triggered by bending failure mode. A special attention is paid to the influence of the axial force on the bending moment - rotation response, especially for the columns behavior computation.

• 한국군사과학기술학회지
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• 제14권1호
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• pp.92-99
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• 2011

In this study, new multi-axial, critical plane based, fretting fatigue crack initiation parameter is developed by the addition of a new term into the Modified Shear Stress Range(MSSR) parameter. The newly developed parameter (MSSR') is then used to evaluate fretting fatigue life of titanium alloy, Ti-6A1-4V with various contact conditions. Finite element analysis is also used in order to obtain stress distribution on the contact surface during fretting fatigue test, which is then used for the calculation of fretting fatigue parameter. The MSSR' parameter shows better performance in predicting fretting fatigue lives from the conventional fatigue data, and less scattering within fretting fatigue data with different contact geometries.

• 한국초전도ㆍ저온공학회논문지
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• 제3권2호
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• pp.1-4
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• 2001

For the practical use of a superconducting wire to magnet application, it is important to assess the Young modulus and other mechanical properties of HTS tapes. In order to establish a test method of mechanical properties for oxide composite superconductors. tensile tests of Bi-2223 multi- filamentary tapes were carried out at room temperature, as an activity of the International round robin test proposed by the committee of VAMAS/TWA 16-Subrgroup. The tapes consisting of mutli-filamentary showed a three stage tensile behavior. At the initial stage of the stress-streain curve. The elastic deformation existed in a quite nattrow strain region. But the plastic deformation was observed in a wide strain region due to the platic flow of the Ag alloy matrix. The results of RRT were also reported and discussed.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2005년도 추계 학술발표회 제17권2호
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• pp.591-594
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• 2005

Concrete structure that has been constructed in real field is on multi-axial stress state condition. After placing of concrete, hydration heat and shrinkage of concrete can cause various stress conditions with respect to the restraint level and condition. So, to predict the early age behavior of concrete structure, multi-axial material model is required and microplane model is acceptable. Recently, many studies have been performed on the microplane model, but the model developed up to now has been related to hardened concrete that material property is constant with concrete age. So, it is inappropriate to apply this model immediately to analyze the early age behavior of concrete. In this study, microplane model that can predict early age behavior of concrete was developed and cracking analysis using that was performed to describe cracking behavior for massive concrete sturucture.