• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.5 no.1
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• pp.29-37
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• 2007

A conventional single compartment model cannot simulate reasonably the migration phenomenon of contaminants through unsaturated zone, due to the intrinsic unrealistic assumption of the compartment model that contaminants entering a compartment are immediately and uniformly mixed. Although, a multi-compartments model, in which even physically identical layer is divided into multiple compartments, may be used for explaining the retardation of contaminant mass flux along with increasing number of compartments, its numerical modeling is usually time-consuming and appropriate analytical solutions have not been reported yet. In order to improve the conventional compartment models on contaminant migration through unsaturated zone, a series of analytical solutions for multi-compartments model were derived and a generalized constraint under which the results from multi-compartments model can be simply approximated by single compartment model was proposed. The simplified approximation method was verified by a simple numerical analysis on the constraint under hypothetical conditions. It was also proved that the influent contaminant transfer rate from the bulk unsaturated zone can be generally represented into a time-dependent nominal transfer rate rather than a constant. In addition, the nominal transfer rate turned out to be very sensitive to the contaminant transfer rate between compartments in unsaturated zone, but to be almost insensitive to the transfer rate from contaminated zone. It is expected that the simplified approximation method developed in this study can be used for rapid and reasonable estimation of the migration phenomenon of contaminant through unsaturated zone, instead of time-consuming multi-compartments modeling.

• Fire Science and Engineering
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• v.27 no.2
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• pp.31-39
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• 2013

The Fire Dynamics Simulator (FDS) has been applied to simulate a full-scale pool fire in well-confined and mechanically ventilated multi-compartments representative of nuclear power plant. The predictive performance of FDS was evaluated through a comparison of the numerical data with experimental data obtained by the OECD/NEA PRISME project. To identify clearly the FDS results regarding to the user-dependence in the process of FDS implementation except for the intrinsic limitation of FDS such as simple combustion model, only the over-ventilated fire condition was chosen. In particular, the importance of accurate boundary conditions (B.C.) in mechanically ventilated system were discussed in details. It was known from FDS results that the B.C. on inlet and outlet vents did significantly affect the thermal and chemical characteristics inside the compartments. Finally, it was confirmed that the FDS imposed an accurate ventilation B.C. provided qualitatively good agreement with temperatures, heat fluxes and concentrations measured inside the nuclear-type multi-compartments.

• Journal of Radiation Protection and Research
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• v.29 no.1
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• pp.41-48
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• 2004

A safety assessment code, called SAGE (Safety Assessment Groundwater Evaluation), has been developed to describe post-closure radionuclide releases and potential radiological doses for low- and intermediate-level radioactive waste (LILW) disposal in an engineered vault facility in Korea. The conceptual model implemented in the code is focused on the release of radionuclide from a gradually degrading engineered barrier system to an underlying unsaturated zone, thence to a saturated groundwater zone. The radionuclide transport equations are solved by spatially discretizing the disposal system into a series of compartments. Mass transfer between compartments is by diffusion/dispersion and advection. In all compartments, radionuclides ate decayed either as a single-member chain or as multi-member chains. The biosphere is represented as a set of steady-state, radionuclide-specific pathway dose conversion factors that are multiplied by the appropriate release rate from the far field for each pathway. The code has the capability to treat input parameters either deterministically or probabilistically. Parameter input is achieved through a user-friendly Graphical User Interface. An application is presented, which is compared against safety assessment results from the other computer codes, to benchmark the reliability of system-level conceptual modeling of the code.

• Fire Science and Engineering
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• v.27 no.2
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• pp.80-88
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• 2013

The validation of Fire Dynamics Simulator (FDS) was conducted for the under-ventilated fire in well-confined multi-compartments representative of nuclear power plant. Numerical results were compared with experimental data obtained by the OECD/NEA PRISME project. The effects of the numerical boundary conditions (B.C.) in ventilated system and the flame suppression model applied within FDS on the thermal and chemical environments inside the compartment were discussed in details. It was found that numerical B.C. on the vent flow resulting from over-pressure at ignition and under-pressure at extinction should be considered carefully in order to predict accurately the species concentrations rather than temperatures and heat fluxes inside the multi-compartment. The default information of suppression model applied within FDS resulted in artificial phenomena such as flame extinction and re-ignition, and thus the FDS results on the under-ventilated fire showed good agreement with the experimental results as the modified suppression criteria of the fuel used was adopted.

