• Archives of Plastic Surgery
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• 제48권2호
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• pp.231-236
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• 2021

Mucormycosis is an invasive, rapidly progressive, life-threatening fungal infection, with a propensity for diabetic, immunosuppressed, and trauma patients. The classic rhinocerebral variation is most common in diabetic patients. While the cutaneous form is usually caused by direct inoculation in immunocompetent patients. Cutaneous mucormycosis manifests in soft tissue and risks involvement of underlying structures. Tibial osteomyelitis can also occur secondary to cutaneous mucormycosis but is rare. Limb salvage is typically successful after lower extremity cutaneous mucormycosis even when the bone is involved. Herein, we report two cases of lower extremity cutaneous mucormycosis in diabetic patients that presented as acute worsening of chronic pretibial ulcers. Despite aggressive antifungal therapy and surgical debridement, both ultimately required amputation. Such aggressive presentation has not been reported in the absence of major penetrating trauma, recent surgery, or burns.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권1호
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• pp.69-73
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• 2004

뮤코르 진균증은 드물게 발생하지만 종종 치명적일 수 있으며, Phycomycetes종의 기회 감염에 의해 발생한다. 이 미생물은 부생의 호기성 진균(saprophytic aerobial fungus)이며 구강 점막, 부비동과 목에 통상적으로 존재하며 부패해 가는 식물, 거름, 고당 함유 음식 등에 나타난다. 뮤코르 진균증은 다양한 유형의 임상 형태로 면역결핍환자들에서 빠른 진행과 높은 치사율로 나타난다. 그러나 건강한 사람에서 두경부 영역에 감염된 예는 거의 없다. 본 교실에서는 58세 당뇨병이 있는 남자 환자에서 상악에 발생한 뮤코르 진균증의 증례에서 외과적 절제술과 ampotericin B의 정맥내 투여로 치료 되었으며, 현재까지 특별한 재발 소견 없이 양호한 결과를 얻었기에 이를 문헌 고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제49권1호
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• pp.117-121
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• 2000

폐모균증은 치명적인 결과를 초래하는 기회감염으로 조기진단 및 치료가 요망된다. 하지만 본 증례와 같이 폐모균증의 방사선학적 소견은 비특이적이므로 조기 진단이 용이하지 않다. 이에 저자들은 폐모균종의 발생 위험인자를 내포한 환자가 항생제에 반응을 보이지 않으면서 방사선 소견상 폐의 경화, 종괴, 결절, 공동 등의 소견을 보이는 경우 폐모균증올 고려함이 필요하다고 생각되어 문헌고찰과 함께 본 증례를 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제45권5호
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• pp.1087-1093
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• 1998

Mucormycosis is the common name given to several different diseases caused by fungi of the order Mucorales. The mucoraceae are ubiquitous fungi and are common inhabitants of decaying matter. In contrast to the widespread distribution of these fungi, disease in humans is limited, in most cases, to people with severe immunocompromised, diabetes mellitus, or trauma. 1be fungus gains entry to the body through the respiratory tract. The spores are presumably deposited in the nasal turbinates and may be inhaled into the pulmonary alveoli. The manifestations of mucormycosis are rhinocerebral, pulmonary, cutaneous, gastrointestinal, central nervous system, and miscellaneous. Sporadic reports can be found of mucormycosis involving other areas : heart, bones, kidney, bladder, mediastinum, and trachea. However, isolated tracheal mucormycosis is very rare. Therefore, we report a 57-year old, noninsulin dependent diabetic woman who presented with acute, severe degree of upper airway obstruction due to isolated mucormycosis of the trachea.

