• Advances in Traditional Medicine
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• 제8권1호
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• pp.93-96
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• 2008

The ethanolic extract of Ficus racemosa Lin. (Moraceae) bark and fruit were tested for its possible antinociceptive activity study on acetic acid induced writhing method in mice. Both the bark and fruit extracts at a dose of 500 mg/kg body weight showed significant antinociceptive activity on the experimental animals. The fruit extract showed most potent inhibition of acetic acid induced writhing in mice (61.38%, P < 0.001) where as the bark extract showed inhibition only 42.6% (P < 0.001) and all the result were statistically significant.

• 생명과학회지
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• 제14권1호
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• pp.104-109
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• 2004

많은 항산화제가 식물 잎에 존재한다고 알려져 있으나, 식물 잎의 성장시기에 따른 항산화제의 변화에 관한 연구는 드물다. 따라서 본 연구는 감잎, 뽕잎, 탱자나무잎에 존재하는 항산화 성분의 양을 잎의 성장 시기별로 조사하였다. 총 polyphenol의 함량은 잎이 성장하면서 감소하는 경향을 보였는데, 생육초기인 4월에 채취한 감잎의 경우 총 polyphenol의 함량이 4.62 g/dried 100 g으로 나타나, 뽕잎 1.70 g/dried 100 g와 탱자나무잎 0.91 g/dried 100 g에 비해 2.7∼5.1배 많이 검출되었다. Ascorbic acid의 함량도 성장함에 따라 감소하는 경향을 보였는데, 뽕잎이 2.7∼6.0, 감잎이 5.3∼9.9, 탱자나뭇잎이 3.7∼6.9 mg/dried 100 g으로 감잎이 뽕잎이나 탱자나무에 비해 높게 나타났다. Glutathione리 함량도 성장함에 따라 감소하는 경향을 나타내었는데, 그 평균함량은 탱자나뭇잎이 35.7, 뽕잎이 15.8, 감잎이 2.3 mg/dried 100 g으로 탱자나뭇잎에서 현저하게 높게 나타났다. $\beta$-Carotene의 함량은 성장을 함에 따라 점차 증가하는 경향을 보였는데, 성장 후기인 9월에 채취한 잎의 경우, 뽕잎이 411.2 mg/dried 100 g으로 나타나, 감잎 198.5, 탱자나뭇잎 144.1 mg/dried 100 g보다 높은 수준으로 검출되었다. $\alpha$-Tocopherol의 함량도 성장함에 따라 증가하는 경향을 나타내었는데, 성장 후기인 9월에는 탱자나뭇잎이 52.8, 뽕잎이 48.6, 감잎이 61.7 mg/dried 100 g으로 나타나, 감잎이 다소 높게 검출되었다.

• Archives of Pharmacal Research
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• 제3권2호
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• pp.75-78
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• 1980

Potential antinumor activity of sixteen Korean medicinal plants was tested against leukemia SN 36, murine tomor model. Survival studies by measuring life span indicated that Morus alba (Moraceae), Verbascum phlomoides (Scrophulariaceae), Curcuma longa (Zingbieraceae), Torilis japonica (Umbelliferae), Bupleurum falcatum (Umbelliferae) and Codonopsis pilosula (Campanulaceae) exhibited significant antitumor activity with the dose-schedule employed in the experiment. Methanol (70%) extracts of Platycodon gradiflorum (Campanulaceae), Bupleurum longeradiatum (Umbelliferae) and Asiasarum sieboldii (Aristolochiaceae) showed rather potent toxicity.

• 식물분류학회지
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• 제39권2호
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• pp.80-85
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• 2009

한국산 닥나무속 식물의 분류학적 특징을 재검토하였다. 한지를 만드는데 사용해 온 닥나무와 꾸지 나무의 교잡종인 꾸지닥나무가 전남 신안군 흑산면 가거도에서 자생하고 있어 새로이 Broussonetia ${\times}$ hanjiana M. Kim으로 명명하였다. 꾸지닥나무는 그동안 일반인들이 닥나무라고 일컫기 때문에 꾸지닥나무 대신에 닥나무라고 하였다. 따라서 Broussonetia kazinoki는 닥나무 대신에 애기닥나무라고 변경하였다. 또한 가거도에서 발견된 자웅이주인 애기닥나무를 가거애기닥나무(B. kazinoki for. koreana M. Kim)라고 새로이 명명하였다.

• Archives of Pharmacal Research
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• 제28권1호
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• pp.44-48
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• 2005

Phytochemical investigation of the MeOH extract of the root barks of Cudrania tricuspidata Bureau (Moraceae), as guided by hepatoprotective activity in vitro, furnished four isoprenylated xanthones, cudratricusxanthone A (1), cudraxanthone L (2), cudratricusxanthone E (3), and macluraxanthone B (4). All of these compounds showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Compounds 1, 2, and 4 also exhibited the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.