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.12
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• pp.1164-1171
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• 2004

A new multi-scale simulation model is proposed to analyze heart mechanics. Electrophysiology of a cardiac cell is numerically approximated using the previous model of human ventricular myocyte. The ion transports across cell membrane initiated by action potential induce an excitation-contraction mechanism in the cell via cross bridge dynamics. Negroni and Lascano model (NL model) is employed to calculate the tension of cross bridge which is closely related to the ion dynamics in cytoplasm. To convert the tension on cell level into contraction force of cardiac muscle, we introduce a simple geometric model of ventricle with a thin-walled hemispheric shape. It is assumed that cardiac tissue is composed of a set of cardiac myocytes and its orientation on the hemispheric surface of ventricle remains constant everywhere in the domain. Application of Laplace law to the ventricle model enables us to determine the ventricular pressure that induces blood circulation in a body. A lumped parameter model with 7 compartments is utilized to describe the systemic circulation interacting with the cardiac cell mechanism via NL model and Laplace law. Numerical simulation shows that the ion transports in cell level eventually generate blood hemodynamics on system level via cross bridge dynamics and Laplace law. Computational results using the present multi-scale model are well compared with the existing ones. Especially it is shown that the typical characteristics of heart mechanics, such as pressure volume relation, stroke volume and ejection fraction, can be generated by the present multi-scale cardiovascular model, covering from cardiac cells to circulation system.

• Journal of the Korea Society for Simulation
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• v.30 no.3
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• pp.19-29
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• 2021

To explain the interregional infections in COVID-19, we designed a multi-group compartmental model by applying the SEIQRD model, a compartmental model of a single group. The model is segmented by compartments to account for hidden infections, such as latent periods and asymptomatic cases, and is capable of comparing infection indices and test rates between regions. Through this, it estimated which region was centered during the second wave in August 2020 and the third wave in November 2020. Subgroups were set up in Seoul, Gyeonggi (including Incheon), and a non-metropolitan area. We fit the model to the Ministry of Health and Welfare's data to estimate the average infection index between regions, average rate of rT-PCR test by region, and the expected number of hidden infections by region.

• Advances in aircraft and spacecraft science
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• v.3 no.1
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• pp.77-93
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• 2016

In this paper, a zero-dimensional mathematical formulation for rapid and explosive decompression analyses of pressurized aircraft is developed. Air flows between two compartments and between the damaged compartment and external ambient are modeled by assuming an adiabatic, reversible transformation. Both supercritical and subcritical decompressions are considered, and the attention focuses on intercompartment venting systems. In particular, passive and active vents are addressed, and mathematical models of both swinging and translational blowout panels are provided. A numerical procedure based on an explicit Euler integration scheme is also discussed for multi-compartment aircraft analysis. Various numerical solutions are presented, which highlight the importance of considering the opening dynamics of blowout panels. The comparisons with the results from the literature demonstrate the validity of the proposed methodology, which can be also applied, with no lack of accuracy, to the decompression analysis of spacecraft.

• Korean Journal of Clinical Pharmacy
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• v.31 no.2
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• pp.125-135
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• 2021

Background: Generally, pharmacokinetics (PK) models could be stratified into two models. The compartment PK model uses the concept of simple compartmentalization to describe complex bodies, and the physiologically based pharmacokinetic (PBPK) model describes the body using multi-compartment networking. Notwithstanding sharing a theoretical background in both models, there was still a lack of knowledge to enhance compatibility in both models. Objective: This study aimed to evaluate the compatibility among PBPK, lumping model and compartment PK model with voriconazole PK case study. Methods: The number of compartments and blood flow on each tissue in the PBPK model were modified using the lumping method, considering physiological similarities. The concentration-time profiles and area under the concentration-time curve (AUC) parameters were simulated at each model, assuming taken voriconazole oral 400 mg single dose. After that, those mentioned PK parameters were compared. Results: The PK profiles and parameters of voriconazole in the three models were similar that proves their compatibility. The AUC of central compartment in the PBPK and lumping model was within a 2-fold range compared to those in the 2- compartment model. The AUC of non-eliminating tissues compartment in the PBPK model was similar to those in the lumping model. Conclusion: Regarding the compatibility of the three PK models, the utilization of the lumping method was confirmed by suggesting its reliable PK parameters with PBPK and compartment PK models. Further case studies are recommended to confirm our findings.