• Title/Summary/Keyword: Multi-functional groups

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Analysis on the Temperature of Multi-core Processors according to Placement of Functional Units and L2 Cache (코어 내부 구성요소와 L2 캐쉬의 배치 관계에 따른 멀티코어 프로세서의 온도 분석)

  • Son, Dong-Oh;Kim, Jong-Myon;Kim, Cheol-Hong
    • Journal of the Korea Society of Computer and Information
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    • v.19 no.4
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    • pp.1-8
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    • 2014
  • As cores in multi-core processors are integrated in a single chip, power density increased considerably, resulting in high temperature. For this reason, many research groups have focused on the techniques to solve thermal problems. In general, the approaches using mechanical cooling system or DTM(Dynamic Thermal Management) have been used to reduce the temperature in the microprocessors. However, existing approaches cannot solve thermal problems due to high cost and performance degradation. However, floorplan scheme does not require extra cooling cost and performance degradation. In this paper, we propose the diverse floorplan schemes in order to alleviate the thermal problem caused by the hottest unit in multi-core processors. Simulation results show that the peak temperature can be reduced efficiently when the hottest unit is located near to L2 cache. Compared to baseline floorplan, the peak temperature of core-central and core-edge are decreased by $8.04^{\circ}C$, $8.05^{\circ}C$ on average, respectively.

Effect of Stem Cell Transplantation on Pain Behavior and Locomotor Function in Spinal Cord Contusion Model

  • Park, Hea-Woon;Kim, Su-Jeong;Cho, Yun-Woo;Hwang, Se-Jin;Lee, Won-Yub;Ahn, Sang-Ho;Jang, Sung-Ho
    • The Journal of Korean Physical Therapy
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    • v.22 no.3
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    • pp.79-85
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    • 2010
  • Purpose: Many trials for new therapeutic approaches such as stem cell-based transplantation have been conducted to improve the repair and regeneration of injured cord tissue and to restore functions following spinal cord injury (SCI) in animals and humans. Adipose tissue-derived stromal cells (ATSCs) have multi-lineage potential to differentiate into cells with neuron-like morphology. Most studies of stem cell transplantation therapy after SCI are focused on cellular regeneration and restoration of motor function, but not on unwanted effects after transplantation such as neuropathic pain. This study was focused on whether transplantation of ATSCs could facilitate or attenuate hindpaw pain responses to heat, cold and mechanical stimulation, as well as on improvement of locomotor function in a rat with SCI. Methods: A spinal cord injury rat model was produced using an NYU impactor by dropping a 10 g rod from a height of 25 mm on to the T9 segment. Human ATSCs (hATSCs; approximately $5{\times}10^5$ cells) or DMEM were injected into the perilesional area 9 days after the SCI. After transplantation, hindpaw withdrawal responses to heat, cold and mechanical allodynia were measured over 7 weeks. Motor recovery on the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale and on the inclined plane test were also evaluated. Results: The present study demonstrated that increased hindpaw withdrawal responses to cold allodynia was observed in both groups after transplantation, but the development of cold-induced allodynia in the hATSC transplantation group was significantly larger than in the control group. The difference between the two groups in locomotor functional improvement after SCI was also significant. Conclusion: Careful consideration not only of optimal functional benefits but also of unintended side effects such as neuropathic pain is necessary before stem cell transplantation therapy after SCI.

Psychosocial Characteristics and Quality of Life in Patients with Functional Gastrointestinal Disorder (기능성위장질환 환자들의 정신사회적 특성과 삶의 질)

