• Journal of Life Science
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• v.24 no.8
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• pp.820-826
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• 2014

The localization to specific subcellular sites and the regulation of cell surface receptors and channels are crucial for proper functioning. Postsynaptic density-95/Disks large/Zonula occludens-1 (PDZ)-domain is involved in recognition of and interaction between various proteins, by which the localization and the regulation are mediated. Multi-PDZ domain protein 1 (MUPP1) contains 13 PDZ domains. MUPP1 serves a scaffolding function for structure proteins and signaling proteins, but the mechanism how MUPP1 is stabilized and signalized has not yet been elucidated. We used the yeast two-hybrid system to identify proteins that interact with PDZ domains of MUPP1. We found an interaction between MUPP1 and Parkin. Parkin is an E3 ubiquitin ligase. Loss-of-function mutations of Parkin gene are known to cause an autosomal recessive juvenile parkinsonism. Parkin bound to the $12^{th}$ PDZ domain, but not to other PDZ domains of MUPP1. The C-terminal end of Parkin has a type II PDZ-association motif, which was essential for the interaction with MUPP1 in the yeast two-hybrid assay. When co-expressed in HEK-293T cells, Parkin co-localized with MUPP1. When co-expressed with ubiquitin in HEK-293T cells, MUPP1 has been strongly ubiquitinated by Parkin. These findings collectively suggest that MUPP1 is a novel substrate of Parkin and its function or stability could be modulated by Parkin-mediated ubiquitination.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.9
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• pp.7-13
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• 2009

This paper presents a multi-channel transceiver that achieves a data rate of 3.125Gb/s/ch. The LVDS is used because of its noise immunity and low power consumption. And a pre-emphasis circuit is also proposed to increase the transmitter speed. On the receiver side, a low-power CDR(clock and data recovery) using 1/4-rate clock based on dual-interpolator is proposed. The CDR generates needed additional clocks in each recovery part internally using only inverters. Therefore each part can be supplied with the same number of 1/4-rate clocks from a clock generator as in 1/2-rate clock method. Thus, the reduction of a clock frequency relaxes the speed limitation and lowers power dissipation. The prototype chip is comprised of two channels and was fabricated in a $0.18{\mu}m$ standard CMOS process. The output jitter of transmitter is loops, peak-to-peak(0.31UI) and the measured recovered clock jitter is 47.33ps, peak-to-peak which is equivalent to 3.7% of a clock period. The area of the chip is $3.5mm^2$ and the power consumption is about 119mW/ch.

• Journal of the Korean Association of Geographic Information Studies
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• v.12 no.1
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• pp.1-11
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• 2009

Rapid visualization of flood area of downstream according to the dam effluent in flood season is very important in dam management works. Overlay zone of river bight should be removed to represent flood area efficiently based on flood stage which was modeled in river channels. This study applied drainage enforcement algorithm to visualize flood area considering river bight by coupling Coordinate Operation System for Flood control In Multi-reservoir (COSFIM) and Flood Wave routing model (FLDWAV). The drainage enforcement algorithm is a kind of interpolation which gives to advantage into hydrological process studies by removing spurious sinks of terrain in automatic drainage algorithm. This study presented mapping technique of flood area layer considering river bight in Namgang-Dam downstream, and developed system based on Arcobject component to execute this process automatically. Automatic extraction system of flood area layer could save time-consuming efficiently in flood inundation visualization work which was propelled based on large volume data. Also, flood area layer by coupling with IKONOS satellite image presented real information in flood disaster works.

• Journal of Broadcast Engineering
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• v.19 no.6
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• pp.767-788
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• 2014