• 약학회지
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• 제36권1호
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• pp.40-45
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• 1992

Four flavonoids have been isolated from the leaves and stems of Cudrania tricuspidata Bureau (Moraceae) in Korea. They were kaempferol and kaempferol $7-O-{\beta}-D-glucopyranoside$ from the leaves, and kaempferide $7-O-{\beta}-D-glucopyranoside$ and naringenin $7-O-{\beta}-D-glucopyranoside$ from the stem respectively. The structures were established by spectroscopic and chemical methods.

• Natural Product Sciences
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• 제8권4호
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• pp.129-132
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• 2002

The MeOH extract of the twig of Morus alba L. (Moraceae) inhibited strong lipid peroxidation activity. In order to find out active principle from the plant, acivity-guided fractionation was performed and five antioxidant compounds were isolated. Their chemical structures were identified as 6-geranylapigenin (1), 6-geranylnorartocarpetin (2), resveratrol (3), oxyresveratrol (4) and quercetin (5) by physicochemical and spectrometric methods. Compounds 1-5 significantly inhibited lipid peroxidation in rat brain homogenate $(IC_{50}\;values\;of\;3.37,\;3.74,\;0.23,\;0.29\;and\;0.06\; {\mu}M,\;respectively)$.

• Archives of Pharmacal Research
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• 제22권1호
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• pp.81-85
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• 1999

Nine flavonoids (1-9) were isolated from the leaves of Morus alba (Moraceae). The structures of compounds were determined to be kaempferol-3-O-$\beta$-glucopyranoisde (astragalin, 1) kaempferol-3-O-(6"-O-acetyl)-$\beta$-D-glucopyranoside (2), quercetin-3-O-(6"-O-acetyl)-$\beta$-D-glucopyranoside (3), quercetin-3-O-$\beta$-D-glucopyranoside (4), kaempferol-3-O-$\alpha$-L-rhamnopyranosyl-(1 6)-$\beta$-D-glucopyranoside (5), quercetin-3-O-$\alpha$-L-rhamnopyranosyl-(1 6)-$\beta$-D-glucopyranoside (rutin, 6), quercetin-3-O-$\beta$-D-glucopyranosyl-(1 6)-$\beta$-D-glucopyranoside (7), quercetin-3,7-di-O-$\beta$-D-glucopyranoside (8) and quercetin (9) on th basis of spectroscopic and chemical studies. Compounds 7 and 9 exhibited significant radical scavenging effect on 1,1-diphenyl-2-picryl-hydrazyl radical.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2019년도 추계학술대회
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• pp.41-41
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• 2019

The genus Ficus L., containing approximately 850 species, is by far the largest genus in the Moraceae. They are mainly distributed worldwide, mainly in tropical countries. In South Korea, there are three native Ficus (including F. erecta Thunb, F. sarmentosa var. nipponica (Franch. & Sav.) Corner, and F. thunbergii Maxim.). Among them, F. erecta is effectively natural resources for the improvement of senile cognitive impairment. However, the chloroplast (cp) genome sequences and information of F. erecta have not been addressed. Therefore, in this study, we provide the complete cp genome of F. erecta and its allied species using next-generation sequencing technology. The chloroplast of Ficus species has typical structure which includes large and small single copy regions and a pair of inverted repeats (IRs). The sizes of cp genomes range from 160,276 bp to 160,603 bp. To determine the phylogenetic positions of these species, we conducted a maximum likelihood analysis using common protein-coding genes in chloroplast sequences. Also, we describe a newly developed single nucleotide polymorphism (SNP) markers using multiplex PCR to identify F. erecta based on amplification-refractory mutation system (ARMS) technique. We analyzed matK, atpB of the chloroplast genes and ITS from F. erecta and three related taxa, F. carica, F. sarmentosa var. nipponica and F. thunbergii. It provides useful information for molecular identification between F. erecta and related Korean native species.

• 약학회지
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• 제41권4호
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• pp.439-443
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• 1997

From the root bark of Broussonetia kazinoki (Moraceae) two antioxidant components were identified. Their structures were determined as kazinol A (1) and kazinol E (2) (is oprenylated flavan and isoprenylated 1,3-diphenyl propan derivatives) by comparing NMR data with those of the reported compounds from relative plants. The antioxidant activity of 1 and 2 were monitored by the method of DPPH radical scavenging activity, whose $SC_{50}$ values were $41.4{\mu}M\;and\;33.4{\mu}M$, respectively. These compounds also exhibited inhibitory activity against tyrosinase, which is the sole key enzyme for the melanin biosynthesis and play a role in conversion of tyrosine to dopa, and dopa to dopaquinone. The antioxidant effect and the suppression of melanin biosynthesis are useful for anti-aging, increasing vitality in the incidence of major degenerative diseases, and cosmetic products in relation to hyperpigmentation.