  • Lee, Dong-Ho;Lee, Sang-Yeol;Ryu, Han-Seung;Choi, Suck-Chei;Yang, Chan-Mo;Jang, Seung-Ho
    • Korean Journal of Psychosomatic Medicine
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    • v.28 no.1
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    • pp.20-28
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    • 2020
  • Objectives : The aim of this study was to compare psychosocial characteristics of the functional gastrointestinal disorders FGID group, non-FGID group, and control group and determine factors affecting the QOL of patients with FGID. Methods : 135 patients diagnosed with FGID were selected. 79 adults had no observable symptoms of FGID (control group) and 88 adults showed symptoms of FGID (non-FGID group). Demographic factors were investigated. The Korean-Beck Depression Inventory-II, Korean-Beck Anxiety Inventory, Korean-Childhood Trauma Questionnaire, Multidimensional Scale of Perceived Social Support, Connor-Davidson Resilience Scale, Patient Health Questionnaire-15 and WHO Quality of Life Assessment Instrument Brief Form were used to assess psychosocial factors. A one-way ANOVA was used to compare differences among groups. Pearson correlation test was performed to analyze the correlation of psychosocial factors and QOL of the FGID group. Further, a hierarchical regression analysis was conducted to determine factors affecting the QOL of the FGID group. Results : Between-group differences were not significant in demographic characteristics. Depression (F=48.75, p<0.001), anxiety (F=14.48, p<0.001), somatization (F=24.42, p<0.001) and childhood trauma (F=12.71, p<0.001) were significantly higher in FGID group than in other groups. Social support (F=39.95, p<0.001) and resilience (F=17.51, p<0.001) were significantly lower in FGID group than in other groups. Resilience (β=0.373, p<0.01) was the most important explanatory variable. The explained variance was 47.2%. Conclusions : Significantly more symptoms of depression, anxiety, childhood trauma, and somatization were observed for the FGID group. This group also had less social support, resilience, and quality of life than the non-FGID and control groups. The key factor for quality of life of the FGID group was resilience.

The Effects of Weighted Vest During Task-Oriented Training on Gross Motor Performance and Balance Abilities of Children With Spastic Diplegia : A Randomized Clinical Trial Study (경직형 양마비 아동의 과제지향훈련 시 무게조끼 적용이 대동작 수행력과 균형 능력에 미치는 영향: 무작위배정 위약비교 연구)

  • Kwon, Hae-Yeon
    • The Journal of Korean Academy of Sensory Integration
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    • v.15 no.2
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    • pp.46-65
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    • 2017
  • Objective : The purpose of this research is to find clinical effects of application of weighted vest during task-oriented training focused on gross motor performance and balance abilities of children with spastic diplegia. Methods : 34 subjects were divided by simple random sampling into two groups; experimental group (male : 9, female : 8, average age : 8.12) and placebo group (male : 9, female : 9, average age : 7.53). Both two groups underwent to 40 minute intervention, twice a week for 12 weeks. The intervention was task-oriented training focused on facilitating closed kinematic chain and multi-joint functional movement pattern. During the training, the experimental group received loaded-resistance weighted vest and placebo group also received weighted vest but without loaded-resistance. Participants in both groups underwent 8 to 10 reps of the task-oriented training and there were 3 minutes break time between tasks. There were pre-test of gross motor performance and balance abilities, and two times of post-tests were performed upon 6 weeks and 12 weeks after the intervention completed. And in final, an additional follow-up test was performed 12 weeks after the evaluation was finished in order to find any difference between the two groups over time. Results : There was significant difference in Gross Motor Performance Measure (GMPM) between two groups. It is found that average score of the experimental group increased more than the placebo group after 6 weeks and 12 weeks intervention (p<.05). There was significant difference in Pediatric Berg's Balance Scale (PBS) between two groups. It is found that average score of the experimental group increased more than the placebo group after 6 weeks and 12 weeks intervention (p<.05). Conclusion : Based on the results in this study, it is proposed that application of weighted vest into task-oriented training to facilitating closed kinematic chain and multi-joint movement can improve gross motor performance and balance abilities of children with cerebral palsy.

Traffic Control using Multi Rule-Base in an ATM Network (ATM 네트워크에서 멀티 룰-베이스 기법을 이용한 트래픽 제어)