The worldwide transition from analog to digital broadcasting has now been completed and the need to study next generation standards for Ultra High Definition TV (UHDTV) broadcasting, and broadcasting & communication convergence systems is rapidly growing. In particular, high resolution mobile broadcasting services are needed to satisfy recent consumers. Therefore, the development of highly efficient convergence broadcasting systems that provide fixed/mobile broadcasting through a single channel is needed. In this paper, a service scenario and requirements for providing 4K UHD & HD convergence broadcasting services through a terrestrial single channel are analyzed by employing the latest transmission and A/V codec technologies. Optimized transmission parameters for 6 MHz & 8 MHz terrestrial bandwidths are drawn, and receiving performances are measured under Additive White Gaussian Noise (AWGN) and time-varying multipath channels. From the results, in a 6 MHz bandwidth, the reliable receiving of HD layer data can be achieved when the receiver velocity is maximum 140 Km/h and is not achieved when the velocity is over 140 Km/h due to the limit of bandwidth. When the bandwidth is extended to 8 MHz, the reliable receiving of both 4K UHD and HD layer data is achieved under a very fast fading multipath channel.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.6
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• pp.356-362
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• 2019

Scutellaria baicalensis (SB) has widely used in the treatment for various brain diseases in the field of Oriental medicine. Biofermantation of SB can make major chemical constituents of SB to pass blood-brain barrier easily and to have more potent anti-oxidant ability. There is a little information about the contribution of fermented SB (FSB) to the formation or maintenance of the neural plasticity in the hippocampus. The purpose of this study was to evaluate effects of FSB extract on hydrogen peroxide (H₂O₂) - induced impairments of the induction and maintenance of long-term potentiation (LTP), an electrophysiological marker for the neural plasticity in the hippocampus. From hippocampal slices of rats, the field excitatory postsynaptic potentials (fEPSPs) were evoked by the electrical stimulation to the Schaffer collaterals - commissural fibers in the CA1 areas and LTP by theta-burst stimulation by using 64 - channels in vitro multi-extracellular recording system. In order to induce oxidative stress to hippocampal slices two different concentrations (200, 400 μM) of H₂O₂ were given to the perfused aCSF before and after the LTP induction, respectively. The ethanol extract of FBS with concentration of 25 ㎍/ml, 50 ㎍/ml was diluted in perfused aCSF that had 200 μM H₂O₂, respectively. Oxidative stress by the treatment of H₂O₂ resulted in decrease of the induction rate of LTP in the CA1 area with a dose - dependent manner. However, the ethanol extract of FSB prevented the reduction of the induction rate of LTP caused by H₂O₂ - induced oxidative stress with a dose - dependent manner. These results may support a potential application of FSB to ameliorate impairments of hippocampal dependent neural plasticity or memory caused by oxidative stress.

• The Korean Journal of Applied Statistics
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• v.33 no.2
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• pp.215-228
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• 2020

Under Article 19, Paragraph 1 of the Food Industry Promotion Act, Rural Development Administration renews the Korean foods composition table every five years. Before the publication of the tenth revision of the Korean foods composition table in 2021, this paper suggests methods for collecting representative samples of 182 highly consumed foods in Korea. Food markets are categorized by their distribution channels, which are supermarkets and local markets. Eight samples are collected from each category by applying the National Food and Nutrient Analysis Program (NFNAP)'s stratified multi-stage sampling. The NFNAP was implemented in 1997 as a collaborative food composition research effort between the National Institute of Health (NIH) and the US Department of Agriculture (USDA) to secure reliable estimates for the nutrient content of food and beverages consumed by the US population. Selected supermarkets for selecting representative food samples are Emart Kayang, Homeplus Siheung, Lottemart Dongducheon, Emart Suwon, Lottemart Dunsan, Lottemart Yeosu, Emart Ulsan, and Hanaroclub Ulsan. Selected local markets also are Doksandongusijang in Geumcheon-gu and Pungnapsijang in Songpa-gu, Seoul, Ilsansijang in Ilsanseo-gu, Goyang, Unamsijang in Buk-gu, Gwangju, Beopdongsijang in Daedeok-gu, Daejeon, Bongnaesijang in Yeongdo-gu and Jwadongjaeraesijang in Haeundae-gu, Busan, and Jungangsijang in Jinhae-gu, Changwon.