• 대한영상의학회지
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• 제85권2호
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• pp.474-479
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• 2024

Mucormycosis는 Mucorales에 의해 유발되는 진균 감염으로, 다양한 장기를 침범할 수 있으며 그중에서도 폐점균증은 드물지만 특히 면역 저하 환자에서 생명을 위협하는 기회 감염이다. 폐점균증의 영상 소견은 다양하지만, 폐점액진균증 환자에서 점점 커지는 폐동맥색전증을 모방하는 경우는 드물게 보고되었다. 저자들은 골수이형성 증후군 환자에서 종괴와 폐색전증을 모방한 혈관 침습성 점막 진균증의 증례에 대해 보고하고자 한다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제15권1호
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• pp.21-25
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• 1993

We experienced a case of rhinocerebral form of mucormycosis in a 9-year-old male suffered from acute lymphocytic leukemia (FAB $L_2$). On 15th day of induction chemotherapy (Hospital day 23) pain, tenderness and swelling on left maxillary area of face were noticed. We confirmed mucormycosis by biopsy of mass in left maxillary sinus. He expired on Hospital day 47.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제42권2호
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• pp.105-110
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• 2016

Oral mucormycosis is a fungal infection observed mainly in elderly immunocompromised patients. In rare instances, the disease occurs in healthy individuals and those patients that are below preschool age. Although this condition mainly involves the maxilla, it may also manifest in any part of the oral cavity based on the source of infection. Mucormycosis of the maxilla spreads rapidly, leading to necrosis of the palatal bone and palatal perforation. Such patients are usually rehabilitated using bone grafting or free flap surgeries. However, when surgeries are delayed, palatal prosthesis is an interim treatment modality that can prevent nasal regurgitation and aspiration of food or fluids. Palatal prostheses also help with mastication, speech, and swallowing. The present case describes a rare case of oral mucormycosis in an 18-month-old male involving the maxilla that was managed by palatal prosthesis.

• Journal of Oral Medicine and Pain
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• 제39권1호
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• pp.29-33
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• 2014

Mucormycosis is a rare but fatal fungal infection with low survival rate in immune-compromised patients. It is caused by a fungus belonging to the Mucoraceae family of the Zygomycetes class. Mucormycosis is classified as rhino-orbital-cerebral, pulmonary, cutaneous, gastrointestinal, disseminated, and miscellaneous types according to its clinical manifestations. Early diagnosis and treatment along with correction of the underlying medical condition is important for favorable results. This case presentation describes mucormycosis involving the anterior maxillary region in a leukemic patient with prolonged neutropenia. The patient benefited from a timely biopsy and immediate treatment with amphotericin B, and was successfully managed with an interdisciplinary team approach consisting of dental and several medical specialists.

• Journal of Korean Neurosurgical Society
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• 제39권6호
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• pp.455-458
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• 2006

Rhinocerebral mucormycosis is rare, but fatal infection of the nasal cavity and sinuses. It can spread to the orbits and cranium within days, and prognosis is directly associated with length of time before diagnosis and treatment. Rhinocerebral mucormycosis can cause cerebral infarction via carotid a artery occlusion. Therefore, neurosurgeon is paramount in making the proper management. We recently encountered a case of rhinocerebral mucormycosis with massive cerebral infarction. The clinical and radiological details of this case are presented here with a brief review of the literature.

• Imaging Science in Dentistry
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• 제52권4호
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• pp.435-440
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• 2022

Mucormycosis is a rare, invasive fungal infection that progresses aggressively and requires prompt surgery and appropriate treatment. The number of cases of mucormycosis in coronavirus disease 2019 (COVID-19) patients has recently increased, and patients with uncontrolled diabetes mellitus are particularly at an elevated risk of infection. This report presents a case of mucormycosis-related osteomyelitis of the maxilla in a 37-year-old man with diabetes mellitus. The patient complained of severe and persistent pain in the right maxilla, accompanied by increased tooth mobility and headache. On contrast-enhanced computed tomographic images, gas-forming osteomyelitis of the right maxilla was observed. Destruction of the maxilla and palatine bone then proceeded aggressively. Sequestrectomy was performed on the right maxilla, and the histopathological diagnosis was mucormycosis. Further investigation after the first operation revealed the patient's history of COVID-19 infection.