  • Kim, Young-Il;Ryoo, In-Tae;Shim, Cheul;Lee, Sang-Bae
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.18 no.12
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    • pp.1870-1883
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    • 1993
  • In this paper, in order to build up the User Network Interface based on ATM, a study on traffic control techniques which should be performed by main function groups-B 75,5 NT2, LEX-is discussed. The structure of B-NT2 which is the most important function group In the User Network Interface is defined in quite a simple manner in addition, the functional blocks of LEX are defined in a similar manner as those of B NT2. It is possible to distribute total traffic control functions by using the similarities between B-NT2 and LEX and by allocating virtual path identifiers fixedly according to the characteristics of the traffics. For the traffic control techniques of ATM, relations among Connection Admtsslon Control, Usage Parameter Control and Bandwidth Allocation Control are defined and Multi Rule Base structure to realize optimal control functions according to the characteristics of the source traffics is proposed. And the Real-time Variable Window algorithmsimply designed to be suitable for the Multi Rule Base architecture is also proposed. The performances of the proposed algorithm are analyzed through the computer simulation by generating on-off source traffic in a virtual system that has the form of the proposed hardware. The analyzed results show that the distributed control is possible and that the implementation of the proposed architecture and algorithm is possible.

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Colonization and community changes in benthic macroinvertebrates in Cheonggye Stream, a restored downtown stream in Seoul, Korea

  • Shin, Il-Kwon;Yi, Hoon-Bok;Bae, Yeon-Jae
    • Journal of Ecology and Environment
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    • v.34 no.2
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    • pp.175-191
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    • 2011
  • Colonization patterns and community changes in benthic macroinvertebrates in the Cheonggye Stream, a functionally restored stream in downtown Seoul, Korea, were studied from November 2005 to November 2007. Benthic macroinvertebrates were quantitatively sampled 15 times from five sites in the stream section. Taxa richness (59 species in total) increased gradually over the first year, whereas the density revealed seasonal differences with significantly lower values in the winter season and after flood events. The benthic macroinvertebrate fauna may have drifted from the upstream reaches during floods and from the Han River, arrived aerially, or hitchhiked on artificially planted aquatic plants. Oligochaeta, Chironommidae, Psychodidae, and Hydropsychidae were identified as major community structure contributors in the stream. Swimmers and clingers colonized relatively earlier in the upper and middle reaches, whereas burrowers dominated particularly in the lower reaches. Collector-gatherers colonized at a relatively early period throughout the stream reaches, and collector-filterers, such as the net-spinning caddisfly (Cheumatopyche brevilineata), predominated in the upper and middle reaches after a 1-year time period. Cluster analyses and multi-response permutation procedures demonstrated that the Cheonggye Stream shares more similarities with the Jungnang Stream than with the Gapyeong Stream. Detrended correspondence analysis and nonmetric multidimensional scaling demonstrated that physical environmental factors (depth, current velocity, dissolved oxygen, and pH) as well as nutrients (total nitrogen and total phosphorous), water temperature, and conductivity could affect the distribution of benthic macroinvertebrates in the study streams.

Verification of lavender(Lavandula angustifolia cv.Hidcote) and lawn(Zoysia japonica Steud.)'s Curative Effect, as a Green Space Composition Factor (녹지구성 인자로써 라벤더(Lavandula angustifolia cv.Hidcote)와 잔디(Zoysia japonica Steud.)의 치유적 효과)

  • Yutaka, Iwasaki;Kim, Yu-Yeong;Cho, Tae-Dong
    • Journal of Environmental Science International
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    • v.21 no.12
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    • pp.1487-1494
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    • 2012
  • This study has been carried out to verify curative effect of lavender and lawn, a green space composition factor. Thus, the physiological index value of blood pressure, heart rate and salivary amylase were measured with object of 16 women in their 20~30s for stress relaxation effect at lavender garden and lawn square, and impression assessment upon SD method as for psychological value was performed in this study. And a survey was conducted on necessity and reason of urban green space with object of 345 men and women urban workers. As a result of variance analysis between groups and multi test of Turkey upon object place, the blood pressure was lowered the same at lavender garden and lawn square, and especially, high blood pressure was greatly lowered to 30 mmHG at lavender garden. On the other hand, low blood pressure group showed the tendency of a little increasing at the same places. And for the pulse, there was difference between high blood pressure group and normal group at the same places. To conclude, at lavender garden and lawn square the blood pressure was made to be lowered when it's high, and when it's low, the effect of returning to sound status, the function of increasing, was verified. In case of impression assessment upon SD method, the lawn square was assessed as resting place and lavender garden diversional place. And over 90% of urban workers responded to the green space's necessity and curative effect, diversion and resting place were adopted for the reason in high-ranking items. As above the green space pattern that urban workers require and curative effect of lavender garden and lawn square were verified. Therefore, the functional green space plan is required, which curative effect, diversion and resting place are considered, for the future green space plan design.