• Journal of Broadcast Engineering
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• v.14 no.4
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• pp.518-536
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• 2009

To verify the performance of a Distributed Translator Network(DTxR) system in the real world conditions, 5 legacy DTV broadcasting repeater sites were implemented with 5 DTxR systems and field-tested by the DTV field test truck. The 4 DTV broadcasting repeater sites are selected in congested areas where their service areas are overlapped and the 5th site is deviated from the other sites to examine the effect of long-delayed multipath signals. First of all, we checked the receiving signal of the main station that used as a transmitting signal in 5 DTxR systems on the pre-selected 60 test points and tested every case of a DTxR system's on & off except 1 repeater site due to the already built-in DTV repeater system. The test items are received signal electric field strength, noise margin, ease of reception and subjective evaluation of the picture quality for received signals. We used 3rd, 5th, and 6th generation DTV receivers to examine the differences of the receivability by each generation of DTV receivers. Reviewing the test results, we conclude that the DTxR system can be adopted in the current DTV Repeater sites and it could improve the quality and receivability of the main signals by extending the service areas and enhancing the signal levels in the shadow areas without using the extra broadcasting channels.

• The Journal of the Korea Contents Association
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• v.20 no.8
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• pp.368-374
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• 2020

Journaling file systems (JFS) manage changes of file systems not yet committed in a data structure known as a journal to restore the file system in the event of an unexpected failure. Extra write operations required for journaling negatively affect the performance of JFS. The high-performance and byte-addressable non-volatile memory (NVM) was expected to easily mitigate these performance problems by providing NVM space as journal storage. However, even with such non-volatile memory technologies, performance problems still arise due to scalability problems inherent in processing transactions of JFS. To solve this problem, we proposes a technique for processing file system transactions for scalable performance. To this end, lock-free data structures are used and multiple I/O requests are allowed to simultaneously be processed on high-performance storage devices with multiple I/O channels. We evaluate the file system with the proposed technique by comparing the original ext4 file system and the recent proposed NVM-based journaling file system on a multi-core server, and experimental results show that our file system has better performance (up-to 2.9/2.3 times) than the original ext4 file system and the recent NVM-based journaling file system, respectively.

• Journal of Advanced Navigation Technology
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• v.6 no.1
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• pp.37-43
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• 2002

This paper describes the performance evaluation and analysis of Wireless Local Area Network (W-LAN) in the 5 GHz ISM-band in compliance with IEEE 802.11a. At present, most W-LAN products are based on 2.4 GHz band, but low speed (11Mbps) has the limitation to serve systems demanding high-speed data transmission. To solve this problem, it is necessary to design next generation W-LAN system with 54Mbps in the 5GHz. It is sure that implementation of next generation W-LAN will bring competitive advantages. In particular, it will support telecommunications for high-speed mobile environments as well as for fixed places such as a school zone, a lecture room, a hospital and other premises. A few simulation methods are applied to more accurate and reliable performance analysis of next generation W-LAN. To verify if continuous data service is supported for a high-speed mobile notebook, multi-path fading channels between wireless Access Point (AP) and wireless Network Interface Card (NIC) are modeled. In addition, low interference is analyzed via convolutional codes and Orthogonal Frequency-Division Multiplexing (OFDM). Also, to obtain reliable Bit Error Rate (BER), a single tap Least Mean Square (LMS) equalizer is applied. Given the above simulation, next generation W-LAN is an ideal solution for continuous data transmission in high-speed mobile environments.

• Journal of the Korea Computer Graphics Society
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• v.15 no.3
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• pp.1-9
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• 2009

Traditional computer simulation uses only traditional input and output devices. With the recent emergence of haptic techniques, which can give users kinetic and tactile feedback, the field of computer simulation is diversifying. In particular, as the virtual-reality-based surgical simulation has been recognized as an effective training tool in medical education, the practical virtual simulation of surgery becomes a stimulating new research area. The surgical simulation framework should represent the realistic properties of human organ for the high immersion of a user interaction with a virtual object. The framework should make proper both haptic and visual feedback for high immersed virtual environment. However, one model may not be suitable to simulate both haptic and visual feedback because the perceptive channels of two feedbacks are different from each other and the system requirements are also different. Therefore, we separated two models to simulate haptic and visual feedback independently but at the same time. We propose an adaptive mass-spring method as a multi-modal simulation technique to synchronize those two separated models and present a framework for a dual model of simulation that can realistically simulate the behavior of the soft, pliable human body, along with haptic feedback from the user's interaction.