Perfusion-Weighted MRI Parameters for Prediction of Early Progressive Infarction in Middle Cerebral Artery Occlusion

  • Kim, Hoon;Kim, Yerim;Kim, Young Woo;Kim, Seong Rim;Yang, Seung Ho
    • Journal of Korean Neurosurgical Society
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    • v.59 no.4
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    • pp.346-351
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    • 2016
  • Objective : Early progressive infarction (EPI) is frequently observed and related to poor functional outcome in patients with middle cerebral artery (MCA) infarction caused by MCA occlusion. We evaluated the perfusion parameters of magnetic resonance imaging (MRI) as a predictor of EPI. Methods : We retrospectively analyzed patients with acute MCA territory infarction caused by MCA occlusion. EPI was defined as a National Institutes of Health Stroke Scale increment ${\geq}2$ points during 24 hours despite receiving standard treatment. Regional parameter ratios, such as cerebral blood flow and volume (rCBV) ratio (ipsilateral value/contralateral value) on perfusion MRI were analyzed to investigate the association with EPI. Results : Sixty-four patients were enrolled in total. EPI was present in 18 (28%) subjects and all EPI occurred within 3 days after hospitalization. Diabetes mellitus, rCBV ratio and regional time to peak (rTTP) ratio showed statically significant differences in both groups. Multi-variate analysis indicated that history of diabetes mellitus [odds ratio (OR), 6.13; 95% confidence interval (CI), 1.55-24.24] and a low rCBV ratio (rCBV, <0.85; OR, 6.57; 95% CI, 1.4-30.27) was significantly correlated with EPI. Conclusion : The incidence of EPI is considerable in patients with acute MCA territory infarction caused by MCA occlusion. We suggest that rCBV ratio is a useful neuro-imaging parameter to predict EPI.

Fabrication of Fluorescent Labeled Bi-compartmental Particles via the Micromolding Method (미세 성형 방법을 이용한 형광 표지된 이중 분획 입자의 제조)

  • Shim, Gyurak;Jeong, Seong-Geun;Hong, Woogyeong;Kang, Koung-Ku;Lee, Chang-Soo
    • Korean Chemical Engineering Research
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    • v.56 no.6
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    • pp.826-831
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    • 2018
  • This study presents fabrication of bi-compartmental particles labeled by multiple fluorescence. To compartmentalize fluorescent expression at the particle, two fluorescent dyes with less overlap of the excitation and emission spectra are selected. To ensure the fluorescence stability, the fluorescent dyes contain acrylate functional groups in the molecules so that they can be cross-linked together with monomers constituting the particle. Strong fluorescent expression and compartmentalization were observed at the particle fabricated using the selected fluorescent dyes through confocal microscopy. Furthermore, long-term fluorescence stability was verified by measuring fluorescent expression and intensity for 4 weeks. We anticipate that the bi-compartmental particles labeled by multiple fluorescence can be widely used for multi-target drug delivery system, analysis of 3 dimensional Brownian motion, and investigation of 3 dimensional complex self-assembled morphologies.

Review on Graphene Oxide-based Nanofiltration Membrane (산화그래핀 기반 나노여과막의 최신 연구동향)

  • Kim, Dae Woo
    • Membrane Journal
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    • v.29 no.3
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    • pp.130-139
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    • 2019
  • Various two-dimensional nano materials such as graphene, zeolite, and metal-organic framework have been utilized to develop an ultra-thin high-performance membrane for water purification, gas separation, and so on. Particularly, in the case of graphene oxide, synthesis methods and thin film coating techniques have been accumulated and established since early 2000s, therefore graphene oxide has been rapidly applied to membrane field. The multi-layered graphene oxide thin film can filter molecules separately by the molecular sieving of interlayer spacing between adjacent layers, and it is also possible to separate various materials depending on the surface functional groups or the degree of interaction to intercalated materials. This review mainly focuses on the nanofiltration application of graphene oxide. The major factors affecting the separation performance of graphene oxide membrane in solvent are summarized and other technical elements required for the commercialization of graphene oxide membranes will be discussed including stability issue and fabrication method.